YJL015C_d

Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL015C / YJL015C

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:3.96|P-value:2.19E-5 ID:SGTC_25|Compound:0118-0223|FD-Score:3.09|P-value:7.14E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:-3.96|P-value:2.19E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:3.37|P-value:2.54E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.70|P-value:6.57E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.70|P-value:2.01E-9 ID:SGTC_143|Compound:4032-1194|FD-Score:3.06|P-value:7.95E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.82|P-value:3.94E-5 ID:SGTC_174|Compound:3553-0389|FD-Score:4.20|P-value:7.06E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:3.26|P-value:3.78E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.67|P-value:7.45E-5 ID:SGTC_225|Compound:nsc-122657|FD-Score:4.31|P-value:4.23E-6 ID:SGTC_353|Compound:1988-1175|FD-Score:3.00|P-value:9.70E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.40|P-value:2.20E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-3.64|P-value:8.40E-5 ID:SGTC_478|Compound:N-arachidonylglycine|FD-Score:-3.10|P-value:6.79E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.02|P-value:9.17E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:-3.05|P-value:8.09E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:4.68|P-value:6.65E-7 ID:SGTC_621|Compound:3584-0052|FD-Score:3.28|P-value:3.56E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.40|P-value:2.25E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.50|P-value:1.49E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.76|P-value:5.11E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:5.15|P-value:5.11E-8 ID:SGTC_795|Compound:0685-0265|FD-Score:4.03|P-value:1.58E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:4.44|P-value:2.23E-6 ID:SGTC_812|Compound:4251-0442|FD-Score:-3.19|P-value:4.91E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.03|P-value:8.71E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.35|P-value:2.67E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.70|P-value:6.53E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.27|P-value:3.66E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-3.80|P-value:4.29E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.37|P-value:2.55E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.52|P-value:1.42E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.02|P-value:9.06E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.30|P-value:3.32E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.13|P-value:1.01E-5 ID:SGTC_1643|Compound:st009866|FD-Score:4.74|P-value:4.86E-7 ID:SGTC_1661|Compound:st013063|FD-Score:3.66|P-value:7.93E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:7.98|P-value:8.68E-17 ID:SGTC_2067|Compound:5224629|FD-Score:3.61|P-value:9.61E-5 ID:SGTC_2163|Compound:5671233|FD-Score:3.32|P-value:3.00E-4 ID:SGTC_2253|Compound:7938677|FD-Score:-3.11|P-value:6.59E-4 ID:SGTC_2282|Compound:7944268|FD-Score:7.65|P-value:1.45E-15 ID:SGTC_2345|Compound:9052315|FD-Score:6.07|P-value:1.86E-10 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.19|P-value:5.01E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.08|P-value:7.36E-4 ID:SGTC_2483|Compound:5729050|FD-Score:-3.55|P-value:1.21E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.07|P-value:7.73E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:3.03|P-value:8.83E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-4.35|P-value:3.54E-6 ID:SGTC_2835|Compound:9006588|FD-Score:-4.19|P-value:7.71E-6 ID:SGTC_2856|Compound:9022925|FD-Score:-3.81|P-value:4.10E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-3.32|P-value:2.99E-4 ID:SGTC_2892|Compound:9047358|FD-Score:-3.18|P-value:5.11E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.49|P-value:1.58E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.73|P-value:5.10E-7 ID:SGTC_3204|Compound:9114183|FD-Score:3.43|P-value:2.02E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.34|P-value:2.83E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:3.96|P-value:2.19E-5 ID:SGTC_25|Compound:0118-0223|FD-Score:3.09|P-value:7.14E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:-3.96|P-value:2.19E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:3.37|P-value:2.54E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.70|P-value:6.57E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.70|P-value:2.01E-9 ID:SGTC_143|Compound:4032-1194|FD-Score:3.06|P-value:7.95E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.82|P-value:3.94E-5 ID:SGTC_174|Compound:3553-0389|FD-Score:4.20|P-value:7.06E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:3.26|P-value:3.78E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.67|P-value:7.45E-5 ID:SGTC_225|Compound:nsc-122657|FD-Score:4.31|P-value:4.23E-6 ID:SGTC_353|Compound:1988-1175|FD-Score:3.00|P-value:9.70E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.40|P-value:2.20E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-3.64|P-value:8.40E-5 ID:SGTC_478|Compound:N-arachidonylglycine|FD-Score:-3.10|P-value:6.79E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.02|P-value:9.17E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:-3.05|P-value:8.09E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:4.68|P-value:6.65E-7 ID:SGTC_621|Compound:3584-0052|FD-Score:3.28|P-value:3.56E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.40|P-value:2.25E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.50|P-value:1.49E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.76|P-value:5.11E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:5.15|P-value:5.11E-8 ID:SGTC_795|Compound:0685-0265|FD-Score:4.03|P-value:1.58E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:4.44|P-value:2.23E-6 ID:SGTC_812|Compound:4251-0442|FD-Score:-3.19|P-value:4.91E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.03|P-value:8.71E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.35|P-value:2.67E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.70|P-value:6.53E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.27|P-value:3.66E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-3.80|P-value:4.29E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.37|P-value:2.55E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.52|P-value:1.42E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.02|P-value:9.06E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.30|P-value:3.32E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.13|P-value:1.01E-5 ID:SGTC_1643|Compound:st009866|FD-Score:4.74|P-value:4.86E-7 ID:SGTC_1661|Compound:st013063|FD-Score:3.66|P-value:7.93E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:7.98|P-value:8.68E-17 ID:SGTC_2067|Compound:5224629|FD-Score:3.61|P-value:9.61E-5 ID:SGTC_2163|Compound:5671233|FD-Score:3.32|P-value:3.00E-4 ID:SGTC_2253|Compound:7938677|FD-Score:-3.11|P-value:6.59E-4 ID:SGTC_2282|Compound:7944268|FD-Score:7.65|P-value:1.45E-15 ID:SGTC_2345|Compound:9052315|FD-Score:6.07|P-value:1.86E-10 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.19|P-value:5.01E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.08|P-value:7.36E-4 ID:SGTC_2483|Compound:5729050|FD-Score:-3.55|P-value:1.21E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.07|P-value:7.73E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:3.03|P-value:8.83E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-4.35|P-value:3.54E-6 ID:SGTC_2835|Compound:9006588|FD-Score:-4.19|P-value:7.71E-6 ID:SGTC_2856|Compound:9022925|FD-Score:-3.81|P-value:4.10E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-3.32|P-value:2.99E-4 ID:SGTC_2892|Compound:9047358|FD-Score:-3.18|P-value:5.11E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.49|P-value:1.58E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.73|P-value:5.10E-7 ID:SGTC_3204|Compound:9114183|FD-Score:3.43|P-value:2.02E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.34|P-value:2.83E-4

Top fitness defect scores for YJL015C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1875 nocodazole 7.98 6.0 µM 8.68E-17 tubulin folding & SWR complex 12 7.39E-16 0.14
2 SGTC_2282 7944268 7.65 200.0 µM 1.45E-15 RPP1 & pyrimidine depletion 3 1.04E-14 1.63
3 SGTC_2345 9052315 6.07 157.4 µM 1.86E-10 1 6.51E-10 1.05
4 SGTC_710 3448-4187 5.15 58.0 µM 5.11E-8 fatty acid desaturase (OLE1) 4 1.27E-7 0.05
5 SGTC_1643 st009866 4.74 20.2 µM 4.86E-7 18 1.06E-6 0.22
6 SGTC_3200 9114385 4.73 49.5 µM 5.10E-7 7 1.10E-6 0.03
7 SGTC_605 1315-0399 4.68 119.0 µM 6.65E-7 Golgi 6 1.42E-6 0.32
8 SGTC_808 0711-0032 4.44 135.0 µM 2.23E-6 5 4.42E-6 0.11
9 SGTC_225 nsc-122657 4.31 1.0 µM 4.23E-6 1 8.06E-6 0.33
10 SGTC_174 3553-0389 4.20 74.3 µM 7.06E-6 2 1.31E-5 0.40
11 SGTC_1585 2',4'-dihydroxychalcone 4.13 10.4 µM 1.01E-5 10 1.83E-5 0.42
12 SGTC_795 0685-0265 4.03 78.0 µM 1.58E-5 excess fatty acid 17 2.79E-5 0.08
13 SGTC_12 0849-0099 3.96 9.3 µM 2.19E-5 6 3.78E-5 0.20
14 SGTC_157 1348-1695 3.82 65.8 µM 3.94E-5 iron homeostasis 35 6.58E-5 0.00
15 SGTC_704 1310-0270 3.76 142.0 µM 5.11E-5 8 8.41E-5 0.20
16 SGTC_975 1335-0046 3.70 28.5 µM 6.53E-5 RPP1 & pyrimidine depletion 11 1.06E-4 0.00
17 SGTC_212 3807-4682 3.67 38.8 µM 7.45E-5 tubulin folding & SWR complex 27 1.20E-4 0.03
18 SGTC_1661 st013063 3.66 9.7 µM 7.93E-5 10 1.27E-4 0.48
19 SGTC_2067 5224629 3.61 34.1 µM 9.61E-5 14 1.52E-4 0.11
20 SGTC_675 1309-0189 3.50 238.0 µM 1.49E-4 8 2.31E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.235 2.96E-43 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.223 6.58E-39 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.165 8.57E-22 YDR212W TCP1 het Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
0.159 2.38E-20 YJL014W CCT3 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.157 7.55E-20 YDR187C_d YDR187C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
0.154 2.66E-19 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.152 8.20E-19 YJL009W_d YJL009W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
0.145 3.05E-17 YIL142W CCT2 het Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.145 3.29E-17 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.137 1.81E-15 YKL025C PAN3 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.133 1.02E-14 YJL179W PFD1 hom Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin
0.131 2.73E-14 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.130 3.85E-14 YJR064W CCT5 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.112 7.27E-11 YJL111W CCT7 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance
0.111 1.23E-10 YDL143W CCT4 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo