YJL022W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL022W / YJL022W

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:3.32|P-value:6.18E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:8.74|P-value:7.49E-18 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.44|P-value:3.65E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.28|P-value:7.18E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.92|P-value:6.64E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:8.95|P-value:1.24E-18 ID:SGTC_151|Compound:3013-0144|FD-Score:-6.04|P-value:1.70E-9 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.16|P-value:9.84E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:32.60|P-value:2.84E-222 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.73|P-value:8.13E-18 ID:SGTC_300|Compound:r073-0011|FD-Score:3.60|P-value:2.29E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.68|P-value:1.73E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.36|P-value:5.34E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:8.89|P-value:2.14E-18 ID:SGTC_378|Compound:3970-0959|FD-Score:-4.62|P-value:3.08E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:40.70|P-value:0 ID:SGTC_628|Compound:1636-0253|FD-Score:3.29|P-value:6.93E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.30|P-value:5.98E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.48|P-value:3.21E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.57|P-value:2.54E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.40|P-value:4.60E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:-3.55|P-value:2.50E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.48|P-value:3.22E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.48|P-value:3.59E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.43|P-value:4.16E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:-3.42|P-value:3.93E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-4.57|P-value:3.74E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-9.11|P-value:2.59E-19 ID:SGTC_1463|Compound:k081-0032|FD-Score:-7.84|P-value:8.65E-15 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.49|P-value:3.37E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.82|P-value:9.98E-5 ID:SGTC_1515|Compound:3460-0031|FD-Score:-5.00|P-value:4.90E-7 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-5.68|P-value:1.35E-8 ID:SGTC_1635|Compound:st007035|FD-Score:17.70|P-value:4.21E-67 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.28|P-value:6.58E-4 ID:SGTC_1796|Compound:st049173|FD-Score:3.54|P-value:2.90E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.31|P-value:5.81E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.48|P-value:3.54E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-3.49|P-value:3.09E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.37|P-value:5.14E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.51|P-value:5.53E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:4.54|P-value:4.88E-6 ID:SGTC_2956|Compound:9076196|FD-Score:3.32|P-value:6.08E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.57|P-value:2.33E-4 ID:SGTC_3092|Compound:9117248|FD-Score:4.10|P-value:3.30E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:3.32|P-value:6.18E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:8.74|P-value:7.49E-18 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.44|P-value:3.65E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.28|P-value:7.18E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.92|P-value:6.64E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:8.95|P-value:1.24E-18 ID:SGTC_151|Compound:3013-0144|FD-Score:-6.04|P-value:1.70E-9 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.16|P-value:9.84E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:32.60|P-value:2.84E-222 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.73|P-value:8.13E-18 ID:SGTC_300|Compound:r073-0011|FD-Score:3.60|P-value:2.29E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.68|P-value:1.73E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.36|P-value:5.34E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:8.89|P-value:2.14E-18 ID:SGTC_378|Compound:3970-0959|FD-Score:-4.62|P-value:3.08E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:40.70|P-value:0 ID:SGTC_628|Compound:1636-0253|FD-Score:3.29|P-value:6.93E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.30|P-value:5.98E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.48|P-value:3.21E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.57|P-value:2.54E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.40|P-value:4.60E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:-3.55|P-value:2.50E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.48|P-value:3.22E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.48|P-value:3.59E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.43|P-value:4.16E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:-3.42|P-value:3.93E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-4.57|P-value:3.74E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-9.11|P-value:2.59E-19 ID:SGTC_1463|Compound:k081-0032|FD-Score:-7.84|P-value:8.65E-15 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.49|P-value:3.37E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.82|P-value:9.98E-5 ID:SGTC_1515|Compound:3460-0031|FD-Score:-5.00|P-value:4.90E-7 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-5.68|P-value:1.35E-8 ID:SGTC_1635|Compound:st007035|FD-Score:17.70|P-value:4.21E-67 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.28|P-value:6.58E-4 ID:SGTC_1796|Compound:st049173|FD-Score:3.54|P-value:2.90E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.31|P-value:5.81E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.48|P-value:3.54E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-3.49|P-value:3.09E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.37|P-value:5.14E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.51|P-value:5.53E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:4.54|P-value:4.88E-6 ID:SGTC_2956|Compound:9076196|FD-Score:3.32|P-value:6.08E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.57|P-value:2.33E-4 ID:SGTC_3092|Compound:9117248|FD-Score:4.10|P-value:3.30E-5

Top fitness defect scores for YJL022W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_386 1509-0011 40.70 3.1 µM 0 1 0
2 SGTC_236 1509-0011 32.60 5.3 µM 2.84E-222 7 5.40E-233
3 SGTC_1635 st007035 17.70 42.4 µM 4.21E-67 25 2.58E-70
4 SGTC_134 0269-0018 8.95 6.9 µM 1.24E-18 47 1.73E-19
5 SGTC_365 0121-0052 8.89 13.6 µM 2.14E-18 mitochondrial response to ROS 4 3.07E-19
6 SGTC_70 0141-0289 8.74 43.3 µM 7.49E-18 mitochondrial stress 28 1.14E-18
7 SGTC_275 trichlorophene 8.73 5.7 µM 8.13E-18 mitochondrial stress 60 1.25E-18
8 SGTC_2777 climbazole 4.54 1.5 µM 4.88E-6 iron homeostasis 31 2.81E-6
9 SGTC_2582 agaric acid 4.51 100.0 µM 5.53E-6 redox potentiating 256 3.21E-6
10 SGTC_3092 9117248 4.10 49.5 µM 3.30E-5 cell wall signaling 4 2.09E-5
11 SGTC_119 0121-0043 3.92 24.8 µM 6.64E-5 mitochondrial stress 115 4.35E-5
12 SGTC_1512 0259-0544 3.82 12.2 µM 9.98E-5 18 6.66E-5
13 SGTC_310 1273-0058 3.68 1.1 µM 1.73E-4 mitochondrial stress 264 1.19E-4
14 SGTC_300 r073-0011 3.60 5.0 µM 2.29E-4 31 1.59E-4
15 SGTC_994 3910-0338 3.57 138.0 µM 2.54E-4 calcium & mitochondrial duress 60 1.77E-4
16 SGTC_1796 st049173 3.54 110.4 µM 2.90E-4 23 2.04E-4
17 SGTC_1508 1080-0625 3.49 72.9 µM 3.37E-4 33 2.39E-4
18 SGTC_2294 7971431 3.48 200.0 µM 3.54E-4 26 2.51E-4
19 SGTC_1222 0366-0074 3.48 1.2 µM 3.59E-4 TSC3-RPN4 33 2.55E-4
20 SGTC_1452 4194-0072 3.43 190.0 µM 4.16E-4 27 2.97E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.783 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.774 0 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.749 0 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.733 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.725 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.705 0 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.702 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.694 0 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.684 0 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.672 0 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.662 0 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.653 0 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.646 0 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.645 0 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.645 0 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase