YJL030W / MAD2

Component of the spindle-assembly checkpoint complex; delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL030W / MAD2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.17|P-value:9.04E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:-4.33|P-value:9.22E-6 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.33|P-value:5.27E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.53|P-value:2.55E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.16|P-value:9.26E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.31|P-value:6.53E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:3.37|P-value:3.14E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.05|P-value:9.82E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.64|P-value:1.38E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.44|P-value:3.48E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-4.35|P-value:8.49E-6 ID:SGTC_623|Compound:k072-0108|FD-Score:4.21|P-value:1.05E-5 ID:SGTC_655|Compound:k060-0012|FD-Score:3.09|P-value:8.54E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.27|P-value:4.52E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.04|P-value:2.16E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:3.66|P-value:1.05E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.82|P-value:5.58E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.86|P-value:4.65E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.34|P-value:3.57E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.22|P-value:5.50E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.15|P-value:6.96E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.15|P-value:6.85E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.17|P-value:6.42E-4 ID:SGTC_1767|Compound:st044992|FD-Score:4.20|P-value:1.08E-5 ID:SGTC_1846|Compound:st056244|FD-Score:3.18|P-value:6.23E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.15|P-value:9.80E-4 ID:SGTC_2013|Compound:4024628|FD-Score:7.99|P-value:4.60E-16 ID:SGTC_2020|Compound:4017018|FD-Score:4.77|P-value:7.35E-7 ID:SGTC_2027|Compound:5150920|FD-Score:3.19|P-value:6.09E-4 ID:SGTC_2040|Compound:5100729|FD-Score:4.22|P-value:9.90E-6 ID:SGTC_2199|Compound:6590217|FD-Score:3.16|P-value:6.79E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.40|P-value:2.85E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:4.11|P-value:1.62E-5 ID:SGTC_2427|Compound:5545055|FD-Score:-3.31|P-value:5.61E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.05|P-value:9.67E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-3.23|P-value:7.43E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-4.46|P-value:5.24E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.49|P-value:2.03E-4 ID:SGTC_2709|Compound:st078560|FD-Score:3.16|P-value:6.82E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.25|P-value:6.96E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.78|P-value:6.57E-5 ID:SGTC_2743|Compound:auranofin|FD-Score:3.40|P-value:2.85E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.65|P-value:1.10E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.28|P-value:4.45E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-4.31|P-value:1.05E-5 ID:SGTC_2933|Compound:9026794|FD-Score:3.50|P-value:1.98E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.25|P-value:4.84E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.71|P-value:8.75E-5 ID:SGTC_3094|Compound:9117742|FD-Score:3.19|P-value:6.15E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.19|P-value:6.13E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.27|P-value:4.53E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.94|P-value:3.36E-5 ID:SGTC_3331|Compound:9141060|FD-Score:-3.35|P-value:4.83E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.17|P-value:9.04E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:-4.33|P-value:9.22E-6 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.33|P-value:5.27E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.53|P-value:2.55E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.16|P-value:9.26E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.31|P-value:6.53E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:3.37|P-value:3.14E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.05|P-value:9.82E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.64|P-value:1.38E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.44|P-value:3.48E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-4.35|P-value:8.49E-6 ID:SGTC_623|Compound:k072-0108|FD-Score:4.21|P-value:1.05E-5 ID:SGTC_655|Compound:k060-0012|FD-Score:3.09|P-value:8.54E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.27|P-value:4.52E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.04|P-value:2.16E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:3.66|P-value:1.05E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.82|P-value:5.58E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.86|P-value:4.65E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.34|P-value:3.57E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.22|P-value:5.50E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.15|P-value:6.96E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.15|P-value:6.85E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.17|P-value:6.42E-4 ID:SGTC_1767|Compound:st044992|FD-Score:4.20|P-value:1.08E-5 ID:SGTC_1846|Compound:st056244|FD-Score:3.18|P-value:6.23E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.15|P-value:9.80E-4 ID:SGTC_2013|Compound:4024628|FD-Score:7.99|P-value:4.60E-16 ID:SGTC_2020|Compound:4017018|FD-Score:4.77|P-value:7.35E-7 ID:SGTC_2027|Compound:5150920|FD-Score:3.19|P-value:6.09E-4 ID:SGTC_2040|Compound:5100729|FD-Score:4.22|P-value:9.90E-6 ID:SGTC_2199|Compound:6590217|FD-Score:3.16|P-value:6.79E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.40|P-value:2.85E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:4.11|P-value:1.62E-5 ID:SGTC_2427|Compound:5545055|FD-Score:-3.31|P-value:5.61E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.05|P-value:9.67E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-3.23|P-value:7.43E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-4.46|P-value:5.24E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.49|P-value:2.03E-4 ID:SGTC_2709|Compound:st078560|FD-Score:3.16|P-value:6.82E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.25|P-value:6.96E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.78|P-value:6.57E-5 ID:SGTC_2743|Compound:auranofin|FD-Score:3.40|P-value:2.85E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.65|P-value:1.10E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.28|P-value:4.45E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-4.31|P-value:1.05E-5 ID:SGTC_2933|Compound:9026794|FD-Score:3.50|P-value:1.98E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.25|P-value:4.84E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.71|P-value:8.75E-5 ID:SGTC_3094|Compound:9117742|FD-Score:3.19|P-value:6.15E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.19|P-value:6.13E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.27|P-value:4.53E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.94|P-value:3.36E-5 ID:SGTC_3331|Compound:9141060|FD-Score:-3.35|P-value:4.83E-4

Top fitness defect scores for YJL030W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2013 4024628 7.99 200.0 µM 4.60E-16 7 6.54E-16
2 SGTC_2020 4017018 4.77 200.0 µM 7.35E-7 6 9.22E-7
3 SGTC_379 3970-0972 4.64 5.9 µM 1.38E-6 tubulin folding & SWR complex 16 1.72E-6
4 SGTC_149 3970-0822 4.31 46.1 µM 6.53E-6 tubulin folding & SWR complex 76 8.03E-6
5 SGTC_2040 5100729 4.22 123.0 µM 9.90E-6 37 1.21E-5
6 SGTC_623 k072-0108 4.21 16.9 µM 1.05E-5 heme biosynthesis & mitochondrial translocase 12 1.29E-5
7 SGTC_1767 st044992 4.20 70.3 µM 1.08E-5 18 1.32E-5
8 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 4.11 200.0 µM 1.62E-5 11 1.97E-5
9 SGTC_788 1182-0090 4.04 188.0 µM 2.16E-5 endomembrane recycling 74 2.63E-5
10 SGTC_3244 9134489 3.94 49.5 µM 3.36E-5 18 4.07E-5
11 SGTC_1338 1486-1223 3.86 76.0 µM 4.65E-5 27 5.62E-5
12 SGTC_1150 3909-7983 3.82 10.9 µM 5.58E-5 28 6.73E-5
13 SGTC_2739 tacrine 3.78 100.9 µM 6.57E-5 heme requiring 19 7.91E-5
14 SGTC_3061 glucosamine 3.71 200.0 µM 8.75E-5 15 1.05E-4
15 SGTC_819 1013-0258 3.66 27.7 µM 1.05E-4 42 1.26E-4
16 SGTC_2807 7945238 3.65 52.0 µM 1.10E-4 33 1.31E-4
17 SGTC_2933 9026794 3.50 32.5 µM 1.98E-4 40 2.36E-4
18 SGTC_2651 1327-0036 3.49 5.0 µM 2.03E-4 196 2.42E-4
19 SGTC_2743 auranofin 3.40 4.3 µM 2.85E-4 RPP1 & pyrimidine depletion 48 3.37E-4
20 SGTC_2391 6285546 3.40 200.0 µM 2.85E-4 31 3.38E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 4.36E-13 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.123 7.07E-13 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.122 1.48E-12 YDL004W ATP16 het Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
0.121 1.89E-12 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.112 7.28E-11 YLR086W SMC4 het Subunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate
0.105 1.18E-9 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.100 5.69E-9 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.100 7.55E-9 YML046W PRP39 het U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
0.099 1.06E-8 YMR094W CTF13 het Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
0.096 2.60E-8 YPL247C_p YPL247C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest
0.095 3.36E-8 YGR149W_p YGR149W_p hom Putative protein of unknown function; predicted to be an integal membrane protein
0.095 3.65E-8 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.093 6.17E-8 YNR067C DSE4 hom Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
0.089 2.42E-7 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.086 5.22E-7 YHL040C ARN1 hom ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress