YJL036W / SNX4

Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL036W / SNX4

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:4.03|P-value:2.17E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.65|P-value:7.26E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:8.18|P-value:3.41E-13 ID:SGTC_144|Compound:4161-2749|FD-Score:4.84|P-value:1.15E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:5.34|P-value:1.46E-6 ID:SGTC_161|Compound:4065-0411|FD-Score:3.56|P-value:9.48E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:4.28|P-value:8.97E-5 ID:SGTC_302|Compound:1094-0063|FD-Score:3.66|P-value:6.96E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:5.02|P-value:5.54E-6 ID:SGTC_362|Compound:0310-0100|FD-Score:5.01|P-value:5.67E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:7.49|P-value:2.43E-11 ID:SGTC_365|Compound:0121-0052|FD-Score:-6.08|P-value:3.34E-8 ID:SGTC_366|Compound:0181-0206|FD-Score:-6.35|P-value:8.65E-9 ID:SGTC_455|Compound:paf C-16|FD-Score:-3.92|P-value:2.43E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.84|P-value:1.12E-5 ID:SGTC_508|Compound:roscovitine|FD-Score:-4.60|P-value:2.17E-5 ID:SGTC_569|Compound:4130-2812|FD-Score:3.81|P-value:4.32E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.99|P-value:2.45E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.61|P-value:8.13E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:5.16|P-value:3.12E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:3.84|P-value:3.96E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:4.09|P-value:1.73E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.93|P-value:2.98E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.61|P-value:2.76E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.78|P-value:4.85E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.67|P-value:6.75E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:4.15|P-value:1.42E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:5.38|P-value:1.24E-6 ID:SGTC_1335|Compound:1486-0900|FD-Score:4.97|P-value:6.78E-6 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.90|P-value:3.32E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:4.40|P-value:5.97E-5 ID:SGTC_1489|Compound:4065-0444|FD-Score:5.02|P-value:5.53E-6 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.59|P-value:8.55E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-4.63|P-value:1.89E-5 ID:SGTC_1634|Compound:st006576|FD-Score:6.28|P-value:1.83E-8 ID:SGTC_1635|Compound:st007035|FD-Score:-4.10|P-value:1.32E-4 ID:SGTC_1805|Compound:st050013|FD-Score:3.58|P-value:8.78E-4 ID:SGTC_1817|Compound:st052116|FD-Score:-3.50|P-value:8.99E-4 ID:SGTC_1847|Compound:st056231|FD-Score:4.90|P-value:9.01E-6 ID:SGTC_1849|Compound:st056239|FD-Score:4.41|P-value:5.68E-5 ID:SGTC_1871|Compound:st057448|FD-Score:4.80|P-value:1.35E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.81|P-value:3.41E-4 ID:SGTC_1932|Compound:st074806|FD-Score:-4.23|P-value:8.33E-5 ID:SGTC_1975|Compound:st070967|FD-Score:-3.53|P-value:8.31E-4 ID:SGTC_1977|Compound:st070720|FD-Score:4.28|P-value:9.23E-5 ID:SGTC_1979|Compound:st071809|FD-Score:-4.82|P-value:8.90E-6 ID:SGTC_1999|Compound:st074831|FD-Score:-4.62|P-value:2.00E-5 ID:SGTC_2090|Compound:5301565|FD-Score:3.75|P-value:5.28E-4 ID:SGTC_2137|Compound:5261020|FD-Score:4.99|P-value:6.35E-6 ID:SGTC_2147|Compound:5545932|FD-Score:3.99|P-value:2.43E-4 ID:SGTC_2308|Compound:7584454|FD-Score:4.79|P-value:1.37E-5 ID:SGTC_2331|Compound:7980721|FD-Score:4.65|P-value:2.32E-5 ID:SGTC_2472|Compound:5377652|FD-Score:3.65|P-value:7.23E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:3.96|P-value:2.67E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.59|P-value:6.79E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.58|P-value:3.13E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.56|P-value:3.27E-5 ID:SGTC_2801|Compound:7907800|FD-Score:-3.53|P-value:8.21E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.48|P-value:4.40E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-4.61|P-value:2.03E-5 ID:SGTC_2841|Compound:9004761|FD-Score:4.27|P-value:9.49E-5 ID:SGTC_2902|Compound:5787006|FD-Score:5.47|P-value:8.34E-7 ID:SGTC_2908|Compound:7930301|FD-Score:4.05|P-value:2.00E-4 ID:SGTC_2916|Compound:7875993|FD-Score:4.39|P-value:6.12E-5 ID:SGTC_2947|Compound:9072639|FD-Score:-3.93|P-value:2.30E-4 ID:SGTC_2976|Compound:9009005|FD-Score:4.43|P-value:5.27E-5 ID:SGTC_3022|Compound:9087993|FD-Score:-4.27|P-value:7.19E-5 ID:SGTC_3056|Compound:9094900|FD-Score:4.48|P-value:4.41E-5 ID:SGTC_3080|Compound:9117754|FD-Score:3.70|P-value:6.12E-4 ID:SGTC_3238|Compound:9133470|FD-Score:3.70|P-value:6.09E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:4.03|P-value:2.17E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.65|P-value:7.26E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:8.18|P-value:3.41E-13 ID:SGTC_144|Compound:4161-2749|FD-Score:4.84|P-value:1.15E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:5.34|P-value:1.46E-6 ID:SGTC_161|Compound:4065-0411|FD-Score:3.56|P-value:9.48E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:4.28|P-value:8.97E-5 ID:SGTC_302|Compound:1094-0063|FD-Score:3.66|P-value:6.96E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:5.02|P-value:5.54E-6 ID:SGTC_362|Compound:0310-0100|FD-Score:5.01|P-value:5.67E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:7.49|P-value:2.43E-11 ID:SGTC_365|Compound:0121-0052|FD-Score:-6.08|P-value:3.34E-8 ID:SGTC_366|Compound:0181-0206|FD-Score:-6.35|P-value:8.65E-9 ID:SGTC_455|Compound:paf C-16|FD-Score:-3.92|P-value:2.43E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.84|P-value:1.12E-5 ID:SGTC_508|Compound:roscovitine|FD-Score:-4.60|P-value:2.17E-5 ID:SGTC_569|Compound:4130-2812|FD-Score:3.81|P-value:4.32E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.99|P-value:2.45E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.61|P-value:8.13E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:5.16|P-value:3.12E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:3.84|P-value:3.96E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:4.09|P-value:1.73E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.93|P-value:2.98E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.61|P-value:2.76E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.78|P-value:4.85E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.67|P-value:6.75E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:4.15|P-value:1.42E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:5.38|P-value:1.24E-6 ID:SGTC_1335|Compound:1486-0900|FD-Score:4.97|P-value:6.78E-6 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.90|P-value:3.32E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:4.40|P-value:5.97E-5 ID:SGTC_1489|Compound:4065-0444|FD-Score:5.02|P-value:5.53E-6 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.59|P-value:8.55E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-4.63|P-value:1.89E-5 ID:SGTC_1634|Compound:st006576|FD-Score:6.28|P-value:1.83E-8 ID:SGTC_1635|Compound:st007035|FD-Score:-4.10|P-value:1.32E-4 ID:SGTC_1805|Compound:st050013|FD-Score:3.58|P-value:8.78E-4 ID:SGTC_1817|Compound:st052116|FD-Score:-3.50|P-value:8.99E-4 ID:SGTC_1847|Compound:st056231|FD-Score:4.90|P-value:9.01E-6 ID:SGTC_1849|Compound:st056239|FD-Score:4.41|P-value:5.68E-5 ID:SGTC_1871|Compound:st057448|FD-Score:4.80|P-value:1.35E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.81|P-value:3.41E-4 ID:SGTC_1932|Compound:st074806|FD-Score:-4.23|P-value:8.33E-5 ID:SGTC_1975|Compound:st070967|FD-Score:-3.53|P-value:8.31E-4 ID:SGTC_1977|Compound:st070720|FD-Score:4.28|P-value:9.23E-5 ID:SGTC_1979|Compound:st071809|FD-Score:-4.82|P-value:8.90E-6 ID:SGTC_1999|Compound:st074831|FD-Score:-4.62|P-value:2.00E-5 ID:SGTC_2090|Compound:5301565|FD-Score:3.75|P-value:5.28E-4 ID:SGTC_2137|Compound:5261020|FD-Score:4.99|P-value:6.35E-6 ID:SGTC_2147|Compound:5545932|FD-Score:3.99|P-value:2.43E-4 ID:SGTC_2308|Compound:7584454|FD-Score:4.79|P-value:1.37E-5 ID:SGTC_2331|Compound:7980721|FD-Score:4.65|P-value:2.32E-5 ID:SGTC_2472|Compound:5377652|FD-Score:3.65|P-value:7.23E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:3.96|P-value:2.67E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.59|P-value:6.79E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.58|P-value:3.13E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.56|P-value:3.27E-5 ID:SGTC_2801|Compound:7907800|FD-Score:-3.53|P-value:8.21E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.48|P-value:4.40E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-4.61|P-value:2.03E-5 ID:SGTC_2841|Compound:9004761|FD-Score:4.27|P-value:9.49E-5 ID:SGTC_2902|Compound:5787006|FD-Score:5.47|P-value:8.34E-7 ID:SGTC_2908|Compound:7930301|FD-Score:4.05|P-value:2.00E-4 ID:SGTC_2916|Compound:7875993|FD-Score:4.39|P-value:6.12E-5 ID:SGTC_2947|Compound:9072639|FD-Score:-3.93|P-value:2.30E-4 ID:SGTC_2976|Compound:9009005|FD-Score:4.43|P-value:5.27E-5 ID:SGTC_3022|Compound:9087993|FD-Score:-4.27|P-value:7.19E-5 ID:SGTC_3056|Compound:9094900|FD-Score:4.48|P-value:4.41E-5 ID:SGTC_3080|Compound:9117754|FD-Score:3.70|P-value:6.12E-4 ID:SGTC_3238|Compound:9133470|FD-Score:3.70|P-value:6.09E-4

Top fitness defect scores for YJL036W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_18 0111-0177 8.18 500.0 nM 3.41E-13 9 1.43E-16
2 SGTC_363 0455-0021 7.49 3.1 µM 2.43E-11 azole & statin 17 3.43E-14
3 SGTC_1634 st006576 6.28 41.0 µM 1.83E-8 TSC3-RPN4 4 1.70E-10
4 SGTC_2902 5787006 5.47 60.5 µM 8.34E-7 Golgi 6 2.29E-8
5 SGTC_1279 0874-0590 5.38 65.2 µM 1.24E-6 10 3.79E-8
6 SGTC_148 3253-0744 5.34 288.0 µM 1.46E-6 7 4.67E-8
7 SGTC_739 1486-1183 5.16 203.0 µM 3.12E-6 6 1.24E-7
8 SGTC_1489 4065-0444 5.02 182.0 µM 5.53E-6 8 2.59E-7
9 SGTC_319 1348-1596 5.02 45.5 µM 5.54E-6 RSC & ERG11 7 2.59E-7
10 SGTC_362 0310-0100 5.01 9.0 µM 5.67E-6 RPP1 & pyrimidine depletion 10 2.67E-7
11 SGTC_2137 5261020 4.99 140.0 µM 6.35E-6 21 3.08E-7
12 SGTC_1335 1486-0900 4.97 202.0 µM 6.78E-6 15 3.35E-7
13 SGTC_1847 st056231 4.90 15.0 µM 9.01E-6 15 4.83E-7
14 SGTC_501 nsc-95397 4.84 161.0 µM 1.12E-5 4 6.38E-7
15 SGTC_144 4161-2749 4.84 112.4 µM 1.15E-5 DNA intercalators 12 6.64E-7
16 SGTC_1871 st057448 4.80 67.3 µM 1.35E-5 9 8.08E-7
17 SGTC_2308 7584454 4.79 197.6 µM 1.37E-5 9 8.30E-7
18 SGTC_2331 7980721 4.65 200.0 µM 2.32E-5 8 1.62E-6
19 SGTC_1097 itavastatin 4.61 7.2 µM 2.76E-5 azole & statin 12 2.03E-6
20 SGTC_2638 epoxomicin 4.58 18.0 µM 3.13E-5 20 2.38E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 4.81E-15 YGR208W SER2 hom Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
0.112 7.62E-11 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.104 1.78E-9 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.098 1.29E-8 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.095 3.04E-8 YHL029C_p OCA5_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.087 4.15E-7 YJR139C HOM6 hom Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
0.084 1.11E-6 YMR312W ELP6 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.084 1.25E-6 YJL156C SSY5 het Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p
0.083 1.30E-6 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.083 1.34E-6 YIR023W DAL81 hom Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
0.082 1.84E-6 YKL143W LTV1 hom Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature
0.082 2.05E-6 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.081 2.44E-6 YOL082W ATG19 hom Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles
0.078 5.84E-6 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.077 8.33E-6 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication