YJL008C / CCT8

Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL008C / CCT8

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:4.48|P-value:1.32E-5 ID:SGTC_104|Compound:0074-0074|FD-Score:3.34|P-value:9.33E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.50|P-value:5.45E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:3.50|P-value:5.41E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:9.15|P-value:2.29E-18 ID:SGTC_229|Compound:benomyl|FD-Score:7.50|P-value:6.56E-13 ID:SGTC_252|Compound:miconazole|FD-Score:3.34|P-value:9.16E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:3.56|P-value:4.47E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.46|P-value:6.23E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:3.54|P-value:4.73E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:5.54|P-value:9.09E-8 ID:SGTC_420|Compound:mitomycin C|FD-Score:-4.25|P-value:1.70E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.40|P-value:7.73E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:3.34|P-value:9.42E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.35|P-value:9.01E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:4.67|P-value:5.82E-6 ID:SGTC_594|Compound:1487-1584|FD-Score:4.82|P-value:3.00E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:3.47|P-value:6.01E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:-3.36|P-value:5.02E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.54|P-value:4.82E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:6.04|P-value:6.16E-9 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.11|P-value:6.07E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.81|P-value:1.86E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:-3.55|P-value:2.59E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-3.49|P-value:3.13E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.18|P-value:9.12E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.60|P-value:3.94E-4 ID:SGTC_1643|Compound:st009866|FD-Score:4.21|P-value:3.98E-5 ID:SGTC_1661|Compound:st013063|FD-Score:4.14|P-value:5.40E-5 ID:SGTC_1757|Compound:st041620|FD-Score:-4.04|P-value:4.11E-5 ID:SGTC_1759|Compound:st043059|FD-Score:3.58|P-value:4.15E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-3.85|P-value:8.63E-5 ID:SGTC_1860|Compound:st056228|FD-Score:4.86|P-value:2.48E-6 ID:SGTC_1875|Compound:nocodazole|FD-Score:17.30|P-value:3.16E-61 ID:SGTC_1909|Compound:st060837|FD-Score:-3.25|P-value:7.17E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-3.49|P-value:3.17E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.23|P-value:3.68E-5 ID:SGTC_2089|Compound:5281248|FD-Score:6.09|P-value:4.64E-9 ID:SGTC_2132|Compound:5317594|FD-Score:-3.84|P-value:8.74E-5 ID:SGTC_2183|Compound:6420625|FD-Score:3.34|P-value:9.19E-4 ID:SGTC_2189|Compound:6047310|FD-Score:3.33|P-value:9.50E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.33|P-value:9.57E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.81|P-value:1.88E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-4.02|P-value:4.35E-5 ID:SGTC_2309|Compound:7664088|FD-Score:-3.50|P-value:3.10E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.73|P-value:2.47E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.51|P-value:5.34E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.26|P-value:7.05E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.23|P-value:3.75E-5 ID:SGTC_2476|Compound:5806916|FD-Score:3.40|P-value:7.60E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.68|P-value:1.62E-4 ID:SGTC_2601|Compound:securinine|FD-Score:4.05|P-value:7.52E-5 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:3.38|P-value:8.07E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.61|P-value:3.71E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.30|P-value:6.17E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.46|P-value:3.55E-4 ID:SGTC_2880|Compound:9042983|FD-Score:4.20|P-value:4.12E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-3.83|P-value:9.16E-5 ID:SGTC_3027|Compound:9089541|FD-Score:4.08|P-value:6.65E-5 ID:SGTC_3053|Compound:9095903|FD-Score:3.37|P-value:8.43E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-3.72|P-value:1.39E-4 ID:SGTC_3081|Compound:9117243|FD-Score:4.37|P-value:2.13E-5 ID:SGTC_3113|Compound:9123498|FD-Score:3.87|P-value:1.46E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.66|P-value:3.10E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:4.48|P-value:1.32E-5 ID:SGTC_104|Compound:0074-0074|FD-Score:3.34|P-value:9.33E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.50|P-value:5.45E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:3.50|P-value:5.41E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:9.15|P-value:2.29E-18 ID:SGTC_229|Compound:benomyl|FD-Score:7.50|P-value:6.56E-13 ID:SGTC_252|Compound:miconazole|FD-Score:3.34|P-value:9.16E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:3.56|P-value:4.47E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.46|P-value:6.23E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:3.54|P-value:4.73E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:5.54|P-value:9.09E-8 ID:SGTC_420|Compound:mitomycin C|FD-Score:-4.25|P-value:1.70E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.40|P-value:7.73E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:3.34|P-value:9.42E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.35|P-value:9.01E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:4.67|P-value:5.82E-6 ID:SGTC_594|Compound:1487-1584|FD-Score:4.82|P-value:3.00E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:3.47|P-value:6.01E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:-3.36|P-value:5.02E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.54|P-value:4.82E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:6.04|P-value:6.16E-9 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.11|P-value:6.07E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.81|P-value:1.86E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:-3.55|P-value:2.59E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-3.49|P-value:3.13E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.18|P-value:9.12E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.60|P-value:3.94E-4 ID:SGTC_1643|Compound:st009866|FD-Score:4.21|P-value:3.98E-5 ID:SGTC_1661|Compound:st013063|FD-Score:4.14|P-value:5.40E-5 ID:SGTC_1757|Compound:st041620|FD-Score:-4.04|P-value:4.11E-5 ID:SGTC_1759|Compound:st043059|FD-Score:3.58|P-value:4.15E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-3.85|P-value:8.63E-5 ID:SGTC_1860|Compound:st056228|FD-Score:4.86|P-value:2.48E-6 ID:SGTC_1875|Compound:nocodazole|FD-Score:17.30|P-value:3.16E-61 ID:SGTC_1909|Compound:st060837|FD-Score:-3.25|P-value:7.17E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-3.49|P-value:3.17E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.23|P-value:3.68E-5 ID:SGTC_2089|Compound:5281248|FD-Score:6.09|P-value:4.64E-9 ID:SGTC_2132|Compound:5317594|FD-Score:-3.84|P-value:8.74E-5 ID:SGTC_2183|Compound:6420625|FD-Score:3.34|P-value:9.19E-4 ID:SGTC_2189|Compound:6047310|FD-Score:3.33|P-value:9.50E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.33|P-value:9.57E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.81|P-value:1.88E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-4.02|P-value:4.35E-5 ID:SGTC_2309|Compound:7664088|FD-Score:-3.50|P-value:3.10E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.73|P-value:2.47E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.51|P-value:5.34E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.26|P-value:7.05E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.23|P-value:3.75E-5 ID:SGTC_2476|Compound:5806916|FD-Score:3.40|P-value:7.60E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.68|P-value:1.62E-4 ID:SGTC_2601|Compound:securinine|FD-Score:4.05|P-value:7.52E-5 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:3.38|P-value:8.07E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.61|P-value:3.71E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.30|P-value:6.17E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.46|P-value:3.55E-4 ID:SGTC_2880|Compound:9042983|FD-Score:4.20|P-value:4.12E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-3.83|P-value:9.16E-5 ID:SGTC_3027|Compound:9089541|FD-Score:4.08|P-value:6.65E-5 ID:SGTC_3053|Compound:9095903|FD-Score:3.37|P-value:8.43E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-3.72|P-value:1.39E-4 ID:SGTC_3081|Compound:9117243|FD-Score:4.37|P-value:2.13E-5 ID:SGTC_3113|Compound:9123498|FD-Score:3.87|P-value:1.46E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.66|P-value:3.10E-4

Top fitness defect scores for YJL008C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1875 nocodazole 17.30 6.0 µM 3.16E-61 tubulin folding & SWR complex 2 1.90E-67 0.26
2 SGTC_212 3807-4682 9.15 38.8 µM 2.29E-18 tubulin folding & SWR complex 5 2.90E-20 0.34
3 SGTC_229 benomyl 7.50 22.9 µM 6.56E-13 tubulin folding & SWR complex 6 3.08E-14 0.20
4 SGTC_2089 5281248 6.09 129.7 µM 4.64E-9 superoxide 6 5.54E-10 1.17
5 SGTC_1087 pterostilbene 6.04 9.1 µM 6.16E-9 1 7.58E-10 1.35
6 SGTC_419 nsc-638432 5.54 893.0 µM 9.09E-8 DNA damage response 1 1.49E-8 1.20
7 SGTC_1860 st056228 4.86 74.6 µM 2.48E-6 2 5.81E-7 0.57
8 SGTC_594 1487-1584 4.82 10.8 µM 3.00E-6 5 7.19E-7 0.48
9 SGTC_565 1418-0001 4.67 44.5 µM 5.82E-6 4 1.50E-6 0.48
10 SGTC_12 0849-0099 4.48 9.3 µM 1.32E-5 4 3.71E-6 0.12
11 SGTC_3081 9117243 4.37 49.5 µM 2.13E-5 fatty acid desaturase (OLE1) 23 6.32E-6 0.01
12 SGTC_1934 st074720 4.23 32.6 µM 3.68E-5 8 1.16E-5 0.00
13 SGTC_2405 ticlatone 4.23 3.5 µM 3.75E-5 21 1.18E-5 0.47
14 SGTC_1643 st009866 4.21 20.2 µM 3.98E-5 22 1.26E-5 0.24
15 SGTC_2880 9042983 4.20 58.4 µM 4.12E-5 fatty acid desaturase (OLE1) 10 1.32E-5 0.03
16 SGTC_1661 st013063 4.14 9.7 µM 5.40E-5 7 1.77E-5 0.12
17 SGTC_1357 1503-1303 4.11 39.5 µM 6.07E-5 7 2.02E-5 0.20
18 SGTC_3027 9089541 4.08 49.5 µM 6.65E-5 fatty acid desaturase (OLE1) 14 2.24E-5 0.23
19 SGTC_2601 securinine 4.05 100.0 µM 7.52E-5 18 2.57E-5 0.20
20 SGTC_3113 9123498 3.87 49.5 µM 1.46E-4 5 5.37E-5 0.16

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.389 8.38E-122 YIL142W CCT2 het Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.386 1.17E-119 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.380 2.07E-115 YJL014W CCT3 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.356 1.67E-100 YJR064W CCT5 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.336 2.23E-89 YDR212W TCP1 het Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
0.329 1.03E-85 YJL009W_d YJL009W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
0.327 1.59E-84 YDR187C_d YDR187C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
0.294 6.15E-68 YDL143W CCT4 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.289 1.41E-65 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.280 2.50E-61 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.270 2.53E-57 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.238 1.23E-44 YKL025C PAN3 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.223 6.58E-39 YJL015C_d YJL015C_d het Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W
0.216 1.08E-36 YJL111W CCT7 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance
0.194 1.02E-29 YDR188W CCT6 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif