YIR038C / GTT1

ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR038C / GTT1

Click on Significant Values for Screen Details ID:SGTC_294|Compound:k038-0071|FD-Score:3.39|P-value:5.31E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.64|P-value:2.21E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.43|P-value:4.69E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.67|P-value:2.01E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-7.14|P-value:5.32E-12 ID:SGTC_1111|Compound:tnp00062|FD-Score:-5.23|P-value:3.36E-7 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.28|P-value:7.76E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.46|P-value:4.23E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.79|P-value:1.28E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:4.75|P-value:2.35E-6 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.65|P-value:2.16E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:5.27|P-value:1.97E-7 ID:SGTC_1521|Compound:st012942|FD-Score:-3.42|P-value:5.90E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:4.88|P-value:1.31E-6 ID:SGTC_1830|Compound:st055982|FD-Score:-5.06|P-value:7.37E-7 ID:SGTC_2050|Compound:5263056|FD-Score:3.47|P-value:4.05E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.21|P-value:9.48E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.72|P-value:1.66E-4 ID:SGTC_2138|Compound:5575593|FD-Score:4.98|P-value:8.13E-7 ID:SGTC_2145|Compound:5634607|FD-Score:3.42|P-value:4.78E-4 ID:SGTC_2152|Compound:5568786|FD-Score:4.48|P-value:7.99E-6 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.88|P-value:9.10E-5 ID:SGTC_2287|Compound:7945887|FD-Score:4.12|P-value:3.52E-5 ID:SGTC_2291|Compound:7917025|FD-Score:5.45|P-value:7.97E-8 ID:SGTC_2304|Compound:7443016|FD-Score:5.15|P-value:3.62E-7 ID:SGTC_2311|Compound:7694451|FD-Score:-3.41|P-value:6.11E-4 ID:SGTC_2382|Compound:9035899|FD-Score:4.04|P-value:4.97E-5 ID:SGTC_2427|Compound:5545055|FD-Score:3.74|P-value:1.52E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.64|P-value:2.80E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.21|P-value:9.66E-4 ID:SGTC_2696|Compound:st077691|FD-Score:4.07|P-value:4.27E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.27|P-value:9.72E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.85|P-value:1.00E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.63|P-value:2.33E-4 ID:SGTC_3224|Compound:9130643|FD-Score:5.47|P-value:6.98E-8 ID:SGTC_3325|Compound:9138760|FD-Score:4.24|P-value:2.22E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:3.39|P-value:5.31E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.64|P-value:2.21E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.43|P-value:4.69E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.67|P-value:2.01E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-7.14|P-value:5.32E-12 ID:SGTC_1111|Compound:tnp00062|FD-Score:-5.23|P-value:3.36E-7 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.28|P-value:7.76E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.46|P-value:4.23E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.79|P-value:1.28E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:4.75|P-value:2.35E-6 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.65|P-value:2.16E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:5.27|P-value:1.97E-7 ID:SGTC_1521|Compound:st012942|FD-Score:-3.42|P-value:5.90E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:4.88|P-value:1.31E-6 ID:SGTC_1830|Compound:st055982|FD-Score:-5.06|P-value:7.37E-7 ID:SGTC_2050|Compound:5263056|FD-Score:3.47|P-value:4.05E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.21|P-value:9.48E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.72|P-value:1.66E-4 ID:SGTC_2138|Compound:5575593|FD-Score:4.98|P-value:8.13E-7 ID:SGTC_2145|Compound:5634607|FD-Score:3.42|P-value:4.78E-4 ID:SGTC_2152|Compound:5568786|FD-Score:4.48|P-value:7.99E-6 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.88|P-value:9.10E-5 ID:SGTC_2287|Compound:7945887|FD-Score:4.12|P-value:3.52E-5 ID:SGTC_2291|Compound:7917025|FD-Score:5.45|P-value:7.97E-8 ID:SGTC_2304|Compound:7443016|FD-Score:5.15|P-value:3.62E-7 ID:SGTC_2311|Compound:7694451|FD-Score:-3.41|P-value:6.11E-4 ID:SGTC_2382|Compound:9035899|FD-Score:4.04|P-value:4.97E-5 ID:SGTC_2427|Compound:5545055|FD-Score:3.74|P-value:1.52E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.64|P-value:2.80E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.21|P-value:9.66E-4 ID:SGTC_2696|Compound:st077691|FD-Score:4.07|P-value:4.27E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.27|P-value:9.72E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.85|P-value:1.00E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.63|P-value:2.33E-4 ID:SGTC_3224|Compound:9130643|FD-Score:5.47|P-value:6.98E-8 ID:SGTC_3325|Compound:9138760|FD-Score:4.24|P-value:2.22E-5

Top fitness defect scores for YIR038C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3224 9130643 5.47 49.5 µM 6.98E-8 RPP1 & pyrimidine depletion 6 2.23E-8
2 SGTC_2291 7917025 5.45 104.3 µM 7.97E-8 iron homeostasis 25 2.57E-8
3 SGTC_1337 1486-1011 5.27 40.3 µM 1.97E-7 3 6.87E-8
4 SGTC_2304 7443016 5.15 91.4 µM 3.62E-7 9 1.33E-7
5 SGTC_2138 5575593 4.98 77.7 µM 8.13E-7 1 3.19E-7
6 SGTC_1527 coumarin 4.88 137.0 µM 1.31E-6 4 5.36E-7
7 SGTC_1293 1000-1278 4.75 195.0 µM 2.35E-6 2 1.00E-6
8 SGTC_2152 5568786 4.48 200.0 µM 7.99E-6 6 3.78E-6
9 SGTC_3325 9138760 4.24 55.2 µM 2.22E-5 Golgi 20 1.14E-5
10 SGTC_2287 7945887 4.12 168.8 µM 3.52E-5 6 1.88E-5
11 SGTC_2696 st077691 4.07 74.3 µM 4.27E-5 30 2.31E-5
12 SGTC_2382 9035899 4.04 200.0 µM 4.97E-5 60S ribosome export 14 2.72E-5
13 SGTC_2251 lansoprazole 3.88 556.0 µM 9.10E-5 22 5.23E-5
14 SGTC_2930 9013230 3.85 14.9 µM 1.00E-4 heme biosynthesis & mitochondrial translocase 43 5.80E-5
15 SGTC_1241 0364-0022 3.79 50.8 µM 1.28E-4 ERG2 37 7.58E-5
16 SGTC_2427 5545055 3.74 42.8 µM 1.52E-4 19 9.10E-5
17 SGTC_2086 5274770 3.72 176.6 µM 1.66E-4 29 1.00E-4
18 SGTC_1045 1348-1485 3.67 165.0 µM 2.01E-4 43 1.23E-4
19 SGTC_1321 1326-2144 3.65 215.0 µM 2.16E-4 15 1.33E-4
20 SGTC_621 3584-0052 3.64 32.1 µM 2.21E-4 32 1.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.34E-18 YNL305C BXI1 hom Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p
0.137 1.71E-15 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.132 1.61E-14 YLL051C FRE6 hom Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels
0.120 2.75E-12 YHR097C_p YHR097C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
0.109 2.87E-10 YGL086W MAD1 hom Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p
0.104 1.37E-9 YOR080W DIA2 hom Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.099 8.85E-9 YJL130C URA2 hom Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
0.097 2.28E-8 YPR126C_d YPR126C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.093 7.72E-8 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.087 4.03E-7 YLR167W RPS31 het Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog
0.086 5.93E-7 YOR286W RDL2 hom Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss
0.085 7.38E-7 YLR407W_p YLR407W_p hom Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus
0.085 9.29E-7 YCL023C_d YCL023C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
0.084 1.16E-6 YER145C FTR1 hom High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress
0.083 1.69E-6 YKR045C_p YKR045C_p hom Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm