YIR028W / DAL4

Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR028W / DAL4

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.63|P-value:7.82E-7 ID:SGTC_13|Compound:0199-0087|FD-Score:2.99|P-value:9.93E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.21|P-value:4.38E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.78|P-value:4.52E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-4.06|P-value:1.18E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:5.04|P-value:8.78E-8 ID:SGTC_541|Compound:4513-1321|FD-Score:3.14|P-value:5.79E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.51|P-value:1.38E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.21|P-value:4.45E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:3.63|P-value:8.36E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:-3.08|P-value:6.70E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:5.75|P-value:1.22E-9 ID:SGTC_996|Compound:3970-0799|FD-Score:7.39|P-value:9.41E-15 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.01|P-value:9.25E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-4.78|P-value:3.28E-7 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.73|P-value:5.71E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.02|P-value:8.78E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.65|P-value:7.79E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:-3.13|P-value:5.64E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.04|P-value:8.30E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.44|P-value:1.85E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.81|P-value:3.97E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.30|P-value:3.15E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.70|P-value:6.31E-5 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.10|P-value:6.53E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:4.24|P-value:5.48E-6 ID:SGTC_1607|Compound:st000305|FD-Score:-3.30|P-value:2.99E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.29|P-value:3.30E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.01|P-value:9.17E-4 ID:SGTC_1783|Compound:st039459|FD-Score:9.50|P-value:3.40E-23 ID:SGTC_1795|Compound:st049545|FD-Score:3.11|P-value:6.34E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-3.31|P-value:2.89E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.61|P-value:9.16E-5 ID:SGTC_1866|Compound:st057638|FD-Score:3.08|P-value:7.16E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-3.03|P-value:7.99E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.79|P-value:4.33E-5 ID:SGTC_2142|Compound:5622915|FD-Score:3.39|P-value:2.26E-4 ID:SGTC_2194|Compound:5927483|FD-Score:5.36|P-value:1.39E-8 ID:SGTC_2321|Compound:7390090|FD-Score:3.00|P-value:9.53E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.49|P-value:1.50E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.25|P-value:3.82E-4 ID:SGTC_2380|Compound:9035439|FD-Score:-3.18|P-value:4.71E-4 ID:SGTC_2382|Compound:9035899|FD-Score:4.18|P-value:7.40E-6 ID:SGTC_2398|Compound:5228213|FD-Score:3.03|P-value:8.46E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.30|P-value:3.20E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.37|P-value:2.43E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:5.40|P-value:1.11E-8 ID:SGTC_2860|Compound:9025725|FD-Score:3.99|P-value:1.76E-5 ID:SGTC_2866|Compound:9034245|FD-Score:5.36|P-value:1.40E-8 ID:SGTC_2869|Compound:9037858|FD-Score:-4.92|P-value:1.58E-7 ID:SGTC_2875|Compound:9039966|FD-Score:-4.39|P-value:2.52E-6 ID:SGTC_3003|Compound:9075612|FD-Score:3.31|P-value:3.02E-4 ID:SGTC_3062|Compound:9077494|FD-Score:3.11|P-value:6.52E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-3.19|P-value:4.46E-4 ID:SGTC_3125|Compound:9127534|FD-Score:4.73|P-value:4.81E-7 ID:SGTC_3212|Compound:9128307|FD-Score:-3.87|P-value:2.83E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:4.63|P-value:7.82E-7 ID:SGTC_13|Compound:0199-0087|FD-Score:2.99|P-value:9.93E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.21|P-value:4.38E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.78|P-value:4.52E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-4.06|P-value:1.18E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:5.04|P-value:8.78E-8 ID:SGTC_541|Compound:4513-1321|FD-Score:3.14|P-value:5.79E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.51|P-value:1.38E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.21|P-value:4.45E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:3.63|P-value:8.36E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:-3.08|P-value:6.70E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:5.75|P-value:1.22E-9 ID:SGTC_996|Compound:3970-0799|FD-Score:7.39|P-value:9.41E-15 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.01|P-value:9.25E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-4.78|P-value:3.28E-7 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.73|P-value:5.71E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.02|P-value:8.78E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.65|P-value:7.79E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:-3.13|P-value:5.64E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.04|P-value:8.30E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.44|P-value:1.85E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.81|P-value:3.97E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.30|P-value:3.15E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.70|P-value:6.31E-5 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.10|P-value:6.53E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:4.24|P-value:5.48E-6 ID:SGTC_1607|Compound:st000305|FD-Score:-3.30|P-value:2.99E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.29|P-value:3.30E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.01|P-value:9.17E-4 ID:SGTC_1783|Compound:st039459|FD-Score:9.50|P-value:3.40E-23 ID:SGTC_1795|Compound:st049545|FD-Score:3.11|P-value:6.34E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-3.31|P-value:2.89E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.61|P-value:9.16E-5 ID:SGTC_1866|Compound:st057638|FD-Score:3.08|P-value:7.16E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-3.03|P-value:7.99E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.79|P-value:4.33E-5 ID:SGTC_2142|Compound:5622915|FD-Score:3.39|P-value:2.26E-4 ID:SGTC_2194|Compound:5927483|FD-Score:5.36|P-value:1.39E-8 ID:SGTC_2321|Compound:7390090|FD-Score:3.00|P-value:9.53E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.49|P-value:1.50E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.25|P-value:3.82E-4 ID:SGTC_2380|Compound:9035439|FD-Score:-3.18|P-value:4.71E-4 ID:SGTC_2382|Compound:9035899|FD-Score:4.18|P-value:7.40E-6 ID:SGTC_2398|Compound:5228213|FD-Score:3.03|P-value:8.46E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.30|P-value:3.20E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.37|P-value:2.43E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:5.40|P-value:1.11E-8 ID:SGTC_2860|Compound:9025725|FD-Score:3.99|P-value:1.76E-5 ID:SGTC_2866|Compound:9034245|FD-Score:5.36|P-value:1.40E-8 ID:SGTC_2869|Compound:9037858|FD-Score:-4.92|P-value:1.58E-7 ID:SGTC_2875|Compound:9039966|FD-Score:-4.39|P-value:2.52E-6 ID:SGTC_3003|Compound:9075612|FD-Score:3.31|P-value:3.02E-4 ID:SGTC_3062|Compound:9077494|FD-Score:3.11|P-value:6.52E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-3.19|P-value:4.46E-4 ID:SGTC_3125|Compound:9127534|FD-Score:4.73|P-value:4.81E-7 ID:SGTC_3212|Compound:9128307|FD-Score:-3.87|P-value:2.83E-5

Top fitness defect scores for YIR028W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1783 st039459 9.50 87.5 µM 3.40E-23 Golgi 2 1.07E-21
2 SGTC_996 3970-0799 7.39 1.8 µM 9.41E-15 25 7.58E-14
3 SGTC_910 3454-3003 5.75 490.0 µM 1.22E-9 3 4.35E-9
4 SGTC_2565 isoliquiritigenin 5.40 100.0 µM 1.11E-8 13 3.39E-8
5 SGTC_2194 5927483 5.36 104.5 µM 1.39E-8 10 4.18E-8
6 SGTC_2866 9034245 5.36 58.4 µM 1.40E-8 1 4.22E-8
7 SGTC_519 k048-0011 5.04 62.8 µM 8.78E-8 7 2.33E-7
8 SGTC_3125 9127534 4.73 49.5 µM 4.81E-7 4 1.14E-6
9 SGTC_10 0279-0212 4.63 42.6 µM 7.82E-7 TRP & mitochondrial translation 82 1.79E-6
10 SGTC_1568 digitonin 4.24 820.0 nM 5.48E-6 sphingolipid biosynthesis & PDR1 26 1.10E-5
11 SGTC_2382 9035899 4.18 200.0 µM 7.40E-6 60S ribosome export 12 1.45E-5
12 SGTC_2860 9025725 3.99 39.0 µM 1.76E-5 RPP1 & pyrimidine depletion 8 3.26E-5
13 SGTC_1454 4239-0054 3.81 42.6 µM 3.97E-5 41 6.96E-5
14 SGTC_1962 st076595 3.79 64.5 µM 4.33E-5 redox potentiating 29 7.55E-5
15 SGTC_164 4100-3994 3.78 89.6 µM 4.52E-5 39 7.86E-5
16 SGTC_1245 0418-0076 3.73 17.2 µM 5.71E-5 ERG2 37 9.76E-5
17 SGTC_1494 4358-1428 3.70 177.0 µM 6.31E-5 30 1.07E-4
18 SGTC_1297 1068-0111 3.65 14.1 µM 7.79E-5 15 1.31E-4
19 SGTC_589 1227-0070 3.63 34.1 µM 8.36E-5 37 1.39E-4
20 SGTC_1846 st056244 3.61 14.8 µM 9.16E-5 41 1.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.229 4.15E-41 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.207 1.07E-33 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.162 5.35E-21 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.157 6.58E-20 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.147 1.26E-17 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.144 5.60E-17 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.139 7.29E-16 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.126 2.83E-13 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.125 3.80E-13 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.125 4.24E-13 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
0.121 1.94E-12 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.118 6.35E-12 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.116 1.81E-11 YJR014W TMA22 hom Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress
0.116 1.96E-11 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.111 1.26E-10 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication