YJL014W / CCT3

Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL014W / CCT3

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:4.36|P-value:4.39E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:4.72|P-value:1.56E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:4.11|P-value:8.62E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:6.42|P-value:4.57E-7 ID:SGTC_177|Compound:1327-0068|FD-Score:-5.15|P-value:3.61E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:4.75|P-value:1.45E-4 ID:SGTC_229|Compound:benomyl|FD-Score:9.92|P-value:1.63E-14 ID:SGTC_367|Compound:0335-0881|FD-Score:-7.27|P-value:1.11E-8 ID:SGTC_375|Compound:3970-0961|FD-Score:4.87|P-value:9.91E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:4.62|P-value:2.12E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:7.05|P-value:3.48E-8 ID:SGTC_435|Compound:c-PAF|FD-Score:8.40|P-value:6.43E-11 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.49|P-value:1.40E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:5.66|P-value:7.63E-6 ID:SGTC_490|Compound:phenamil|FD-Score:-4.50|P-value:2.66E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:4.06|P-value:9.72E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:4.65|P-value:1.96E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:-4.17|P-value:6.54E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:-6.92|P-value:5.00E-8 ID:SGTC_763|Compound:3453-1109|FD-Score:4.42|P-value:3.74E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:-6.22|P-value:8.53E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:4.17|P-value:7.34E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:6.26|P-value:8.66E-7 ID:SGTC_894|Compound:0960-0238|FD-Score:-4.20|P-value:5.98E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:4.28|P-value:5.44E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:4.74|P-value:1.50E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:5.13|P-value:4.46E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:-5.23|P-value:2.82E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.59|P-value:2.32E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.28|P-value:5.41E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:-4.03|P-value:9.34E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:5.51|P-value:1.27E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.93|P-value:8.29E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:-5.29|P-value:2.29E-5 ID:SGTC_1289|Compound:0976-0073|FD-Score:4.89|P-value:9.56E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:4.11|P-value:8.48E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:4.44|P-value:3.50E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:5.93|P-value:2.96E-6 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.55|P-value:2.58E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:-4.11|P-value:7.58E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-5.30|P-value:2.22E-5 ID:SGTC_1547|Compound:harmine|FD-Score:-4.03|P-value:9.40E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:4.94|P-value:8.14E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-5.03|P-value:5.34E-5 ID:SGTC_1643|Compound:st009866|FD-Score:6.91|P-value:6.40E-8 ID:SGTC_1715|Compound:st032160|FD-Score:-4.19|P-value:6.27E-4 ID:SGTC_1719|Compound:st032227|FD-Score:5.17|P-value:3.97E-5 ID:SGTC_1773|Compound:st048542|FD-Score:6.01|P-value:2.21E-6 ID:SGTC_1786|Compound:berberine|FD-Score:-7.31|P-value:9.34E-9 ID:SGTC_1827|Compound:berberine|FD-Score:-4.45|P-value:3.04E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-5.56|P-value:9.30E-6 ID:SGTC_1875|Compound:nocodazole|FD-Score:22.50|P-value:6.82E-67 ID:SGTC_1880|Compound:MG-132|FD-Score:-4.88|P-value:8.66E-5 ID:SGTC_1884|Compound:5633444|FD-Score:4.06|P-value:9.73E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-5.17|P-value:3.42E-5 ID:SGTC_1953|Compound:st076800|FD-Score:4.34|P-value:4.62E-4 ID:SGTC_2023|Compound:5144124|FD-Score:6.65|P-value:1.83E-7 ID:SGTC_2030|Compound:5175110|FD-Score:4.38|P-value:4.18E-4 ID:SGTC_2035|Compound:5154463|FD-Score:4.72|P-value:1.58E-4 ID:SGTC_2085|Compound:5307070|FD-Score:4.78|P-value:1.33E-4 ID:SGTC_2089|Compound:5281248|FD-Score:6.34|P-value:6.36E-7 ID:SGTC_2151|Compound:5563267|FD-Score:9.67|P-value:6.94E-14 ID:SGTC_2174|Compound:5790901|FD-Score:12.20|P-value:4.59E-21 ID:SGTC_2183|Compound:6420625|FD-Score:6.52|P-value:3.12E-7 ID:SGTC_2254|Compound:7938975|FD-Score:5.66|P-value:7.79E-6 ID:SGTC_2391|Compound:6285546|FD-Score:5.42|P-value:1.74E-5 ID:SGTC_2400|Compound:5203494|FD-Score:4.76|P-value:1.41E-4 ID:SGTC_2451|Compound:5856223|FD-Score:4.14|P-value:7.96E-4 ID:SGTC_2481|Compound:5478948|FD-Score:4.38|P-value:4.12E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-6.47|P-value:3.21E-7 ID:SGTC_2507|Compound:purpurin|FD-Score:-4.51|P-value:2.53E-4 ID:SGTC_2601|Compound:securinine|FD-Score:5.11|P-value:4.84E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-5.97|P-value:2.17E-6 ID:SGTC_2739|Compound:tacrine|FD-Score:-6.58|P-value:2.03E-7 ID:SGTC_2745|Compound:rifampicin|FD-Score:5.36|P-value:2.15E-5 ID:SGTC_2803|Compound:7707263|FD-Score:4.75|P-value:1.43E-4 ID:SGTC_2935|Compound:9038016|FD-Score:4.15|P-value:7.64E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-5.26|P-value:2.56E-5 ID:SGTC_3071|Compound:9117417|FD-Score:5.16|P-value:4.08E-5 ID:SGTC_3081|Compound:9117243|FD-Score:4.14|P-value:7.87E-4 ID:SGTC_3091|Compound:9116372|FD-Score:4.39|P-value:4.09E-4 ID:SGTC_3139|Compound:9095020|FD-Score:4.47|P-value:3.23E-4 ID:SGTC_3200|Compound:9114385|FD-Score:5.04|P-value:5.94E-5 ID:SGTC_3266|Compound:9136860|FD-Score:4.36|P-value:4.41E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:4.36|P-value:4.39E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:4.72|P-value:1.56E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:4.11|P-value:8.62E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:6.42|P-value:4.57E-7 ID:SGTC_177|Compound:1327-0068|FD-Score:-5.15|P-value:3.61E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:4.75|P-value:1.45E-4 ID:SGTC_229|Compound:benomyl|FD-Score:9.92|P-value:1.63E-14 ID:SGTC_367|Compound:0335-0881|FD-Score:-7.27|P-value:1.11E-8 ID:SGTC_375|Compound:3970-0961|FD-Score:4.87|P-value:9.91E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:4.62|P-value:2.12E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:7.05|P-value:3.48E-8 ID:SGTC_435|Compound:c-PAF|FD-Score:8.40|P-value:6.43E-11 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.49|P-value:1.40E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:5.66|P-value:7.63E-6 ID:SGTC_490|Compound:phenamil|FD-Score:-4.50|P-value:2.66E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:4.06|P-value:9.72E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:4.65|P-value:1.96E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:-4.17|P-value:6.54E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:-6.92|P-value:5.00E-8 ID:SGTC_763|Compound:3453-1109|FD-Score:4.42|P-value:3.74E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:-6.22|P-value:8.53E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:4.17|P-value:7.34E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:6.26|P-value:8.66E-7 ID:SGTC_894|Compound:0960-0238|FD-Score:-4.20|P-value:5.98E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:4.28|P-value:5.44E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:4.74|P-value:1.50E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:5.13|P-value:4.46E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:-5.23|P-value:2.82E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.59|P-value:2.32E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.28|P-value:5.41E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:-4.03|P-value:9.34E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:5.51|P-value:1.27E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.93|P-value:8.29E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:-5.29|P-value:2.29E-5 ID:SGTC_1289|Compound:0976-0073|FD-Score:4.89|P-value:9.56E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:4.11|P-value:8.48E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:4.44|P-value:3.50E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:5.93|P-value:2.96E-6 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.55|P-value:2.58E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:-4.11|P-value:7.58E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-5.30|P-value:2.22E-5 ID:SGTC_1547|Compound:harmine|FD-Score:-4.03|P-value:9.40E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:4.94|P-value:8.14E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-5.03|P-value:5.34E-5 ID:SGTC_1643|Compound:st009866|FD-Score:6.91|P-value:6.40E-8 ID:SGTC_1715|Compound:st032160|FD-Score:-4.19|P-value:6.27E-4 ID:SGTC_1719|Compound:st032227|FD-Score:5.17|P-value:3.97E-5 ID:SGTC_1773|Compound:st048542|FD-Score:6.01|P-value:2.21E-6 ID:SGTC_1786|Compound:berberine|FD-Score:-7.31|P-value:9.34E-9 ID:SGTC_1827|Compound:berberine|FD-Score:-4.45|P-value:3.04E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-5.56|P-value:9.30E-6 ID:SGTC_1875|Compound:nocodazole|FD-Score:22.50|P-value:6.82E-67 ID:SGTC_1880|Compound:MG-132|FD-Score:-4.88|P-value:8.66E-5 ID:SGTC_1884|Compound:5633444|FD-Score:4.06|P-value:9.73E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-5.17|P-value:3.42E-5 ID:SGTC_1953|Compound:st076800|FD-Score:4.34|P-value:4.62E-4 ID:SGTC_2023|Compound:5144124|FD-Score:6.65|P-value:1.83E-7 ID:SGTC_2030|Compound:5175110|FD-Score:4.38|P-value:4.18E-4 ID:SGTC_2035|Compound:5154463|FD-Score:4.72|P-value:1.58E-4 ID:SGTC_2085|Compound:5307070|FD-Score:4.78|P-value:1.33E-4 ID:SGTC_2089|Compound:5281248|FD-Score:6.34|P-value:6.36E-7 ID:SGTC_2151|Compound:5563267|FD-Score:9.67|P-value:6.94E-14 ID:SGTC_2174|Compound:5790901|FD-Score:12.20|P-value:4.59E-21 ID:SGTC_2183|Compound:6420625|FD-Score:6.52|P-value:3.12E-7 ID:SGTC_2254|Compound:7938975|FD-Score:5.66|P-value:7.79E-6 ID:SGTC_2391|Compound:6285546|FD-Score:5.42|P-value:1.74E-5 ID:SGTC_2400|Compound:5203494|FD-Score:4.76|P-value:1.41E-4 ID:SGTC_2451|Compound:5856223|FD-Score:4.14|P-value:7.96E-4 ID:SGTC_2481|Compound:5478948|FD-Score:4.38|P-value:4.12E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-6.47|P-value:3.21E-7 ID:SGTC_2507|Compound:purpurin|FD-Score:-4.51|P-value:2.53E-4 ID:SGTC_2601|Compound:securinine|FD-Score:5.11|P-value:4.84E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-5.97|P-value:2.17E-6 ID:SGTC_2739|Compound:tacrine|FD-Score:-6.58|P-value:2.03E-7 ID:SGTC_2745|Compound:rifampicin|FD-Score:5.36|P-value:2.15E-5 ID:SGTC_2803|Compound:7707263|FD-Score:4.75|P-value:1.43E-4 ID:SGTC_2935|Compound:9038016|FD-Score:4.15|P-value:7.64E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-5.26|P-value:2.56E-5 ID:SGTC_3071|Compound:9117417|FD-Score:5.16|P-value:4.08E-5 ID:SGTC_3081|Compound:9117243|FD-Score:4.14|P-value:7.87E-4 ID:SGTC_3091|Compound:9116372|FD-Score:4.39|P-value:4.09E-4 ID:SGTC_3139|Compound:9095020|FD-Score:4.47|P-value:3.23E-4 ID:SGTC_3200|Compound:9114385|FD-Score:5.04|P-value:5.94E-5 ID:SGTC_3266|Compound:9136860|FD-Score:4.36|P-value:4.41E-4

Top fitness defect scores for YJL014W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1875 nocodazole 22.50 6.0 µM 6.82E-67 tubulin folding & SWR complex 1 2.05E-112 5.19
2 SGTC_2174 5790901 12.20 200.0 µM 4.59E-21 tubulin folding & SWR complex 2 1.42E-34 4.08
3 SGTC_229 benomyl 9.92 22.9 µM 1.63E-14 tubulin folding & SWR complex 3 1.78E-23 1.64
4 SGTC_2151 5563267 9.67 85.4 µM 6.94E-14 4 2.06E-22 0.19
5 SGTC_435 c-PAF 8.40 6.7 µM 6.43E-11 3 2.15E-17 1.37
6 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 7.05 8.0 µM 3.48E-8 4 8.78E-13 0.52
7 SGTC_1643 st009866 6.91 20.2 µM 6.40E-8 8 2.44E-12 0.29
8 SGTC_2023 5144124 6.65 124.0 µM 1.83E-7 3 1.43E-11 2.39
9 SGTC_2183 6420625 6.52 130.5 µM 3.12E-7 mitochondrial processes 7 3.50E-11 1.32
10 SGTC_124 0136-0217 6.42 7.1 µM 4.57E-7 mitochondrial stress 6 6.66E-11 0.37
11 SGTC_2089 5281248 6.34 129.7 µM 6.36E-7 superoxide 4 1.16E-10 1.17
12 SGTC_887 0885-0007 6.26 9.6 µM 8.66E-7 endomembrane recycling 7 1.95E-10 0.71
13 SGTC_1773 st048542 6.01 73.6 µM 2.21E-6 11 9.42E-10 0.03
14 SGTC_1307 1187-1599 5.93 12.2 µM 2.96E-6 PDR1 1 1.54E-9 1.41
15 SGTC_464 bw-b 70c 5.66 158.0 µM 7.63E-6 2 7.51E-9 1.30
16 SGTC_2254 7938975 5.66 95.2 µM 7.79E-6 1 7.78E-9 0.62
17 SGTC_1171 0368-0077 5.51 21.4 µM 1.27E-5 5 1.75E-8 0.40
18 SGTC_453 enantio-paf c16 5.49 10.0 µM 1.40E-5 7 2.07E-8 0.34
19 SGTC_2391 6285546 5.42 200.0 µM 1.74E-5 1 3.00E-8 0.84
20 SGTC_2745 rifampicin 5.36 24.3 µM 2.15E-5 1 4.25E-8 2.76

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.380 2.07E-115 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.372 2.46E-110 YIL142W CCT2 het Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.370 3.11E-109 YJL111W CCT7 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance
0.341 9.40E-92 YDR212W TCP1 het Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
0.332 4.42E-87 YJL009W_d YJL009W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
0.317 4.10E-79 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.313 3.22E-77 YJR064W CCT5 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.308 1.65E-74 YDL143W CCT4 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.278 1.09E-60 YDR187C_d YDR187C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
0.236 1.05E-43 YDR188W CCT6 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
0.227 2.06E-40 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.221 1.84E-38 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.220 7.59E-38 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.207 9.73E-34 YKL025C PAN3 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.191 1.09E-28 YLR163C MAS1 het Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins