YIR030C / DCG1

Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR030C / DCG1

Click on Significant Values for Screen Details ID:SGTC_117|Compound:lucigenin|FD-Score:3.61|P-value:9.02E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:3.98|P-value:1.88E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:6.63|P-value:3.20E-12 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.76|P-value:4.82E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:4.53|P-value:1.31E-6 ID:SGTC_355|Compound:1311-2252|FD-Score:4.40|P-value:2.55E-6 ID:SGTC_385|Compound:1494-0393|FD-Score:4.06|P-value:1.30E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.22|P-value:4.19E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-3.01|P-value:9.18E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.28|P-value:3.36E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.22|P-value:4.28E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.99|P-value:1.76E-5 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.40|P-value:2.12E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.01|P-value:9.00E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.19|P-value:4.76E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.17|P-value:5.02E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.08|P-value:7.06E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.32|P-value:2.88E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.28|P-value:3.33E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.53|P-value:1.29E-4 ID:SGTC_1759|Compound:st043059|FD-Score:4.67|P-value:6.38E-7 ID:SGTC_1850|Compound:st056238|FD-Score:3.14|P-value:5.65E-4 ID:SGTC_1940|Compound:st075990|FD-Score:4.14|P-value:8.81E-6 ID:SGTC_1952|Compound:st077036|FD-Score:4.23|P-value:5.77E-6 ID:SGTC_1956|Compound:st077085|FD-Score:-3.15|P-value:5.59E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.38|P-value:2.28E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.36|P-value:2.50E-4 ID:SGTC_2026|Compound:5148700|FD-Score:3.30|P-value:3.11E-4 ID:SGTC_2085|Compound:5307070|FD-Score:4.08|P-value:1.19E-5 ID:SGTC_2150|Compound:5556613|FD-Score:3.43|P-value:1.90E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.26|P-value:3.69E-4 ID:SGTC_2206|Compound:7254556|FD-Score:3.33|P-value:2.81E-4 ID:SGTC_2269|Compound:7935389|FD-Score:5.19|P-value:3.65E-8 ID:SGTC_2302|Compound:7771753|FD-Score:3.28|P-value:3.33E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.38|P-value:2.31E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.22|P-value:4.21E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.30|P-value:3.10E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.63|P-value:8.36E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.65|P-value:7.29E-7 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.08|P-value:7.20E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:7.03|P-value:1.59E-13 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.05|P-value:7.97E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.31|P-value:4.06E-6 ID:SGTC_2825|Compound:7998094|FD-Score:3.22|P-value:4.20E-4 ID:SGTC_2865|Compound:9030313|FD-Score:4.99|P-value:1.16E-7 ID:SGTC_2869|Compound:9037858|FD-Score:-6.56|P-value:5.22E-12 ID:SGTC_2873|Compound:9040596|FD-Score:-5.71|P-value:1.62E-9 ID:SGTC_2897|Compound:9048598|FD-Score:3.61|P-value:9.15E-5 ID:SGTC_3310|Compound:9130229|FD-Score:3.36|P-value:2.44E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:3.61|P-value:9.02E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:3.98|P-value:1.88E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:6.63|P-value:3.20E-12 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.76|P-value:4.82E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:4.53|P-value:1.31E-6 ID:SGTC_355|Compound:1311-2252|FD-Score:4.40|P-value:2.55E-6 ID:SGTC_385|Compound:1494-0393|FD-Score:4.06|P-value:1.30E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.22|P-value:4.19E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-3.01|P-value:9.18E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.28|P-value:3.36E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.22|P-value:4.28E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.99|P-value:1.76E-5 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.40|P-value:2.12E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.01|P-value:9.00E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.19|P-value:4.76E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.17|P-value:5.02E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.08|P-value:7.06E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.32|P-value:2.88E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.28|P-value:3.33E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.53|P-value:1.29E-4 ID:SGTC_1759|Compound:st043059|FD-Score:4.67|P-value:6.38E-7 ID:SGTC_1850|Compound:st056238|FD-Score:3.14|P-value:5.65E-4 ID:SGTC_1940|Compound:st075990|FD-Score:4.14|P-value:8.81E-6 ID:SGTC_1952|Compound:st077036|FD-Score:4.23|P-value:5.77E-6 ID:SGTC_1956|Compound:st077085|FD-Score:-3.15|P-value:5.59E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.38|P-value:2.28E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.36|P-value:2.50E-4 ID:SGTC_2026|Compound:5148700|FD-Score:3.30|P-value:3.11E-4 ID:SGTC_2085|Compound:5307070|FD-Score:4.08|P-value:1.19E-5 ID:SGTC_2150|Compound:5556613|FD-Score:3.43|P-value:1.90E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.26|P-value:3.69E-4 ID:SGTC_2206|Compound:7254556|FD-Score:3.33|P-value:2.81E-4 ID:SGTC_2269|Compound:7935389|FD-Score:5.19|P-value:3.65E-8 ID:SGTC_2302|Compound:7771753|FD-Score:3.28|P-value:3.33E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.38|P-value:2.31E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.22|P-value:4.21E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.30|P-value:3.10E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.63|P-value:8.36E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.65|P-value:7.29E-7 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.08|P-value:7.20E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:7.03|P-value:1.59E-13 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.05|P-value:7.97E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.31|P-value:4.06E-6 ID:SGTC_2825|Compound:7998094|FD-Score:3.22|P-value:4.20E-4 ID:SGTC_2865|Compound:9030313|FD-Score:4.99|P-value:1.16E-7 ID:SGTC_2869|Compound:9037858|FD-Score:-6.56|P-value:5.22E-12 ID:SGTC_2873|Compound:9040596|FD-Score:-5.71|P-value:1.62E-9 ID:SGTC_2897|Compound:9048598|FD-Score:3.61|P-value:9.15E-5 ID:SGTC_3310|Compound:9130229|FD-Score:3.36|P-value:2.44E-4

Top fitness defect scores for YIR030C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2596 sinensetin 7.03 100.0 µM 1.59E-13 3 1.02E-12
2 SGTC_349 k015-0014 6.63 24.0 µM 3.20E-12 2 1.68E-11
3 SGTC_2269 7935389 5.19 174.4 µM 3.65E-8 tubulin folding & SWR complex 13 1.03E-7
4 SGTC_2865 9030313 4.99 52.0 µM 1.16E-7 7 3.01E-7
5 SGTC_1759 st043059 4.67 70.0 µM 6.38E-7 amide catabolism 11 1.48E-6
6 SGTC_2504 purpurogallin 4.65 52.3 µM 7.29E-7 RPP1 & pyrimidine depletion 10 1.68E-6
7 SGTC_353 1988-1175 4.53 58.3 µM 1.31E-6 unfolded protein response 17 2.90E-6
8 SGTC_355 1311-2252 4.40 105.0 µM 2.55E-6 11 5.40E-6
9 SGTC_2782 7736369 4.31 71.4 µM 4.06E-6 31 8.34E-6
10 SGTC_1952 st077036 4.23 64.1 µM 5.77E-6 27 1.16E-5
11 SGTC_1940 st075990 4.14 51.1 µM 8.81E-6 60S ribosome export 18 1.72E-5
12 SGTC_2085 5307070 4.08 144.1 µM 1.19E-5 superoxide 24 2.28E-5
13 SGTC_385 1494-0393 4.06 12.4 µM 1.30E-5 19 2.47E-5
14 SGTC_992 3909-8734 3.99 162.0 µM 1.76E-5 19 3.28E-5
15 SGTC_200 k038-0079 3.98 37.5 µM 1.88E-5 ubiquinone biosynthesis & proteasome 53 3.48E-5
16 SGTC_2499 avocadenofuran 3.63 51.5 µM 8.36E-5 51 1.41E-4
17 SGTC_117 lucigenin 3.61 22.1 µM 9.02E-5 redox potentiating 102 1.51E-4
18 SGTC_2897 9048598 3.61 13.0 µM 9.15E-5 22 1.53E-4
19 SGTC_1720 st037298 3.53 9.5 µM 1.29E-4 51 2.11E-4
20 SGTC_2150 5556613 3.43 200.0 µM 1.90E-4 28 3.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.81E-15 YMR017W SPO20 hom Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
0.090 1.98E-7 YGL047W ALG13 het Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress
0.089 2.38E-7 YDL008W APC11 het Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity
0.087 4.70E-7 YJL162C JJJ2 hom Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.086 6.11E-7 YJL038C LOH1 hom Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1
0.084 1.14E-6 YIL095W PRK1 hom Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog, ARK1, that arose from the whole genome duplication
0.082 1.76E-6 YDR483W KRE2 hom Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication
0.081 2.42E-6 YBR177C EHT1 hom Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication
0.080 3.36E-6 YOL052C-A DDR2 hom Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication
0.077 8.47E-6 YMR299C DYN3 hom Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration
0.075 1.23E-5 YOL077C BRX1 het Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif
0.070 4.79E-5 YGL032C AGA2 hom Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds
0.069 6.72E-5 YMR062C ARG7 hom Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine
0.069 6.79E-5 YOL137W BSC6 hom Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.068 7.76E-5 YLR142W PUT1 hom Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source