YJL032W_d

Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential BET4 gene encoding the alpha subunit of Type II geranylgeranyltransferase

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL032W / YJL032W

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.15|P-value:3.53E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.30|P-value:1.88E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:3.41|P-value:1.17E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:2.91|P-value:8.64E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:3.63|P-value:4.47E-5 ID:SGTC_193|Compound:1273-0060|FD-Score:4.23|P-value:2.44E-6 ID:SGTC_259|Compound:usnic acid|FD-Score:3.42|P-value:1.13E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.19|P-value:2.98E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:-3.09|P-value:3.24E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-2.99|P-value:4.67E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:4.23|P-value:2.41E-6 ID:SGTC_619|Compound:1652-1634|FD-Score:2.96|P-value:7.18E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:4.02|P-value:6.92E-6 ID:SGTC_653|Compound:0203-0016|FD-Score:2.93|P-value:7.98E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.44|P-value:1.05E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.56|P-value:6.13E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.29|P-value:1.39E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.37|P-value:1.40E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:2.87|P-value:0.00100 ID:SGTC_946|Compound:3434-1334|FD-Score:3.85|P-value:1.61E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:-2.89|P-value:7.02E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.02|P-value:4.22E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:-3.38|P-value:9.41E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:-6.23|P-value:4.05E-12 ID:SGTC_1141|Compound:3253-0389|FD-Score:-3.06|P-value:3.59E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.01|P-value:6.04E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:7.72|P-value:2.75E-17 ID:SGTC_1379|Compound:2144-0755|FD-Score:4.51|P-value:5.55E-7 ID:SGTC_1482|Compound:3346-2049|FD-Score:2.91|P-value:8.86E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:4.08|P-value:5.12E-6 ID:SGTC_1738|Compound:st035555|FD-Score:2.90|P-value:9.07E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-3.10|P-value:3.11E-4 ID:SGTC_1773|Compound:st048542|FD-Score:5.30|P-value:4.92E-9 ID:SGTC_1776|Compound:st049249|FD-Score:3.66|P-value:3.98E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:-3.62|P-value:3.23E-5 ID:SGTC_1961|Compound:st076550|FD-Score:2.91|P-value:8.57E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.26|P-value:2.22E-4 ID:SGTC_2149|Compound:5554786|FD-Score:5.02|P-value:2.83E-8 ID:SGTC_2330|Compound:7979373|FD-Score:3.26|P-value:2.24E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-3.11|P-value:2.95E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.49|P-value:8.50E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.07|P-value:4.76E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.99|P-value:8.18E-6 ID:SGTC_2457|Compound:5731572|FD-Score:-3.20|P-value:2.05E-4 ID:SGTC_2465|Compound:5809242|FD-Score:-3.13|P-value:2.71E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.24|P-value:2.40E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.99|P-value:8.25E-6 ID:SGTC_2794|Compound:7785382|FD-Score:3.40|P-value:1.26E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.22|P-value:2.63E-4 ID:SGTC_2831|Compound:7999036|FD-Score:2.95|P-value:7.43E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-3.06|P-value:3.55E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.10|P-value:4.14E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:3.15|P-value:3.53E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.30|P-value:1.88E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:3.41|P-value:1.17E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:2.91|P-value:8.64E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:3.63|P-value:4.47E-5 ID:SGTC_193|Compound:1273-0060|FD-Score:4.23|P-value:2.44E-6 ID:SGTC_259|Compound:usnic acid|FD-Score:3.42|P-value:1.13E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.19|P-value:2.98E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:-3.09|P-value:3.24E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-2.99|P-value:4.67E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:4.23|P-value:2.41E-6 ID:SGTC_619|Compound:1652-1634|FD-Score:2.96|P-value:7.18E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:4.02|P-value:6.92E-6 ID:SGTC_653|Compound:0203-0016|FD-Score:2.93|P-value:7.98E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.44|P-value:1.05E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.56|P-value:6.13E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.29|P-value:1.39E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.37|P-value:1.40E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:2.87|P-value:0.00100 ID:SGTC_946|Compound:3434-1334|FD-Score:3.85|P-value:1.61E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:-2.89|P-value:7.02E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.02|P-value:4.22E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:-3.38|P-value:9.41E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:-6.23|P-value:4.05E-12 ID:SGTC_1141|Compound:3253-0389|FD-Score:-3.06|P-value:3.59E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.01|P-value:6.04E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:7.72|P-value:2.75E-17 ID:SGTC_1379|Compound:2144-0755|FD-Score:4.51|P-value:5.55E-7 ID:SGTC_1482|Compound:3346-2049|FD-Score:2.91|P-value:8.86E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:4.08|P-value:5.12E-6 ID:SGTC_1738|Compound:st035555|FD-Score:2.90|P-value:9.07E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-3.10|P-value:3.11E-4 ID:SGTC_1773|Compound:st048542|FD-Score:5.30|P-value:4.92E-9 ID:SGTC_1776|Compound:st049249|FD-Score:3.66|P-value:3.98E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:-3.62|P-value:3.23E-5 ID:SGTC_1961|Compound:st076550|FD-Score:2.91|P-value:8.57E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.26|P-value:2.22E-4 ID:SGTC_2149|Compound:5554786|FD-Score:5.02|P-value:2.83E-8 ID:SGTC_2330|Compound:7979373|FD-Score:3.26|P-value:2.24E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-3.11|P-value:2.95E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.49|P-value:8.50E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.07|P-value:4.76E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.99|P-value:8.18E-6 ID:SGTC_2457|Compound:5731572|FD-Score:-3.20|P-value:2.05E-4 ID:SGTC_2465|Compound:5809242|FD-Score:-3.13|P-value:2.71E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.24|P-value:2.40E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.99|P-value:8.25E-6 ID:SGTC_2794|Compound:7785382|FD-Score:3.40|P-value:1.26E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.22|P-value:2.63E-4 ID:SGTC_2831|Compound:7999036|FD-Score:2.95|P-value:7.43E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-3.06|P-value:3.55E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.10|P-value:4.14E-4

Top fitness defect scores for YJL032W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1306 1185-0270 7.72 9.0 µM 2.75E-17 Golgi 3 5.88E-15 0.54
2 SGTC_1773 st048542 5.30 73.6 µM 4.92E-9 15 5.91E-8 0.11
3 SGTC_2149 5554786 5.02 194.8 µM 2.83E-8 cell wall signaling 4 2.62E-7 0.22
4 SGTC_1379 2144-0755 4.51 36.5 µM 5.55E-7 3 3.31E-6 0.33
5 SGTC_535 2293-4129 4.23 48.2 µM 2.41E-6 NEO1 6 1.16E-5 0.15
6 SGTC_193 1273-0060 4.23 1.6 µM 2.44E-6 ergosterol biosynthesis 5 1.17E-5 0.32
7 SGTC_1568 digitonin 4.08 820.0 nM 5.12E-6 sphingolipid biosynthesis & PDR1 14 2.21E-5 0.14
8 SGTC_636 0kpi-0074 4.02 126.0 µM 6.92E-6 4 2.85E-5 0.42
9 SGTC_2455 5377712 3.99 9.8 µM 8.18E-6 3 3.29E-5 0.39
10 SGTC_2645 abamectin 3.99 100.0 µM 8.25E-6 heme requiring 9 3.32E-5 0.05
11 SGTC_946 3434-1334 3.85 87.4 µM 1.61E-5 12 5.89E-5 0.13
12 SGTC_1776 st049249 3.66 45.9 µM 3.98E-5 7 1.28E-4 0.04
13 SGTC_152 4469-0003 3.63 551.2 µM 4.47E-5 17 1.41E-4 0.02
14 SGTC_798 1287-0182 3.56 476.0 µM 6.13E-5 3 1.85E-4 0.09
15 SGTC_2401 5128683 3.49 200.0 µM 8.50E-5 15 2.44E-4 0.09
16 SGTC_664 1222-0054 3.44 14.9 µM 1.05E-4 sphingolipid biosynthesis & PDR1 11 2.92E-4 0.03
17 SGTC_259 usnic acid 3.42 108.9 µM 1.13E-4 12 3.13E-4 0.08
18 SGTC_35 0133-0054 3.41 64.1 µM 1.17E-4 18 3.20E-4 0.11
19 SGTC_2794 7785382 3.40 27.3 µM 1.26E-4 20 3.43E-4 0.06
20 SGTC_927 2425-1185 3.37 123.0 µM 1.40E-4 9 3.74E-4 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.161 5.82E-21 YJL130C URA2 hom Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
0.140 3.65E-16 YLR309C IMH1 hom Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi
0.132 1.50E-14 YLR190W MMR1 hom Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
0.123 8.33E-13 YPR175W DPB2 het Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for maintenance of fidelity of chromosomal replication; expression peaks at the G1/S phase boundary; Cdc28p substrate
0.116 1.37E-11 YPL244C HUT1 hom Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
0.111 9.82E-11 YML021C UNG1 hom Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
0.111 1.08E-10 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.108 2.93E-10 YFL031W HAC1 hom Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress
0.106 8.69E-10 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.100 6.01E-9 YPR176C BET2 het Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.099 9.72E-9 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.097 1.74E-8 YLR269C_d YLR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.094 5.38E-8 YGL005C COG7 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.093 6.43E-8 YFR051C RET2 het Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
0.092 8.23E-8 YPL243W SRP68 het Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress