YIR021W-A_p

Putative protein of unknown function; identified by expression profiling and mass spectrometry

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR021W-A / YIR021W-A

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:3.46|P-value:3.03E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.87|P-value:6.12E-5 ID:SGTC_92|Compound:0063-0024|FD-Score:-3.67|P-value:1.33E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.20|P-value:7.48E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:-4.21|P-value:1.46E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.16|P-value:8.66E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-4.79|P-value:1.01E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:3.14|P-value:9.13E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.06|P-value:9.19E-10 ID:SGTC_353|Compound:1988-1175|FD-Score:-4.08|P-value:2.53E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:3.48|P-value:2.77E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.15|P-value:9.05E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:7.49|P-value:5.38E-14 ID:SGTC_800|Compound:3448-7362|FD-Score:5.73|P-value:6.59E-9 ID:SGTC_802|Compound:4112-3352|FD-Score:3.22|P-value:7.09E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:-3.20|P-value:7.50E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.34|P-value:4.57E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.57|P-value:2.02E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.68|P-value:1.29E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.67|P-value:1.37E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.49|P-value:2.72E-4 ID:SGTC_1714|Compound:st033236|FD-Score:4.42|P-value:5.84E-6 ID:SGTC_1716|Compound:st033144|FD-Score:3.27|P-value:5.86E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.37|P-value:4.17E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.32|P-value:4.99E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.04|P-value:3.10E-5 ID:SGTC_2466|Compound:5983409|FD-Score:4.77|P-value:1.11E-6 ID:SGTC_2474|Compound:5321570|FD-Score:3.50|P-value:2.64E-4 ID:SGTC_2602|Compound:kawain|FD-Score:4.02|P-value:3.37E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.85|P-value:6.85E-5 ID:SGTC_2809|Compound:7964133|FD-Score:3.60|P-value:1.79E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-6.19|P-value:4.06E-10 ID:SGTC_2932|Compound:9016711|FD-Score:4.42|P-value:5.95E-6 ID:SGTC_2935|Compound:9038016|FD-Score:4.25|P-value:1.24E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:3.46|P-value:3.03E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.87|P-value:6.12E-5 ID:SGTC_92|Compound:0063-0024|FD-Score:-3.67|P-value:1.33E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.20|P-value:7.48E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:-4.21|P-value:1.46E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.16|P-value:8.66E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-4.79|P-value:1.01E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:3.14|P-value:9.13E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.06|P-value:9.19E-10 ID:SGTC_353|Compound:1988-1175|FD-Score:-4.08|P-value:2.53E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:3.48|P-value:2.77E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.15|P-value:9.05E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:7.49|P-value:5.38E-14 ID:SGTC_800|Compound:3448-7362|FD-Score:5.73|P-value:6.59E-9 ID:SGTC_802|Compound:4112-3352|FD-Score:3.22|P-value:7.09E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:-3.20|P-value:7.50E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.34|P-value:4.57E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.57|P-value:2.02E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.68|P-value:1.29E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.67|P-value:1.37E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.49|P-value:2.72E-4 ID:SGTC_1714|Compound:st033236|FD-Score:4.42|P-value:5.84E-6 ID:SGTC_1716|Compound:st033144|FD-Score:3.27|P-value:5.86E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.37|P-value:4.17E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.32|P-value:4.99E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.04|P-value:3.10E-5 ID:SGTC_2466|Compound:5983409|FD-Score:4.77|P-value:1.11E-6 ID:SGTC_2474|Compound:5321570|FD-Score:3.50|P-value:2.64E-4 ID:SGTC_2602|Compound:kawain|FD-Score:4.02|P-value:3.37E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.85|P-value:6.85E-5 ID:SGTC_2809|Compound:7964133|FD-Score:3.60|P-value:1.79E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-6.19|P-value:4.06E-10 ID:SGTC_2932|Compound:9016711|FD-Score:4.42|P-value:5.95E-6 ID:SGTC_2935|Compound:9038016|FD-Score:4.25|P-value:1.24E-5

Top fitness defect scores for YIR021W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_625 k213-0058 7.49 121.0 µM 5.38E-14 translation 16 3.37E-14
2 SGTC_236 1509-0011 6.06 5.3 µM 9.19E-10 291 6.74E-10
3 SGTC_800 3448-7362 5.73 155.0 µM 6.59E-9 translation 58 4.99E-9
4 SGTC_2466 5983409 4.77 37.1 µM 1.11E-6 11 9.10E-7
5 SGTC_1714 st033236 4.42 13.6 µM 5.84E-6 13 4.92E-6
6 SGTC_2932 9016711 4.42 44.5 µM 5.95E-6 34 5.01E-6
7 SGTC_2935 9038016 4.25 30.0 µM 1.24E-5 12 1.06E-5
8 SGTC_2396 5342950 4.04 42.8 µM 3.10E-5 RSC complex & mRNA processing 40 2.69E-5
9 SGTC_2602 kawain 4.02 100.0 µM 3.37E-5 24 2.92E-5
10 SGTC_90 0870-0863 3.87 4.6 µM 6.12E-5 47 5.36E-5
11 SGTC_2752 diclazuril 3.85 33.1 µM 6.85E-5 127 6.00E-5
12 SGTC_1296 1068-0102 3.68 11.9 µM 1.29E-4 12 1.14E-4
13 SGTC_1311 1190-0148 3.67 100.0 µM 1.37E-4 azole & statin 33 1.21E-4
14 SGTC_2809 7964133 3.60 13.0 µM 1.79E-4 60S ribosome export 50 1.59E-4
15 SGTC_1022 4477-0945 3.57 21.3 µM 2.02E-4 39 1.80E-4
16 SGTC_2474 5321570 3.50 43.3 µM 2.64E-4 25 2.36E-4
17 SGTC_1635 st007035 3.49 42.4 µM 2.72E-4 252 2.43E-4
18 SGTC_371 0195-0006 3.48 7.4 µM 2.77E-4 35 2.48E-4
19 SGTC_56 0957-0365 3.46 83.2 µM 3.03E-4 Golgi 69 2.72E-4
20 SGTC_2130 NSC 7 3.37 2.5 µM 4.17E-4 copper-dependent oxidative stress 56 3.76E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.251 1.80E-49 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.244 1.14E-46 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.243 2.74E-46 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.242 4.21E-46 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.242 4.45E-46 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.241 1.76E-45 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.238 1.68E-44 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.236 9.60E-44 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.235 1.87E-43 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.235 2.38E-43 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.233 1.41E-42 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.232 4.85E-42 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.229 5.89E-41 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.228 6.92E-41 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.227 1.52E-40 YDL107W MSS2 hom Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p