HIPHOP chemogenomics database

YIR037W / HYR1

Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor

Zygosity: Homozygous strain

fixedexpanded
Profile for YIR037W / HYR1

Click on Significant Values for Screen Details

Top fitness defect scores for YIR037W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2643	anethole	5.34	100.0 µM	1.19E-7		5	4.70E-8
2	SGTC_722	3534-0461	5.24	190.0 µM	1.97E-7	PDR1	15	8.06E-8
3	SGTC_1251	0490-5699	5.18	265.0 µM	2.67E-7		14	1.11E-7
4	SGTC_1987	st072290	4.67	61.9 µM	3.07E-6		7	1.50E-6
5	SGTC_3149	9097855	4.33	49.5 µM	1.39E-5	Golgi	18	7.47E-6
6	SGTC_2396	5342950	4.27	42.8 µM	1.76E-5	RSC complex & mRNA processing	32	9.65E-6
7	SGTC_2921	7974240	4.23	10.7 µM	2.13E-5		39	1.18E-5
8	SGTC_1516	st013856	4.14	110.0 µM	3.11E-5		11	1.77E-5
9	SGTC_3151	9099821	4.13	49.5 µM	3.13E-5		15	1.78E-5
10	SGTC_2163	5671233	3.93	125.0 µM	7.16E-5		26	4.29E-5
11	SGTC_2974	9094440	3.92	9.7 µM	7.30E-5	ergosterol biosynthesis	47	4.37E-5
12	SGTC_1785	bathophenanthroline	3.87	24.0 µM	9.03E-5	heme requiring	52	5.48E-5
13	SGTC_911	3456-4043	3.86	236.0 µM	9.43E-5	mitochondrial processes	30	5.74E-5
14	SGTC_2342	7990637	3.84	118.9 µM	9.93E-5	RNA processing & uracil transport	39	6.06E-5
15	SGTC_2302	7771753	3.82	200.0 µM	1.08E-4		45	6.60E-5
16	SGTC_2841	9004761	3.82	39.0 µM	1.09E-4	amide catabolism	34	6.67E-5
17	SGTC_3088	9117578	3.76	49.5 µM	1.34E-4	amide catabolism	12	8.33E-5
18	SGTC_1052	3253-3998	3.68	198.0 µM	1.83E-4		26	1.16E-4
19	SGTC_2088	5278280	3.64	127.4 µM	2.15E-4		34	1.38E-4
20	SGTC_2524	avocatin b	3.62	10.6 µM	2.32E-4		31	1.49E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.094	5.10E-8	YML007W	YAP1	hom	Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.092	9.35E-8	YKR087C	OMA1	hom	Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes
0.084	1.06E-6	YHR103W	SBE22	hom	Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth
0.084	1.12E-6	YDR210W_p	YDR210W_p	hom	Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.083	1.68E-6	YIL053W	RHR2	hom	Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication
0.081	2.97E-6	YLR345W_p	YLR345W_p	hom	Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene
0.079	4.60E-6	YMR242C	RPL20A	hom	Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication
0.079	4.89E-6	YPL242C	IQG1	het	Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.076	9.26E-6	YGR284C	ERV29	hom	Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress
0.074	1.90E-5	YNL326C	PFA3	hom	Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions
0.073	2.36E-5	YCL074W	YCL074W	hom	Pseudogene: encodes fragment of Ty Pol protein
0.072	2.79E-5	YBR107C	IML3	hom	Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1
0.071	3.97E-5	YBR074W_p	YBR074W_p	hom	Putative metalloprotease
0.071	4.36E-5	YOL108C	INO4	hom	Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain
0.068	8.17E-5	YOR298W	MUM3	hom	Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases