YJL023C / PET130

Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL023C / PET130

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.41|P-value:2.74E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:3.24|P-value:5.12E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:6.67|P-value:8.07E-12 ID:SGTC_134|Compound:0269-0018|FD-Score:4.00|P-value:2.62E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.29|P-value:7.76E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:4.47|P-value:3.13E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:32.30|P-value:4.07E-234 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.60|P-value:8.28E-32 ID:SGTC_283|Compound:0987-0079|FD-Score:3.35|P-value:3.42E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.46|P-value:2.52E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:8.70|P-value:7.65E-19 ID:SGTC_327|Compound:1273-0057|FD-Score:4.38|P-value:4.74E-6 ID:SGTC_365|Compound:0121-0052|FD-Score:3.28|P-value:4.44E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:7.25|P-value:1.15E-13 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.03|P-value:2.56E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.29|P-value:4.73E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:5.41|P-value:2.23E-8 ID:SGTC_520|Compound:3584-0023|FD-Score:3.27|P-value:4.61E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.08|P-value:9.82E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:3.46|P-value:2.32E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.63|P-value:1.22E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:5.42|P-value:2.10E-8 ID:SGTC_1401|Compound:3807-4679|FD-Score:-5.32|P-value:4.28E-8 ID:SGTC_1521|Compound:st012942|FD-Score:5.45|P-value:1.78E-8 ID:SGTC_1527|Compound:coumarin|FD-Score:3.32|P-value:3.91E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-3.16|P-value:7.47E-4 ID:SGTC_1635|Compound:st007035|FD-Score:9.62|P-value:1.33E-22 ID:SGTC_1707|Compound:st032323|FD-Score:-3.93|P-value:3.91E-5 ID:SGTC_1742|Compound:st038235|FD-Score:3.06|P-value:9.82E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.81|P-value:6.26E-5 ID:SGTC_1800|Compound:st050079|FD-Score:-3.48|P-value:2.30E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.31|P-value:4.41E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.24|P-value:5.18E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.47|P-value:3.11E-6 ID:SGTC_2014|Compound:4013930|FD-Score:4.15|P-value:1.35E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-3.87|P-value:4.98E-5 ID:SGTC_2022|Compound:5136654|FD-Score:4.02|P-value:2.35E-5 ID:SGTC_2183|Compound:6420625|FD-Score:3.88|P-value:4.34E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-4.31|P-value:7.16E-6 ID:SGTC_2300|Compound:7976697|FD-Score:-4.83|P-value:5.86E-7 ID:SGTC_2318|Compound:6029776|FD-Score:-3.36|P-value:3.61E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.19|P-value:6.79E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.30|P-value:7.55E-6 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.25|P-value:5.42E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.33|P-value:3.99E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.81|P-value:5.80E-7 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.23|P-value:5.44E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.56|P-value:2.04E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.61|P-value:1.39E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.65|P-value:1.19E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-4.39|P-value:5.07E-6 ID:SGTC_2858|Compound:9025781|FD-Score:-5.08|P-value:1.56E-7 ID:SGTC_2896|Compound:9052656|FD-Score:-3.77|P-value:7.35E-5 ID:SGTC_2980|Compound:9014342|FD-Score:3.08|P-value:9.22E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-3.21|P-value:6.29E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-3.77|P-value:7.42E-5 ID:SGTC_3203|Compound:9113543|FD-Score:6.24|P-value:1.40E-10 ID:SGTC_3210|Compound:9128157|FD-Score:-3.97|P-value:3.18E-5 ID:SGTC_3249|Compound:9135183|FD-Score:-3.07|P-value:9.98E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.78|P-value:6.50E-5 ID:SGTC_3349|Compound:9149703|FD-Score:-3.45|P-value:2.65E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.41|P-value:2.74E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:3.24|P-value:5.12E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:6.67|P-value:8.07E-12 ID:SGTC_134|Compound:0269-0018|FD-Score:4.00|P-value:2.62E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.29|P-value:7.76E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:4.47|P-value:3.13E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:32.30|P-value:4.07E-234 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.60|P-value:8.28E-32 ID:SGTC_283|Compound:0987-0079|FD-Score:3.35|P-value:3.42E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.46|P-value:2.52E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:8.70|P-value:7.65E-19 ID:SGTC_327|Compound:1273-0057|FD-Score:4.38|P-value:4.74E-6 ID:SGTC_365|Compound:0121-0052|FD-Score:3.28|P-value:4.44E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:7.25|P-value:1.15E-13 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.03|P-value:2.56E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.29|P-value:4.73E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:5.41|P-value:2.23E-8 ID:SGTC_520|Compound:3584-0023|FD-Score:3.27|P-value:4.61E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.08|P-value:9.82E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:3.46|P-value:2.32E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.63|P-value:1.22E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:5.42|P-value:2.10E-8 ID:SGTC_1401|Compound:3807-4679|FD-Score:-5.32|P-value:4.28E-8 ID:SGTC_1521|Compound:st012942|FD-Score:5.45|P-value:1.78E-8 ID:SGTC_1527|Compound:coumarin|FD-Score:3.32|P-value:3.91E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-3.16|P-value:7.47E-4 ID:SGTC_1635|Compound:st007035|FD-Score:9.62|P-value:1.33E-22 ID:SGTC_1707|Compound:st032323|FD-Score:-3.93|P-value:3.91E-5 ID:SGTC_1742|Compound:st038235|FD-Score:3.06|P-value:9.82E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.81|P-value:6.26E-5 ID:SGTC_1800|Compound:st050079|FD-Score:-3.48|P-value:2.30E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.31|P-value:4.41E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.24|P-value:5.18E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.47|P-value:3.11E-6 ID:SGTC_2014|Compound:4013930|FD-Score:4.15|P-value:1.35E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-3.87|P-value:4.98E-5 ID:SGTC_2022|Compound:5136654|FD-Score:4.02|P-value:2.35E-5 ID:SGTC_2183|Compound:6420625|FD-Score:3.88|P-value:4.34E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-4.31|P-value:7.16E-6 ID:SGTC_2300|Compound:7976697|FD-Score:-4.83|P-value:5.86E-7 ID:SGTC_2318|Compound:6029776|FD-Score:-3.36|P-value:3.61E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.19|P-value:6.79E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.30|P-value:7.55E-6 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.25|P-value:5.42E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.33|P-value:3.99E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.81|P-value:5.80E-7 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.23|P-value:5.44E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.56|P-value:2.04E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.61|P-value:1.39E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.65|P-value:1.19E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-4.39|P-value:5.07E-6 ID:SGTC_2858|Compound:9025781|FD-Score:-5.08|P-value:1.56E-7 ID:SGTC_2896|Compound:9052656|FD-Score:-3.77|P-value:7.35E-5 ID:SGTC_2980|Compound:9014342|FD-Score:3.08|P-value:9.22E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-3.21|P-value:6.29E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-3.77|P-value:7.42E-5 ID:SGTC_3203|Compound:9113543|FD-Score:6.24|P-value:1.40E-10 ID:SGTC_3210|Compound:9128157|FD-Score:-3.97|P-value:3.18E-5 ID:SGTC_3249|Compound:9135183|FD-Score:-3.07|P-value:9.98E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.78|P-value:6.50E-5 ID:SGTC_3349|Compound:9149703|FD-Score:-3.45|P-value:2.65E-4

Top fitness defect scores for YJL023C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 32.30 5.3 µM 4.07E-234 8 7.09E-230
2 SGTC_275 trichlorophene 11.60 5.7 µM 8.28E-32 mitochondrial stress 27 3.16E-31
3 SGTC_1635 st007035 9.62 42.4 µM 1.33E-22 79 3.43E-22
4 SGTC_310 1273-0058 8.70 1.1 µM 7.65E-19 mitochondrial stress 69 1.68E-18
5 SGTC_386 1509-0011 7.25 3.1 µM 1.15E-13 76 2.02E-13
6 SGTC_70 0141-0289 6.67 43.3 µM 8.07E-12 mitochondrial stress 58 1.31E-11
7 SGTC_3203 9113543 6.24 49.5 µM 1.40E-10 3 2.16E-10
8 SGTC_1521 st012942 5.45 49.4 µM 1.78E-8 9 2.49E-8
9 SGTC_908 3448-7491 5.42 47.7 µM 2.10E-8 mitochondrial stress 63 2.93E-8
10 SGTC_503 tyrphostin 8 5.41 294.0 µM 2.23E-8 TSC3-RPN4 8 3.12E-8
11 SGTC_2582 agaric acid 4.81 100.0 µM 5.80E-7 redox potentiating 233 7.61E-7
12 SGTC_2626 ethyl orsellinate 4.56 100.0 µM 2.04E-6 21 2.62E-6
13 SGTC_1883 5-benzylidenerhodanine 4.47 20.0 µM 3.11E-6 TRP & mitochondrial translation 49 3.96E-6
14 SGTC_173 1273-0061 4.47 2.7 µM 3.13E-6 mitochondrial stress 168 3.98E-6
15 SGTC_327 1273-0057 4.38 4.0 µM 4.74E-6 azole & statin 22 5.98E-6
16 SGTC_2014 4013930 4.15 200.0 µM 1.35E-5 24 1.66E-5
17 SGTC_2022 5136654 4.02 200.0 µM 2.35E-5 20 2.87E-5
18 SGTC_134 0269-0018 4.00 6.9 µM 2.62E-5 132 3.19E-5
19 SGTC_2183 6420625 3.88 130.5 µM 4.34E-5 mitochondrial processes 61 5.24E-5
20 SGTC_3310 9130229 3.78 44.1 µM 6.50E-5 Golgi 32 7.79E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.714 0 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.709 0 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.660 0 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.650 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.644 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.639 0 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.637 0 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.636 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.630 0 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.626 0 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.623 0 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.620 0 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.619 0 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.618 0 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.613 0 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies