YIR025W / MND2

Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR025W / MND2

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:3.27|P-value:9.58E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:4.01|P-value:7.20E-5 ID:SGTC_94|Compound:0334-0113|FD-Score:7.00|P-value:1.55E-11 ID:SGTC_257|Compound:daunorubicin|FD-Score:6.13|P-value:3.00E-9 ID:SGTC_264|Compound:promethazine|FD-Score:4.20|P-value:3.41E-5 ID:SGTC_369|Compound:0957-0393|FD-Score:4.10|P-value:5.02E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:3.33|P-value:7.95E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:3.86|P-value:1.24E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:-4.17|P-value:3.75E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:3.48|P-value:4.78E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:4.44|P-value:1.25E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:-3.51|P-value:4.29E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.90|P-value:1.08E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:4.66|P-value:4.97E-6 ID:SGTC_857|Compound:0438-0306|FD-Score:3.26|P-value:9.91E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.61|P-value:3.14E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-4.08|P-value:5.45E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:-5.52|P-value:7.96E-8 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.42|P-value:5.87E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:5.62|P-value:4.86E-8 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.09|P-value:5.16E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.38|P-value:1.66E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.68|P-value:2.44E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.49|P-value:4.75E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.58|P-value:3.46E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.66|P-value:2.64E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:-4.51|P-value:9.17E-6 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.56|P-value:3.72E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:-4.52|P-value:8.82E-6 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.45|P-value:5.32E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:4.50|P-value:9.73E-6 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.31|P-value:8.38E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.31|P-value:2.21E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:5.67|P-value:3.77E-8 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.44|P-value:5.47E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-3.29|P-value:8.84E-4 ID:SGTC_1938|Compound:st074717|FD-Score:5.90|P-value:1.13E-8 ID:SGTC_1953|Compound:st076800|FD-Score:-3.46|P-value:5.17E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.66|P-value:2.59E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.34|P-value:7.68E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-3.66|P-value:2.61E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.51|P-value:4.41E-4 ID:SGTC_2478|Compound:5763493|FD-Score:3.43|P-value:5.65E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.70|P-value:2.22E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.41|P-value:6.18E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.31|P-value:8.56E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.76|P-value:1.85E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.63|P-value:5.73E-6 ID:SGTC_2833|Compound:9001315|FD-Score:4.80|P-value:2.61E-6 ID:SGTC_2835|Compound:9006588|FD-Score:5.72|P-value:2.88E-8 ID:SGTC_2845|Compound:9003024|FD-Score:-3.34|P-value:7.51E-4 ID:SGTC_2918|Compound:7977171|FD-Score:5.41|P-value:1.43E-7 ID:SGTC_2971|Compound:9092186|FD-Score:4.15|P-value:4.20E-5 ID:SGTC_2998|Compound:9066762|FD-Score:-4.42|P-value:1.38E-5 ID:SGTC_3016|Compound:9080866|FD-Score:4.88|P-value:1.88E-6 ID:SGTC_3027|Compound:9089541|FD-Score:4.05|P-value:6.24E-5 ID:SGTC_3103|Compound:9120822|FD-Score:-3.46|P-value:5.20E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.33|P-value:7.91E-4 ID:SGTC_3116|Compound:9124943|FD-Score:4.03|P-value:6.51E-5 ID:SGTC_3151|Compound:9099821|FD-Score:-3.58|P-value:3.42E-4 ID:SGTC_3189|Compound:9110682|FD-Score:5.92|P-value:1.01E-8 ID:SGTC_11|Compound:0438-0307|FD-Score:3.27|P-value:9.58E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:4.01|P-value:7.20E-5 ID:SGTC_94|Compound:0334-0113|FD-Score:7.00|P-value:1.55E-11 ID:SGTC_257|Compound:daunorubicin|FD-Score:6.13|P-value:3.00E-9 ID:SGTC_264|Compound:promethazine|FD-Score:4.20|P-value:3.41E-5 ID:SGTC_369|Compound:0957-0393|FD-Score:4.10|P-value:5.02E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:3.33|P-value:7.95E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:3.86|P-value:1.24E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:-4.17|P-value:3.75E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:3.48|P-value:4.78E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:4.44|P-value:1.25E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:-3.51|P-value:4.29E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.90|P-value:1.08E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:4.66|P-value:4.97E-6 ID:SGTC_857|Compound:0438-0306|FD-Score:3.26|P-value:9.91E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.61|P-value:3.14E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-4.08|P-value:5.45E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:-5.52|P-value:7.96E-8 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.42|P-value:5.87E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:5.62|P-value:4.86E-8 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.09|P-value:5.16E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.38|P-value:1.66E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.68|P-value:2.44E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.49|P-value:4.75E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.58|P-value:3.46E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.66|P-value:2.64E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:-4.51|P-value:9.17E-6 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.56|P-value:3.72E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:-4.52|P-value:8.82E-6 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.45|P-value:5.32E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:4.50|P-value:9.73E-6 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.31|P-value:8.38E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.31|P-value:2.21E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:5.67|P-value:3.77E-8 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.44|P-value:5.47E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-3.29|P-value:8.84E-4 ID:SGTC_1938|Compound:st074717|FD-Score:5.90|P-value:1.13E-8 ID:SGTC_1953|Compound:st076800|FD-Score:-3.46|P-value:5.17E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.66|P-value:2.59E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.34|P-value:7.68E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-3.66|P-value:2.61E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.51|P-value:4.41E-4 ID:SGTC_2478|Compound:5763493|FD-Score:3.43|P-value:5.65E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.70|P-value:2.22E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.41|P-value:6.18E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.31|P-value:8.56E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.76|P-value:1.85E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.63|P-value:5.73E-6 ID:SGTC_2833|Compound:9001315|FD-Score:4.80|P-value:2.61E-6 ID:SGTC_2835|Compound:9006588|FD-Score:5.72|P-value:2.88E-8 ID:SGTC_2845|Compound:9003024|FD-Score:-3.34|P-value:7.51E-4 ID:SGTC_2918|Compound:7977171|FD-Score:5.41|P-value:1.43E-7 ID:SGTC_2971|Compound:9092186|FD-Score:4.15|P-value:4.20E-5 ID:SGTC_2998|Compound:9066762|FD-Score:-4.42|P-value:1.38E-5 ID:SGTC_3016|Compound:9080866|FD-Score:4.88|P-value:1.88E-6 ID:SGTC_3027|Compound:9089541|FD-Score:4.05|P-value:6.24E-5 ID:SGTC_3103|Compound:9120822|FD-Score:-3.46|P-value:5.20E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.33|P-value:7.91E-4 ID:SGTC_3116|Compound:9124943|FD-Score:4.03|P-value:6.51E-5 ID:SGTC_3151|Compound:9099821|FD-Score:-3.58|P-value:3.42E-4 ID:SGTC_3189|Compound:9110682|FD-Score:5.92|P-value:1.01E-8

Top fitness defect scores for YIR025W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_94 0334-0113 7.00 514.8 µM 1.55E-11 1 1.25E-12
2 SGTC_257 daunorubicin 6.13 18.5 µM 3.00E-9 anthracycline transcription coupled DNA repair 10 4.30E-10
3 SGTC_3189 9110682 5.92 49.5 µM 1.01E-8 11 1.65E-9
4 SGTC_1938 st074717 5.90 56.4 µM 1.13E-8 4 1.87E-9
5 SGTC_2835 9006588 5.72 71.4 µM 2.88E-8 9 5.28E-9
6 SGTC_1527 coumarin 5.67 137.0 µM 3.77E-8 1 7.11E-9
7 SGTC_962 1254-0300 5.62 21.5 µM 4.86E-8 8 9.41E-9
8 SGTC_2918 7977171 5.41 22.1 µM 1.43E-7 9 3.11E-8
9 SGTC_3016 9080866 4.88 49.5 µM 1.88E-6 11 5.41E-7
10 SGTC_2833 9001315 4.80 45.5 µM 2.61E-6 amide catabolism 31 7.76E-7
11 SGTC_815 1582-0027 4.66 36.9 µM 4.97E-6 10 1.58E-6
12 SGTC_2831 7999036 4.63 19.5 µM 5.73E-6 26 1.86E-6
13 SGTC_1461 k072-0203 4.50 53.8 µM 9.73E-6 5 3.33E-6
14 SGTC_751 0833-0568 4.44 350.0 µM 1.25E-5 10 4.41E-6
15 SGTC_1043 0916-0009 4.38 19.3 µM 1.66E-5 16 6.01E-6
16 SGTC_1520 flindersine 4.31 88.0 µM 2.21E-5 23 8.27E-6
17 SGTC_264 promethazine 4.20 12.5 mM 3.41E-5 DNA intercalators 44 1.33E-5
18 SGTC_2971 9092186 4.15 9.9 µM 4.20E-5 ergosterol biosynthesis 25 1.68E-5
19 SGTC_369 0957-0393 4.10 4.5 µM 5.02E-5 cell wall signaling 20 2.05E-5
20 SGTC_1028 k015-0029 4.09 4.8 µM 5.16E-5 21 2.11E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 4.11E-14 YGR012W YGR012W hom Putative cysteine synthase, localized to the mitochondrial outer membrane
0.127 1.66E-13 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.122 1.47E-12 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.116 1.55E-11 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.105 1.03E-9 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.105 1.10E-9 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.102 3.62E-9 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.100 6.14E-9 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.099 9.92E-9 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.098 1.19E-8 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.094 4.95E-8 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.090 1.58E-7 YLR037C PAU23 hom Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth
0.085 7.97E-7 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.080 3.30E-6 YPL072W UBP16 hom Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria
0.073 2.06E-5 YBR170C NPL4 hom Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)