YIR027C / DAL1

Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR027C / DAL1

Click on Significant Values for Screen Details ID:SGTC_529|Compound:4076-0302|FD-Score:-3.31|P-value:8.18E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.47|P-value:5.12E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.76|P-value:1.86E-4 ID:SGTC_719|Compound:2810-4230|FD-Score:3.63|P-value:2.95E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:3.42|P-value:6.09E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.60|P-value:6.65E-6 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.30|P-value:8.85E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.37|P-value:7.04E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.39|P-value:6.35E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:-3.66|P-value:2.45E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.78|P-value:1.76E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.62|P-value:3.12E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.37|P-value:7.27E-4 ID:SGTC_1634|Compound:st006576|FD-Score:4.59|P-value:6.87E-6 ID:SGTC_1734|Compound:st037168|FD-Score:3.87|P-value:1.24E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.30|P-value:9.12E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.31|P-value:8.67E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.58|P-value:3.48E-4 ID:SGTC_1885|Compound:st057546|FD-Score:-4.44|P-value:1.20E-5 ID:SGTC_1916|Compound:st067606|FD-Score:3.52|P-value:4.32E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.77|P-value:3.21E-6 ID:SGTC_2049|Compound:5262831|FD-Score:4.58|P-value:7.35E-6 ID:SGTC_2301|Compound:7769476|FD-Score:3.93|P-value:9.85E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.37|P-value:7.23E-4 ID:SGTC_2511|Compound:berberine|FD-Score:4.59|P-value:6.96E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.83|P-value:1.33E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.66|P-value:2.63E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.50|P-value:4.66E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.45|P-value:5.51E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.31|P-value:8.77E-4 ID:SGTC_2801|Compound:7907800|FD-Score:5.30|P-value:2.58E-7 ID:SGTC_2971|Compound:9092186|FD-Score:6.09|P-value:3.94E-9 ID:SGTC_3071|Compound:9117417|FD-Score:-4.34|P-value:1.84E-5 ID:SGTC_3249|Compound:9135183|FD-Score:3.71|P-value:2.23E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.61|P-value:3.23E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.74|P-value:2.03E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:-3.31|P-value:8.18E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.47|P-value:5.12E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.76|P-value:1.86E-4 ID:SGTC_719|Compound:2810-4230|FD-Score:3.63|P-value:2.95E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:3.42|P-value:6.09E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.60|P-value:6.65E-6 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.30|P-value:8.85E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.37|P-value:7.04E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.39|P-value:6.35E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:-3.66|P-value:2.45E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.78|P-value:1.76E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.62|P-value:3.12E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.37|P-value:7.27E-4 ID:SGTC_1634|Compound:st006576|FD-Score:4.59|P-value:6.87E-6 ID:SGTC_1734|Compound:st037168|FD-Score:3.87|P-value:1.24E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.30|P-value:9.12E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.31|P-value:8.67E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.58|P-value:3.48E-4 ID:SGTC_1885|Compound:st057546|FD-Score:-4.44|P-value:1.20E-5 ID:SGTC_1916|Compound:st067606|FD-Score:3.52|P-value:4.32E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.77|P-value:3.21E-6 ID:SGTC_2049|Compound:5262831|FD-Score:4.58|P-value:7.35E-6 ID:SGTC_2301|Compound:7769476|FD-Score:3.93|P-value:9.85E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.37|P-value:7.23E-4 ID:SGTC_2511|Compound:berberine|FD-Score:4.59|P-value:6.96E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.83|P-value:1.33E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.66|P-value:2.63E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.50|P-value:4.66E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.45|P-value:5.51E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.31|P-value:8.77E-4 ID:SGTC_2801|Compound:7907800|FD-Score:5.30|P-value:2.58E-7 ID:SGTC_2971|Compound:9092186|FD-Score:6.09|P-value:3.94E-9 ID:SGTC_3071|Compound:9117417|FD-Score:-4.34|P-value:1.84E-5 ID:SGTC_3249|Compound:9135183|FD-Score:3.71|P-value:2.23E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.61|P-value:3.23E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.74|P-value:2.03E-4

Top fitness defect scores for YIR027C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2971 9092186 6.09 9.9 µM 3.94E-9 ergosterol biosynthesis 6 5.58E-10
2 SGTC_2801 7907800 5.30 81.8 µM 2.58E-7 10 5.78E-8
3 SGTC_1920 st075728 4.77 45.7 µM 3.21E-6 6 9.43E-7
4 SGTC_1011 4112-3381 4.60 17.4 µM 6.65E-6 23 2.12E-6
5 SGTC_1634 st006576 4.59 41.0 µM 6.87E-6 TSC3-RPN4 11 2.20E-6
6 SGTC_2511 berberine 4.59 10.5 µM 6.96E-6 60S ribosome export 12 2.23E-6
7 SGTC_2049 5262831 4.58 67.2 µM 7.35E-6 17 2.37E-6
8 SGTC_2301 7769476 3.93 200.0 µM 9.85E-5 25 4.19E-5
9 SGTC_1734 st037168 3.87 69.4 µM 1.24E-4 26 5.38E-5
10 SGTC_1415 3966-0071 3.78 78.1 µM 1.76E-4 DNA intercalators 13 7.94E-5
11 SGTC_573 3702-0553 3.76 84.7 µM 1.86E-4 20 8.45E-5
12 SGTC_3353 9151644 3.74 39.3 µM 2.03E-4 17 9.33E-5
13 SGTC_3249 9135183 3.71 49.5 µM 2.23E-4 60S ribosome export 16 1.04E-4
14 SGTC_2562 3',7'-dimethoxyflavone 3.66 64.9 µM 2.63E-4 43 1.25E-4
15 SGTC_719 2810-4230 3.63 27.3 µM 2.95E-4 10 1.41E-4
16 SGTC_1444 4112-3581 3.62 28.0 µM 3.12E-4 19 1.50E-4
17 SGTC_3352 9151559 3.61 45.6 µM 3.23E-4 20 1.56E-4
18 SGTC_1840 st055363 3.58 71.0 µM 3.48E-4 21 1.69E-4
19 SGTC_1916 st067606 3.52 49.2 µM 4.32E-4 59 2.15E-4
20 SGTC_2698 st077697 3.50 67.5 µM 4.66E-4 25 2.34E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.78E-10 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.099 1.00E-8 YBL097W BRN1 het Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission
0.091 1.30E-7 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.074 1.97E-5 YBR052C RFS1 hom Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication
0.073 2.50E-5 YGL056C SDS23 hom One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication
0.071 3.63E-5 YOR352W TFB6 hom Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.071 4.12E-5 YPR127W YPR127W hom Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.069 5.94E-5 YNR073C_p YNR073C_p hom Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p
0.068 7.73E-5 YMR026C PEX12 hom C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder
0.068 8.64E-5 YIL115C NUP159 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)
0.068 8.68E-5 YER173W RAD24 hom Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein
0.067 1.05E-4 YLR258W GSY2 hom Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress
0.066 1.21E-4 YER057C HMF1 hom Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro
0.066 1.41E-4 YLR090W XDJ1 hom Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.065 1.51E-4 YLR262C-A TMA7 hom Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress