YIR022W / SEC11

18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIR022W / SEC11

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:-3.91|P-value:2.69E-5 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.62|P-value:1.06E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:-3.00|P-value:9.32E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:5.35|P-value:1.95E-8 ID:SGTC_625|Compound:k213-0058|FD-Score:3.46|P-value:1.99E-4 ID:SGTC_678|Compound:1218-2179|FD-Score:3.10|P-value:7.53E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:4.96|P-value:1.82E-7 ID:SGTC_706|Compound:4262-0057|FD-Score:4.26|P-value:6.39E-6 ID:SGTC_874|Compound:0599-0792|FD-Score:-3.19|P-value:4.76E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.14|P-value:6.41E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-3.19|P-value:4.73E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.08|P-value:8.14E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.56|P-value:1.32E-4 ID:SGTC_1784|Compound:st039334|FD-Score:4.35|P-value:3.99E-6 ID:SGTC_1850|Compound:st056238|FD-Score:3.53|P-value:1.46E-4 ID:SGTC_1899|Compound:st063254|FD-Score:3.32|P-value:3.38E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.20|P-value:5.18E-4 ID:SGTC_1954|Compound:st077032|FD-Score:4.06|P-value:1.55E-5 ID:SGTC_2020|Compound:4017018|FD-Score:9.39|P-value:2.33E-22 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.74|P-value:5.81E-7 ID:SGTC_2338|Compound:7999974|FD-Score:3.18|P-value:5.64E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:4.14|P-value:1.09E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.39|P-value:2.56E-4 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:3.12|P-value:7.12E-4 ID:SGTC_2715|Compound:st079500|FD-Score:5.52|P-value:7.45E-9 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.65|P-value:9.31E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.35|P-value:3.04E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.29|P-value:3.80E-4 ID:SGTC_2920|Compound:7982904|FD-Score:4.42|P-value:2.92E-6 ID:SGTC_2925|Compound:9010536|FD-Score:3.32|P-value:3.37E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-4.71|P-value:5.79E-7 ID:SGTC_2927|Compound:9011802|FD-Score:3.80|P-value:5.01E-5 ID:SGTC_2944|Compound:9067346|FD-Score:6.86|P-value:9.05E-13 ID:SGTC_2945|Compound:9067681|FD-Score:3.20|P-value:5.27E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.14|P-value:6.61E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.88|P-value:3.05E-5 ID:SGTC_3065|Compound:9113888|FD-Score:7.84|P-value:4.12E-16 ID:SGTC_3071|Compound:9117417|FD-Score:-3.97|P-value:2.06E-5 ID:SGTC_3074|Compound:9116018|FD-Score:3.22|P-value:4.86E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.85|P-value:3.92E-5 ID:SGTC_3202|Compound:9113761|FD-Score:-3.18|P-value:5.02E-4 ID:SGTC_3243|Compound:9134147|FD-Score:3.45|P-value:2.07E-4 ID:SGTC_3289|Compound:9119912|FD-Score:-3.04|P-value:8.31E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.39|P-value:2.55E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:-3.91|P-value:2.69E-5 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.62|P-value:1.06E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:-3.00|P-value:9.32E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:5.35|P-value:1.95E-8 ID:SGTC_625|Compound:k213-0058|FD-Score:3.46|P-value:1.99E-4 ID:SGTC_678|Compound:1218-2179|FD-Score:3.10|P-value:7.53E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:4.96|P-value:1.82E-7 ID:SGTC_706|Compound:4262-0057|FD-Score:4.26|P-value:6.39E-6 ID:SGTC_874|Compound:0599-0792|FD-Score:-3.19|P-value:4.76E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.14|P-value:6.41E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-3.19|P-value:4.73E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.08|P-value:8.14E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.56|P-value:1.32E-4 ID:SGTC_1784|Compound:st039334|FD-Score:4.35|P-value:3.99E-6 ID:SGTC_1850|Compound:st056238|FD-Score:3.53|P-value:1.46E-4 ID:SGTC_1899|Compound:st063254|FD-Score:3.32|P-value:3.38E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.20|P-value:5.18E-4 ID:SGTC_1954|Compound:st077032|FD-Score:4.06|P-value:1.55E-5 ID:SGTC_2020|Compound:4017018|FD-Score:9.39|P-value:2.33E-22 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.74|P-value:5.81E-7 ID:SGTC_2338|Compound:7999974|FD-Score:3.18|P-value:5.64E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:4.14|P-value:1.09E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.39|P-value:2.56E-4 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:3.12|P-value:7.12E-4 ID:SGTC_2715|Compound:st079500|FD-Score:5.52|P-value:7.45E-9 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.65|P-value:9.31E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.35|P-value:3.04E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.29|P-value:3.80E-4 ID:SGTC_2920|Compound:7982904|FD-Score:4.42|P-value:2.92E-6 ID:SGTC_2925|Compound:9010536|FD-Score:3.32|P-value:3.37E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-4.71|P-value:5.79E-7 ID:SGTC_2927|Compound:9011802|FD-Score:3.80|P-value:5.01E-5 ID:SGTC_2944|Compound:9067346|FD-Score:6.86|P-value:9.05E-13 ID:SGTC_2945|Compound:9067681|FD-Score:3.20|P-value:5.27E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.14|P-value:6.61E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.88|P-value:3.05E-5 ID:SGTC_3065|Compound:9113888|FD-Score:7.84|P-value:4.12E-16 ID:SGTC_3071|Compound:9117417|FD-Score:-3.97|P-value:2.06E-5 ID:SGTC_3074|Compound:9116018|FD-Score:3.22|P-value:4.86E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.85|P-value:3.92E-5 ID:SGTC_3202|Compound:9113761|FD-Score:-3.18|P-value:5.02E-4 ID:SGTC_3243|Compound:9134147|FD-Score:3.45|P-value:2.07E-4 ID:SGTC_3289|Compound:9119912|FD-Score:-3.04|P-value:8.31E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.39|P-value:2.55E-4

Top fitness defect scores for YIR022W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2020 4017018 9.39 200.0 µM 2.33E-22 1 2.86E-21 2.06
2 SGTC_3065 9113888 7.84 49.5 µM 4.12E-16 1 2.33E-15 1.89
3 SGTC_2944 9067346 6.86 25.6 µM 9.05E-13 3 3.38E-12 0.99
4 SGTC_2715 st079500 5.52 56.4 µM 7.45E-9 1 1.73E-8 0.89
5 SGTC_425 3825-7017 5.35 13.1 µM 1.95E-8 5 4.28E-8 1.10
6 SGTC_680 0417-1641 4.96 114.0 µM 1.82E-7 RPP1 & pyrimidine depletion 3 3.56E-7 0.23
7 SGTC_2250 alverine citrate 4.74 130.0 µM 5.81E-7 26 1.07E-6 0.04
8 SGTC_2920 7982904 4.42 15.8 µM 2.92E-6 9 4.96E-6 0.56
9 SGTC_1784 st039334 4.35 36.3 µM 3.99E-6 6 6.68E-6 0.15
10 SGTC_706 4262-0057 4.26 46.9 µM 6.39E-6 fatty acid desaturase (OLE1) 7 1.04E-5 0.00
11 SGTC_2510 benzyl isothiocyanate 4.14 8.3 µM 1.09E-5 23 1.73E-5 0.07
12 SGTC_1954 st077032 4.06 68.9 µM 1.55E-5 7 2.41E-5 0.44
13 SGTC_3124 9127567 3.85 49.5 µM 3.92E-5 DNA damage response 5 5.84E-5 0.02
14 SGTC_2927 9011802 3.80 47.9 µM 5.01E-5 9 7.37E-5 0.17
15 SGTC_2773 thioridazine 3.65 9.1 µM 9.31E-5 3 1.33E-4 0.35
16 SGTC_231 b-estradiol 3.62 524.0 µM 1.06E-4 2 1.50E-4 0.22
17 SGTC_1525 8-methoxypsoralen 3.56 92.5 µM 1.32E-4 DNA damage response 18 1.85E-4 0.06
18 SGTC_1850 st056238 3.53 17.0 µM 1.46E-4 RPP1 & pyrimidine depletion 5 2.04E-4 0.10
19 SGTC_625 k213-0058 3.46 121.0 µM 1.99E-4 translation 29 2.74E-4 0.04
20 SGTC_3243 9134147 3.45 49.5 µM 2.07E-4 6 2.84E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 9.46E-13 YLR262C-A TMA7 hom Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress
0.080 3.65E-6 YPR043W RPL43A hom Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication
0.077 7.65E-6 YMR299C DYN3 hom Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration
0.075 1.53E-5 YER115C SPR6 hom Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation
0.074 1.62E-5 YJL001W PRE3 het Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
0.073 2.49E-5 YNR057C BIO4 hom Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels
0.073 2.55E-5 YMR163C INP2 hom Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene
0.072 2.75E-5 YBR028C YPK3 hom An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner
0.071 3.69E-5 YER124C DSE1 hom Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.070 4.72E-5 YGR210C_p YGR210C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.070 5.02E-5 YLR092W SUL2 hom High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
0.070 5.07E-5 YDL141W BPL1 het Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation
0.069 6.57E-5 YFR048W RMD8 hom Cytosolic protein required for sporulation
0.068 7.59E-5 YER049W TPA1 hom Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate
0.068 7.59E-5 YHR120W MSH1 hom DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis