HIPHOP chemogenomics database
YIR031C / DAL7 
Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YIR031C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.097 | 2.03E-8 | YDR329C | PEX3 | hom | Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p |
| 0.096 | 2.62E-8 | YHR066W | SSF1 | hom | Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication |
| 0.096 | 2.74E-8 | YFR015C | GSY1 | hom | Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress |
| 0.093 | 6.69E-8 | YPR041W | TIF5 | het | Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2 |
| 0.091 | 1.45E-7 | YNR072W | HXT17 | hom | Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose |
| 0.087 | 4.93E-7 | YIL067C_p | YIL067C_p | hom | Uncharacterized protein of unknown function |
| 0.086 | 6.80E-7 | YNL101W | AVT4 | hom | Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters |
| 0.084 | 1.12E-6 | YHR137W | ARO9 | hom | Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism |
| 0.076 | 1.06E-5 | YBL009W | ALK2 | hom | Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins |
| 0.076 | 1.07E-5 | YGR035W-A_p | YGR035W-A_p | hom | Putative protein of unknown function |
| 0.074 | 1.78E-5 | YNL303W_d | YNL303W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.073 | 2.62E-5 | YOR331C_d | YOR331C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W |
| 0.071 | 3.67E-5 | YOL013W-B_d | YOL013W-B_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element |
| 0.064 | 1.95E-4 | YIL024C_p | YIL024C_p | hom | Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p |
| 0.064 | 2.02E-4 | YKR052C | MRS4 | hom | Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication |