YIR032C / DAL3

Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR032C / DAL3

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.84|P-value:5.04E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:3.40|P-value:3.40E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:-3.39|P-value:2.95E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.54|P-value:1.64E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.12|P-value:9.07E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.63|P-value:1.39E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.05|P-value:9.89E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.10|P-value:8.18E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.31|P-value:4.68E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.56|P-value:1.88E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.23|P-value:6.32E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:3.40|P-value:3.39E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:-3.16|P-value:6.67E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.55|P-value:1.94E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.67|P-value:1.20E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.10|P-value:9.79E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:6.49|P-value:3.75E-11 ID:SGTC_902|Compound:1120-0002|FD-Score:3.73|P-value:9.47E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:4.54|P-value:2.76E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.67|P-value:1.23E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.29|P-value:5.13E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:4.90|P-value:4.59E-7 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.17|P-value:7.74E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.47|P-value:2.61E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:4.65|P-value:1.58E-6 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:4.61|P-value:1.97E-6 ID:SGTC_1554|Compound:st069299|FD-Score:5.97|P-value:1.06E-9 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.71|P-value:1.02E-4 ID:SGTC_1725|Compound:st036284|FD-Score:4.70|P-value:1.24E-6 ID:SGTC_1729|Compound:st035615|FD-Score:3.68|P-value:1.18E-4 ID:SGTC_1812|Compound:st052057|FD-Score:-7.14|P-value:2.77E-13 ID:SGTC_1842|Compound:st055362|FD-Score:3.74|P-value:9.25E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.25|P-value:5.74E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.83|P-value:6.49E-7 ID:SGTC_2188|Compound:6126565|FD-Score:3.36|P-value:3.95E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.64|P-value:1.38E-4 ID:SGTC_2413|Compound:inermin|FD-Score:7.74|P-value:3.95E-15 ID:SGTC_2416|Compound:tofa|FD-Score:8.31|P-value:3.67E-17 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.94|P-value:4.07E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:5.70|P-value:5.67E-9 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.62|P-value:1.49E-4 ID:SGTC_2591|Compound:skatole|FD-Score:3.39|P-value:3.58E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.02|P-value:2.89E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.61|P-value:1.53E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.24|P-value:6.06E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.69|P-value:1.13E-4 ID:SGTC_2782|Compound:7736369|FD-Score:8.34|P-value:2.78E-17 ID:SGTC_2808|Compound:7946468|FD-Score:-3.19|P-value:6.12E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.41|P-value:2.75E-4 ID:SGTC_2836|Compound:9010338|FD-Score:4.71|P-value:1.22E-6 ID:SGTC_2985|Compound:9022375|FD-Score:3.13|P-value:8.71E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-3.09|P-value:8.49E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-3.72|P-value:8.15E-5 ID:SGTC_3089|Compound:9117425|FD-Score:3.80|P-value:7.33E-5 ID:SGTC_3218|Compound:9131285|FD-Score:-3.33|P-value:3.74E-4 ID:SGTC_3277|Compound:9138724|FD-Score:-4.29|P-value:6.94E-6 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.84|P-value:5.04E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:3.40|P-value:3.40E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:-3.39|P-value:2.95E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.54|P-value:1.64E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.12|P-value:9.07E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.63|P-value:1.39E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.05|P-value:9.89E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.10|P-value:8.18E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.31|P-value:4.68E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.56|P-value:1.88E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.23|P-value:6.32E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:3.40|P-value:3.39E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:-3.16|P-value:6.67E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.55|P-value:1.94E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.67|P-value:1.20E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.10|P-value:9.79E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:6.49|P-value:3.75E-11 ID:SGTC_902|Compound:1120-0002|FD-Score:3.73|P-value:9.47E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:4.54|P-value:2.76E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.67|P-value:1.23E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.29|P-value:5.13E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:4.90|P-value:4.59E-7 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.17|P-value:7.74E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.47|P-value:2.61E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:4.65|P-value:1.58E-6 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:4.61|P-value:1.97E-6 ID:SGTC_1554|Compound:st069299|FD-Score:5.97|P-value:1.06E-9 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.71|P-value:1.02E-4 ID:SGTC_1725|Compound:st036284|FD-Score:4.70|P-value:1.24E-6 ID:SGTC_1729|Compound:st035615|FD-Score:3.68|P-value:1.18E-4 ID:SGTC_1812|Compound:st052057|FD-Score:-7.14|P-value:2.77E-13 ID:SGTC_1842|Compound:st055362|FD-Score:3.74|P-value:9.25E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.25|P-value:5.74E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.83|P-value:6.49E-7 ID:SGTC_2188|Compound:6126565|FD-Score:3.36|P-value:3.95E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.64|P-value:1.38E-4 ID:SGTC_2413|Compound:inermin|FD-Score:7.74|P-value:3.95E-15 ID:SGTC_2416|Compound:tofa|FD-Score:8.31|P-value:3.67E-17 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.94|P-value:4.07E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:5.70|P-value:5.67E-9 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.62|P-value:1.49E-4 ID:SGTC_2591|Compound:skatole|FD-Score:3.39|P-value:3.58E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.02|P-value:2.89E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.61|P-value:1.53E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.24|P-value:6.06E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.69|P-value:1.13E-4 ID:SGTC_2782|Compound:7736369|FD-Score:8.34|P-value:2.78E-17 ID:SGTC_2808|Compound:7946468|FD-Score:-3.19|P-value:6.12E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.41|P-value:2.75E-4 ID:SGTC_2836|Compound:9010338|FD-Score:4.71|P-value:1.22E-6 ID:SGTC_2985|Compound:9022375|FD-Score:3.13|P-value:8.71E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-3.09|P-value:8.49E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-3.72|P-value:8.15E-5 ID:SGTC_3089|Compound:9117425|FD-Score:3.80|P-value:7.33E-5 ID:SGTC_3218|Compound:9131285|FD-Score:-3.33|P-value:3.74E-4 ID:SGTC_3277|Compound:9138724|FD-Score:-4.29|P-value:6.94E-6

Top fitness defect scores for YIR032C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2782 7736369 8.34 71.4 µM 2.78E-17 2 3.60E-17
2 SGTC_2416 tofa 8.31 880.0 nM 3.67E-17 sphingolipid biosynthesis & PDR1 13 4.73E-17
3 SGTC_2413 inermin 7.74 26.1 µM 3.95E-15 9 4.86E-15
4 SGTC_825 1988-2224 6.49 89.6 µM 3.75E-11 cell wall signaling 11 4.23E-11
5 SGTC_1554 st069299 5.97 38.7 µM 1.06E-9 2 1.16E-9
6 SGTC_2519 cryptotanshinone 5.70 88.0 µM 5.67E-9 heme biosynthesis & mitochondrial translocase 3 6.11E-9
7 SGTC_1303 1160-0052 4.90 261.0 µM 4.59E-7 4 4.77E-7
8 SGTC_2021 4019055 4.83 173.0 µM 6.49E-7 endomembrane recycling 72 6.73E-7
9 SGTC_2836 9010338 4.71 19.5 µM 1.22E-6 RPP1 & pyrimidine depletion 14 1.25E-6
10 SGTC_1725 st036284 4.70 20.6 µM 1.24E-6 18 1.28E-6
11 SGTC_1538 2',3',6-trimethoxyflavanone 4.65 63.6 µM 1.58E-6 9 1.63E-6
12 SGTC_1551 6-bromo-3'-methylflavone 4.61 63.5 µM 1.97E-6 6 2.02E-6
13 SGTC_972 1319-0219 4.54 195.0 µM 2.76E-6 11 2.83E-6
14 SGTC_2620 irigenin 4.02 100.0 µM 2.89E-5 38 2.91E-5
15 SGTC_2418 pentamidine 3.94 31.7 µM 4.07E-5 mitochondrial processes 44 4.10E-5
16 SGTC_3089 9117425 3.80 49.5 µM 7.33E-5 26 7.34E-5
17 SGTC_1842 st055362 3.74 61.2 µM 9.25E-5 18 9.25E-5
18 SGTC_902 1120-0002 3.73 2.1 µM 9.47E-5 azole & statin 54 9.47E-5
19 SGTC_1589 2',5'-dimethoxyflavone 3.71 47.2 µM 1.02E-4 23 1.02E-4
20 SGTC_2780 5215298 3.69 71.4 µM 1.13E-4 44 1.12E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.207 1.17E-33 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.182 2.72E-26 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.135 3.44E-15 YJL218W_p YJL218W_p hom Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
0.127 1.34E-13 YGL113W SLD3 het Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress
0.122 1.13E-12 YNL338W_d YNL338W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
0.114 4.11E-11 YPL247C_p YPL247C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest
0.112 7.18E-11 YLR044C PDC1 hom Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
0.112 7.22E-11 YPL150W_p YPL150W_p hom Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study
0.112 7.44E-11 YER177W BMH1 hom 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.107 4.44E-10 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.104 1.35E-9 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.098 1.13E-8 YOL077C BRX1 het Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif
0.098 1.15E-8 YKL053C-A MDM35 hom Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.097 1.63E-8 YOL146W PSF3 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.094 4.75E-8 YPL112C PEX25 hom Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p