Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YIR029W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.121 | 2.17E-12 | YFR032C-B_p | YFR032C-B_p | hom | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
0.117 | 1.22E-11 | YKL133C_p | YKL133C_p | hom | Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype) |
0.103 | 1.89E-9 | YHR164C | DNA2 | het | Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress |
0.102 | 2.96E-9 | YLR237W | THI7 | hom | Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia |
0.098 | 1.45E-8 | YOR227W | HER1 | hom | Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication |
0.096 | 2.74E-8 | YLL062C | MHT1 | hom | S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio |
0.089 | 2.72E-7 | YMR242W-A_p | YMR242W-A_p | hom | Putative protein of unknown function |
0.087 | 4.31E-7 | YGR239C | PEX21 | hom | Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress |
0.084 | 1.25E-6 | YNL043C_d | YNL043C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W |
0.082 | 2.00E-6 | YJR115W_p | YJR115W_p | hom | Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication |
0.080 | 3.46E-6 | YLR402W_d | YLR402W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
0.079 | 4.03E-6 | YLR291C | GCD7 | het | Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression |
0.077 | 7.54E-6 | YHL040C | ARN1 | hom | ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress |
0.077 | 8.24E-6 | YAR030C_d | YAR030C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9 |
0.076 | 1.16E-5 | YIL112W | HOS4 | hom | Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate |