YJL010C / NOP9

Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL010C / NOP9

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:-3.81|P-value:3.12E-5 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.35|P-value:2.13E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.65|P-value:6.31E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.76|P-value:4.75E-5 ID:SGTC_196|Compound:k015-0023|FD-Score:4.10|P-value:1.04E-5 ID:SGTC_338|Compound:4055-0136|FD-Score:4.30|P-value:4.02E-6 ID:SGTC_360|Compound:0957-0399|FD-Score:3.20|P-value:4.63E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.08|P-value:5.87E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.67|P-value:6.93E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:3.80|P-value:3.95E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.57|P-value:1.06E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:4.46|P-value:1.83E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:4.23|P-value:5.77E-6 ID:SGTC_1150|Compound:3909-7983|FD-Score:-4.07|P-value:9.38E-6 ID:SGTC_1272|Compound:0839-0021|FD-Score:4.46|P-value:1.83E-6 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.51|P-value:1.36E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.33|P-value:2.74E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-4.64|P-value:5.64E-7 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.55|P-value:1.17E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:4.20|P-value:6.48E-6 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.27|P-value:3.45E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.15|P-value:5.52E-4 ID:SGTC_1761|Compound:st044296|FD-Score:-3.40|P-value:1.74E-4 ID:SGTC_1762|Compound:st045503|FD-Score:-2.97|P-value:8.90E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.29|P-value:2.71E-4 ID:SGTC_1766|Compound:st045414|FD-Score:4.08|P-value:1.12E-5 ID:SGTC_1770|Compound:st043884|FD-Score:-3.39|P-value:1.80E-4 ID:SGTC_1771|Compound:st048882|FD-Score:6.15|P-value:7.80E-11 ID:SGTC_1777|Compound:st045864|FD-Score:-3.06|P-value:6.40E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.56|P-value:1.10E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-4.06|P-value:1.02E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.90|P-value:1.76E-7 ID:SGTC_1859|Compound:st055998|FD-Score:-3.02|P-value:7.32E-4 ID:SGTC_1865|Compound:st057639|FD-Score:3.09|P-value:6.91E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.38|P-value:2.68E-6 ID:SGTC_1984|Compound:st072354|FD-Score:-2.98|P-value:8.64E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.31|P-value:2.55E-4 ID:SGTC_2097|Compound:5376186|FD-Score:4.17|P-value:7.42E-6 ID:SGTC_2101|Compound:5377231|FD-Score:3.12|P-value:6.12E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:-3.02|P-value:7.52E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-3.62|P-value:7.24E-5 ID:SGTC_2294|Compound:7971431|FD-Score:-2.99|P-value:8.25E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.38|P-value:2.34E-4 ID:SGTC_2315|Compound:7733312|FD-Score:3.32|P-value:2.94E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.18|P-value:4.94E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.52|P-value:1.33E-6 ID:SGTC_2400|Compound:5203494|FD-Score:3.01|P-value:9.05E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-3.07|P-value:6.21E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-3.01|P-value:7.68E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.63|P-value:7.78E-7 ID:SGTC_2709|Compound:st078560|FD-Score:-3.06|P-value:6.50E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.31|P-value:2.98E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.35|P-value:2.11E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.02|P-value:7.35E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-6.27|P-value:2.57E-11 ID:SGTC_2878|Compound:9043973|FD-Score:-4.04|P-value:1.10E-5 ID:SGTC_2895|Compound:9054447|FD-Score:-3.53|P-value:1.01E-4 ID:SGTC_2954|Compound:9074818|FD-Score:4.40|P-value:2.48E-6 ID:SGTC_2959|Compound:9079155|FD-Score:4.80|P-value:3.08E-7 ID:SGTC_3143|Compound:9086658|FD-Score:-4.21|P-value:4.97E-6 ID:SGTC_3351|Compound:9150312|FD-Score:3.41|P-value:2.03E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.81|P-value:3.12E-5 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.35|P-value:2.13E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.65|P-value:6.31E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.76|P-value:4.75E-5 ID:SGTC_196|Compound:k015-0023|FD-Score:4.10|P-value:1.04E-5 ID:SGTC_338|Compound:4055-0136|FD-Score:4.30|P-value:4.02E-6 ID:SGTC_360|Compound:0957-0399|FD-Score:3.20|P-value:4.63E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.08|P-value:5.87E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.67|P-value:6.93E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:3.80|P-value:3.95E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.57|P-value:1.06E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:4.46|P-value:1.83E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:4.23|P-value:5.77E-6 ID:SGTC_1150|Compound:3909-7983|FD-Score:-4.07|P-value:9.38E-6 ID:SGTC_1272|Compound:0839-0021|FD-Score:4.46|P-value:1.83E-6 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.51|P-value:1.36E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.33|P-value:2.74E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-4.64|P-value:5.64E-7 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.55|P-value:1.17E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:4.20|P-value:6.48E-6 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.27|P-value:3.45E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.15|P-value:5.52E-4 ID:SGTC_1761|Compound:st044296|FD-Score:-3.40|P-value:1.74E-4 ID:SGTC_1762|Compound:st045503|FD-Score:-2.97|P-value:8.90E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.29|P-value:2.71E-4 ID:SGTC_1766|Compound:st045414|FD-Score:4.08|P-value:1.12E-5 ID:SGTC_1770|Compound:st043884|FD-Score:-3.39|P-value:1.80E-4 ID:SGTC_1771|Compound:st048882|FD-Score:6.15|P-value:7.80E-11 ID:SGTC_1777|Compound:st045864|FD-Score:-3.06|P-value:6.40E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.56|P-value:1.10E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-4.06|P-value:1.02E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.90|P-value:1.76E-7 ID:SGTC_1859|Compound:st055998|FD-Score:-3.02|P-value:7.32E-4 ID:SGTC_1865|Compound:st057639|FD-Score:3.09|P-value:6.91E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.38|P-value:2.68E-6 ID:SGTC_1984|Compound:st072354|FD-Score:-2.98|P-value:8.64E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.31|P-value:2.55E-4 ID:SGTC_2097|Compound:5376186|FD-Score:4.17|P-value:7.42E-6 ID:SGTC_2101|Compound:5377231|FD-Score:3.12|P-value:6.12E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:-3.02|P-value:7.52E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-3.62|P-value:7.24E-5 ID:SGTC_2294|Compound:7971431|FD-Score:-2.99|P-value:8.25E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.38|P-value:2.34E-4 ID:SGTC_2315|Compound:7733312|FD-Score:3.32|P-value:2.94E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.18|P-value:4.94E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.52|P-value:1.33E-6 ID:SGTC_2400|Compound:5203494|FD-Score:3.01|P-value:9.05E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-3.07|P-value:6.21E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-3.01|P-value:7.68E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.63|P-value:7.78E-7 ID:SGTC_2709|Compound:st078560|FD-Score:-3.06|P-value:6.50E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.31|P-value:2.98E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.35|P-value:2.11E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.02|P-value:7.35E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-6.27|P-value:2.57E-11 ID:SGTC_2878|Compound:9043973|FD-Score:-4.04|P-value:1.10E-5 ID:SGTC_2895|Compound:9054447|FD-Score:-3.53|P-value:1.01E-4 ID:SGTC_2954|Compound:9074818|FD-Score:4.40|P-value:2.48E-6 ID:SGTC_2959|Compound:9079155|FD-Score:4.80|P-value:3.08E-7 ID:SGTC_3143|Compound:9086658|FD-Score:-4.21|P-value:4.97E-6 ID:SGTC_3351|Compound:9150312|FD-Score:3.41|P-value:2.03E-4

Top fitness defect scores for YJL010C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1771 st048882 6.15 4.2 µM 7.80E-11 RPP1 & pyrimidine depletion 3 3.78E-10 1.47
2 SGTC_1789 tunicamycin 4.90 25.0 nM 1.76E-7 unfolded protein response 8 4.73E-7 0.27
3 SGTC_2959 9079155 4.80 11.0 µM 3.08E-7 6 7.95E-7 0.25
4 SGTC_2620 irigenin 4.63 100.0 µM 7.78E-7 8 1.87E-6 0.07
5 SGTC_2336 9001819 4.52 198.7 µM 1.33E-6 heme biosynthesis & mitochondrial translocase 29 3.07E-6 0.01
6 SGTC_1272 0839-0021 4.46 27.0 µM 1.83E-6 2 4.12E-6 0.26
7 SGTC_1018 4259-0013 4.46 28.1 µM 1.83E-6 4 4.12E-6 0.09
8 SGTC_2954 9074818 4.40 52.7 µM 2.48E-6 3 5.47E-6 0.20
9 SGTC_1921 5740136 4.38 50.0 µM 2.68E-6 TRP & mitochondrial translation 9 5.87E-6 0.98
10 SGTC_338 4055-0136 4.30 114.0 µM 4.02E-6 1 8.53E-6 0.65
11 SGTC_1081 sertraline 4.23 6.0 µM 5.77E-6 60S ribosome export 5 1.19E-5 0.20
12 SGTC_1581 himbacine 4.20 57.9 µM 6.48E-6 Golgi 5 1.33E-5 0.58
13 SGTC_2097 5376186 4.17 200.0 µM 7.42E-6 2 1.51E-5 0.40
14 SGTC_196 k015-0023 4.10 18.1 µM 1.04E-5 PDR1 1 2.06E-5 0.38
15 SGTC_1766 st045414 4.08 44.8 µM 1.12E-5 RPP1 & pyrimidine depletion 12 2.21E-5 0.36
16 SGTC_891 0929-0073 3.80 133.0 µM 3.95E-5 2 7.09E-5 0.07
17 SGTC_151 3013-0144 3.76 2.3 µM 4.75E-5 iron homeostasis 13 8.42E-5 0.02
18 SGTC_813 k007-0158 3.67 173.0 µM 6.93E-5 fatty acid desaturase (OLE1) 7 1.19E-4 0.01
19 SGTC_1003 4049-0218 3.57 100.0 µM 1.06E-4 12 1.78E-4 0.01
20 SGTC_1785 bathophenanthroline 3.56 24.0 µM 1.10E-4 heme requiring 31 1.84E-4 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.152 8.31E-19 YCR007C_p YCR007C_p hom Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
0.142 1.08E-16 YOL102C TPT1 het tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
0.133 1.06E-14 YDR325W YCG1 het Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.115 2.32E-11 YMR119W-A_d YMR119W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.115 2.35E-11 YDR291W HRQ1 hom 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
0.113 4.40E-11 YOR114W_p YOR114W_p hom Putative protein of unknown function; null mutant is viable
0.112 7.68E-11 YNL047C SLM2 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication
0.111 1.36E-10 YDR314C RAD34 hom Protein involved in nucleotide excision repair (NER); homologous to RAD4
0.107 5.72E-10 YMR114C YMR114C hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene
0.104 1.54E-9 YOR092W ECM3 hom Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication
0.102 4.48E-9 YBL065W_d YBL065W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.099 1.09E-8 YDR112W_d IRC2_d hom Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
0.097 2.03E-8 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.095 3.82E-8 YEL065W SIT1 hom Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
0.094 4.41E-8 YGR295C COS6 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins