YIR029W / DAL2

Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR029W / DAL2

Click on Significant Values for Screen Details ID:SGTC_213|Compound:1246-0773|FD-Score:3.36|P-value:2.56E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:3.59|P-value:1.05E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.46|P-value:1.77E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.35|P-value:3.54E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.18|P-value:5.84E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.49|P-value:1.52E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.11|P-value:6.41E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.10|P-value:6.70E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:-4.66|P-value:9.28E-7 ID:SGTC_540|Compound:1187-0821|FD-Score:5.66|P-value:2.70E-9 ID:SGTC_583|Compound:1488-1091|FD-Score:4.24|P-value:6.05E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:3.18|P-value:5.05E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.46|P-value:1.76E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.91|P-value:2.66E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:3.70|P-value:6.62E-5 ID:SGTC_918|Compound:glabranin|FD-Score:3.04|P-value:8.17E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.83|P-value:4.38E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.37|P-value:3.23E-6 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.37|P-value:2.51E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.78|P-value:4.65E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.69|P-value:6.90E-5 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.95|P-value:2.25E-5 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.32|P-value:2.93E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.04|P-value:8.28E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:-3.09|P-value:7.87E-4 ID:SGTC_1614|Compound:st002383|FD-Score:3.38|P-value:2.36E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.15|P-value:5.55E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-4.15|P-value:1.09E-5 ID:SGTC_2060|Compound:5238662|FD-Score:5.90|P-value:5.78E-10 ID:SGTC_2087|Compound:5276107|FD-Score:3.51|P-value:1.45E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.06|P-value:7.77E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.51|P-value:1.42E-4 ID:SGTC_2368|Compound:9071271|FD-Score:-3.92|P-value:2.97E-5 ID:SGTC_2476|Compound:5806916|FD-Score:-3.09|P-value:7.86E-4 ID:SGTC_2484|Compound:5809818|FD-Score:4.76|P-value:4.57E-7 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.18|P-value:9.35E-6 ID:SGTC_2643|Compound:anethole|FD-Score:3.29|P-value:3.39E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.41|P-value:2.49E-4 ID:SGTC_2792|Compound:7535235|FD-Score:4.74|P-value:4.98E-7 ID:SGTC_2795|Compound:7780010|FD-Score:4.09|P-value:1.20E-5 ID:SGTC_2802|Compound:7925815|FD-Score:4.74|P-value:5.08E-7 ID:SGTC_2824|Compound:7998404|FD-Score:3.08|P-value:7.24E-4 ID:SGTC_2837|Compound:9008476|FD-Score:-3.14|P-value:6.56E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.16|P-value:5.42E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.32|P-value:3.03E-4 ID:SGTC_3070|Compound:9117005|FD-Score:3.01|P-value:9.36E-4 ID:SGTC_3071|Compound:9117417|FD-Score:-3.03|P-value:9.78E-4 ID:SGTC_3125|Compound:9127534|FD-Score:4.37|P-value:3.14E-6 ID:SGTC_3128|Compound:9127691|FD-Score:-3.43|P-value:2.23E-4 ID:SGTC_3284|Compound:9108171|FD-Score:4.60|P-value:1.03E-6 ID:SGTC_213|Compound:1246-0773|FD-Score:3.36|P-value:2.56E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:3.59|P-value:1.05E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.46|P-value:1.77E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.35|P-value:3.54E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.18|P-value:5.84E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.49|P-value:1.52E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.11|P-value:6.41E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.10|P-value:6.70E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:-4.66|P-value:9.28E-7 ID:SGTC_540|Compound:1187-0821|FD-Score:5.66|P-value:2.70E-9 ID:SGTC_583|Compound:1488-1091|FD-Score:4.24|P-value:6.05E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:3.18|P-value:5.05E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.46|P-value:1.76E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.91|P-value:2.66E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:3.70|P-value:6.62E-5 ID:SGTC_918|Compound:glabranin|FD-Score:3.04|P-value:8.17E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.83|P-value:4.38E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.37|P-value:3.23E-6 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.37|P-value:2.51E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.78|P-value:4.65E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.69|P-value:6.90E-5 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.95|P-value:2.25E-5 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.32|P-value:2.93E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.04|P-value:8.28E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:-3.09|P-value:7.87E-4 ID:SGTC_1614|Compound:st002383|FD-Score:3.38|P-value:2.36E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.15|P-value:5.55E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-4.15|P-value:1.09E-5 ID:SGTC_2060|Compound:5238662|FD-Score:5.90|P-value:5.78E-10 ID:SGTC_2087|Compound:5276107|FD-Score:3.51|P-value:1.45E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.06|P-value:7.77E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.51|P-value:1.42E-4 ID:SGTC_2368|Compound:9071271|FD-Score:-3.92|P-value:2.97E-5 ID:SGTC_2476|Compound:5806916|FD-Score:-3.09|P-value:7.86E-4 ID:SGTC_2484|Compound:5809818|FD-Score:4.76|P-value:4.57E-7 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.18|P-value:9.35E-6 ID:SGTC_2643|Compound:anethole|FD-Score:3.29|P-value:3.39E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.41|P-value:2.49E-4 ID:SGTC_2792|Compound:7535235|FD-Score:4.74|P-value:4.98E-7 ID:SGTC_2795|Compound:7780010|FD-Score:4.09|P-value:1.20E-5 ID:SGTC_2802|Compound:7925815|FD-Score:4.74|P-value:5.08E-7 ID:SGTC_2824|Compound:7998404|FD-Score:3.08|P-value:7.24E-4 ID:SGTC_2837|Compound:9008476|FD-Score:-3.14|P-value:6.56E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.16|P-value:5.42E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.32|P-value:3.03E-4 ID:SGTC_3070|Compound:9117005|FD-Score:3.01|P-value:9.36E-4 ID:SGTC_3071|Compound:9117417|FD-Score:-3.03|P-value:9.78E-4 ID:SGTC_3125|Compound:9127534|FD-Score:4.37|P-value:3.14E-6 ID:SGTC_3128|Compound:9127691|FD-Score:-3.43|P-value:2.23E-4 ID:SGTC_3284|Compound:9108171|FD-Score:4.60|P-value:1.03E-6

Top fitness defect scores for YIR029W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2060 5238662 5.90 140.0 µM 5.78E-10 7 1.81E-9
2 SGTC_540 1187-0821 5.66 17.3 µM 2.70E-9 4 7.77E-9
3 SGTC_2484 5809818 4.76 12.0 µM 4.57E-7 10 9.88E-7
4 SGTC_2792 7535235 4.74 81.8 µM 4.98E-7 fatty acid desaturase (OLE1) 18 1.07E-6
5 SGTC_2802 7925815 4.74 54.5 µM 5.08E-7 23 1.09E-6
6 SGTC_3284 9108171 4.60 64.9 µM 1.03E-6 15 2.12E-6
7 SGTC_3125 9127534 4.37 49.5 µM 3.14E-6 7 6.09E-6
8 SGTC_1002 4049-0206 4.37 172.0 µM 3.23E-6 19 6.27E-6
9 SGTC_366 0181-0206 4.35 4.3 µM 3.54E-6 Golgi 29 6.84E-6
10 SGTC_583 1488-1091 4.24 88.9 µM 6.05E-6 13 1.13E-5
11 SGTC_2795 7780010 4.09 54.5 µM 1.20E-5 25 2.17E-5
12 SGTC_1268 0828-0275 3.95 2.5 µM 2.25E-5 20 3.91E-5
13 SGTC_815 1582-0027 3.91 36.9 µM 2.66E-5 28 4.59E-5
14 SGTC_1238 0333-0287 3.78 48.8 µM 4.65E-5 Golgi 30 7.78E-5
15 SGTC_911 3456-4043 3.70 236.0 µM 6.62E-5 mitochondrial processes 35 1.08E-4
16 SGTC_1256 0570-0116 3.69 285.0 µM 6.90E-5 24 1.13E-4
17 SGTC_317 4495-0002 3.59 170.0 µM 1.05E-4 16 1.68E-4
18 SGTC_2264 7948757 3.51 110.8 µM 1.42E-4 27 2.23E-4
19 SGTC_2087 5276107 3.51 200.0 µM 1.45E-4 27 2.28E-4
20 SGTC_392 N-ethylmaleimide 3.49 8.3 µM 1.52E-4 RNA pol III & RNase P/MRP 24 2.38E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.17E-12 YFR032C-B_p YFR032C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.117 1.22E-11 YKL133C_p YKL133C_p hom Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype)
0.103 1.89E-9 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.102 2.96E-9 YLR237W THI7 hom Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.098 1.45E-8 YOR227W HER1 hom Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication
0.096 2.74E-8 YLL062C MHT1 hom S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
0.089 2.72E-7 YMR242W-A_p YMR242W-A_p hom Putative protein of unknown function
0.087 4.31E-7 YGR239C PEX21 hom Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress
0.084 1.25E-6 YNL043C_d YNL043C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
0.082 2.00E-6 YJR115W_p YJR115W_p hom Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication
0.080 3.46E-6 YLR402W_d YLR402W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.079 4.03E-6 YLR291C GCD7 het Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.077 7.54E-6 YHL040C ARN1 hom ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress
0.077 8.24E-6 YAR030C_d YAR030C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9
0.076 1.16E-5 YIL112W HOS4 hom Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate