YJL002C / OST1

Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL002C / OST1

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:2.90|P-value:6.70E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.17|P-value:2.32E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.25|P-value:1.62E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.88|P-value:9.12E-6 ID:SGTC_125|Compound:0133-0007|FD-Score:-2.98|P-value:5.87E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.66|P-value:1.77E-7 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.09|P-value:3.22E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.41|P-value:8.40E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.28|P-value:1.43E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-4.06|P-value:4.59E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:2.93|P-value:5.91E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.78|P-value:1.82E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:2.82|P-value:8.99E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.75|P-value:2.12E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:3.28|P-value:1.42E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.01|P-value:5.26E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.26|P-value:1.87E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.63|P-value:3.69E-5 ID:SGTC_1142|Compound:3253-1408|FD-Score:2.85|P-value:8.22E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.26|P-value:1.57E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:-4.14|P-value:3.14E-6 ID:SGTC_1401|Compound:3807-4679|FD-Score:-4.40|P-value:7.62E-7 ID:SGTC_1418|Compound:3966-3099|FD-Score:2.87|P-value:7.61E-4 ID:SGTC_1649|Compound:st011737|FD-Score:2.81|P-value:9.33E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.81|P-value:1.27E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.97|P-value:5.81E-6 ID:SGTC_2056|Compound:5235370|FD-Score:3.46|P-value:6.55E-5 ID:SGTC_2096|Compound:5468907|FD-Score:3.29|P-value:1.36E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-2.92|P-value:7.27E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.52|P-value:4.95E-5 ID:SGTC_2352|Compound:9027995|FD-Score:-3.23|P-value:2.16E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-5.80|P-value:1.18E-10 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:2.81|P-value:9.34E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.48|P-value:3.82E-7 ID:SGTC_2624|Compound:nerol|FD-Score:-3.34|P-value:1.38E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.97|P-value:5.75E-6 ID:SGTC_2785|Compound:7756463|FD-Score:-3.05|P-value:4.50E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.97|P-value:7.55E-6 ID:SGTC_2807|Compound:7945238|FD-Score:2.92|P-value:6.13E-4 ID:SGTC_2871|Compound:9038510|FD-Score:5.92|P-value:3.49E-11 ID:SGTC_2885|Compound:9057732|FD-Score:5.20|P-value:5.11E-9 ID:SGTC_2936|Compound:9038235|FD-Score:2.88|P-value:7.19E-4 ID:SGTC_3023|Compound:9089636|FD-Score:3.76|P-value:1.68E-5 ID:SGTC_3037|Compound:9091026|FD-Score:3.00|P-value:4.47E-4 ID:SGTC_3038|Compound:9091290|FD-Score:2.92|P-value:6.23E-4 ID:SGTC_3270|Compound:9137563|FD-Score:2.98|P-value:5.01E-4 ID:SGTC_3272|Compound:9137413|FD-Score:2.86|P-value:7.73E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.42|P-value:9.79E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:2.90|P-value:6.70E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.17|P-value:2.32E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.25|P-value:1.62E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.88|P-value:9.12E-6 ID:SGTC_125|Compound:0133-0007|FD-Score:-2.98|P-value:5.87E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.66|P-value:1.77E-7 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.09|P-value:3.22E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.41|P-value:8.40E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.28|P-value:1.43E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-4.06|P-value:4.59E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:2.93|P-value:5.91E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.78|P-value:1.82E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:2.82|P-value:8.99E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.75|P-value:2.12E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:3.28|P-value:1.42E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.01|P-value:5.26E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.26|P-value:1.87E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.63|P-value:3.69E-5 ID:SGTC_1142|Compound:3253-1408|FD-Score:2.85|P-value:8.22E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.26|P-value:1.57E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:-4.14|P-value:3.14E-6 ID:SGTC_1401|Compound:3807-4679|FD-Score:-4.40|P-value:7.62E-7 ID:SGTC_1418|Compound:3966-3099|FD-Score:2.87|P-value:7.61E-4 ID:SGTC_1649|Compound:st011737|FD-Score:2.81|P-value:9.33E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.81|P-value:1.27E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.97|P-value:5.81E-6 ID:SGTC_2056|Compound:5235370|FD-Score:3.46|P-value:6.55E-5 ID:SGTC_2096|Compound:5468907|FD-Score:3.29|P-value:1.36E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-2.92|P-value:7.27E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.52|P-value:4.95E-5 ID:SGTC_2352|Compound:9027995|FD-Score:-3.23|P-value:2.16E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-5.80|P-value:1.18E-10 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:2.81|P-value:9.34E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.48|P-value:3.82E-7 ID:SGTC_2624|Compound:nerol|FD-Score:-3.34|P-value:1.38E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.97|P-value:5.75E-6 ID:SGTC_2785|Compound:7756463|FD-Score:-3.05|P-value:4.50E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.97|P-value:7.55E-6 ID:SGTC_2807|Compound:7945238|FD-Score:2.92|P-value:6.13E-4 ID:SGTC_2871|Compound:9038510|FD-Score:5.92|P-value:3.49E-11 ID:SGTC_2885|Compound:9057732|FD-Score:5.20|P-value:5.11E-9 ID:SGTC_2936|Compound:9038235|FD-Score:2.88|P-value:7.19E-4 ID:SGTC_3023|Compound:9089636|FD-Score:3.76|P-value:1.68E-5 ID:SGTC_3037|Compound:9091026|FD-Score:3.00|P-value:4.47E-4 ID:SGTC_3038|Compound:9091290|FD-Score:2.92|P-value:6.23E-4 ID:SGTC_3270|Compound:9137563|FD-Score:2.98|P-value:5.01E-4 ID:SGTC_3272|Compound:9137413|FD-Score:2.86|P-value:7.73E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.42|P-value:9.79E-5

Top fitness defect scores for YJL002C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2871 9038510 5.92 13.0 µM 3.49E-11 1 1.62E-9 1.24
2 SGTC_2885 9057732 5.20 52.0 µM 5.11E-9 3 1.02E-7 0.99
3 SGTC_2562 3',7'-dimethoxyflavone 4.48 64.9 µM 3.82E-7 9 3.70E-6 0.71
4 SGTC_2724 maprotiline 3.97 69.6 µM 5.75E-6 ERG2 6 3.53E-5 0.09
5 SGTC_1733 st037357 3.97 54.9 µM 5.81E-6 60S ribosome export 7 3.56E-5 0.06
6 SGTC_112 phenothiazine 3.88 287.2 µM 9.12E-6 unfolded protein response 5 5.18E-5 0.29
7 SGTC_1731 st035964 3.81 63.0 µM 1.27E-5 13 6.83E-5 0.01
8 SGTC_3023 9089636 3.76 49.5 µM 1.68E-5 1 8.61E-5 0.35
9 SGTC_2348 9022543 3.52 33.4 µM 4.95E-5 mitochondrial processes 40 2.12E-4 0.05
10 SGTC_2056 5235370 3.46 200.0 µM 6.55E-5 8 2.68E-4 0.10
11 SGTC_284 0988-0104 3.41 32.6 µM 8.40E-5 heme requiring 4 3.30E-4 0.04
12 SGTC_2096 5468907 3.29 200.0 µM 1.36E-4 4 4.94E-4 0.02
13 SGTC_994 3910-0338 3.28 138.0 µM 1.42E-4 calcium & mitochondrial duress 23 5.12E-4 0.01
14 SGTC_373 0844-0104 3.28 25.9 µM 1.43E-4 ERAD & cell cycle 20 5.16E-4 0.02
15 SGTC_1350 1495-0454 3.26 146.0 µM 1.57E-4 7 5.57E-4 0.02
16 SGTC_41 0478-0632 3.25 82.6 µM 1.62E-4 20 5.71E-4 0.03
17 SGTC_39 0986-0283 3.17 58.4 µM 2.32E-4 calcium & mitochondrial duress 15 7.70E-4 0.02
18 SGTC_234 nsc-17383 3.09 10.7 µM 3.22E-4 ERG2 15 0.00101 0.03
19 SGTC_3037 9091026 3.00 49.5 µM 4.47E-4 NEO1-PIK1 29 0.00133 0.09
20 SGTC_3270 9137563 2.98 49.5 µM 5.01E-4 RPP1 & pyrimidine depletion 8 0.00146 0.12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.183 9.79E-27 YER171W RAD3 het 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress
0.182 1.60E-26 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.174 2.56E-24 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.169 5.73E-23 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.167 1.83E-22 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.166 2.91E-22 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.161 5.68E-21 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.149 4.99E-18 YLR267W_p BOP2_p hom Protein of unknown function
0.148 6.59E-18 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.143 6.55E-17 YGR117C_p YGR117C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.141 2.44E-16 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.138 8.58E-16 YLL038C ENT4 hom Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome
0.133 8.38E-15 YDR057W YOS9 hom ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family
0.133 1.07E-14 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.131 2.10E-14 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential