YJL031C / BET4

Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL031C / BET4

Click on Significant Values for Screen Details ID:SGTC_63|Compound:0099-0242|FD-Score:5.95|P-value:4.50E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:6.91|P-value:2.99E-10 ID:SGTC_81|Compound:0411-0046|FD-Score:6.68|P-value:1.05E-9 ID:SGTC_86|Compound:0417-1630|FD-Score:3.70|P-value:4.15E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.42|P-value:9.90E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.62|P-value:1.60E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:11.90|P-value:1.56E-26 ID:SGTC_208|Compound:k072-0098|FD-Score:5.54|P-value:3.26E-7 ID:SGTC_214|Compound:4373-3496|FD-Score:3.80|P-value:2.97E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.77|P-value:6.49E-10 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.43|P-value:9.41E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.52|P-value:7.27E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.81|P-value:7.45E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.75|P-value:5.43E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.69|P-value:1.22E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:3.50|P-value:7.60E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:6.00|P-value:3.58E-8 ID:SGTC_339|Compound:3091-4833|FD-Score:-5.14|P-value:3.36E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:4.07|P-value:1.19E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.53|P-value:7.02E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:6.41|P-value:4.39E-9 ID:SGTC_401|Compound:neomycin|FD-Score:4.05|P-value:1.27E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:4.29|P-value:5.43E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.28|P-value:9.08E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.44|P-value:9.15E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.56|P-value:6.40E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.59|P-value:5.80E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.22|P-value:7.11E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:5.10|P-value:2.24E-6 ID:SGTC_704|Compound:1310-0270|FD-Score:-3.69|P-value:6.45E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-3.66|P-value:7.17E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:5.48|P-value:4.25E-7 ID:SGTC_730|Compound:1436-0052|FD-Score:3.62|P-value:5.35E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.63|P-value:5.21E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:8.28|P-value:6.27E-14 ID:SGTC_745|Compound:0469-0705|FD-Score:12.00|P-value:3.94E-27 ID:SGTC_794|Compound:k038-0031|FD-Score:4.13|P-value:9.73E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:6.51|P-value:2.57E-9 ID:SGTC_839|Compound:0122-0028|FD-Score:4.41|P-value:3.46E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:8.18|P-value:1.21E-13 ID:SGTC_879|Compound:0831-1030|FD-Score:-4.05|P-value:2.00E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:5.30|P-value:9.30E-7 ID:SGTC_966|Compound:1300-0360|FD-Score:4.24|P-value:6.63E-5 ID:SGTC_969|Compound:1313-0238|FD-Score:4.37|P-value:4.01E-5 ID:SGTC_983|Compound:1491-0821|FD-Score:3.96|P-value:1.77E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.44|P-value:9.37E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.98|P-value:3.73E-6 ID:SGTC_1113|Compound:artemisinin|FD-Score:4.75|P-value:9.42E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.62|P-value:5.34E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.13|P-value:1.98E-6 ID:SGTC_1320|Compound:1313-0481|FD-Score:4.37|P-value:4.14E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.92|P-value:2.03E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:11.50|P-value:3.87E-25 ID:SGTC_1524|Compound:corynanthine|FD-Score:4.53|P-value:2.20E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:5.53|P-value:3.42E-7 ID:SGTC_1563|Compound:conessine|FD-Score:-3.69|P-value:6.45E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:6.78|P-value:6.02E-10 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.78|P-value:4.93E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.59|P-value:5.87E-4 ID:SGTC_1727|Compound:st034309|FD-Score:5.48|P-value:4.30E-7 ID:SGTC_1729|Compound:st035615|FD-Score:4.23|P-value:6.74E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:6.74|P-value:7.57E-10 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.20|P-value:7.49E-5 ID:SGTC_1797|Compound:st048695|FD-Score:6.65|P-value:1.24E-9 ID:SGTC_1831|Compound:st055328|FD-Score:3.67|P-value:4.53E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-3.61|P-value:8.33E-4 ID:SGTC_1861|Compound:st057647|FD-Score:4.39|P-value:3.80E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:4.12|P-value:9.93E-5 ID:SGTC_1917|Compound:st066507|FD-Score:4.25|P-value:6.31E-5 ID:SGTC_2023|Compound:5144124|FD-Score:-3.79|P-value:4.70E-4 ID:SGTC_2066|Compound:5222451|FD-Score:4.50|P-value:2.51E-5 ID:SGTC_2095|Compound:5432005|FD-Score:4.60|P-value:1.71E-5 ID:SGTC_2183|Compound:6420625|FD-Score:3.42|P-value:9.71E-4 ID:SGTC_2312|Compound:7706453|FD-Score:5.03|P-value:2.96E-6 ID:SGTC_2336|Compound:9001819|FD-Score:9.55|P-value:6.60E-18 ID:SGTC_2396|Compound:5342950|FD-Score:3.91|P-value:2.09E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:8.56|P-value:9.21E-15 ID:SGTC_2544|Compound:sphondin|FD-Score:3.47|P-value:8.54E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.22|P-value:7.07E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.95|P-value:1.80E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:6.65|P-value:1.24E-9 ID:SGTC_2645|Compound:abamectin|FD-Score:6.81|P-value:5.10E-10 ID:SGTC_2712|Compound:st079126|FD-Score:3.61|P-value:5.45E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.49|P-value:2.64E-5 ID:SGTC_2835|Compound:9006588|FD-Score:-4.54|P-value:3.48E-5 ID:SGTC_2905|Compound:7799065|FD-Score:6.65|P-value:1.26E-9 ID:SGTC_2912|Compound:7964298|FD-Score:3.55|P-value:6.65E-4 ID:SGTC_2930|Compound:9013230|FD-Score:12.80|P-value:9.87E-31 ID:SGTC_2931|Compound:9014674|FD-Score:-4.43|P-value:5.31E-5 ID:SGTC_2932|Compound:9016711|FD-Score:-4.74|P-value:1.65E-5 ID:SGTC_3029|Compound:9088683|FD-Score:3.45|P-value:8.96E-4 ID:SGTC_3081|Compound:9117243|FD-Score:6.28|P-value:8.51E-9 ID:SGTC_3094|Compound:9117742|FD-Score:4.06|P-value:1.22E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.90|P-value:2.17E-4 ID:SGTC_3142|Compound:9086498|FD-Score:5.62|P-value:2.25E-7 ID:SGTC_3329|Compound:9141233|FD-Score:-3.93|P-value:2.98E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.95|P-value:4.50E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:6.91|P-value:2.99E-10 ID:SGTC_81|Compound:0411-0046|FD-Score:6.68|P-value:1.05E-9 ID:SGTC_86|Compound:0417-1630|FD-Score:3.70|P-value:4.15E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.42|P-value:9.90E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.62|P-value:1.60E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:11.90|P-value:1.56E-26 ID:SGTC_208|Compound:k072-0098|FD-Score:5.54|P-value:3.26E-7 ID:SGTC_214|Compound:4373-3496|FD-Score:3.80|P-value:2.97E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.77|P-value:6.49E-10 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.43|P-value:9.41E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.52|P-value:7.27E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.81|P-value:7.45E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.75|P-value:5.43E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.69|P-value:1.22E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:3.50|P-value:7.60E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:6.00|P-value:3.58E-8 ID:SGTC_339|Compound:3091-4833|FD-Score:-5.14|P-value:3.36E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:4.07|P-value:1.19E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.53|P-value:7.02E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:6.41|P-value:4.39E-9 ID:SGTC_401|Compound:neomycin|FD-Score:4.05|P-value:1.27E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:4.29|P-value:5.43E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.28|P-value:9.08E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.44|P-value:9.15E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.56|P-value:6.40E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.59|P-value:5.80E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.22|P-value:7.11E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:5.10|P-value:2.24E-6 ID:SGTC_704|Compound:1310-0270|FD-Score:-3.69|P-value:6.45E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-3.66|P-value:7.17E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:5.48|P-value:4.25E-7 ID:SGTC_730|Compound:1436-0052|FD-Score:3.62|P-value:5.35E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.63|P-value:5.21E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:8.28|P-value:6.27E-14 ID:SGTC_745|Compound:0469-0705|FD-Score:12.00|P-value:3.94E-27 ID:SGTC_794|Compound:k038-0031|FD-Score:4.13|P-value:9.73E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:6.51|P-value:2.57E-9 ID:SGTC_839|Compound:0122-0028|FD-Score:4.41|P-value:3.46E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:8.18|P-value:1.21E-13 ID:SGTC_879|Compound:0831-1030|FD-Score:-4.05|P-value:2.00E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:5.30|P-value:9.30E-7 ID:SGTC_966|Compound:1300-0360|FD-Score:4.24|P-value:6.63E-5 ID:SGTC_969|Compound:1313-0238|FD-Score:4.37|P-value:4.01E-5 ID:SGTC_983|Compound:1491-0821|FD-Score:3.96|P-value:1.77E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.44|P-value:9.37E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.98|P-value:3.73E-6 ID:SGTC_1113|Compound:artemisinin|FD-Score:4.75|P-value:9.42E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.62|P-value:5.34E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.13|P-value:1.98E-6 ID:SGTC_1320|Compound:1313-0481|FD-Score:4.37|P-value:4.14E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.92|P-value:2.03E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:11.50|P-value:3.87E-25 ID:SGTC_1524|Compound:corynanthine|FD-Score:4.53|P-value:2.20E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:5.53|P-value:3.42E-7 ID:SGTC_1563|Compound:conessine|FD-Score:-3.69|P-value:6.45E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:6.78|P-value:6.02E-10 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.78|P-value:4.93E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.59|P-value:5.87E-4 ID:SGTC_1727|Compound:st034309|FD-Score:5.48|P-value:4.30E-7 ID:SGTC_1729|Compound:st035615|FD-Score:4.23|P-value:6.74E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:6.74|P-value:7.57E-10 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.20|P-value:7.49E-5 ID:SGTC_1797|Compound:st048695|FD-Score:6.65|P-value:1.24E-9 ID:SGTC_1831|Compound:st055328|FD-Score:3.67|P-value:4.53E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-3.61|P-value:8.33E-4 ID:SGTC_1861|Compound:st057647|FD-Score:4.39|P-value:3.80E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:4.12|P-value:9.93E-5 ID:SGTC_1917|Compound:st066507|FD-Score:4.25|P-value:6.31E-5 ID:SGTC_2023|Compound:5144124|FD-Score:-3.79|P-value:4.70E-4 ID:SGTC_2066|Compound:5222451|FD-Score:4.50|P-value:2.51E-5 ID:SGTC_2095|Compound:5432005|FD-Score:4.60|P-value:1.71E-5 ID:SGTC_2183|Compound:6420625|FD-Score:3.42|P-value:9.71E-4 ID:SGTC_2312|Compound:7706453|FD-Score:5.03|P-value:2.96E-6 ID:SGTC_2336|Compound:9001819|FD-Score:9.55|P-value:6.60E-18 ID:SGTC_2396|Compound:5342950|FD-Score:3.91|P-value:2.09E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:8.56|P-value:9.21E-15 ID:SGTC_2544|Compound:sphondin|FD-Score:3.47|P-value:8.54E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.22|P-value:7.07E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.95|P-value:1.80E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:6.65|P-value:1.24E-9 ID:SGTC_2645|Compound:abamectin|FD-Score:6.81|P-value:5.10E-10 ID:SGTC_2712|Compound:st079126|FD-Score:3.61|P-value:5.45E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.49|P-value:2.64E-5 ID:SGTC_2835|Compound:9006588|FD-Score:-4.54|P-value:3.48E-5 ID:SGTC_2905|Compound:7799065|FD-Score:6.65|P-value:1.26E-9 ID:SGTC_2912|Compound:7964298|FD-Score:3.55|P-value:6.65E-4 ID:SGTC_2930|Compound:9013230|FD-Score:12.80|P-value:9.87E-31 ID:SGTC_2931|Compound:9014674|FD-Score:-4.43|P-value:5.31E-5 ID:SGTC_2932|Compound:9016711|FD-Score:-4.74|P-value:1.65E-5 ID:SGTC_3029|Compound:9088683|FD-Score:3.45|P-value:8.96E-4 ID:SGTC_3081|Compound:9117243|FD-Score:6.28|P-value:8.51E-9 ID:SGTC_3094|Compound:9117742|FD-Score:4.06|P-value:1.22E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.90|P-value:2.17E-4 ID:SGTC_3142|Compound:9086498|FD-Score:5.62|P-value:2.25E-7 ID:SGTC_3329|Compound:9141233|FD-Score:-3.93|P-value:2.98E-4

Top fitness defect scores for YJL031C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2930 9013230 12.80 14.9 µM 9.87E-31 heme biosynthesis & mitochondrial translocase 3 4.64E-38 2.37
2 SGTC_745 0469-0705 12.00 296.0 µM 3.94E-27 mitochondrial processes 2 1.59E-33 2.36
3 SGTC_173 1273-0061 11.90 2.7 µM 1.56E-26 mitochondrial stress 3 9.02E-33 0.63
4 SGTC_1453 4237-0541 11.50 195.0 µM 3.87E-25 heme biosynthesis & mitochondrial translocase 1 5.12E-31 2.26
5 SGTC_2336 9001819 9.55 198.7 µM 6.60E-18 heme biosynthesis & mitochondrial translocase 10 6.33E-22 0.25
6 SGTC_2418 pentamidine 8.56 31.7 µM 9.21E-15 mitochondrial processes 4 5.61E-18 0.95
7 SGTC_743 1275-0778 8.28 158.0 µM 6.27E-14 excess fatty acid 2 6.21E-17 0.56
8 SGTC_851 0394-0702 8.18 453.0 µM 1.21E-13 mitochondrial processes 4 1.42E-16 1.62
9 SGTC_70 0141-0289 6.91 43.3 µM 2.99E-10 mitochondrial stress 8 2.51E-12 0.21
10 SGTC_2645 abamectin 6.81 100.0 µM 5.10E-10 heme requiring 2 4.89E-12 0.68
11 SGTC_1568 digitonin 6.78 820.0 nM 6.02E-10 sphingolipid biosynthesis & PDR1 2 6.01E-12 0.20
12 SGTC_236 1509-0011 6.77 5.3 µM 6.49E-10 7 6.60E-12 0.12
13 SGTC_1785 bathophenanthroline 6.74 24.0 µM 7.57E-10 heme requiring 5 8.00E-12 0.03
14 SGTC_81 0411-0046 6.68 10.0 µM 1.05E-9 17 1.20E-11 0.21
15 SGTC_2640 pentamidine 6.65 10.4 µM 1.24E-9 mitochondrial processes 5 1.48E-11 0.35
16 SGTC_1797 st048695 6.65 56.8 µM 1.24E-9 NEO1 6 1.49E-11 0.97
17 SGTC_2905 7799065 6.65 20.1 µM 1.26E-9 1 1.51E-11 0.88
18 SGTC_808 0711-0032 6.51 135.0 µM 2.57E-9 2 3.68E-11 1.71
19 SGTC_368 fentichlor 6.41 4.6 µM 4.39E-9 1 7.19E-11 0.81
20 SGTC_3081 9117243 6.28 49.5 µM 8.51E-9 fatty acid desaturase (OLE1) 11 1.64E-10 0.21

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.278 2.88E-60 YBR192W RIM2 het Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
0.248 5.27E-48 YMR203W TOM40 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
0.242 6.50E-46 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.239 1.27E-44 YKL195W MIA40 het Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
0.234 7.08E-43 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.201 7.65E-32 YML091C RPM2 het Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
0.192 5.37E-29 YEL034W HYP2 het Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.187 1.15E-27 YBL105C PKC1 het Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
0.183 1.15E-26 YNL112W DBP2 het ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites
0.178 3.88E-25 YER021W RPN3 het Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
0.165 9.34E-22 YEL035C_p UTR5_p het Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions
0.164 1.20E-21 YLR355C ILV5 het Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids
0.161 6.51E-21 YJL086C_d YJL086C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1
0.161 8.59E-21 YDL196W_d YDL196W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
0.160 1.34E-20 YIL126W STH1 het ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p