YIR036C_p / IRC24

Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR036C / IRC24

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:-3.65|P-value:1.41E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:3.19|P-value:7.65E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:-5.63|P-value:1.08E-8 ID:SGTC_124|Compound:0136-0217|FD-Score:-4.37|P-value:6.90E-6 ID:SGTC_130|Compound:0136-0219|FD-Score:3.55|P-value:2.13E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:4.39|P-value:6.43E-6 ID:SGTC_422|Compound:cantharidin|FD-Score:-4.03|P-value:3.10E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:3.91|P-value:5.15E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:3.94|P-value:4.54E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:3.36|P-value:4.20E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.78|P-value:8.88E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.33|P-value:4.68E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.45|P-value:3.12E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.97|P-value:4.03E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.51|P-value:2.48E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.74|P-value:1.24E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.11|P-value:9.99E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.66|P-value:1.42E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:-3.38|P-value:3.87E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.64|P-value:1.49E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:7.06|P-value:1.17E-12 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.61|P-value:1.67E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.12|P-value:9.90E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-4.83|P-value:7.96E-7 ID:SGTC_1531|Compound:st059297|FD-Score:3.68|P-value:1.27E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.59|P-value:1.83E-4 ID:SGTC_1840|Compound:st055363|FD-Score:5.24|P-value:9.57E-8 ID:SGTC_2002|Compound:4023503|FD-Score:4.73|P-value:1.35E-6 ID:SGTC_2193|Compound:5925765|FD-Score:3.15|P-value:8.84E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-3.94|P-value:4.47E-5 ID:SGTC_2291|Compound:7917025|FD-Score:3.42|P-value:3.48E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.39|P-value:3.89E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:4.72|P-value:1.39E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.21|P-value:7.15E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.68|P-value:1.27E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.21|P-value:1.45E-5 ID:SGTC_3043|Compound:9092303|FD-Score:3.25|P-value:6.26E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.44|P-value:3.16E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-4.24|P-value:1.27E-5 ID:SGTC_3180|Compound:9109287|FD-Score:-3.23|P-value:6.52E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.14|P-value:9.06E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.67|P-value:1.34E-4 ID:SGTC_3287|Compound:9117173|FD-Score:3.38|P-value:3.89E-4 ID:SGTC_3294|Compound:9122953|FD-Score:5.39|P-value:4.27E-8 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.65|P-value:1.41E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:3.19|P-value:7.65E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:-5.63|P-value:1.08E-8 ID:SGTC_124|Compound:0136-0217|FD-Score:-4.37|P-value:6.90E-6 ID:SGTC_130|Compound:0136-0219|FD-Score:3.55|P-value:2.13E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:4.39|P-value:6.43E-6 ID:SGTC_422|Compound:cantharidin|FD-Score:-4.03|P-value:3.10E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:3.91|P-value:5.15E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:3.94|P-value:4.54E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:3.36|P-value:4.20E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.78|P-value:8.88E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.33|P-value:4.68E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.45|P-value:3.12E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.97|P-value:4.03E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.51|P-value:2.48E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.74|P-value:1.24E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.11|P-value:9.99E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.66|P-value:1.42E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:-3.38|P-value:3.87E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.64|P-value:1.49E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:7.06|P-value:1.17E-12 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.61|P-value:1.67E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.12|P-value:9.90E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-4.83|P-value:7.96E-7 ID:SGTC_1531|Compound:st059297|FD-Score:3.68|P-value:1.27E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.59|P-value:1.83E-4 ID:SGTC_1840|Compound:st055363|FD-Score:5.24|P-value:9.57E-8 ID:SGTC_2002|Compound:4023503|FD-Score:4.73|P-value:1.35E-6 ID:SGTC_2193|Compound:5925765|FD-Score:3.15|P-value:8.84E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-3.94|P-value:4.47E-5 ID:SGTC_2291|Compound:7917025|FD-Score:3.42|P-value:3.48E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.39|P-value:3.89E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:4.72|P-value:1.39E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.21|P-value:7.15E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.68|P-value:1.27E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.21|P-value:1.45E-5 ID:SGTC_3043|Compound:9092303|FD-Score:3.25|P-value:6.26E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.44|P-value:3.16E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-4.24|P-value:1.27E-5 ID:SGTC_3180|Compound:9109287|FD-Score:-3.23|P-value:6.52E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.14|P-value:9.06E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.67|P-value:1.34E-4 ID:SGTC_3287|Compound:9117173|FD-Score:3.38|P-value:3.89E-4 ID:SGTC_3294|Compound:9122953|FD-Score:5.39|P-value:4.27E-8

Top fitness defect scores for YIR036C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1305 1181-0477 7.06 144.0 µM 1.17E-12 3 8.27E-13
2 SGTC_3294 9122953 5.39 26.3 µM 4.27E-8 tubulin folding & SWR complex 12 3.47E-8
3 SGTC_1840 st055363 5.24 71.0 µM 9.57E-8 1 7.85E-8
4 SGTC_1264 0783-0040 4.74 158.0 µM 1.24E-6 10 1.05E-6
5 SGTC_2002 4023503 4.73 131.0 µM 1.35E-6 mitochondrial processes 16 1.14E-6
6 SGTC_2516 gossypol 4.72 71.5 µM 1.39E-6 8 1.18E-6
7 SGTC_135 0933-0004 4.39 26.4 µM 6.43E-6 60S ribosome export 13 5.58E-6
8 SGTC_2767 sibutramine 4.21 71.5 µM 1.45E-5 17 1.27E-5
9 SGTC_1257 0669-0121 3.97 16.0 µM 4.03E-5 25 3.59E-5
10 SGTC_431 k089-0097 3.94 107.0 µM 4.54E-5 iron homeostasis 42 4.04E-5
11 SGTC_427 1354-0053 3.91 47.3 µM 5.15E-5 22 4.59E-5
12 SGTC_815 1582-0027 3.78 36.9 µM 8.88E-5 34 7.98E-5
13 SGTC_1531 st059297 3.68 52.4 µM 1.27E-4 24 1.14E-4
14 SGTC_3286 9117135 3.67 37.2 µM 1.34E-4 21 1.21E-4
15 SGTC_1279 0874-0590 3.66 65.2 µM 1.42E-4 45 1.28E-4
16 SGTC_1295 1013-0063 3.64 9.8 µM 1.49E-4 19 1.34E-4
17 SGTC_1311 1190-0148 3.61 100.0 µM 1.67E-4 azole & statin 36 1.51E-4
18 SGTC_1685 st024049 3.59 53.1 µM 1.83E-4 TSC3-RPN4 20 1.65E-4
19 SGTC_130 0136-0219 3.55 337.7 µM 2.13E-4 34 1.93E-4
20 SGTC_1262 0737-0114 3.51 49.6 µM 2.48E-4 35 2.26E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 5.99E-15 YLR037C PAU23 hom Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth
0.118 7.43E-12 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.114 3.35E-11 YLR177W_p YLR177W_p hom Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication
0.095 3.09E-8 YMR252C_p YMR252C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene
0.090 1.75E-7 YLR298C YHC1 het Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site
0.084 1.08E-6 YFR012W DCV1 hom Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication
0.084 1.19E-6 YPL033C SRL4 hom Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p
0.083 1.45E-6 YDR258C HSP78 hom Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates
0.083 1.46E-6 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.081 2.41E-6 YLR305C STT4 het Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization
0.079 4.15E-6 YDR436W PPZ2 hom Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.077 7.47E-6 YBR199W KTR4 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
0.076 1.11E-5 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.075 1.20E-5 YDL091C UBX3 hom Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10
0.074 1.62E-5 YPR012W_d YPR012W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene