YIR042C_p

Putative protein of unknown function; YIR042C is a non-essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR042C / YIR042C

Click on Significant Values for Screen Details ID:SGTC_101|Compound:0490-5701|FD-Score:3.23|P-value:3.25E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.54|P-value:9.46E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:-4.17|P-value:5.81E-6 ID:SGTC_126|Compound:0417-1624|FD-Score:-4.44|P-value:1.51E-6 ID:SGTC_189|Compound:3970-0742|FD-Score:3.19|P-value:3.80E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:3.68|P-value:5.18E-5 ID:SGTC_443|Compound:clozapine|FD-Score:-3.55|P-value:9.49E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:3.52|P-value:1.04E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:-3.68|P-value:5.45E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:3.47|P-value:1.25E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.06|P-value:6.35E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.75|P-value:3.79E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:3.02|P-value:7.33E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:3.61|P-value:7.18E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.20|P-value:3.96E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:4.35|P-value:2.30E-6 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.33|P-value:2.26E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.14|P-value:4.71E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.20|P-value:3.71E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:2.99|P-value:7.94E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:-3.19|P-value:4.02E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:4.17|P-value:5.64E-6 ID:SGTC_1460|Compound:k062-0059|FD-Score:-3.09|P-value:5.92E-4 ID:SGTC_1526|Compound:st051518|FD-Score:4.59|P-value:6.60E-7 ID:SGTC_1527|Compound:coumarin|FD-Score:3.85|P-value:2.49E-5 ID:SGTC_1637|Compound:st007924|FD-Score:3.57|P-value:8.33E-5 ID:SGTC_1683|Compound:st010134|FD-Score:3.21|P-value:3.52E-4 ID:SGTC_1715|Compound:st032160|FD-Score:2.94|P-value:9.74E-4 ID:SGTC_1738|Compound:st035555|FD-Score:7.72|P-value:2.22E-16 ID:SGTC_1740|Compound:st038286|FD-Score:4.93|P-value:1.05E-7 ID:SGTC_1769|Compound:st044406|FD-Score:-3.12|P-value:5.33E-4 ID:SGTC_1839|Compound:st053978|FD-Score:2.96|P-value:8.84E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.46|P-value:1.33E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.30|P-value:2.68E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.96|P-value:1.51E-5 ID:SGTC_2366|Compound:9070441|FD-Score:3.17|P-value:4.23E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.29|P-value:3.02E-6 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-3.19|P-value:4.07E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.47|P-value:1.26E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.44|P-value:1.42E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.09|P-value:5.77E-4 ID:SGTC_2701|Compound:st077767|FD-Score:4.38|P-value:1.98E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.63|P-value:6.85E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.81|P-value:2.99E-5 ID:SGTC_2921|Compound:7974240|FD-Score:-3.39|P-value:1.85E-4 ID:SGTC_2931|Compound:9014674|FD-Score:4.73|P-value:3.10E-7 ID:SGTC_2944|Compound:9067346|FD-Score:-3.15|P-value:4.71E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.05|P-value:6.50E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.23|P-value:3.25E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.54|P-value:9.46E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:-4.17|P-value:5.81E-6 ID:SGTC_126|Compound:0417-1624|FD-Score:-4.44|P-value:1.51E-6 ID:SGTC_189|Compound:3970-0742|FD-Score:3.19|P-value:3.80E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:3.68|P-value:5.18E-5 ID:SGTC_443|Compound:clozapine|FD-Score:-3.55|P-value:9.49E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:3.52|P-value:1.04E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:-3.68|P-value:5.45E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:3.47|P-value:1.25E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.06|P-value:6.35E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.75|P-value:3.79E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:3.02|P-value:7.33E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:3.61|P-value:7.18E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.20|P-value:3.96E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:4.35|P-value:2.30E-6 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.33|P-value:2.26E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.14|P-value:4.71E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.20|P-value:3.71E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:2.99|P-value:7.94E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:-3.19|P-value:4.02E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:4.17|P-value:5.64E-6 ID:SGTC_1460|Compound:k062-0059|FD-Score:-3.09|P-value:5.92E-4 ID:SGTC_1526|Compound:st051518|FD-Score:4.59|P-value:6.60E-7 ID:SGTC_1527|Compound:coumarin|FD-Score:3.85|P-value:2.49E-5 ID:SGTC_1637|Compound:st007924|FD-Score:3.57|P-value:8.33E-5 ID:SGTC_1683|Compound:st010134|FD-Score:3.21|P-value:3.52E-4 ID:SGTC_1715|Compound:st032160|FD-Score:2.94|P-value:9.74E-4 ID:SGTC_1738|Compound:st035555|FD-Score:7.72|P-value:2.22E-16 ID:SGTC_1740|Compound:st038286|FD-Score:4.93|P-value:1.05E-7 ID:SGTC_1769|Compound:st044406|FD-Score:-3.12|P-value:5.33E-4 ID:SGTC_1839|Compound:st053978|FD-Score:2.96|P-value:8.84E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.46|P-value:1.33E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.30|P-value:2.68E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.96|P-value:1.51E-5 ID:SGTC_2366|Compound:9070441|FD-Score:3.17|P-value:4.23E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.29|P-value:3.02E-6 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-3.19|P-value:4.07E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.47|P-value:1.26E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.44|P-value:1.42E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.09|P-value:5.77E-4 ID:SGTC_2701|Compound:st077767|FD-Score:4.38|P-value:1.98E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.63|P-value:6.85E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.81|P-value:2.99E-5 ID:SGTC_2921|Compound:7974240|FD-Score:-3.39|P-value:1.85E-4 ID:SGTC_2931|Compound:9014674|FD-Score:4.73|P-value:3.10E-7 ID:SGTC_2944|Compound:9067346|FD-Score:-3.15|P-value:4.71E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.05|P-value:6.50E-4

Top fitness defect scores for YIR042C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1738 st035555 7.72 74.0 µM 2.22E-16 TSC3-RPN4 3 6.03E-15
2 SGTC_1740 st038286 4.93 13.2 µM 1.05E-7 11 4.18E-7
3 SGTC_2931 9014674 4.73 55.7 µM 3.10E-7 11 1.12E-6
4 SGTC_1526 st051518 4.59 75.0 µM 6.60E-7 12 2.22E-6
5 SGTC_2701 st077767 4.38 14.7 µM 1.98E-6 32 6.00E-6
6 SGTC_984 1492-0255 4.35 2.9 µM 2.30E-6 SWF1 & branched chain AA biosynthesis 23 6.86E-6
7 SGTC_2431 5490079 4.29 200.0 µM 3.02E-6 22 8.79E-6
8 SGTC_1269 0831-0796 4.17 3.0 µM 5.64E-6 60S ribosome export 13 1.55E-5
9 SGTC_2131 toluylene red 3.96 5.3 µM 1.51E-5 60S ribosome export 23 3.78E-5
10 SGTC_1527 coumarin 3.85 137.0 µM 2.49E-5 28 5.93E-5
11 SGTC_2850 9015429 3.81 58.4 µM 2.99E-5 14 7.02E-5
12 SGTC_878 0828-0289 3.75 13.7 µM 3.79E-5 55 8.69E-5
13 SGTC_342 k048-0088 3.68 23.3 µM 5.18E-5 RSC & ERG11 25 1.15E-4
14 SGTC_970 1315-0089 3.61 19.5 µM 7.18E-5 RSC & ERG11 37 1.55E-4
15 SGTC_1637 st007924 3.57 17.4 µM 8.33E-5 37 1.78E-4
16 SGTC_116 0155-0182 3.54 31.8 µM 9.46E-5 mitochondrial response to ROS 114 1.99E-4
17 SGTC_674 0498-0004 3.52 451.0 µM 1.04E-4 heme requiring 35 2.17E-4
18 SGTC_686 1319-0111 3.47 510.0 µM 1.25E-4 60S ribosome export 42 2.56E-4
19 SGTC_2500 5-alpha-androstan-3,17-dione 3.47 61.4 µM 1.26E-4 53 2.59E-4
20 SGTC_1909 st060837 3.46 51.5 µM 1.33E-4 73 2.72E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.18E-10 YLR001C_p YLR001C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated
0.105 1.01E-9 YAL004W_d YAL004W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C
0.104 1.34E-9 YOR192C THI72 hom Transporter of thiamine or related compound; shares sequence similarity with Thi7p
0.104 1.48E-9 YMR241W YHM2 hom Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome
0.103 2.56E-9 YIL113W SDP1 hom Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
0.103 2.58E-9 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.101 4.57E-9 YDL078C MDH3 hom Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle
0.101 5.25E-9 YMR189W GCV2 hom P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm
0.099 1.08E-8 YMR003W AIM34 hom Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss
0.098 1.45E-8 YNL222W SSU72 het Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo
0.091 1.30E-7 YOL114C_p YOL114C_p hom Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene
0.088 3.73E-7 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.084 1.28E-6 YNL308C KRI1 het Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p
0.082 2.16E-6 YPL100W ATG21 hom Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein
0.082 2.20E-6 YGR010W NMA2 hom Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication