YJL026W / RNR2

Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL026W / RNR2

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:-3.09|P-value:7.86E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-5.98|P-value:5.25E-10 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.82|P-value:4.72E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.90|P-value:4.13E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:5.40|P-value:2.28E-8 ID:SGTC_363|Compound:0455-0021|FD-Score:3.21|P-value:6.13E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:3.41|P-value:2.94E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:-3.85|P-value:4.16E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.35|P-value:3.01E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.56|P-value:1.64E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:-3.31|P-value:3.50E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.16|P-value:7.29E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.53|P-value:1.85E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.66|P-value:1.08E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.39|P-value:3.14E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:5.29|P-value:4.39E-8 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.88|P-value:4.44E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:-3.04|P-value:9.32E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:-3.30|P-value:3.63E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:4.06|P-value:2.03E-5 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.45|P-value:2.47E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:5.06|P-value:1.56E-7 ID:SGTC_1518|Compound:st038567|FD-Score:-4.95|P-value:2.18E-7 ID:SGTC_1519|Compound:esterone|FD-Score:-4.93|P-value:2.45E-7 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:4.00|P-value:2.63E-5 ID:SGTC_1581|Compound:himbacine|FD-Score:-3.07|P-value:8.42E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-3.39|P-value:2.58E-4 ID:SGTC_1710|Compound:st031758|FD-Score:-3.69|P-value:8.02E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.09|P-value:9.34E-4 ID:SGTC_1741|Compound:st038134|FD-Score:4.37|P-value:4.94E-6 ID:SGTC_1742|Compound:st038235|FD-Score:-3.58|P-value:1.26E-4 ID:SGTC_1748|Compound:st037455|FD-Score:4.36|P-value:5.31E-6 ID:SGTC_1750|Compound:st081859|FD-Score:8.51|P-value:3.20E-18 ID:SGTC_1870|Compound:st057514|FD-Score:3.77|P-value:7.14E-5 ID:SGTC_2110|Compound:5483698|FD-Score:3.19|P-value:6.44E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.07|P-value:9.97E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.70|P-value:9.30E-5 ID:SGTC_2325|Compound:6158266|FD-Score:3.15|P-value:7.53E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.00|P-value:2.71E-5 ID:SGTC_2415|Compound:st077333|FD-Score:4.20|P-value:1.12E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.16|P-value:6.11E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.45|P-value:2.49E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.12|P-value:1.60E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.12|P-value:7.04E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.26|P-value:8.57E-6 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.22|P-value:5.91E-4 ID:SGTC_2823|Compound:7987624|FD-Score:5.41|P-value:2.16E-8 ID:SGTC_2894|Compound:9048625|FD-Score:-3.15|P-value:6.32E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-3.79|P-value:5.40E-5 ID:SGTC_2988|Compound:9073640|FD-Score:3.14|P-value:7.82E-4 ID:SGTC_3009|Compound:9080819|FD-Score:-3.07|P-value:8.23E-4 ID:SGTC_3231|Compound:9132313|FD-Score:4.07|P-value:1.95E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:-3.09|P-value:7.86E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-5.98|P-value:5.25E-10 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.82|P-value:4.72E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.90|P-value:4.13E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:5.40|P-value:2.28E-8 ID:SGTC_363|Compound:0455-0021|FD-Score:3.21|P-value:6.13E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:3.41|P-value:2.94E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:-3.85|P-value:4.16E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.35|P-value:3.01E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.56|P-value:1.64E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:-3.31|P-value:3.50E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.16|P-value:7.29E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.53|P-value:1.85E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.66|P-value:1.08E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.39|P-value:3.14E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:5.29|P-value:4.39E-8 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.88|P-value:4.44E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:-3.04|P-value:9.32E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:-3.30|P-value:3.63E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:4.06|P-value:2.03E-5 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.45|P-value:2.47E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:5.06|P-value:1.56E-7 ID:SGTC_1518|Compound:st038567|FD-Score:-4.95|P-value:2.18E-7 ID:SGTC_1519|Compound:esterone|FD-Score:-4.93|P-value:2.45E-7 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:4.00|P-value:2.63E-5 ID:SGTC_1581|Compound:himbacine|FD-Score:-3.07|P-value:8.42E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-3.39|P-value:2.58E-4 ID:SGTC_1710|Compound:st031758|FD-Score:-3.69|P-value:8.02E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.09|P-value:9.34E-4 ID:SGTC_1741|Compound:st038134|FD-Score:4.37|P-value:4.94E-6 ID:SGTC_1742|Compound:st038235|FD-Score:-3.58|P-value:1.26E-4 ID:SGTC_1748|Compound:st037455|FD-Score:4.36|P-value:5.31E-6 ID:SGTC_1750|Compound:st081859|FD-Score:8.51|P-value:3.20E-18 ID:SGTC_1870|Compound:st057514|FD-Score:3.77|P-value:7.14E-5 ID:SGTC_2110|Compound:5483698|FD-Score:3.19|P-value:6.44E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.07|P-value:9.97E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.70|P-value:9.30E-5 ID:SGTC_2325|Compound:6158266|FD-Score:3.15|P-value:7.53E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.00|P-value:2.71E-5 ID:SGTC_2415|Compound:st077333|FD-Score:4.20|P-value:1.12E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.16|P-value:6.11E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.45|P-value:2.49E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.12|P-value:1.60E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.12|P-value:7.04E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.26|P-value:8.57E-6 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.22|P-value:5.91E-4 ID:SGTC_2823|Compound:7987624|FD-Score:5.41|P-value:2.16E-8 ID:SGTC_2894|Compound:9048625|FD-Score:-3.15|P-value:6.32E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-3.79|P-value:5.40E-5 ID:SGTC_2988|Compound:9073640|FD-Score:3.14|P-value:7.82E-4 ID:SGTC_3009|Compound:9080819|FD-Score:-3.07|P-value:8.23E-4 ID:SGTC_3231|Compound:9132313|FD-Score:4.07|P-value:1.95E-5

Top fitness defect scores for YJL026W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1750 st081859 8.51 2.4 µM 3.20E-18 endomembrane recycling 9 8.48E-18 0.48
2 SGTC_2823 7987624 5.41 58.4 µM 2.16E-8 5 3.07E-8 0.15
3 SGTC_303 1348-1668 5.40 34.2 µM 2.28E-8 1 3.24E-8 0.96
4 SGTC_1265 0819-1001 5.29 68.8 µM 4.39E-8 3 6.12E-8 0.32
5 SGTC_1510 1123-0200 5.06 71.5 µM 1.56E-7 7 2.11E-7 0.34
6 SGTC_1741 st038134 4.37 10.2 µM 4.94E-6 3 6.10E-6 0.36
7 SGTC_1748 st037455 4.36 53.6 µM 5.31E-6 5 6.55E-6 0.03
8 SGTC_2758 dehydroepiandrosterone 4.26 69.3 µM 8.57E-6 4 1.04E-5 0.11
9 SGTC_2415 st077333 4.20 57.7 µM 1.12E-5 14 1.35E-5 0.17
10 SGTC_2617 dihydrotanshinone i 4.12 20.8 µM 1.60E-5 copper-dependent oxidative stress 21 1.92E-5 0.04
11 SGTC_3231 9132313 4.07 49.5 µM 1.95E-5 1 2.33E-5 0.31
12 SGTC_1491 4138-0063 4.06 26.5 µM 2.03E-5 3 2.42E-5 0.43
13 SGTC_1528 arabinosylhypoxanthine 4.00 74.6 µM 2.63E-5 2 3.12E-5 0.05
14 SGTC_2406 ethylparaben 4.00 405.7 µM 2.71E-5 9 3.21E-5 0.49
15 SGTC_273 hydroxyurea 3.90 18.1 mM 4.13E-5 heme biosynthesis & mitochondrial translocase 23 4.84E-5 0.04
16 SGTC_1419 3993-2473 3.88 62.6 µM 4.44E-5 5 5.19E-5 0.09
17 SGTC_1870 st057514 3.77 26.5 µM 7.14E-5 RSC & ERG11 11 8.25E-5 0.09
18 SGTC_2213 7173844 3.70 200.0 µM 9.30E-5 1 1.07E-4 0.25
19 SGTC_1149 3909-7961 3.66 23.3 µM 1.08E-4 7 1.24E-4 0.11
20 SGTC_1005 4092-0690 3.56 4.4 µM 1.64E-4 plasma membrane duress 14 1.86E-4 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.242 4.33E-46 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.201 8.14E-32 YPR153W YPR153W hom Putative protein of unknown function
0.186 1.35E-27 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.159 1.68E-20 YML072C TCB3 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.147 1.23E-17 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.141 1.85E-16 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.141 2.65E-16 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.133 1.28E-14 YCL046W_d YCL046W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C
0.131 2.23E-14 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.131 2.95E-14 YOR202W HIS3 hom Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p
0.124 4.97E-13 YKL136W_d YKL136W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C
0.123 8.80E-13 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.123 9.06E-13 YBR255W MTC4 hom Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1
0.110 2.01E-10 YPL111W CAR1 hom Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
0.107 4.24E-10 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport