HIPHOP chemogenomics database

YIR029W / DAL2

Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation

Zygosity: Homozygous strain

fixedexpanded
Profile for YIR029W / DAL2

Click on Significant Values for Screen Details

Top fitness defect scores for YIR029W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2060	5238662	5.90	140.0 µM	5.78E-10		7	1.81E-9
2	SGTC_540	1187-0821	5.66	17.3 µM	2.70E-9		4	7.77E-9
3	SGTC_2484	5809818	4.76	12.0 µM	4.57E-7		10	9.88E-7
4	SGTC_2792	7535235	4.74	81.8 µM	4.98E-7	fatty acid desaturase (OLE1)	18	1.07E-6
5	SGTC_2802	7925815	4.74	54.5 µM	5.08E-7		23	1.09E-6
6	SGTC_3284	9108171	4.60	64.9 µM	1.03E-6		15	2.12E-6
7	SGTC_3125	9127534	4.37	49.5 µM	3.14E-6		7	6.09E-6
8	SGTC_1002	4049-0206	4.37	172.0 µM	3.23E-6		19	6.27E-6
9	SGTC_366	0181-0206	4.35	4.3 µM	3.54E-6	Golgi	29	6.84E-6
10	SGTC_583	1488-1091	4.24	88.9 µM	6.05E-6		13	1.13E-5
11	SGTC_2795	7780010	4.09	54.5 µM	1.20E-5		25	2.17E-5
12	SGTC_1268	0828-0275	3.95	2.5 µM	2.25E-5		20	3.91E-5
13	SGTC_815	1582-0027	3.91	36.9 µM	2.66E-5		28	4.59E-5
14	SGTC_1238	0333-0287	3.78	48.8 µM	4.65E-5	Golgi	30	7.78E-5
15	SGTC_911	3456-4043	3.70	236.0 µM	6.62E-5	mitochondrial processes	35	1.08E-4
16	SGTC_1256	0570-0116	3.69	285.0 µM	6.90E-5		24	1.13E-4
17	SGTC_317	4495-0002	3.59	170.0 µM	1.05E-4		16	1.68E-4
18	SGTC_2264	7948757	3.51	110.8 µM	1.42E-4		27	2.23E-4
19	SGTC_2087	5276107	3.51	200.0 µM	1.45E-4		27	2.28E-4
20	SGTC_392	N-ethylmaleimide	3.49	8.3 µM	1.52E-4	RNA pol III & RNase P/MRP	24	2.38E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.121	2.17E-12	YFR032C-B_p	YFR032C-B_p	hom	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.117	1.22E-11	YKL133C_p	YKL133C_p	hom	Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype)
0.103	1.89E-9	YHR164C	DNA2	het	Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.102	2.96E-9	YLR237W	THI7	hom	Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.098	1.45E-8	YOR227W	HER1	hom	Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication
0.096	2.74E-8	YLL062C	MHT1	hom	S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
0.089	2.72E-7	YMR242W-A_p	YMR242W-A_p	hom	Putative protein of unknown function
0.087	4.31E-7	YGR239C	PEX21	hom	Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress
0.084	1.25E-6	YNL043C_d	YNL043C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
0.082	2.00E-6	YJR115W_p	YJR115W_p	hom	Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication
0.080	3.46E-6	YLR402W_d	YLR402W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.079	4.03E-6	YLR291C	GCD7	het	Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.077	7.54E-6	YHL040C	ARN1	hom	ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress
0.077	8.24E-6	YAR030C_d	YAR030C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9
0.076	1.16E-5	YIL112W	HOS4	hom	Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate