YJL003W / COX16

Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL003W / COX16

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:3.92|P-value:6.27E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.28|P-value:1.49E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:4.29|P-value:1.38E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:4.63|P-value:3.24E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:9.77|P-value:1.88E-21 ID:SGTC_248|Compound:streptozotocin|FD-Score:-3.40|P-value:7.38E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.53|P-value:2.70E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.04|P-value:4.73E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:6.57|P-value:9.36E-11 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.65|P-value:3.11E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:-4.20|P-value:4.07E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:-4.63|P-value:6.59E-6 ID:SGTC_1126|Compound:isoteolin|FD-Score:6.28|P-value:5.61E-10 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.50|P-value:3.01E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.29|P-value:6.24E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.37|P-value:4.64E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.66|P-value:1.70E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.96|P-value:5.48E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.32|P-value:1.22E-5 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.86|P-value:8.06E-5 ID:SGTC_1521|Compound:st012942|FD-Score:4.88|P-value:9.97E-7 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.39|P-value:4.36E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:4.61|P-value:3.54E-6 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.54|P-value:2.59E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.58|P-value:2.29E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.38|P-value:7.82E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.13|P-value:6.60E-7 ID:SGTC_1761|Compound:st044296|FD-Score:3.29|P-value:6.21E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.36|P-value:4.81E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.18|P-value:8.76E-4 ID:SGTC_2287|Compound:7945887|FD-Score:-3.89|P-value:1.33E-4 ID:SGTC_2381|Compound:9035592|FD-Score:-3.47|P-value:5.89E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.30|P-value:5.90E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.36|P-value:4.82E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-5.89|P-value:1.35E-8 ID:SGTC_2807|Compound:7945238|FD-Score:3.68|P-value:1.55E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.23|P-value:4.09E-7 ID:SGTC_2897|Compound:9048598|FD-Score:-3.73|P-value:2.42E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.27|P-value:6.72E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-3.81|P-value:1.80E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.92|P-value:6.27E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.28|P-value:1.49E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:4.29|P-value:1.38E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:4.63|P-value:3.24E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:9.77|P-value:1.88E-21 ID:SGTC_248|Compound:streptozotocin|FD-Score:-3.40|P-value:7.38E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.53|P-value:2.70E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.04|P-value:4.73E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:6.57|P-value:9.36E-11 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.65|P-value:3.11E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:-4.20|P-value:4.07E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:-4.63|P-value:6.59E-6 ID:SGTC_1126|Compound:isoteolin|FD-Score:6.28|P-value:5.61E-10 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.50|P-value:3.01E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.29|P-value:6.24E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.37|P-value:4.64E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.66|P-value:1.70E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.96|P-value:5.48E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.32|P-value:1.22E-5 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.86|P-value:8.06E-5 ID:SGTC_1521|Compound:st012942|FD-Score:4.88|P-value:9.97E-7 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.39|P-value:4.36E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:4.61|P-value:3.54E-6 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.54|P-value:2.59E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.58|P-value:2.29E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.38|P-value:7.82E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.13|P-value:6.60E-7 ID:SGTC_1761|Compound:st044296|FD-Score:3.29|P-value:6.21E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.36|P-value:4.81E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.18|P-value:8.76E-4 ID:SGTC_2287|Compound:7945887|FD-Score:-3.89|P-value:1.33E-4 ID:SGTC_2381|Compound:9035592|FD-Score:-3.47|P-value:5.89E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.30|P-value:5.90E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.36|P-value:4.82E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-5.89|P-value:1.35E-8 ID:SGTC_2807|Compound:7945238|FD-Score:3.68|P-value:1.55E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.23|P-value:4.09E-7 ID:SGTC_2897|Compound:9048598|FD-Score:-3.73|P-value:2.42E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.27|P-value:6.72E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-3.81|P-value:1.80E-4

Top fitness defect scores for YJL003W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 9.77 5.3 µM 1.88E-21 199 7.43E-23
2 SGTC_386 1509-0011 6.57 3.1 µM 9.36E-11 83 2.53E-11
3 SGTC_1126 isoteolin 6.28 1.0 µM 5.61E-10 6 1.73E-10
4 SGTC_310 1273-0058 5.04 1.1 µM 4.73E-7 mitochondrial stress 183 2.38E-7
5 SGTC_1521 st012942 4.88 49.4 µM 9.97E-7 15 5.29E-7
6 SGTC_173 1273-0061 4.63 2.7 µM 3.24E-6 mitochondrial stress 163 1.86E-6
7 SGTC_1535 tetrahydropapaveroline hydrobromide 4.61 54.3 µM 3.54E-6 RPP1 & pyrimidine depletion 3 2.05E-6
8 SGTC_1474 0330-0125 4.32 5.3 µM 1.22E-5 22 7.65E-6
9 SGTC_134 0269-0018 4.29 6.9 µM 1.38E-5 120 8.79E-6
10 SGTC_118 0083-0097 4.28 135.3 µM 1.49E-5 translation 104 9.54E-6
11 SGTC_1458 k015-0034 3.96 6.3 µM 5.48E-5 16 3.82E-5
12 SGTC_87 0100-0052 3.92 35.5 µM 6.27E-5 108 4.40E-5
13 SGTC_1517 deoxycholic acid methyl ester 3.86 49.2 µM 8.06E-5 11 5.75E-5
14 SGTC_2807 7945238 3.68 52.0 µM 1.55E-4 30 1.16E-4
15 SGTC_1444 4112-3581 3.66 28.0 µM 1.70E-4 16 1.27E-4
16 SGTC_1635 st007035 3.58 42.4 µM 2.29E-4 241 1.75E-4
17 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 3.54 19.1 µM 2.59E-4 35 1.99E-4
18 SGTC_275 trichlorophene 3.53 5.7 µM 2.70E-4 mitochondrial stress 250 2.08E-4
19 SGTC_1132 3456-3614 3.50 2.5 µM 3.01E-4 tubulin folding & SWR complex 76 2.33E-4
20 SGTC_1533 dihydroergotamine mesylate 3.39 29.4 µM 4.36E-4 DNA intercalators 22 3.46E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.428 6.68E-150 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.422 3.33E-145 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.420 3.02E-143 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.409 2.23E-135 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.408 1.38E-134 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.405 7.71E-133 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.405 1.99E-132 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.397 9.41E-127 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.395 1.60E-125 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.393 1.23E-124 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.391 2.70E-123 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.391 1.07E-122 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.389 1.13E-121 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.387 5.32E-120 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.385 6.91E-119 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme