HIPHOP chemogenomics database

YIR023W / DAL81

Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism

Zygosity: Homozygous strain

fixedexpanded
Profile for YIR023W / DAL81

Click on Significant Values for Screen Details

Top fitness defect scores for YIR023W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2460	5552655	41.60	174.2 µM	3.37E-120	amide catabolism	1	0
2	SGTC_2845	9003024	39.30	43.0 µM	9.99E-108	amide catabolism	1	0
3	SGTC_486	niguldipine	35.50	82.0 µM	5.99E-88	amide catabolism	1	8.94E-276
4	SGTC_990	3985-0011	26.40	41.3 µM	1.31E-49	amide catabolism	1	7.04E-154
5	SGTC_337	1315-0038	25.50	354.0 µM	2.52E-46	amide catabolism	1	1.89E-143
6	SGTC_1058	3448-5425	21.50	97.3 µM	1.12E-33		1	2.89E-103
7	SGTC_2093	5331342	21.00	194.4 µM	3.41E-32		1	1.48E-98
8	SGTC_2573	2',4'-dihydroxychalcone	21.00	15.0 µM	4.58E-32		1	3.78E-98
9	SGTC_1056	3448-1962	20.50	115.0 µM	1.57E-30	amide catabolism	1	2.82E-93
10	SGTC_569	4130-2812	19.10	160.0 µM	8.19E-27	amide catabolism	1	1.79E-81
11	SGTC_2833	9001315	18.80	45.5 µM	3.45E-26	amide catabolism	1	1.70E-79
12	SGTC_700	3453-2283	18.30	142.0 µM	8.31E-25	amide catabolism	1	4.14E-75
13	SGTC_581	0958-0271	17.80	211.0 µM	1.49E-23		1	3.96E-71
14	SGTC_2090	5301565	17.70	104.5 µM	2.46E-23	TSC3-RPN4	2	1.92E-70
15	SGTC_161	4065-0411	16.60	162.2 µM	1.05E-20		1	4.15E-62
16	SGTC_2618	avocadyne	16.00	43.4 µM	2.04E-19		8	5.09E-58
17	SGTC_2137	5261020	15.50	140.0 µM	2.67E-18		3	1.77E-54
18	SGTC_823	0417-1665	15.30	178.0 µM	6.43E-18		2	2.85E-53
19	SGTC_3237	9133362	15.20	49.5 µM	1.37E-17		1	3.12E-52
20	SGTC_2980	9014342	15.10	25.3 µM	2.22E-17		2	1.44E-51

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.338	8.73E-90	YBR069C	TAT1	hom	Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress
0.256	6.23E-51	YDR127W	ARO1	hom	Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
0.232	3.24E-42	YKL211C	TRP3	hom	Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
0.224	3.10E-39	YML123C	PHO84	hom	High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity
0.220	7.74E-38	YER090W	TRP2	hom	Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
0.208	6.36E-34	YDR008C_d	YDR008C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.204	8.73E-33	YGR063C	SPT4	hom	Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions
0.200	1.29E-31	YDR007W	TRP1	hom	Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
0.193	1.74E-29	YHL011C	PRS3	hom	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
0.172	1.11E-23	YPR060C	ARO7	hom	Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis
0.170	3.71E-23	YDR354W	TRP4	hom	Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
0.165	6.15E-22	YDR463W	STP1	hom	Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication
0.164	1.59E-21	YKR019C	IRS4	hom	EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
0.156	8.21E-20	YGL026C	TRP5	hom	Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis
0.155	2.51E-19	YHR062C	RPP1	het	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs