YJL016W_p

Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL016W / YJL016W

Click on Significant Values for Screen Details ID:SGTC_374|Compound:0880-0231|FD-Score:-3.56|P-value:3.91E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.45|P-value:4.93E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.54|P-value:3.65E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.81|P-value:1.43E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:3.49|P-value:4.40E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.84|P-value:1.25E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.60|P-value:2.94E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:4.75|P-value:2.99E-6 ID:SGTC_918|Compound:glabranin|FD-Score:4.09|P-value:4.78E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:-4.99|P-value:1.20E-6 ID:SGTC_966|Compound:1300-0360|FD-Score:3.53|P-value:3.76E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.57|P-value:3.28E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.46|P-value:4.82E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:4.88|P-value:1.72E-6 ID:SGTC_1281|Compound:0884-0031|FD-Score:-3.39|P-value:6.72E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:-3.33|P-value:8.32E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-4.13|P-value:4.67E-5 ID:SGTC_1674|Compound:st016616|FD-Score:-3.49|P-value:4.88E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.72|P-value:2.17E-4 ID:SGTC_1840|Compound:st055363|FD-Score:4.03|P-value:6.10E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.23|P-value:2.78E-5 ID:SGTC_1909|Compound:st060837|FD-Score:3.27|P-value:8.94E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.66|P-value:2.43E-4 ID:SGTC_1983|Compound:st071813|FD-Score:4.11|P-value:4.42E-5 ID:SGTC_2011|Compound:4012611|FD-Score:4.01|P-value:6.56E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-3.78|P-value:1.77E-4 ID:SGTC_2412|Compound:st077135|FD-Score:4.26|P-value:2.47E-5 ID:SGTC_2523|Compound:spermine|FD-Score:-3.73|P-value:2.11E-4 ID:SGTC_2806|Compound:7952793|FD-Score:7.03|P-value:1.10E-11 ID:SGTC_3102|Compound:9121669|FD-Score:-3.40|P-value:6.51E-4 ID:SGTC_3196|Compound:9111891|FD-Score:3.68|P-value:2.25E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.45|P-value:4.95E-4 ID:SGTC_3295|Compound:9122362|FD-Score:-3.57|P-value:3.76E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.56|P-value:3.91E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.45|P-value:4.93E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.54|P-value:3.65E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.81|P-value:1.43E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:3.49|P-value:4.40E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.84|P-value:1.25E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.60|P-value:2.94E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:4.75|P-value:2.99E-6 ID:SGTC_918|Compound:glabranin|FD-Score:4.09|P-value:4.78E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:-4.99|P-value:1.20E-6 ID:SGTC_966|Compound:1300-0360|FD-Score:3.53|P-value:3.76E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.57|P-value:3.28E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.46|P-value:4.82E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:4.88|P-value:1.72E-6 ID:SGTC_1281|Compound:0884-0031|FD-Score:-3.39|P-value:6.72E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:-3.33|P-value:8.32E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-4.13|P-value:4.67E-5 ID:SGTC_1674|Compound:st016616|FD-Score:-3.49|P-value:4.88E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.72|P-value:2.17E-4 ID:SGTC_1840|Compound:st055363|FD-Score:4.03|P-value:6.10E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.23|P-value:2.78E-5 ID:SGTC_1909|Compound:st060837|FD-Score:3.27|P-value:8.94E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.66|P-value:2.43E-4 ID:SGTC_1983|Compound:st071813|FD-Score:4.11|P-value:4.42E-5 ID:SGTC_2011|Compound:4012611|FD-Score:4.01|P-value:6.56E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-3.78|P-value:1.77E-4 ID:SGTC_2412|Compound:st077135|FD-Score:4.26|P-value:2.47E-5 ID:SGTC_2523|Compound:spermine|FD-Score:-3.73|P-value:2.11E-4 ID:SGTC_2806|Compound:7952793|FD-Score:7.03|P-value:1.10E-11 ID:SGTC_3102|Compound:9121669|FD-Score:-3.40|P-value:6.51E-4 ID:SGTC_3196|Compound:9111891|FD-Score:3.68|P-value:2.25E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.45|P-value:4.95E-4 ID:SGTC_3295|Compound:9122362|FD-Score:-3.57|P-value:3.76E-4

Top fitness defect scores for YJL016W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2806 7952793 7.03 58.4 µM 1.10E-11 4 1.00E-12
2 SGTC_1273 0849-0096 4.88 14.1 µM 1.72E-6 RPP1 & pyrimidine depletion 7 5.42E-7
3 SGTC_904 1141-0088 4.75 396.0 µM 2.99E-6 8 1.00E-6
4 SGTC_2412 st077135 4.26 33.4 µM 2.47E-5 18 1.03E-5
5 SGTC_1844 rapamycin 4.23 4.0 nM 2.78E-5 144 1.16E-5
6 SGTC_1983 st071813 4.11 46.9 µM 4.42E-5 RPP1 & pyrimidine depletion 13 1.94E-5
7 SGTC_918 glabranin 4.09 770.7 nM 4.78E-5 28 2.12E-5
8 SGTC_1840 st055363 4.03 71.0 µM 6.10E-5 8 2.77E-5
9 SGTC_2011 4012611 4.01 177.0 µM 6.56E-5 mitochondrial processes 28 3.00E-5
10 SGTC_785 1270-0111 3.84 65.3 µM 1.25E-4 27 6.11E-5
11 SGTC_580 1123-0028 3.81 41.0 µM 1.43E-4 DNA damage response 43 7.06E-5
12 SGTC_3196 9111891 3.68 49.5 µM 2.25E-4 mitochondrial processes 27 1.16E-4
13 SGTC_1966 st070145 3.66 16.1 µM 2.43E-4 30 1.26E-4
14 SGTC_903 1134-0042 3.60 114.0 µM 2.94E-4 28 1.56E-4
15 SGTC_1070 indatraline 3.57 8.8 µM 3.28E-4 60S ribosome export 37 1.76E-4
16 SGTC_579 4491-1009 3.54 110.0 µM 3.65E-4 60S ribosome export 37 1.98E-4
17 SGTC_966 1300-0360 3.53 30.2 µM 3.76E-4 heme requiring 39 2.04E-4
18 SGTC_724 3910-0327 3.49 137.0 µM 4.40E-4 ERG2 33 2.43E-4
19 SGTC_1149 3909-7961 3.46 23.3 µM 4.82E-4 38 2.69E-4
20 SGTC_422 cantharidin 3.45 155.0 µM 4.93E-4 cell wall signaling 77 2.75E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 4.34E-10 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.107 4.42E-10 YLR191W PEX13 hom Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
0.101 4.36E-9 YOR005C DNL4 hom DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth
0.095 3.37E-8 YPR182W SMX3 het Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F
0.094 5.35E-8 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.093 7.09E-8 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.093 7.65E-8 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.089 2.56E-7 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.087 4.57E-7 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.087 4.45E-7 YER056C-A RPL34A hom Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication
0.086 5.88E-7 YMR312W ELP6 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.085 8.26E-7 YMR271C URA10 hom Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication
0.084 1.24E-6 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.080 3.67E-6 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.076 1.13E-5 YER154W OXA1 hom Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals