YIR044C

Possible pseudogene in strain S288C; YIR044C and the adjacent ORF, YIR043C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR044C / YIR044C

Click on Significant Values for Screen Details ID:SGTC_60|Compound:0986-0278|FD-Score:4.76|P-value:1.85E-6 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.24|P-value:8.68E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.46|P-value:3.75E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.18|P-value:9.69E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.30|P-value:6.62E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.45|P-value:3.96E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.57|P-value:2.85E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:-3.31|P-value:7.04E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.24|P-value:8.86E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.40|P-value:4.61E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-5.23|P-value:2.10E-7 ID:SGTC_881|Compound:0833-0569|FD-Score:3.25|P-value:7.77E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:5.61|P-value:2.47E-8 ID:SGTC_902|Compound:1120-0002|FD-Score:-3.24|P-value:8.82E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:-3.38|P-value:5.49E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-4.33|P-value:1.44E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:-5.25|P-value:1.89E-7 ID:SGTC_1034|Compound:k072-0165|FD-Score:-4.83|P-value:1.53E-6 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.31|P-value:6.36E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.33|P-value:5.98E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:4.60|P-value:3.86E-6 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.06|P-value:3.85E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.86|P-value:8.61E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:5.84|P-value:6.92E-9 ID:SGTC_1466|Compound:k213-0079|FD-Score:-3.60|P-value:2.56E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.26|P-value:8.22E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.26|P-value:7.53E-4 ID:SGTC_1831|Compound:st055328|FD-Score:-3.52|P-value:3.35E-4 ID:SGTC_1850|Compound:st056238|FD-Score:3.24|P-value:8.03E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.36|P-value:5.38E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.18|P-value:9.93E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-3.73|P-value:1.54E-4 ID:SGTC_2436|Compound:5633522|FD-Score:-5.09|P-value:4.36E-7 ID:SGTC_2537|Compound:larixol|FD-Score:-3.49|P-value:3.72E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.34|P-value:6.20E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.22|P-value:2.06E-5 ID:SGTC_2692|Compound:st077426|FD-Score:4.61|P-value:3.74E-6 ID:SGTC_2694|Compound:st077685|FD-Score:-5.94|P-value:4.48E-9 ID:SGTC_2707|Compound:st078556|FD-Score:3.94|P-value:6.36E-5 ID:SGTC_2781|Compound:5567276|FD-Score:3.99|P-value:5.13E-5 ID:SGTC_2782|Compound:7736369|FD-Score:3.21|P-value:8.83E-4 ID:SGTC_2814|Compound:7977482|FD-Score:4.74|P-value:2.06E-6 ID:SGTC_2983|Compound:9022671|FD-Score:3.38|P-value:4.97E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.49|P-value:3.36E-4 ID:SGTC_3195|Compound:9113082|FD-Score:3.99|P-value:5.25E-5 ID:SGTC_3248|Compound:9135562|FD-Score:4.16|P-value:2.58E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:4.76|P-value:1.85E-6 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.24|P-value:8.68E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.46|P-value:3.75E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.18|P-value:9.69E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.30|P-value:6.62E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.45|P-value:3.96E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.57|P-value:2.85E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:-3.31|P-value:7.04E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.24|P-value:8.86E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.40|P-value:4.61E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-5.23|P-value:2.10E-7 ID:SGTC_881|Compound:0833-0569|FD-Score:3.25|P-value:7.77E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:5.61|P-value:2.47E-8 ID:SGTC_902|Compound:1120-0002|FD-Score:-3.24|P-value:8.82E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:-3.38|P-value:5.49E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-4.33|P-value:1.44E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:-5.25|P-value:1.89E-7 ID:SGTC_1034|Compound:k072-0165|FD-Score:-4.83|P-value:1.53E-6 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.31|P-value:6.36E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.33|P-value:5.98E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:4.60|P-value:3.86E-6 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.06|P-value:3.85E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.86|P-value:8.61E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:5.84|P-value:6.92E-9 ID:SGTC_1466|Compound:k213-0079|FD-Score:-3.60|P-value:2.56E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.26|P-value:8.22E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.26|P-value:7.53E-4 ID:SGTC_1831|Compound:st055328|FD-Score:-3.52|P-value:3.35E-4 ID:SGTC_1850|Compound:st056238|FD-Score:3.24|P-value:8.03E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.36|P-value:5.38E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.18|P-value:9.93E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-3.73|P-value:1.54E-4 ID:SGTC_2436|Compound:5633522|FD-Score:-5.09|P-value:4.36E-7 ID:SGTC_2537|Compound:larixol|FD-Score:-3.49|P-value:3.72E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.34|P-value:6.20E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.22|P-value:2.06E-5 ID:SGTC_2692|Compound:st077426|FD-Score:4.61|P-value:3.74E-6 ID:SGTC_2694|Compound:st077685|FD-Score:-5.94|P-value:4.48E-9 ID:SGTC_2707|Compound:st078556|FD-Score:3.94|P-value:6.36E-5 ID:SGTC_2781|Compound:5567276|FD-Score:3.99|P-value:5.13E-5 ID:SGTC_2782|Compound:7736369|FD-Score:3.21|P-value:8.83E-4 ID:SGTC_2814|Compound:7977482|FD-Score:4.74|P-value:2.06E-6 ID:SGTC_2983|Compound:9022671|FD-Score:3.38|P-value:4.97E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.49|P-value:3.36E-4 ID:SGTC_3195|Compound:9113082|FD-Score:3.99|P-value:5.25E-5 ID:SGTC_3248|Compound:9135562|FD-Score:4.16|P-value:2.58E-5

Top fitness defect scores for YIR044C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1360 1598-0022 5.84 39.8 µM 6.92E-9 ERG2 8 2.61E-9
2 SGTC_893 0958-0369 5.61 48.9 µM 2.47E-8 6 1.01E-8
3 SGTC_60 0986-0278 4.76 202.0 µM 1.85E-6 4 9.74E-7
4 SGTC_2814 7977482 4.74 43.0 µM 2.06E-6 29 1.09E-6
5 SGTC_2692 st077426 4.61 47.7 µM 3.74E-6 13 2.05E-6
6 SGTC_1343 1487-0095 4.60 224.0 µM 3.86E-6 5 2.11E-6
7 SGTC_2581 avocatin a 4.22 64.0 µM 2.06E-5 sphingolipid biosynthesis & PDR1 43 1.25E-5
8 SGTC_3248 9135562 4.16 49.5 µM 2.58E-5 4 1.58E-5
9 SGTC_1350 1495-0454 4.06 146.0 µM 3.85E-5 21 2.41E-5
10 SGTC_2781 5567276 3.99 71.4 µM 5.13E-5 46 3.26E-5
11 SGTC_3195 9113082 3.99 49.5 µM 5.25E-5 17 3.35E-5
12 SGTC_2707 st078556 3.94 66.6 µM 6.36E-5 11 4.10E-5
13 SGTC_1351 1496-0003 3.86 46.5 µM 8.61E-5 23 5.65E-5
14 SGTC_2998 9066762 3.49 71.4 µM 3.36E-4 RPP1 & pyrimidine depletion 37 2.38E-4
15 SGTC_139 0099-0334 3.46 718.6 µM 3.75E-4 53 2.67E-4
16 SGTC_243 5hr heat shock (37°C) + splitomicin 3.45 1.0 µM 3.96E-4 heat shock/prefoldin 74 2.83E-4
17 SGTC_414 piperonyl butoxide 3.40 100.0 µM 4.61E-4 19 3.32E-4
18 SGTC_2983 9022671 3.38 13.0 µM 4.97E-4 60S ribosome export 27 3.59E-4
19 SGTC_1962 st076595 3.36 64.5 µM 5.38E-4 redox potentiating 52 3.91E-4
20 SGTC_1089 terbinafine 3.33 2.2 µM 5.98E-4 35 4.38E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 2.28E-14 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.105 1.02E-9 YFL017C GNA1 het Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA
0.089 2.16E-7 YOR060C SLD7 het Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria
0.086 6.75E-7 YOR154W_p SLP1_p hom Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p
0.081 2.77E-6 YBL081W_p YBL081W_p hom Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport
0.076 1.14E-5 YAR019C CDC15 het Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress
0.076 1.15E-5 YKL031W_d YKL031W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
0.074 1.70E-5 YJR154W_p YJR154W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.073 2.12E-5 YER080W AIM9 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
0.072 2.81E-5 YCR017C CWH43 hom Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion
0.071 3.70E-5 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.070 5.26E-5 YHL012W_p YHL012W_p hom Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication
0.070 5.31E-5 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.068 7.32E-5 YDR130C FIN1 hom Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress
0.068 8.57E-5 YDR020C_p DAS2_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases