YJL028W

Protein of unknown function; may interact with ribosomes, based on co-purification experiments

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL028W / YJL028W

Click on Significant Values for Screen Details ID:SGTC_577|Compound:r071-0003|FD-Score:3.27|P-value:1.10E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.02|P-value:3.26E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.50|P-value:4.04E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:-2.87|P-value:9.14E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.03|P-value:3.07E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.02|P-value:3.18E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:2.93|P-value:4.59E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:2.77|P-value:8.55E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:2.83|P-value:6.88E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.90|P-value:5.56E-6 ID:SGTC_1782|Compound:st039423|FD-Score:-4.12|P-value:3.38E-6 ID:SGTC_1863|Compound:st057641|FD-Score:2.97|P-value:4.00E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.23|P-value:1.33E-4 ID:SGTC_1908|Compound:st060353|FD-Score:4.32|P-value:6.20E-7 ID:SGTC_1910|Compound:st062352|FD-Score:-3.72|P-value:2.42E-5 ID:SGTC_1919|Compound:st067113|FD-Score:3.24|P-value:1.28E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.24|P-value:1.26E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.19|P-value:1.55E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:2.90|P-value:5.23E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:6.30|P-value:8.96E-13 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.96|P-value:4.27E-6 ID:SGTC_2505|Compound:galangin|FD-Score:6.66|P-value:4.56E-14 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.67|P-value:1.78E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.59|P-value:2.59E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.40|P-value:6.34E-5 ID:SGTC_2667|Compound:digitoxin|FD-Score:2.95|P-value:4.18E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.01|P-value:5.41E-4 ID:SGTC_2866|Compound:9034245|FD-Score:2.79|P-value:8.04E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-3.12|P-value:3.51E-4 ID:SGTC_2973|Compound:9094665|FD-Score:2.89|P-value:5.30E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.77|P-value:1.09E-5 ID:SGTC_3095|Compound:9117207|FD-Score:2.86|P-value:6.01E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.27|P-value:1.10E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.02|P-value:3.26E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.50|P-value:4.04E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:-2.87|P-value:9.14E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.03|P-value:3.07E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.02|P-value:3.18E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:2.93|P-value:4.59E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:2.77|P-value:8.55E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:2.83|P-value:6.88E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.90|P-value:5.56E-6 ID:SGTC_1782|Compound:st039423|FD-Score:-4.12|P-value:3.38E-6 ID:SGTC_1863|Compound:st057641|FD-Score:2.97|P-value:4.00E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.23|P-value:1.33E-4 ID:SGTC_1908|Compound:st060353|FD-Score:4.32|P-value:6.20E-7 ID:SGTC_1910|Compound:st062352|FD-Score:-3.72|P-value:2.42E-5 ID:SGTC_1919|Compound:st067113|FD-Score:3.24|P-value:1.28E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.24|P-value:1.26E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.19|P-value:1.55E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:2.90|P-value:5.23E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:6.30|P-value:8.96E-13 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.96|P-value:4.27E-6 ID:SGTC_2505|Compound:galangin|FD-Score:6.66|P-value:4.56E-14 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.67|P-value:1.78E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.59|P-value:2.59E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.40|P-value:6.34E-5 ID:SGTC_2667|Compound:digitoxin|FD-Score:2.95|P-value:4.18E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.01|P-value:5.41E-4 ID:SGTC_2866|Compound:9034245|FD-Score:2.79|P-value:8.04E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-3.12|P-value:3.51E-4 ID:SGTC_2973|Compound:9094665|FD-Score:2.89|P-value:5.30E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.77|P-value:1.09E-5 ID:SGTC_3095|Compound:9117207|FD-Score:2.86|P-value:6.01E-4

Top fitness defect scores for YJL028W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2505 galangin 6.66 7.9 µM 4.56E-14 RPP1 & pyrimidine depletion 1 1.33E-11
2 SGTC_2496 diffractaic acid 6.30 79.8 µM 8.96E-13 4 1.48E-10
3 SGTC_1908 st060353 4.32 56.5 µM 6.20E-7 RPP1 & pyrimidine depletion 28 7.97E-6
4 SGTC_2504 purpurogallin 3.96 52.3 µM 4.27E-6 RPP1 & pyrimidine depletion 23 3.80E-5
5 SGTC_1779 st039427 3.90 55.0 µM 5.56E-6 29 4.71E-5
6 SGTC_3090 9117696 3.77 49.5 µM 1.09E-5 16 8.14E-5
7 SGTC_2531 methyl deoxycholate 3.67 70.1 µM 1.78E-5 32 1.21E-4
8 SGTC_2617 dihydrotanshinone i 3.59 20.8 µM 2.59E-5 copper-dependent oxidative stress 58 1.64E-4
9 SGTC_644 1498-1197 3.50 63.3 µM 4.04E-5 42 2.35E-4
10 SGTC_2619 obliquin 3.40 87.9 µM 6.34E-5 cell wall 184 3.39E-4
11 SGTC_577 r071-0003 3.27 38.6 µM 1.10E-4 fatty acid desaturase (OLE1) 97 5.29E-4
12 SGTC_2024 5144227 3.24 134.0 µM 1.26E-4 62 5.92E-4
13 SGTC_1919 st067113 3.24 52.3 µM 1.28E-4 TSC3-RPN4 59 5.99E-4
14 SGTC_1868 st057644 3.23 42.7 µM 1.33E-4 65 6.17E-4
15 SGTC_2402 5553605 3.19 200.0 µM 1.55E-4 67 7.01E-4
16 SGTC_839 0122-0028 3.03 230.0 µM 3.07E-4 RSC complex & mRNA processing 88 0.00122
17 SGTC_887 0885-0007 3.02 9.6 µM 3.18E-4 endomembrane recycling 78 0.00126
18 SGTC_602 3130-1533 3.02 38.1 µM 3.26E-4 54 0.00128
19 SGTC_1863 st057641 2.97 20.1 µM 4.00E-4 55 0.00151
20 SGTC_2667 digitoxin 2.95 100.0 µM 4.18E-4 22 0.00157

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.161 7.50E-21 YLR101C_d YLR101C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W
0.158 3.28E-20 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.156 1.17E-19 YNL306W MRPS18 het Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins
0.143 7.97E-17 YIL044C AGE2 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif
0.127 1.72E-13 YHR131C_p YHR131C_p hom Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study
0.112 7.44E-11 YDR156W RPA14 hom RNA polymerase I subunit A14
0.109 2.71E-10 YIL020C HIS6 hom Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
0.108 4.26E-10 YJR076C CDC11 het Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells
0.105 1.17E-9 YGR273C_p YGR273C_p hom Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene
0.103 1.92E-9 YPL140C MKK2 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication
0.101 5.42E-9 YNL190W_p YNL190W_p hom Hydrophilin essential in dessication-rehydration process; cell wall protein; contains a putative GPI-attachment site
0.100 5.65E-9 YOR141C ARP8 hom Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity
0.100 6.31E-9 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.099 7.86E-9 YCR036W RBK1 hom Putative ribokinase
0.092 9.97E-8 YNL222W SSU72 het Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo