YIR039C / YPS6

Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR039C / YPS6

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:4.94|P-value:1.18E-6 ID:SGTC_68|Compound:0986-0284|FD-Score:4.13|P-value:4.07E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:3.26|P-value:9.75E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:4.55|P-value:7.07E-6 ID:SGTC_167|Compound:3672-0051|FD-Score:4.27|P-value:2.37E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:3.72|P-value:1.99E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:-3.59|P-value:2.16E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.66|P-value:2.52E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.42|P-value:1.24E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:3.57|P-value:3.44E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.29|P-value:6.14E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.56|P-value:3.56E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.69|P-value:3.76E-6 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.47|P-value:4.88E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.94|P-value:8.73E-5 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.52|P-value:4.11E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.31|P-value:8.48E-4 ID:SGTC_1590|Compound:st077108|FD-Score:3.51|P-value:4.18E-4 ID:SGTC_1651|Compound:st011928|FD-Score:3.43|P-value:5.55E-4 ID:SGTC_1655|Compound:st012546|FD-Score:3.35|P-value:7.42E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-4.50|P-value:5.35E-6 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.30|P-value:8.60E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.59|P-value:3.24E-4 ID:SGTC_2101|Compound:5377231|FD-Score:-3.17|P-value:9.04E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.27|P-value:9.47E-4 ID:SGTC_2269|Compound:7935389|FD-Score:4.01|P-value:6.63E-5 ID:SGTC_2332|Compound:7982454|FD-Score:3.64|P-value:2.69E-4 ID:SGTC_2338|Compound:7999974|FD-Score:4.15|P-value:3.81E-5 ID:SGTC_2350|Compound:9023895|FD-Score:-3.37|P-value:4.67E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.47|P-value:4.87E-4 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.71|P-value:2.11E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.33|P-value:7.69E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:7.93|P-value:1.39E-14 ID:SGTC_2848|Compound:9016370|FD-Score:-3.23|P-value:7.45E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.94|P-value:8.80E-5 ID:SGTC_2927|Compound:9011802|FD-Score:3.76|P-value:1.73E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.48|P-value:4.64E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.78|P-value:1.59E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:4.94|P-value:1.18E-6 ID:SGTC_68|Compound:0986-0284|FD-Score:4.13|P-value:4.07E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:3.26|P-value:9.75E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:4.55|P-value:7.07E-6 ID:SGTC_167|Compound:3672-0051|FD-Score:4.27|P-value:2.37E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:3.72|P-value:1.99E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:-3.59|P-value:2.16E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.66|P-value:2.52E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.42|P-value:1.24E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:3.57|P-value:3.44E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.29|P-value:6.14E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.56|P-value:3.56E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.69|P-value:3.76E-6 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.47|P-value:4.88E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.94|P-value:8.73E-5 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.52|P-value:4.11E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.31|P-value:8.48E-4 ID:SGTC_1590|Compound:st077108|FD-Score:3.51|P-value:4.18E-4 ID:SGTC_1651|Compound:st011928|FD-Score:3.43|P-value:5.55E-4 ID:SGTC_1655|Compound:st012546|FD-Score:3.35|P-value:7.42E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-4.50|P-value:5.35E-6 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.30|P-value:8.60E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.59|P-value:3.24E-4 ID:SGTC_2101|Compound:5377231|FD-Score:-3.17|P-value:9.04E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.27|P-value:9.47E-4 ID:SGTC_2269|Compound:7935389|FD-Score:4.01|P-value:6.63E-5 ID:SGTC_2332|Compound:7982454|FD-Score:3.64|P-value:2.69E-4 ID:SGTC_2338|Compound:7999974|FD-Score:4.15|P-value:3.81E-5 ID:SGTC_2350|Compound:9023895|FD-Score:-3.37|P-value:4.67E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.47|P-value:4.87E-4 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.71|P-value:2.11E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.33|P-value:7.69E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:7.93|P-value:1.39E-14 ID:SGTC_2848|Compound:9016370|FD-Score:-3.23|P-value:7.45E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.94|P-value:8.80E-5 ID:SGTC_2927|Compound:9011802|FD-Score:3.76|P-value:1.73E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.48|P-value:4.64E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.78|P-value:1.59E-4

Top fitness defect scores for YIR039C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2779 methotrexate 7.93 400.0 µM 1.39E-14 6 1.08E-15
2 SGTC_35 0133-0054 4.94 64.1 µM 1.18E-6 12 3.85E-7
3 SGTC_1155 4088-0394 4.69 48.2 µM 3.76E-6 14 1.35E-6
4 SGTC_160 3453-0671 4.55 289.7 µM 7.07E-6 26 2.68E-6
5 SGTC_805 3852-0218 4.42 479.0 µM 1.24E-5 ERAD & cell cycle 52 4.93E-6
6 SGTC_167 3672-0051 4.27 66.2 µM 2.37E-5 36 9.88E-6
7 SGTC_2338 7999974 4.15 200.0 µM 3.81E-5 17 1.66E-5
8 SGTC_68 0986-0284 4.13 82.8 µM 4.07E-5 62 1.78E-5
9 SGTC_2269 7935389 4.01 174.4 µM 6.63E-5 tubulin folding & SWR complex 25 3.01E-5
10 SGTC_1224 0823-0416 3.94 294.0 µM 8.73E-5 7 4.05E-5
11 SGTC_2887 9044784 3.94 58.4 µM 8.80E-5 fatty acid desaturase (OLE1) 28 4.09E-5
12 SGTC_3188 9110789 3.78 49.5 µM 1.59E-4 iron homeostasis 27 7.76E-5
13 SGTC_2927 9011802 3.76 47.9 µM 1.73E-4 31 8.50E-5
14 SGTC_574 1315-0397 3.72 40.0 µM 1.99E-4 43 9.89E-5
15 SGTC_2738 aclarubicin 3.71 5.5 µM 2.11E-4 RNA pol III & RNase P/MRP 13 1.05E-4
16 SGTC_684 1140-0066 3.66 328.0 µM 2.52E-4 Golgi 38 1.27E-4
17 SGTC_2332 7982454 3.64 138.9 µM 2.69E-4 63 1.37E-4
18 SGTC_1901 st060216 3.59 58.6 µM 3.24E-4 32 1.67E-4
19 SGTC_857 0438-0306 3.57 1.4 µM 3.44E-4 copper-dependent oxidative stress 19 1.79E-4
20 SGTC_881 0833-0569 3.56 170.0 µM 3.56E-4 46 1.85E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.255 3.99E-51 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.189 2.48E-28 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.173 6.28E-24 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.137 1.45E-15 YLL047W_d YLL047W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1
0.098 1.48E-8 YPL195W APL5 hom Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function
0.095 3.09E-8 YBR288C APM3 hom Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
0.090 1.75E-7 YML069W POB3 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress
0.090 1.99E-7 YIL133C RPL16A hom Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.088 3.48E-7 YGR261C APL6 hom Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
0.084 1.06E-6 YMR258C ROY1 hom GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p
0.083 1.70E-6 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.081 2.62E-6 YLR385C SWC7 hom Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin
0.080 3.29E-6 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.078 5.32E-6 YHR196W UTP9 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.074 2.01E-5 YPL006W NCR1 hom Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein