YIR037W / HYR1

Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR037W / HYR1

Click on Significant Values for Screen Details ID:SGTC_131|Compound:0141-0277|FD-Score:-3.99|P-value:5.56E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:-4.22|P-value:2.24E-5 ID:SGTC_251|Compound:melphalan|FD-Score:3.48|P-value:3.74E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.85|P-value:9.59E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:5.24|P-value:1.97E-7 ID:SGTC_764|Compound:1951-2361|FD-Score:3.51|P-value:3.39E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.60|P-value:2.42E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.86|P-value:9.43E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:-3.70|P-value:1.73E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:-4.20|P-value:2.41E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:3.33|P-value:6.24E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:-4.61|P-value:4.11E-6 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.68|P-value:1.83E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.36|P-value:5.71E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.21|P-value:9.49E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.39|P-value:5.18E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:5.18|P-value:2.67E-7 ID:SGTC_1516|Compound:st013856|FD-Score:4.14|P-value:3.11E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.87|P-value:9.03E-5 ID:SGTC_1790|Compound:st045711|FD-Score:-3.89|P-value:8.37E-5 ID:SGTC_1849|Compound:st056239|FD-Score:3.45|P-value:4.25E-4 ID:SGTC_1860|Compound:st056228|FD-Score:-3.32|P-value:6.46E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.43|P-value:4.54E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.27|P-value:7.68E-4 ID:SGTC_1963|Compound:st076565|FD-Score:3.35|P-value:5.92E-4 ID:SGTC_1987|Compound:st072290|FD-Score:4.67|P-value:3.07E-6 ID:SGTC_2088|Compound:5278280|FD-Score:3.64|P-value:2.15E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.27|P-value:7.68E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.93|P-value:7.16E-5 ID:SGTC_2279|Compound:7948423|FD-Score:-3.56|P-value:2.82E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.82|P-value:1.08E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.84|P-value:9.93E-5 ID:SGTC_2396|Compound:5342950|FD-Score:4.27|P-value:1.76E-5 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.62|P-value:2.32E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.87|P-value:8.88E-5 ID:SGTC_2643|Compound:anethole|FD-Score:5.34|P-value:1.19E-7 ID:SGTC_2696|Compound:st077691|FD-Score:3.34|P-value:6.02E-4 ID:SGTC_2715|Compound:st079500|FD-Score:3.21|P-value:9.37E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:-3.49|P-value:3.70E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:3.26|P-value:7.94E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.82|P-value:1.09E-4 ID:SGTC_2921|Compound:7974240|FD-Score:4.23|P-value:2.13E-5 ID:SGTC_2974|Compound:9094440|FD-Score:3.92|P-value:7.30E-5 ID:SGTC_2980|Compound:9014342|FD-Score:3.21|P-value:9.51E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.42|P-value:4.61E-4 ID:SGTC_3088|Compound:9117578|FD-Score:3.76|P-value:1.34E-4 ID:SGTC_3149|Compound:9097855|FD-Score:4.33|P-value:1.39E-5 ID:SGTC_3151|Compound:9099821|FD-Score:4.13|P-value:3.13E-5 ID:SGTC_3294|Compound:9122953|FD-Score:3.46|P-value:4.08E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.25|P-value:8.24E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.99|P-value:5.56E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:-4.22|P-value:2.24E-5 ID:SGTC_251|Compound:melphalan|FD-Score:3.48|P-value:3.74E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.85|P-value:9.59E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:5.24|P-value:1.97E-7 ID:SGTC_764|Compound:1951-2361|FD-Score:3.51|P-value:3.39E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.60|P-value:2.42E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.86|P-value:9.43E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:-3.70|P-value:1.73E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:-4.20|P-value:2.41E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:3.33|P-value:6.24E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:-4.61|P-value:4.11E-6 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.68|P-value:1.83E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.36|P-value:5.71E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.21|P-value:9.49E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.39|P-value:5.18E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:5.18|P-value:2.67E-7 ID:SGTC_1516|Compound:st013856|FD-Score:4.14|P-value:3.11E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.87|P-value:9.03E-5 ID:SGTC_1790|Compound:st045711|FD-Score:-3.89|P-value:8.37E-5 ID:SGTC_1849|Compound:st056239|FD-Score:3.45|P-value:4.25E-4 ID:SGTC_1860|Compound:st056228|FD-Score:-3.32|P-value:6.46E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.43|P-value:4.54E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.27|P-value:7.68E-4 ID:SGTC_1963|Compound:st076565|FD-Score:3.35|P-value:5.92E-4 ID:SGTC_1987|Compound:st072290|FD-Score:4.67|P-value:3.07E-6 ID:SGTC_2088|Compound:5278280|FD-Score:3.64|P-value:2.15E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.27|P-value:7.68E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.93|P-value:7.16E-5 ID:SGTC_2279|Compound:7948423|FD-Score:-3.56|P-value:2.82E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.82|P-value:1.08E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.84|P-value:9.93E-5 ID:SGTC_2396|Compound:5342950|FD-Score:4.27|P-value:1.76E-5 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.62|P-value:2.32E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.87|P-value:8.88E-5 ID:SGTC_2643|Compound:anethole|FD-Score:5.34|P-value:1.19E-7 ID:SGTC_2696|Compound:st077691|FD-Score:3.34|P-value:6.02E-4 ID:SGTC_2715|Compound:st079500|FD-Score:3.21|P-value:9.37E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:-3.49|P-value:3.70E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:3.26|P-value:7.94E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.82|P-value:1.09E-4 ID:SGTC_2921|Compound:7974240|FD-Score:4.23|P-value:2.13E-5 ID:SGTC_2974|Compound:9094440|FD-Score:3.92|P-value:7.30E-5 ID:SGTC_2980|Compound:9014342|FD-Score:3.21|P-value:9.51E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.42|P-value:4.61E-4 ID:SGTC_3088|Compound:9117578|FD-Score:3.76|P-value:1.34E-4 ID:SGTC_3149|Compound:9097855|FD-Score:4.33|P-value:1.39E-5 ID:SGTC_3151|Compound:9099821|FD-Score:4.13|P-value:3.13E-5 ID:SGTC_3294|Compound:9122953|FD-Score:3.46|P-value:4.08E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.25|P-value:8.24E-4

Top fitness defect scores for YIR037W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2643 anethole 5.34 100.0 µM 1.19E-7 5 4.70E-8
2 SGTC_722 3534-0461 5.24 190.0 µM 1.97E-7 PDR1 15 8.06E-8
3 SGTC_1251 0490-5699 5.18 265.0 µM 2.67E-7 14 1.11E-7
4 SGTC_1987 st072290 4.67 61.9 µM 3.07E-6 7 1.50E-6
5 SGTC_3149 9097855 4.33 49.5 µM 1.39E-5 Golgi 18 7.47E-6
6 SGTC_2396 5342950 4.27 42.8 µM 1.76E-5 RSC complex & mRNA processing 32 9.65E-6
7 SGTC_2921 7974240 4.23 10.7 µM 2.13E-5 39 1.18E-5
8 SGTC_1516 st013856 4.14 110.0 µM 3.11E-5 11 1.77E-5
9 SGTC_3151 9099821 4.13 49.5 µM 3.13E-5 15 1.78E-5
10 SGTC_2163 5671233 3.93 125.0 µM 7.16E-5 26 4.29E-5
11 SGTC_2974 9094440 3.92 9.7 µM 7.30E-5 ergosterol biosynthesis 47 4.37E-5
12 SGTC_1785 bathophenanthroline 3.87 24.0 µM 9.03E-5 heme requiring 52 5.48E-5
13 SGTC_911 3456-4043 3.86 236.0 µM 9.43E-5 mitochondrial processes 30 5.74E-5
14 SGTC_2342 7990637 3.84 118.9 µM 9.93E-5 RNA processing & uracil transport 39 6.06E-5
15 SGTC_2302 7771753 3.82 200.0 µM 1.08E-4 45 6.60E-5
16 SGTC_2841 9004761 3.82 39.0 µM 1.09E-4 amide catabolism 34 6.67E-5
17 SGTC_3088 9117578 3.76 49.5 µM 1.34E-4 amide catabolism 12 8.33E-5
18 SGTC_1052 3253-3998 3.68 198.0 µM 1.83E-4 26 1.16E-4
19 SGTC_2088 5278280 3.64 127.4 µM 2.15E-4 34 1.38E-4
20 SGTC_2524 avocatin b 3.62 10.6 µM 2.32E-4 31 1.49E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.094 5.10E-8 YML007W YAP1 hom Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.092 9.35E-8 YKR087C OMA1 hom Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes
0.084 1.06E-6 YHR103W SBE22 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth
0.084 1.12E-6 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.083 1.68E-6 YIL053W RHR2 hom Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication
0.081 2.97E-6 YLR345W_p YLR345W_p hom Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene
0.079 4.60E-6 YMR242C RPL20A hom Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication
0.079 4.89E-6 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.076 9.26E-6 YGR284C ERV29 hom Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress
0.074 1.90E-5 YNL326C PFA3 hom Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions
0.073 2.36E-5 YCL074W YCL074W hom Pseudogene: encodes fragment of Ty Pol protein
0.072 2.79E-5 YBR107C IML3 hom Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1
0.071 3.97E-5 YBR074W_p YBR074W_p hom Putative metalloprotease
0.071 4.36E-5 YOL108C INO4 hom Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain
0.068 8.17E-5 YOR298W MUM3 hom Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases