YIR043C

Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR043C / YIR043C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.09|P-value:2.29E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:3.67|P-value:1.29E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.23|P-value:6.52E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.45|P-value:2.94E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.23|P-value:6.56E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.82|P-value:7.00E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.11|P-value:9.71E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:4.30|P-value:9.46E-6 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.19|P-value:7.43E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.50|P-value:2.45E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.72|P-value:1.07E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.60|P-value:1.68E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.01|P-value:3.24E-5 ID:SGTC_1690|Compound:st023502|FD-Score:3.16|P-value:8.28E-4 ID:SGTC_1992|Compound:st073643|FD-Score:3.32|P-value:4.67E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-3.66|P-value:1.36E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-3.79|P-value:8.16E-5 ID:SGTC_2398|Compound:5228213|FD-Score:-3.73|P-value:1.03E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-4.72|P-value:1.29E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.46|P-value:2.86E-4 ID:SGTC_2591|Compound:skatole|FD-Score:4.81|P-value:8.40E-7 ID:SGTC_2655|Compound:perillic acid|FD-Score:4.03|P-value:3.00E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.49|P-value:2.59E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.23|P-value:6.53E-4 ID:SGTC_2841|Compound:9004761|FD-Score:4.33|P-value:7.91E-6 ID:SGTC_2842|Compound:9000675|FD-Score:3.70|P-value:1.14E-4 ID:SGTC_3045|Compound:9092950|FD-Score:4.11|P-value:2.09E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:4.09|P-value:2.29E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:3.67|P-value:1.29E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.23|P-value:6.52E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.45|P-value:2.94E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.23|P-value:6.56E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.82|P-value:7.00E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.11|P-value:9.71E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:4.30|P-value:9.46E-6 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.19|P-value:7.43E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.50|P-value:2.45E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.72|P-value:1.07E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.60|P-value:1.68E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.01|P-value:3.24E-5 ID:SGTC_1690|Compound:st023502|FD-Score:3.16|P-value:8.28E-4 ID:SGTC_1992|Compound:st073643|FD-Score:3.32|P-value:4.67E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-3.66|P-value:1.36E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-3.79|P-value:8.16E-5 ID:SGTC_2398|Compound:5228213|FD-Score:-3.73|P-value:1.03E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-4.72|P-value:1.29E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.46|P-value:2.86E-4 ID:SGTC_2591|Compound:skatole|FD-Score:4.81|P-value:8.40E-7 ID:SGTC_2655|Compound:perillic acid|FD-Score:4.03|P-value:3.00E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.49|P-value:2.59E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.23|P-value:6.53E-4 ID:SGTC_2841|Compound:9004761|FD-Score:4.33|P-value:7.91E-6 ID:SGTC_2842|Compound:9000675|FD-Score:3.70|P-value:1.14E-4 ID:SGTC_3045|Compound:9092950|FD-Score:4.11|P-value:2.09E-5

Top fitness defect scores for YIR043C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2591 skatole 4.81 100.0 µM 8.40E-7 14 7.61E-7
2 SGTC_2841 9004761 4.33 39.0 µM 7.91E-6 amide catabolism 18 7.30E-6
3 SGTC_405 ebelactone b 4.30 50.0 µM 9.46E-6 11 8.73E-6
4 SGTC_3045 9092950 4.11 49.5 µM 2.09E-5 14 1.94E-5
5 SGTC_6 0844-0013 4.09 19.8 µM 2.29E-5 75 2.13E-5
6 SGTC_2655 perillic acid 4.03 100.0 µM 3.00E-5 2 2.79E-5
7 SGTC_1574 spiramycin 4.01 23.7 µM 3.24E-5 25 3.02E-5
8 SGTC_390 dec-rvkr-cmk 3.82 16.7 µM 7.00E-5 calcium & mitochondrial duress 32 6.57E-5
9 SGTC_2842 9000675 3.70 19.5 µM 1.14E-4 29 1.07E-4
10 SGTC_48 0382-0018 3.67 55.0 µM 1.29E-4 16 1.22E-4
11 SGTC_1415 3966-0071 3.60 78.1 µM 1.68E-4 DNA intercalators 16 1.59E-4
12 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.46 3.7 µM 2.86E-4 133 2.71E-4
13 SGTC_1992 st073643 3.32 23.3 µM 4.67E-4 mitochondrial processes 24 4.45E-4
14 SGTC_2760 etidronate 3.23 98.0 µM 6.53E-4 58 6.23E-4
15 SGTC_388 3',4'-dichloroisocoumarin 3.23 16.7 µM 6.56E-4 32 6.26E-4
16 SGTC_1690 st023502 3.16 41.2 µM 8.28E-4 calcium & mitochondrial duress 31 7.91E-4
17 SGTC_1991 st073000 3.10 8.9 µM 0.00102 NEO1 122 9.74E-4
18 SGTC_2291 7917025 3.05 104.3 µM 0.00119 iron homeostasis 96 0.00115
19 SGTC_1554 st069299 3.00 38.7 µM 0.00141 61 0.00135
20 SGTC_841 0251-0215 2.96 91.2 µM 0.00159 121 0.00153

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 2.30E-18 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.134 5.59E-15 YPR022C_p YPR022C_p hom Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.122 1.13E-12 YLR128W DCN1 hom Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation
0.113 5.87E-11 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.110 2.03E-10 YOR220W RCN2 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress
0.108 3.79E-10 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.103 2.08E-9 YEL023C_p YEL023C_p hom Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene
0.101 4.05E-9 YNL242W ATG2 hom Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress
0.101 4.79E-9 YDL235C YPD1 het Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus
0.101 5.10E-9 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.101 5.38E-9 YOL010W RCL1 het Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected
0.099 8.25E-9 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
0.099 9.38E-9 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.098 1.11E-8 YER178W PDA1 hom E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose
0.098 1.11E-8 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress