YJL005W / CYR1

Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL005W / CYR1

Click on Significant Values for Screen Details ID:SGTC_81|Compound:0411-0046|FD-Score:3.08|P-value:4.26E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:-3.12|P-value:3.32E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.39|P-value:1.08E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:11.10|P-value:9.80E-34 ID:SGTC_266|Compound:formosanin C|FD-Score:4.09|P-value:4.85E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:5.49|P-value:1.37E-9 ID:SGTC_380|Compound:3970-0968|FD-Score:4.11|P-value:4.41E-6 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:11.90|P-value:2.14E-38 ID:SGTC_435|Compound:c-PAF|FD-Score:8.42|P-value:3.42E-20 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.94|P-value:4.43E-8 ID:SGTC_455|Compound:paf C-16|FD-Score:7.91|P-value:5.01E-18 ID:SGTC_483|Compound:fpl-64176|FD-Score:-3.59|P-value:4.52E-5 ID:SGTC_489|Compound:paxilline|FD-Score:2.96|P-value:6.89E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.17|P-value:3.16E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:5.17|P-value:1.07E-8 ID:SGTC_568|Compound:1193-0097|FD-Score:3.06|P-value:4.73E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.53|P-value:6.61E-5 ID:SGTC_700|Compound:3453-2283|FD-Score:-3.56|P-value:5.27E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:3.77|P-value:2.26E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.16|P-value:3.17E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.63|P-value:4.26E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:-2.96|P-value:6.15E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.23|P-value:2.38E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:-4.19|P-value:2.53E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.35|P-value:1.45E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.59|P-value:5.09E-5 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.10|P-value:4.05E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.68|P-value:3.35E-5 ID:SGTC_1523|Compound:st012844|FD-Score:-6.92|P-value:2.53E-14 ID:SGTC_1526|Compound:st051518|FD-Score:-4.70|P-value:1.52E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-2.87|P-value:8.61E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.15|P-value:2.93E-4 ID:SGTC_1766|Compound:st045414|FD-Score:-3.17|P-value:2.68E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.13|P-value:3.87E-6 ID:SGTC_1933|Compound:st074711|FD-Score:3.39|P-value:1.23E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.34|P-value:1.52E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.43|P-value:1.02E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.22|P-value:2.52E-4 ID:SGTC_2235|Compound:salicylic acid|FD-Score:3.03|P-value:5.29E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.46|P-value:9.09E-5 ID:SGTC_2464|Compound:5717415|FD-Score:3.05|P-value:4.88E-4 ID:SGTC_2466|Compound:5983409|FD-Score:4.92|P-value:4.90E-8 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-2.91|P-value:7.57E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.23|P-value:7.50E-9 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.67|P-value:3.52E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:14.50|P-value:2.19E-56 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.12|P-value:3.70E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.37|P-value:1.35E-4 ID:SGTC_2781|Compound:5567276|FD-Score:2.92|P-value:7.98E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.26|P-value:2.15E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.52|P-value:6.97E-5 ID:SGTC_2823|Compound:7987624|FD-Score:3.28|P-value:1.97E-4 ID:SGTC_2828|Compound:7998861|FD-Score:3.53|P-value:6.66E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-4.43|P-value:6.77E-7 ID:SGTC_2953|Compound:9074162|FD-Score:5.39|P-value:2.62E-9 ID:SGTC_2965|Compound:9082772|FD-Score:-3.23|P-value:2.15E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.08|P-value:5.04E-6 ID:SGTC_3242|Compound:9133940|FD-Score:3.06|P-value:4.77E-4 ID:SGTC_3251|Compound:9135047|FD-Score:3.02|P-value:5.53E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.08|P-value:4.26E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:-3.12|P-value:3.32E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.39|P-value:1.08E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:11.10|P-value:9.80E-34 ID:SGTC_266|Compound:formosanin C|FD-Score:4.09|P-value:4.85E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:5.49|P-value:1.37E-9 ID:SGTC_380|Compound:3970-0968|FD-Score:4.11|P-value:4.41E-6 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:11.90|P-value:2.14E-38 ID:SGTC_435|Compound:c-PAF|FD-Score:8.42|P-value:3.42E-20 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.94|P-value:4.43E-8 ID:SGTC_455|Compound:paf C-16|FD-Score:7.91|P-value:5.01E-18 ID:SGTC_483|Compound:fpl-64176|FD-Score:-3.59|P-value:4.52E-5 ID:SGTC_489|Compound:paxilline|FD-Score:2.96|P-value:6.89E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.17|P-value:3.16E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:5.17|P-value:1.07E-8 ID:SGTC_568|Compound:1193-0097|FD-Score:3.06|P-value:4.73E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.53|P-value:6.61E-5 ID:SGTC_700|Compound:3453-2283|FD-Score:-3.56|P-value:5.27E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:3.77|P-value:2.26E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.16|P-value:3.17E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.63|P-value:4.26E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:-2.96|P-value:6.15E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.23|P-value:2.38E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:-4.19|P-value:2.53E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.35|P-value:1.45E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.59|P-value:5.09E-5 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.10|P-value:4.05E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.68|P-value:3.35E-5 ID:SGTC_1523|Compound:st012844|FD-Score:-6.92|P-value:2.53E-14 ID:SGTC_1526|Compound:st051518|FD-Score:-4.70|P-value:1.52E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-2.87|P-value:8.61E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.15|P-value:2.93E-4 ID:SGTC_1766|Compound:st045414|FD-Score:-3.17|P-value:2.68E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.13|P-value:3.87E-6 ID:SGTC_1933|Compound:st074711|FD-Score:3.39|P-value:1.23E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.34|P-value:1.52E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.43|P-value:1.02E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.22|P-value:2.52E-4 ID:SGTC_2235|Compound:salicylic acid|FD-Score:3.03|P-value:5.29E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.46|P-value:9.09E-5 ID:SGTC_2464|Compound:5717415|FD-Score:3.05|P-value:4.88E-4 ID:SGTC_2466|Compound:5983409|FD-Score:4.92|P-value:4.90E-8 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-2.91|P-value:7.57E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.23|P-value:7.50E-9 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.67|P-value:3.52E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:14.50|P-value:2.19E-56 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.12|P-value:3.70E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.37|P-value:1.35E-4 ID:SGTC_2781|Compound:5567276|FD-Score:2.92|P-value:7.98E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.26|P-value:2.15E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.52|P-value:6.97E-5 ID:SGTC_2823|Compound:7987624|FD-Score:3.28|P-value:1.97E-4 ID:SGTC_2828|Compound:7998861|FD-Score:3.53|P-value:6.66E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-4.43|P-value:6.77E-7 ID:SGTC_2953|Compound:9074162|FD-Score:5.39|P-value:2.62E-9 ID:SGTC_2965|Compound:9082772|FD-Score:-3.23|P-value:2.15E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.08|P-value:5.04E-6 ID:SGTC_3242|Compound:9133940|FD-Score:3.06|P-value:4.77E-4 ID:SGTC_3251|Compound:9135047|FD-Score:3.02|P-value:5.53E-4

Top fitness defect scores for YJL005W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2651 1327-0036 14.50 5.0 µM 2.19E-56 5 3.38E-48 0.01
2 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 11.90 8.0 µM 2.14E-38 2 6.38E-33 3.98
3 SGTC_163 1327-0036 11.10 7.5 µM 9.80E-34 12 5.80E-29 0.18
4 SGTC_435 c-PAF 8.42 6.7 µM 3.42E-20 2 1.89E-17 1.37
5 SGTC_455 paf C-16 7.91 10.0 µM 5.01E-18 1 1.31E-15 2.38
6 SGTC_309 k408-0051 5.49 1.5 µM 1.37E-9 11 2.02E-8 0.06
7 SGTC_2953 9074162 5.39 66.5 µM 2.62E-9 1 3.52E-8 0.53
8 SGTC_2582 agaric acid 5.23 100.0 µM 7.50E-9 redox potentiating 21 8.63E-8 0.13
9 SGTC_514 4466-0038 5.17 2.6 nM 1.07E-8 cell wall 25 1.17E-7 0.00
10 SGTC_453 enantio-paf c16 4.94 10.0 µM 4.43E-8 10 3.94E-7 0.00
11 SGTC_2466 5983409 4.92 37.1 µM 4.90E-8 4 4.29E-7 0.08
12 SGTC_513 4245-1575 4.17 41.7 µM 3.16E-6 unfolded protein response 25 1.51E-5 0.03
13 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 4.13 70.1 µM 3.87E-6 3 1.80E-5 0.06
14 SGTC_380 3970-0968 4.11 6.0 µM 4.41E-6 1 2.01E-5 0.31
15 SGTC_266 formosanin C 4.09 406.0 nM 4.85E-6 sphingolipid biosynthesis & PDR1 23 2.19E-5 0.34
16 SGTC_3202 9113761 4.08 49.5 µM 5.04E-6 8 2.26E-5 0.01
17 SGTC_704 1310-0270 3.77 142.0 µM 2.26E-5 7 8.16E-5 0.20
18 SGTC_1522 st012842 3.68 45.6 µM 3.35E-5 RNA pol III & RNase P/MRP 15 1.15E-4 0.14
19 SGTC_2629 bisabolol 3.67 100.0 µM 3.52E-5 12 1.19E-4 0.01
20 SGTC_765 1319-0117 3.63 244.0 µM 4.26E-5 60S ribosome export 8 1.41E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.446 1.81E-163 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.421 1.27E-144 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.402 3.16E-130 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.396 3.32E-126 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.381 2.24E-116 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.375 1.95E-112 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.370 4.07E-109 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.361 7.41E-104 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.346 3.63E-95 YHR155W YSP1 hom Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.339 8.86E-91 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.290 3.92E-66 YDL002C NHP10 hom Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair
0.268 3.94E-56 YIL031W ULP2 het Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
0.261 2.09E-53 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.255 1.01E-50 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.250 4.61E-49 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex