YIR031C / DAL7

Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR031C / DAL7

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:3.79|P-value:1.04E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:-4.15|P-value:2.54E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.56|P-value:2.62E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:6.69|P-value:3.17E-11 ID:SGTC_93|Compound:0109-0045|FD-Score:3.50|P-value:3.15E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.77|P-value:1.14E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.47|P-value:3.43E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:3.41|P-value:4.23E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:3.83|P-value:8.90E-5 ID:SGTC_198|Compound:3454-2873|FD-Score:5.10|P-value:3.12E-7 ID:SGTC_305|Compound:1682-2595|FD-Score:3.53|P-value:2.75E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.33|P-value:5.68E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:4.22|P-value:1.87E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.19|P-value:9.47E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:5.18|P-value:2.10E-7 ID:SGTC_456|Compound:gingerol|FD-Score:3.40|P-value:4.37E-4 ID:SGTC_466|Compound:geldanamycin|FD-Score:3.30|P-value:6.24E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.21|P-value:8.39E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:3.44|P-value:3.86E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.34|P-value:5.35E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.20|P-value:8.84E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:4.74|P-value:1.80E-6 ID:SGTC_668|Compound:1682-0499|FD-Score:3.70|P-value:1.46E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.52|P-value:2.89E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:4.75|P-value:1.72E-6 ID:SGTC_997|Compound:3996-0078|FD-Score:4.23|P-value:1.75E-5 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.39|P-value:4.58E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:4.77|P-value:1.55E-6 ID:SGTC_1174|Compound:0739-0097|FD-Score:5.24|P-value:1.53E-7 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.47|P-value:6.24E-6 ID:SGTC_1215|Compound:3852-0577|FD-Score:6.10|P-value:1.27E-9 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.32|P-value:5.92E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:7.17|P-value:1.21E-12 ID:SGTC_1431|Compound:4049-0260|FD-Score:-3.23|P-value:8.25E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.30|P-value:6.23E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:4.47|P-value:6.16E-6 ID:SGTC_1609|Compound:st001574|FD-Score:3.36|P-value:5.08E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.84|P-value:8.70E-5 ID:SGTC_1665|Compound:st014639|FD-Score:3.33|P-value:5.63E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.49|P-value:3.19E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-3.61|P-value:2.19E-4 ID:SGTC_1690|Compound:st023502|FD-Score:-3.38|P-value:4.92E-4 ID:SGTC_1691|Compound:st019933|FD-Score:6.32|P-value:3.33E-10 ID:SGTC_1693|Compound:xanthone|FD-Score:4.09|P-value:3.20E-5 ID:SGTC_1713|Compound:st033146|FD-Score:-6.96|P-value:5.44E-12 ID:SGTC_1714|Compound:st033236|FD-Score:4.44|P-value:6.97E-6 ID:SGTC_1891|Compound:st059073|FD-Score:4.01|P-value:4.36E-5 ID:SGTC_1899|Compound:st063254|FD-Score:4.21|P-value:1.89E-5 ID:SGTC_1905|Compound:st060207|FD-Score:4.51|P-value:5.24E-6 ID:SGTC_1939|Compound:st074455|FD-Score:3.47|P-value:3.41E-4 ID:SGTC_1969|Compound:st069479|FD-Score:4.34|P-value:1.12E-5 ID:SGTC_1970|Compound:st070122|FD-Score:4.73|P-value:1.87E-6 ID:SGTC_2017|Compound:5132927|FD-Score:-3.50|P-value:3.25E-4 ID:SGTC_2041|Compound:5107442|FD-Score:4.31|P-value:1.28E-5 ID:SGTC_2056|Compound:5235370|FD-Score:3.43|P-value:4.01E-4 ID:SGTC_2363|Compound:9053361|FD-Score:5.07|P-value:3.50E-7 ID:SGTC_2375|Compound:9072683|FD-Score:5.19|P-value:1.93E-7 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.26|P-value:7.10E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.23|P-value:8.02E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.77|P-value:1.19E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:8.63|P-value:1.68E-17 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.31|P-value:1.23E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:3.75|P-value:1.23E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.54|P-value:4.57E-6 ID:SGTC_2809|Compound:7964133|FD-Score:3.45|P-value:3.71E-4 ID:SGTC_2848|Compound:9016370|FD-Score:4.14|P-value:2.61E-5 ID:SGTC_2863|Compound:9028737|FD-Score:3.64|P-value:1.82E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.57|P-value:2.38E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.84|P-value:1.12E-6 ID:SGTC_2978|Compound:9011784|FD-Score:3.31|P-value:6.06E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.31|P-value:5.93E-4 ID:SGTC_3210|Compound:9128157|FD-Score:5.37|P-value:7.67E-8 ID:SGTC_3213|Compound:9129884|FD-Score:3.18|P-value:9.45E-4 ID:SGTC_3316|Compound:9136639|FD-Score:6.45|P-value:1.44E-10 ID:SGTC_3317|Compound:9138495|FD-Score:3.58|P-value:2.29E-4 ID:SGTC_26|Compound:0302-0163|FD-Score:3.79|P-value:1.04E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:-4.15|P-value:2.54E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.56|P-value:2.62E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:6.69|P-value:3.17E-11 ID:SGTC_93|Compound:0109-0045|FD-Score:3.50|P-value:3.15E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.77|P-value:1.14E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.47|P-value:3.43E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:3.41|P-value:4.23E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:3.83|P-value:8.90E-5 ID:SGTC_198|Compound:3454-2873|FD-Score:5.10|P-value:3.12E-7 ID:SGTC_305|Compound:1682-2595|FD-Score:3.53|P-value:2.75E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.33|P-value:5.68E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:4.22|P-value:1.87E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.19|P-value:9.47E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:5.18|P-value:2.10E-7 ID:SGTC_456|Compound:gingerol|FD-Score:3.40|P-value:4.37E-4 ID:SGTC_466|Compound:geldanamycin|FD-Score:3.30|P-value:6.24E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.21|P-value:8.39E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:3.44|P-value:3.86E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.34|P-value:5.35E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.20|P-value:8.84E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:4.74|P-value:1.80E-6 ID:SGTC_668|Compound:1682-0499|FD-Score:3.70|P-value:1.46E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.52|P-value:2.89E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:4.75|P-value:1.72E-6 ID:SGTC_997|Compound:3996-0078|FD-Score:4.23|P-value:1.75E-5 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.39|P-value:4.58E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:4.77|P-value:1.55E-6 ID:SGTC_1174|Compound:0739-0097|FD-Score:5.24|P-value:1.53E-7 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.47|P-value:6.24E-6 ID:SGTC_1215|Compound:3852-0577|FD-Score:6.10|P-value:1.27E-9 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.32|P-value:5.92E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:7.17|P-value:1.21E-12 ID:SGTC_1431|Compound:4049-0260|FD-Score:-3.23|P-value:8.25E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.30|P-value:6.23E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:4.47|P-value:6.16E-6 ID:SGTC_1609|Compound:st001574|FD-Score:3.36|P-value:5.08E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.84|P-value:8.70E-5 ID:SGTC_1665|Compound:st014639|FD-Score:3.33|P-value:5.63E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.49|P-value:3.19E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-3.61|P-value:2.19E-4 ID:SGTC_1690|Compound:st023502|FD-Score:-3.38|P-value:4.92E-4 ID:SGTC_1691|Compound:st019933|FD-Score:6.32|P-value:3.33E-10 ID:SGTC_1693|Compound:xanthone|FD-Score:4.09|P-value:3.20E-5 ID:SGTC_1713|Compound:st033146|FD-Score:-6.96|P-value:5.44E-12 ID:SGTC_1714|Compound:st033236|FD-Score:4.44|P-value:6.97E-6 ID:SGTC_1891|Compound:st059073|FD-Score:4.01|P-value:4.36E-5 ID:SGTC_1899|Compound:st063254|FD-Score:4.21|P-value:1.89E-5 ID:SGTC_1905|Compound:st060207|FD-Score:4.51|P-value:5.24E-6 ID:SGTC_1939|Compound:st074455|FD-Score:3.47|P-value:3.41E-4 ID:SGTC_1969|Compound:st069479|FD-Score:4.34|P-value:1.12E-5 ID:SGTC_1970|Compound:st070122|FD-Score:4.73|P-value:1.87E-6 ID:SGTC_2017|Compound:5132927|FD-Score:-3.50|P-value:3.25E-4 ID:SGTC_2041|Compound:5107442|FD-Score:4.31|P-value:1.28E-5 ID:SGTC_2056|Compound:5235370|FD-Score:3.43|P-value:4.01E-4 ID:SGTC_2363|Compound:9053361|FD-Score:5.07|P-value:3.50E-7 ID:SGTC_2375|Compound:9072683|FD-Score:5.19|P-value:1.93E-7 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.26|P-value:7.10E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.23|P-value:8.02E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.77|P-value:1.19E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:8.63|P-value:1.68E-17 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.31|P-value:1.23E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:3.75|P-value:1.23E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.54|P-value:4.57E-6 ID:SGTC_2809|Compound:7964133|FD-Score:3.45|P-value:3.71E-4 ID:SGTC_2848|Compound:9016370|FD-Score:4.14|P-value:2.61E-5 ID:SGTC_2863|Compound:9028737|FD-Score:3.64|P-value:1.82E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.57|P-value:2.38E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.84|P-value:1.12E-6 ID:SGTC_2978|Compound:9011784|FD-Score:3.31|P-value:6.06E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.31|P-value:5.93E-4 ID:SGTC_3210|Compound:9128157|FD-Score:5.37|P-value:7.67E-8 ID:SGTC_3213|Compound:9129884|FD-Score:3.18|P-value:9.45E-4 ID:SGTC_3316|Compound:9136639|FD-Score:6.45|P-value:1.44E-10 ID:SGTC_3317|Compound:9138495|FD-Score:3.58|P-value:2.29E-4

Top fitness defect scores for YIR031C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2636 apigenin dimethyl ether 8.63 100.0 µM 1.68E-17 6 3.07E-18
2 SGTC_1423 4048-0112 7.17 5.6 µM 1.21E-12 2 3.72E-13
3 SGTC_68 0986-0284 6.69 82.8 µM 3.17E-11 13 1.14E-11
4 SGTC_3316 9136639 6.45 10.6 µM 1.44E-10 2 5.55E-11
5 SGTC_1691 st019933 6.32 84.6 µM 3.33E-10 2 1.34E-10
6 SGTC_1215 3852-0577 6.10 11.2 µM 1.27E-9 3 5.44E-10
7 SGTC_3210 9128157 5.37 49.5 µM 7.67E-8 21 3.96E-8
8 SGTC_1174 0739-0097 5.24 51.1 µM 1.53E-7 redox potentiating 11 8.15E-8
9 SGTC_2375 9072683 5.19 200.0 µM 1.93E-7 mitochondrial processes 5 1.04E-7
10 SGTC_432 NS 1619 5.18 61.3 µM 2.10E-7 9 1.14E-7
11 SGTC_198 3454-2873 5.10 16.2 µM 3.12E-7 60S ribosome export 3 1.72E-7
12 SGTC_2363 9053361 5.07 176.0 µM 3.50E-7 Golgi 14 1.94E-7
13 SGTC_2930 9013230 4.84 14.9 µM 1.12E-6 heme biosynthesis & mitochondrial translocase 16 6.52E-7
14 SGTC_1164 k060-0068 4.77 93.7 µM 1.55E-6 11 9.21E-7
15 SGTC_913 3487-1245 4.75 167.0 µM 1.72E-6 11 1.02E-6
16 SGTC_654 1124-0271 4.74 80.9 µM 1.80E-6 10 1.08E-6
17 SGTC_1970 st070122 4.73 35.8 µM 1.87E-6 TSC3-RPN4 14 1.12E-6
18 SGTC_2781 5567276 4.54 71.4 µM 4.57E-6 31 2.84E-6
19 SGTC_1905 st060207 4.51 84.5 µM 5.24E-6 4 3.28E-6
20 SGTC_1596 piperlongumine 4.47 63.0 µM 6.16E-6 5 3.89E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.097 2.03E-8 YDR329C PEX3 hom Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p
0.096 2.62E-8 YHR066W SSF1 hom Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication
0.096 2.74E-8 YFR015C GSY1 hom Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.093 6.69E-8 YPR041W TIF5 het Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2
0.091 1.45E-7 YNR072W HXT17 hom Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose
0.087 4.93E-7 YIL067C_p YIL067C_p hom Uncharacterized protein of unknown function
0.086 6.80E-7 YNL101W AVT4 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.084 1.12E-6 YHR137W ARO9 hom Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
0.076 1.06E-5 YBL009W ALK2 hom Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins
0.076 1.07E-5 YGR035W-A_p YGR035W-A_p hom Putative protein of unknown function
0.074 1.78E-5 YNL303W_d YNL303W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.073 2.62E-5 YOR331C_d YOR331C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W
0.071 3.67E-5 YOL013W-B_d YOL013W-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element
0.064 1.95E-4 YIL024C_p YIL024C_p hom Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
0.064 2.02E-4 YKR052C MRS4 hom Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication