HIPHOP chemogenomics database

YJL016W_p

Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species

Zygosity: Homozygous strain

fixedexpanded
Profile for YJL016W / YJL016W

Click on Significant Values for Screen Details

Top fitness defect scores for YJL016W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2806	7952793	7.03	58.4 µM	1.10E-11		4	1.00E-12
2	SGTC_1273	0849-0096	4.88	14.1 µM	1.72E-6	RPP1 & pyrimidine depletion	7	5.42E-7
3	SGTC_904	1141-0088	4.75	396.0 µM	2.99E-6		8	1.00E-6
4	SGTC_2412	st077135	4.26	33.4 µM	2.47E-5		18	1.03E-5
5	SGTC_1844	rapamycin	4.23	4.0 nM	2.78E-5		144	1.16E-5
6	SGTC_1983	st071813	4.11	46.9 µM	4.42E-5	RPP1 & pyrimidine depletion	13	1.94E-5
7	SGTC_918	glabranin	4.09	770.7 nM	4.78E-5		28	2.12E-5
8	SGTC_1840	st055363	4.03	71.0 µM	6.10E-5		8	2.77E-5
9	SGTC_2011	4012611	4.01	177.0 µM	6.56E-5	mitochondrial processes	28	3.00E-5
10	SGTC_785	1270-0111	3.84	65.3 µM	1.25E-4		27	6.11E-5
11	SGTC_580	1123-0028	3.81	41.0 µM	1.43E-4	DNA damage response	43	7.06E-5
12	SGTC_3196	9111891	3.68	49.5 µM	2.25E-4	mitochondrial processes	27	1.16E-4
13	SGTC_1966	st070145	3.66	16.1 µM	2.43E-4		30	1.26E-4
14	SGTC_903	1134-0042	3.60	114.0 µM	2.94E-4		28	1.56E-4
15	SGTC_1070	indatraline	3.57	8.8 µM	3.28E-4	60S ribosome export	37	1.76E-4
16	SGTC_579	4491-1009	3.54	110.0 µM	3.65E-4	60S ribosome export	37	1.98E-4
17	SGTC_966	1300-0360	3.53	30.2 µM	3.76E-4	heme requiring	39	2.04E-4
18	SGTC_724	3910-0327	3.49	137.0 µM	4.40E-4	ERG2	33	2.43E-4
19	SGTC_1149	3909-7961	3.46	23.3 µM	4.82E-4		38	2.69E-4
20	SGTC_422	cantharidin	3.45	155.0 µM	4.93E-4	cell wall signaling	77	2.75E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.107	4.34E-10	YLR114C	AVL9	hom	Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.107	4.42E-10	YLR191W	PEX13	hom	Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
0.101	4.36E-9	YOR005C	DNL4	hom	DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth
0.095	3.37E-8	YPR182W	SMX3	het	Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F
0.094	5.35E-8	YKL203C	TOR2	het	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.093	7.09E-8	YFL024C	EPL1	het	Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.093	7.65E-8	YJR066W	TOR1	hom	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.089	2.56E-7	YGR163W	GTR2	hom	Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.087	4.57E-7	YNL119W	NCS2	hom	Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.087	4.45E-7	YER056C-A	RPL34A	hom	Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication
0.086	5.88E-7	YMR312W	ELP6	hom	Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.085	8.26E-7	YMR271C	URA10	hom	Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication
0.084	1.24E-6	YHR187W	IKI1	hom	Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.080	3.67E-6	YLR384C	IKI3	hom	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.076	1.13E-5	YER154W	OXA1	hom	Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals