YIR026C / YVH1

Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR026C / YVH1

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-3.43|P-value:3.33E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.86|P-value:6.80E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:4.42|P-value:6.46E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:6.39|P-value:1.35E-10 ID:SGTC_342|Compound:k048-0088|FD-Score:3.98|P-value:4.32E-5 ID:SGTC_462|Compound:ag-879|FD-Score:3.19|P-value:8.21E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:-3.13|P-value:9.57E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.91|P-value:5.66E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:5.38|P-value:5.36E-8 ID:SGTC_791|Compound:1348-1292|FD-Score:4.28|P-value:1.21E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.98|P-value:4.40E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:6.40|P-value:1.29E-10 ID:SGTC_958|Compound:1222-0007|FD-Score:3.91|P-value:5.66E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:3.81|P-value:8.48E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:3.33|P-value:5.07E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.94|P-value:5.33E-7 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.73|P-value:1.50E-6 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.39|P-value:4.02E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.43|P-value:3.50E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.60|P-value:1.89E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.64|P-value:1.64E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.93|P-value:5.22E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.16|P-value:9.03E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.28|P-value:5.95E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.87|P-value:6.59E-5 ID:SGTC_1470|Compound:k295-0292|FD-Score:-3.48|P-value:2.80E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.76|P-value:1.01E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.98|P-value:4.24E-7 ID:SGTC_1696|Compound:st025591|FD-Score:4.27|P-value:1.26E-5 ID:SGTC_1707|Compound:st032323|FD-Score:-3.13|P-value:9.67E-4 ID:SGTC_1746|Compound:st038117|FD-Score:4.11|P-value:2.45E-5 ID:SGTC_1781|Compound:st038725|FD-Score:4.00|P-value:3.90E-5 ID:SGTC_1841|Compound:st054148|FD-Score:-3.42|P-value:3.48E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.88|P-value:6.39E-5 ID:SGTC_1916|Compound:st067606|FD-Score:3.52|P-value:2.58E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.40|P-value:3.99E-4 ID:SGTC_2040|Compound:5100729|FD-Score:-3.39|P-value:3.87E-4 ID:SGTC_2086|Compound:5274770|FD-Score:-5.10|P-value:2.18E-7 ID:SGTC_2098|Compound:5376439|FD-Score:-3.89|P-value:5.72E-5 ID:SGTC_2177|Compound:5811945|FD-Score:3.72|P-value:1.18E-4 ID:SGTC_2258|Compound:7960471|FD-Score:-3.23|P-value:6.71E-4 ID:SGTC_2265|Compound:7929201|FD-Score:9.26|P-value:2.76E-20 ID:SGTC_2315|Compound:7733312|FD-Score:4.84|P-value:8.65E-7 ID:SGTC_2339|Compound:9000433|FD-Score:4.56|P-value:3.26E-6 ID:SGTC_2342|Compound:7990637|FD-Score:-4.28|P-value:1.10E-5 ID:SGTC_2453|Compound:5731132|FD-Score:4.77|P-value:1.25E-6 ID:SGTC_2461|Compound:5755302|FD-Score:3.53|P-value:2.50E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:4.30|P-value:1.09E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.91|P-value:6.04E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.64|P-value:1.62E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.77|P-value:9.96E-5 ID:SGTC_3029|Compound:9088683|FD-Score:3.79|P-value:9.00E-5 ID:SGTC_3068|Compound:9116768|FD-Score:3.80|P-value:8.63E-5 ID:SGTC_3140|Compound:9094243|FD-Score:4.90|P-value:6.51E-7 ID:SGTC_3142|Compound:9086498|FD-Score:-3.97|P-value:4.23E-5 ID:SGTC_3143|Compound:9086658|FD-Score:-3.54|P-value:2.21E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.43|P-value:3.33E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.86|P-value:6.80E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:4.42|P-value:6.46E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:6.39|P-value:1.35E-10 ID:SGTC_342|Compound:k048-0088|FD-Score:3.98|P-value:4.32E-5 ID:SGTC_462|Compound:ag-879|FD-Score:3.19|P-value:8.21E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:-3.13|P-value:9.57E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.91|P-value:5.66E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:5.38|P-value:5.36E-8 ID:SGTC_791|Compound:1348-1292|FD-Score:4.28|P-value:1.21E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.98|P-value:4.40E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:6.40|P-value:1.29E-10 ID:SGTC_958|Compound:1222-0007|FD-Score:3.91|P-value:5.66E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:3.81|P-value:8.48E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:3.33|P-value:5.07E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.94|P-value:5.33E-7 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.73|P-value:1.50E-6 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.39|P-value:4.02E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.43|P-value:3.50E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.60|P-value:1.89E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.64|P-value:1.64E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.93|P-value:5.22E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.16|P-value:9.03E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.28|P-value:5.95E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.87|P-value:6.59E-5 ID:SGTC_1470|Compound:k295-0292|FD-Score:-3.48|P-value:2.80E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.76|P-value:1.01E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.98|P-value:4.24E-7 ID:SGTC_1696|Compound:st025591|FD-Score:4.27|P-value:1.26E-5 ID:SGTC_1707|Compound:st032323|FD-Score:-3.13|P-value:9.67E-4 ID:SGTC_1746|Compound:st038117|FD-Score:4.11|P-value:2.45E-5 ID:SGTC_1781|Compound:st038725|FD-Score:4.00|P-value:3.90E-5 ID:SGTC_1841|Compound:st054148|FD-Score:-3.42|P-value:3.48E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.88|P-value:6.39E-5 ID:SGTC_1916|Compound:st067606|FD-Score:3.52|P-value:2.58E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.40|P-value:3.99E-4 ID:SGTC_2040|Compound:5100729|FD-Score:-3.39|P-value:3.87E-4 ID:SGTC_2086|Compound:5274770|FD-Score:-5.10|P-value:2.18E-7 ID:SGTC_2098|Compound:5376439|FD-Score:-3.89|P-value:5.72E-5 ID:SGTC_2177|Compound:5811945|FD-Score:3.72|P-value:1.18E-4 ID:SGTC_2258|Compound:7960471|FD-Score:-3.23|P-value:6.71E-4 ID:SGTC_2265|Compound:7929201|FD-Score:9.26|P-value:2.76E-20 ID:SGTC_2315|Compound:7733312|FD-Score:4.84|P-value:8.65E-7 ID:SGTC_2339|Compound:9000433|FD-Score:4.56|P-value:3.26E-6 ID:SGTC_2342|Compound:7990637|FD-Score:-4.28|P-value:1.10E-5 ID:SGTC_2453|Compound:5731132|FD-Score:4.77|P-value:1.25E-6 ID:SGTC_2461|Compound:5755302|FD-Score:3.53|P-value:2.50E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:4.30|P-value:1.09E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.91|P-value:6.04E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.64|P-value:1.62E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.77|P-value:9.96E-5 ID:SGTC_3029|Compound:9088683|FD-Score:3.79|P-value:9.00E-5 ID:SGTC_3068|Compound:9116768|FD-Score:3.80|P-value:8.63E-5 ID:SGTC_3140|Compound:9094243|FD-Score:4.90|P-value:6.51E-7 ID:SGTC_3142|Compound:9086498|FD-Score:-3.97|P-value:4.23E-5 ID:SGTC_3143|Compound:9086658|FD-Score:-3.54|P-value:2.21E-4

Top fitness defect scores for YIR026C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2265 7929201 9.26 200.0 µM 2.76E-20 3 1.03E-20
2 SGTC_832 4083-0019 6.40 164.0 µM 1.29E-10 translation 15 7.86E-11
3 SGTC_118 0083-0097 6.39 135.3 µM 1.35E-10 translation 13 8.29E-11
4 SGTC_756 0508-1999 5.38 28.3 µM 5.36E-8 RPP1 & pyrimidine depletion 5 3.75E-8
5 SGTC_1574 spiramycin 4.98 23.7 µM 4.24E-7 10 3.11E-7
6 SGTC_800 3448-7362 4.98 155.0 µM 4.40E-7 translation 89 3.23E-7
7 SGTC_1136 pergolide 4.94 1.1 µM 5.33E-7 15 3.92E-7
8 SGTC_2561 acetosyringone 4.91 100.0 µM 6.04E-7 7 4.46E-7
9 SGTC_3140 9094243 4.90 49.5 µM 6.51E-7 16 4.82E-7
10 SGTC_2315 7733312 4.84 200.0 µM 8.65E-7 10 6.44E-7
11 SGTC_2453 5731132 4.77 22.2 µM 1.25E-6 8 9.40E-7
12 SGTC_1148 3909-7663 4.73 27.7 µM 1.50E-6 5 1.13E-6
13 SGTC_2339 9000433 4.56 200.0 µM 3.26E-6 18 2.50E-6
14 SGTC_69 0096-0274 4.42 206.7 µM 6.46E-6 mitochondrial processes 28 5.03E-6
15 SGTC_2531 methyl deoxycholate 4.30 70.1 µM 1.09E-5 17 8.58E-6
16 SGTC_791 1348-1292 4.28 225.0 µM 1.21E-5 27 9.52E-6
17 SGTC_1696 st025591 4.27 34.8 µM 1.26E-5 SWF1 & branched chain AA biosynthesis 20 9.92E-6
18 SGTC_1746 st038117 4.11 42.0 µM 2.45E-5 28 1.97E-5
19 SGTC_1781 st038725 4.00 66.3 µM 3.90E-5 NEO1 98 3.16E-5
20 SGTC_342 k048-0088 3.98 23.3 µM 4.32E-5 RSC & ERG11 17 3.51E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.227 2.59E-40 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.190 1.72E-28 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.175 1.46E-24 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.164 9.37E-22 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.161 5.59E-21 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.158 3.00E-20 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.155 1.30E-19 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.155 1.52E-19 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.155 1.79E-19 YGR271C-A EFG1 hom Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
0.153 4.62E-19 YOR309C_d YOR309C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
0.150 2.38E-18 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.147 8.70E-18 YPL249C-A RPL36B hom Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication
0.147 1.40E-17 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.146 2.19E-17 YGR214W RPS0A hom Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;
0.139 5.02E-16 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis