YJL037W / IRC18

Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL037W / IRC18

Click on Significant Values for Screen Details ID:SGTC_91|Compound:0417-1751|FD-Score:3.39|P-value:4.15E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.39|P-value:4.23E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:5.82|P-value:4.52E-9 ID:SGTC_126|Compound:0417-1624|FD-Score:3.97|P-value:4.54E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:7.02|P-value:2.01E-12 ID:SGTC_169|Compound:k015-0017|FD-Score:-5.04|P-value:2.98E-7 ID:SGTC_171|Compound:k064-0041|FD-Score:4.96|P-value:4.89E-7 ID:SGTC_174|Compound:3553-0389|FD-Score:3.77|P-value:9.99E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.34|P-value:4.65E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:5.26|P-value:1.02E-7 ID:SGTC_193|Compound:1273-0060|FD-Score:4.07|P-value:2.93E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:5.48|P-value:3.20E-8 ID:SGTC_490|Compound:phenamil|FD-Score:3.64|P-value:1.66E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:-3.18|P-value:8.01E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:3.24|P-value:6.97E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.32|P-value:5.42E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.20|P-value:8.17E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:3.54|P-value:2.39E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:3.20|P-value:8.15E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:4.03|P-value:3.59E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:5.40|P-value:4.94E-8 ID:SGTC_833|Compound:3852-0053|FD-Score:5.23|P-value:1.21E-7 ID:SGTC_867|Compound:0518-0118|FD-Score:3.84|P-value:7.50E-5 ID:SGTC_918|Compound:glabranin|FD-Score:3.48|P-value:3.00E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.17|P-value:9.03E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:6.05|P-value:1.19E-9 ID:SGTC_998|Compound:3996-0085|FD-Score:3.50|P-value:2.82E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.50|P-value:2.80E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.53|P-value:2.50E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.49|P-value:2.89E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:4.38|P-value:7.74E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.35|P-value:4.84E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.51|P-value:2.69E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:5.31|P-value:7.91E-8 ID:SGTC_1279|Compound:0874-0590|FD-Score:5.19|P-value:1.47E-7 ID:SGTC_1368|Compound:1852-0141|FD-Score:-3.60|P-value:1.75E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.61|P-value:2.65E-6 ID:SGTC_1727|Compound:st034309|FD-Score:-3.54|P-value:2.20E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-3.98|P-value:3.87E-5 ID:SGTC_1761|Compound:st044296|FD-Score:6.52|P-value:5.92E-11 ID:SGTC_1819|Compound:st053448|FD-Score:5.49|P-value:3.08E-8 ID:SGTC_1833|Compound:st055984|FD-Score:3.89|P-value:6.26E-5 ID:SGTC_1837|Compound:st055472|FD-Score:3.35|P-value:4.83E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.40|P-value:4.05E-4 ID:SGTC_1979|Compound:st071809|FD-Score:3.52|P-value:2.64E-4 ID:SGTC_2070|Compound:5230947|FD-Score:4.04|P-value:3.43E-5 ID:SGTC_2112|Compound:5488546|FD-Score:3.14|P-value:9.89E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.67|P-value:1.48E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.53|P-value:2.54E-4 ID:SGTC_2162|Compound:5663267|FD-Score:5.90|P-value:2.94E-9 ID:SGTC_2311|Compound:7694451|FD-Score:3.42|P-value:3.73E-4 ID:SGTC_2364|Compound:9055074|FD-Score:7.70|P-value:1.44E-14 ID:SGTC_2432|Compound:5630864|FD-Score:3.53|P-value:2.49E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.40|P-value:4.08E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.87|P-value:6.82E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.63|P-value:1.75E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.23|P-value:7.25E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.23|P-value:7.20E-4 ID:SGTC_3084|Compound:9116877|FD-Score:-3.88|P-value:5.91E-5 ID:SGTC_3088|Compound:9117578|FD-Score:3.18|P-value:8.70E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.16|P-value:9.18E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.47|P-value:3.13E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.59|P-value:2.01E-4 ID:SGTC_3316|Compound:9136639|FD-Score:4.48|P-value:5.04E-6 ID:SGTC_3320|Compound:9137005|FD-Score:5.45|P-value:3.81E-8 ID:SGTC_3346|Compound:9158254|FD-Score:4.16|P-value:2.02E-5 ID:SGTC_3347|Compound:9188721|FD-Score:5.73|P-value:7.62E-9 ID:SGTC_91|Compound:0417-1751|FD-Score:3.39|P-value:4.15E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.39|P-value:4.23E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:5.82|P-value:4.52E-9 ID:SGTC_126|Compound:0417-1624|FD-Score:3.97|P-value:4.54E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:7.02|P-value:2.01E-12 ID:SGTC_169|Compound:k015-0017|FD-Score:-5.04|P-value:2.98E-7 ID:SGTC_171|Compound:k064-0041|FD-Score:4.96|P-value:4.89E-7 ID:SGTC_174|Compound:3553-0389|FD-Score:3.77|P-value:9.99E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.34|P-value:4.65E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:5.26|P-value:1.02E-7 ID:SGTC_193|Compound:1273-0060|FD-Score:4.07|P-value:2.93E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:5.48|P-value:3.20E-8 ID:SGTC_490|Compound:phenamil|FD-Score:3.64|P-value:1.66E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:-3.18|P-value:8.01E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:3.24|P-value:6.97E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.32|P-value:5.42E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.20|P-value:8.17E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:3.54|P-value:2.39E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:3.20|P-value:8.15E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:4.03|P-value:3.59E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:5.40|P-value:4.94E-8 ID:SGTC_833|Compound:3852-0053|FD-Score:5.23|P-value:1.21E-7 ID:SGTC_867|Compound:0518-0118|FD-Score:3.84|P-value:7.50E-5 ID:SGTC_918|Compound:glabranin|FD-Score:3.48|P-value:3.00E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.17|P-value:9.03E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:6.05|P-value:1.19E-9 ID:SGTC_998|Compound:3996-0085|FD-Score:3.50|P-value:2.82E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.50|P-value:2.80E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.53|P-value:2.50E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.49|P-value:2.89E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:4.38|P-value:7.74E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.35|P-value:4.84E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.51|P-value:2.69E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:5.31|P-value:7.91E-8 ID:SGTC_1279|Compound:0874-0590|FD-Score:5.19|P-value:1.47E-7 ID:SGTC_1368|Compound:1852-0141|FD-Score:-3.60|P-value:1.75E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.61|P-value:2.65E-6 ID:SGTC_1727|Compound:st034309|FD-Score:-3.54|P-value:2.20E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-3.98|P-value:3.87E-5 ID:SGTC_1761|Compound:st044296|FD-Score:6.52|P-value:5.92E-11 ID:SGTC_1819|Compound:st053448|FD-Score:5.49|P-value:3.08E-8 ID:SGTC_1833|Compound:st055984|FD-Score:3.89|P-value:6.26E-5 ID:SGTC_1837|Compound:st055472|FD-Score:3.35|P-value:4.83E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.40|P-value:4.05E-4 ID:SGTC_1979|Compound:st071809|FD-Score:3.52|P-value:2.64E-4 ID:SGTC_2070|Compound:5230947|FD-Score:4.04|P-value:3.43E-5 ID:SGTC_2112|Compound:5488546|FD-Score:3.14|P-value:9.89E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.67|P-value:1.48E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.53|P-value:2.54E-4 ID:SGTC_2162|Compound:5663267|FD-Score:5.90|P-value:2.94E-9 ID:SGTC_2311|Compound:7694451|FD-Score:3.42|P-value:3.73E-4 ID:SGTC_2364|Compound:9055074|FD-Score:7.70|P-value:1.44E-14 ID:SGTC_2432|Compound:5630864|FD-Score:3.53|P-value:2.49E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.40|P-value:4.08E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.87|P-value:6.82E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.63|P-value:1.75E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.23|P-value:7.25E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.23|P-value:7.20E-4 ID:SGTC_3084|Compound:9116877|FD-Score:-3.88|P-value:5.91E-5 ID:SGTC_3088|Compound:9117578|FD-Score:3.18|P-value:8.70E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.16|P-value:9.18E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.47|P-value:3.13E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.59|P-value:2.01E-4 ID:SGTC_3316|Compound:9136639|FD-Score:4.48|P-value:5.04E-6 ID:SGTC_3320|Compound:9137005|FD-Score:5.45|P-value:3.81E-8 ID:SGTC_3346|Compound:9158254|FD-Score:4.16|P-value:2.02E-5 ID:SGTC_3347|Compound:9188721|FD-Score:5.73|P-value:7.62E-9

Top fitness defect scores for YJL037W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2364 9055074 7.70 200.0 µM 1.44E-14 2 6.89E-15
2 SGTC_164 4100-3994 7.02 89.6 µM 2.01E-12 3 1.08E-12
3 SGTC_1761 st044296 6.52 37.0 µM 5.92E-11 2 3.44E-11
4 SGTC_960 1222-0186 6.05 7.7 µM 1.19E-9 7 7.42E-10
5 SGTC_2162 5663267 5.90 200.0 µM 2.94E-9 2 1.87E-9
6 SGTC_106 0092-0003 5.82 11.6 µM 4.52E-9 copper-dependent oxidative stress 6 2.90E-9
7 SGTC_3347 9188721 5.73 44.7 µM 7.62E-9 7 4.95E-9
8 SGTC_1819 st053448 5.49 58.6 µM 3.08E-8 amide catabolism 3 2.07E-8
9 SGTC_350 k064-0020 5.48 19.8 µM 3.20E-8 heme requiring 8 2.15E-8
10 SGTC_3320 9137005 5.45 35.1 µM 3.81E-8 endomembrane recycling 4 2.57E-8
11 SGTC_729 4092-0585 5.40 94.1 µM 4.94E-8 6 3.35E-8
12 SGTC_1167 k781-0610 5.31 148.0 µM 7.91E-8 RNA processing & uracil transport 4 5.43E-8
13 SGTC_183 3914-0051 5.26 30.6 µM 1.02E-7 60S ribosome export 3 7.07E-8
14 SGTC_833 3852-0053 5.23 558.0 µM 1.21E-7 5 8.38E-8
15 SGTC_1279 0874-0590 5.19 65.2 µM 1.47E-7 12 1.03E-7
16 SGTC_171 k064-0041 4.96 9.7 µM 4.89E-7 heme requiring 18 3.50E-7
17 SGTC_1457 k015-0032 4.61 57.3 µM 2.65E-6 21 1.97E-6
18 SGTC_3316 9136639 4.48 10.6 µM 5.04E-6 9 3.82E-6
19 SGTC_1076 itraconazole 4.38 331.0 nM 7.74E-6 22 5.92E-6
20 SGTC_3346 9158254 4.16 43.6 µM 2.02E-5 9 1.58E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.093 6.80E-8 YDL118W_d YDL118W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein
0.092 9.83E-8 YBR035C PDX3 hom Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
0.085 7.88E-7 YDR232W HEM1 het 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
0.083 1.56E-6 YBR129C OPY1 hom Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.083 1.60E-6 YKL132C RMA1 hom Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.081 2.60E-6 YLR453C RIF2 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.079 5.17E-6 YDL119C_p YDL119C_p hom Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria
0.077 7.65E-6 YKL042W SPC42 het Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane
0.076 1.16E-5 YOR108W LEU9 hom Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication
0.075 1.29E-5 YLR132C USB1 het Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.072 3.26E-5 YFR041C ERJ5 hom Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response
0.072 3.25E-5 YAL036C RBG1 hom Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid
0.071 3.69E-5 YGR013W SNU71 het Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart
0.070 4.56E-5 YJL075C_d APQ13_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate
0.069 6.74E-5 YHR059W FYV4 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin