YJL039C / NUP192

Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL039C / NUP192

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:6.07|P-value:7.72E-9 ID:SGTC_16|Compound:erodoxin|FD-Score:4.86|P-value:2.95E-6 ID:SGTC_22|Compound:0964-0034|FD-Score:6.10|P-value:6.47E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:4.41|P-value:1.94E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:4.96|P-value:1.89E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:3.66|P-value:3.24E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:-3.61|P-value:3.80E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.94|P-value:1.22E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:14.90|P-value:3.02E-44 ID:SGTC_140|Compound:0062-0056|FD-Score:4.19|P-value:4.77E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:6.60|P-value:3.71E-10 ID:SGTC_151|Compound:3013-0144|FD-Score:5.70|P-value:5.27E-8 ID:SGTC_168|Compound:3970-0862|FD-Score:4.10|P-value:6.71E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:3.34|P-value:9.27E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.74|P-value:2.47E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.91|P-value:1.32E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:9.57|P-value:2.30E-19 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.49|P-value:5.76E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.93|P-value:1.24E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:6.05|P-value:8.36E-9 ID:SGTC_580|Compound:1123-0028|FD-Score:5.15|P-value:8.00E-7 ID:SGTC_586|Compound:0957-0265|FD-Score:7.76|P-value:2.37E-13 ID:SGTC_632|Compound:0781-2353|FD-Score:4.34|P-value:2.56E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.51|P-value:5.29E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.43|P-value:7.01E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:6.84|P-value:9.03E-11 ID:SGTC_709|Compound:3807-1509|FD-Score:3.44|P-value:6.64E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.36|P-value:8.55E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:-3.86|P-value:1.61E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:7.63|P-value:5.83E-13 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.40|P-value:7.77E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.73|P-value:2.53E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.41|P-value:7.49E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:5.79|P-value:3.30E-8 ID:SGTC_1044|Compound:1222-0021|FD-Score:6.27|P-value:2.59E-9 ID:SGTC_1050|Compound:3232-1156|FD-Score:5.60|P-value:8.77E-8 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.71|P-value:2.73E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.70|P-value:2.84E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.69|P-value:2.90E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.76|P-value:2.27E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.35|P-value:9.04E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:-4.12|P-value:6.09E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:4.83|P-value:3.38E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.35|P-value:2.52E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.08|P-value:7.21E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.28|P-value:3.28E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.48|P-value:1.47E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.81|P-value:1.93E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.49|P-value:5.78E-4 ID:SGTC_1722|Compound:st034304|FD-Score:5.95|P-value:1.49E-8 ID:SGTC_1765|Compound:st044815|FD-Score:3.48|P-value:5.84E-4 ID:SGTC_1775|Compound:st081588|FD-Score:-4.36|P-value:2.45E-5 ID:SGTC_1934|Compound:st074720|FD-Score:-3.35|P-value:8.92E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.63|P-value:3.58E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-4.15|P-value:5.40E-5 ID:SGTC_2041|Compound:5107442|FD-Score:3.85|P-value:1.68E-4 ID:SGTC_2066|Compound:5222451|FD-Score:4.47|P-value:1.52E-5 ID:SGTC_2092|Compound:5303694|FD-Score:3.75|P-value:2.36E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.60|P-value:3.97E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.76|P-value:2.27E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.84|P-value:3.29E-6 ID:SGTC_2256|Compound:7954252|FD-Score:4.68|P-value:6.44E-6 ID:SGTC_2322|Compound:7413319|FD-Score:3.92|P-value:1.28E-4 ID:SGTC_2344|Compound:7990960|FD-Score:7.23|P-value:7.77E-12 ID:SGTC_2348|Compound:9022543|FD-Score:5.30|P-value:3.93E-7 ID:SGTC_2408|Compound:sulbentine|FD-Score:10.30|P-value:3.32E-22 ID:SGTC_2430|Compound:5571206|FD-Score:3.36|P-value:8.69E-4 ID:SGTC_2459|Compound:5811157|FD-Score:7.69|P-value:3.73E-13 ID:SGTC_2471|Compound:5466956|FD-Score:4.11|P-value:6.38E-5 ID:SGTC_2475|Compound:5812728|FD-Score:3.48|P-value:5.96E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:4.53|P-value:1.23E-5 ID:SGTC_2534|Compound:helenine|FD-Score:3.55|P-value:4.64E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:4.79|P-value:3.96E-6 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-4.26|P-value:3.63E-5 ID:SGTC_2799|Compound:7812892|FD-Score:8.69|P-value:2.77E-16 ID:SGTC_2844|Compound:9010103|FD-Score:-3.99|P-value:9.89E-5 ID:SGTC_2921|Compound:7974240|FD-Score:4.22|P-value:4.11E-5 ID:SGTC_2924|Compound:9010168|FD-Score:-3.91|P-value:1.36E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-7.20|P-value:9.74E-12 ID:SGTC_2928|Compound:9011484|FD-Score:7.81|P-value:1.70E-13 ID:SGTC_2974|Compound:9094440|FD-Score:9.71|P-value:6.88E-20 ID:SGTC_2980|Compound:9014342|FD-Score:4.30|P-value:3.04E-5 ID:SGTC_3072|Compound:9116419|FD-Score:-5.57|P-value:1.04E-7 ID:SGTC_3201|Compound:9113999|FD-Score:3.49|P-value:5.73E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:6.07|P-value:7.72E-9 ID:SGTC_16|Compound:erodoxin|FD-Score:4.86|P-value:2.95E-6 ID:SGTC_22|Compound:0964-0034|FD-Score:6.10|P-value:6.47E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:4.41|P-value:1.94E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:4.96|P-value:1.89E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:3.66|P-value:3.24E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:-3.61|P-value:3.80E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.94|P-value:1.22E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:14.90|P-value:3.02E-44 ID:SGTC_140|Compound:0062-0056|FD-Score:4.19|P-value:4.77E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:6.60|P-value:3.71E-10 ID:SGTC_151|Compound:3013-0144|FD-Score:5.70|P-value:5.27E-8 ID:SGTC_168|Compound:3970-0862|FD-Score:4.10|P-value:6.71E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:3.34|P-value:9.27E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.74|P-value:2.47E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.91|P-value:1.32E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:9.57|P-value:2.30E-19 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.49|P-value:5.76E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.93|P-value:1.24E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:6.05|P-value:8.36E-9 ID:SGTC_580|Compound:1123-0028|FD-Score:5.15|P-value:8.00E-7 ID:SGTC_586|Compound:0957-0265|FD-Score:7.76|P-value:2.37E-13 ID:SGTC_632|Compound:0781-2353|FD-Score:4.34|P-value:2.56E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.51|P-value:5.29E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.43|P-value:7.01E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:6.84|P-value:9.03E-11 ID:SGTC_709|Compound:3807-1509|FD-Score:3.44|P-value:6.64E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.36|P-value:8.55E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:-3.86|P-value:1.61E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:7.63|P-value:5.83E-13 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.40|P-value:7.77E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.73|P-value:2.53E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.41|P-value:7.49E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:5.79|P-value:3.30E-8 ID:SGTC_1044|Compound:1222-0021|FD-Score:6.27|P-value:2.59E-9 ID:SGTC_1050|Compound:3232-1156|FD-Score:5.60|P-value:8.77E-8 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.71|P-value:2.73E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.70|P-value:2.84E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.69|P-value:2.90E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.76|P-value:2.27E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.35|P-value:9.04E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:-4.12|P-value:6.09E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:4.83|P-value:3.38E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.35|P-value:2.52E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.08|P-value:7.21E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.28|P-value:3.28E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.48|P-value:1.47E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.81|P-value:1.93E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.49|P-value:5.78E-4 ID:SGTC_1722|Compound:st034304|FD-Score:5.95|P-value:1.49E-8 ID:SGTC_1765|Compound:st044815|FD-Score:3.48|P-value:5.84E-4 ID:SGTC_1775|Compound:st081588|FD-Score:-4.36|P-value:2.45E-5 ID:SGTC_1934|Compound:st074720|FD-Score:-3.35|P-value:8.92E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.63|P-value:3.58E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-4.15|P-value:5.40E-5 ID:SGTC_2041|Compound:5107442|FD-Score:3.85|P-value:1.68E-4 ID:SGTC_2066|Compound:5222451|FD-Score:4.47|P-value:1.52E-5 ID:SGTC_2092|Compound:5303694|FD-Score:3.75|P-value:2.36E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.60|P-value:3.97E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.76|P-value:2.27E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.84|P-value:3.29E-6 ID:SGTC_2256|Compound:7954252|FD-Score:4.68|P-value:6.44E-6 ID:SGTC_2322|Compound:7413319|FD-Score:3.92|P-value:1.28E-4 ID:SGTC_2344|Compound:7990960|FD-Score:7.23|P-value:7.77E-12 ID:SGTC_2348|Compound:9022543|FD-Score:5.30|P-value:3.93E-7 ID:SGTC_2408|Compound:sulbentine|FD-Score:10.30|P-value:3.32E-22 ID:SGTC_2430|Compound:5571206|FD-Score:3.36|P-value:8.69E-4 ID:SGTC_2459|Compound:5811157|FD-Score:7.69|P-value:3.73E-13 ID:SGTC_2471|Compound:5466956|FD-Score:4.11|P-value:6.38E-5 ID:SGTC_2475|Compound:5812728|FD-Score:3.48|P-value:5.96E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:4.53|P-value:1.23E-5 ID:SGTC_2534|Compound:helenine|FD-Score:3.55|P-value:4.64E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:4.79|P-value:3.96E-6 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-4.26|P-value:3.63E-5 ID:SGTC_2799|Compound:7812892|FD-Score:8.69|P-value:2.77E-16 ID:SGTC_2844|Compound:9010103|FD-Score:-3.99|P-value:9.89E-5 ID:SGTC_2921|Compound:7974240|FD-Score:4.22|P-value:4.11E-5 ID:SGTC_2924|Compound:9010168|FD-Score:-3.91|P-value:1.36E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-7.20|P-value:9.74E-12 ID:SGTC_2928|Compound:9011484|FD-Score:7.81|P-value:1.70E-13 ID:SGTC_2974|Compound:9094440|FD-Score:9.71|P-value:6.88E-20 ID:SGTC_2980|Compound:9014342|FD-Score:4.30|P-value:3.04E-5 ID:SGTC_3072|Compound:9116419|FD-Score:-5.57|P-value:1.04E-7 ID:SGTC_3201|Compound:9113999|FD-Score:3.49|P-value:5.73E-4

Top fitness defect scores for YJL039C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_138 0850-0259 14.90 40.9 µM 3.02E-44 cell wall 5 1.32E-50 1.97
2 SGTC_2408 sulbentine 10.30 18.4 µM 3.32E-22 4 2.90E-25 0.13
3 SGTC_2974 9094440 9.71 9.7 µM 6.88E-20 ergosterol biosynthesis 3 1.33E-22 0.90
4 SGTC_288 1315-0019 9.57 35.1 µM 2.30E-19 RSC & ERG11 5 5.32E-22 1.79
5 SGTC_2799 7812892 8.69 81.8 µM 2.77E-16 superoxide 2 1.85E-18 0.93
6 SGTC_2928 9011484 7.81 9.8 µM 1.70E-13 heme biosynthesis & mitochondrial translocase 4 2.93E-15 0.05
7 SGTC_586 0957-0265 7.76 8.2 µM 2.37E-13 cell wall 17 4.29E-15 0.67
8 SGTC_2459 5811157 7.69 9.2 µM 3.73E-13 mitochondrial processes 5 7.23E-15 2.64
9 SGTC_829 1635-0120 7.63 117.0 µM 5.83E-13 DNA damage response 19 1.21E-14 0.37
10 SGTC_2344 7990960 7.23 77.0 µM 7.77E-12 14 2.36E-13 0.50
11 SGTC_673 1082-0474 6.84 110.0 µM 9.03E-11 RSC complex & mRNA processing 23 3.94E-12 0.15
12 SGTC_145 3737-0113 6.60 38.4 µM 3.71E-10 DNA intercalators 12 1.99E-11 0.10
13 SGTC_1044 1222-0021 6.27 1.8 µM 2.59E-9 heme biosynthesis & mitochondrial translocase 10 1.86E-10 0.00
14 SGTC_22 0964-0034 6.10 14.5 µM 6.47E-9 unfolded protein response 16 5.29E-10 0.07
15 SGTC_1 0258-0098 6.07 57.4 µM 7.72E-9 heme biosynthesis & mitochondrial translocase 6 6.49E-10 0.28
16 SGTC_546 peri-Naphthalide 6.05 147.0 µM 8.36E-9 DNA damage response 7 7.10E-10 0.31
17 SGTC_1722 st034304 5.95 3.6 µM 1.49E-8 mitochondrial processes 3 1.38E-9 0.43
18 SGTC_994 3910-0338 5.79 138.0 µM 3.30E-8 calcium & mitochondrial duress 1 3.43E-9 0.50
19 SGTC_151 3013-0144 5.70 2.3 µM 5.27E-8 iron homeostasis 3 5.86E-9 0.15
20 SGTC_1050 3232-1156 5.60 69.3 µM 8.77E-8 RSC complex & mRNA processing 11 1.05E-8 0.13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.435 6.38E-155 YDR016C DAD1 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.396 8.95E-126 YIL126W STH1 het ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
0.352 6.84E-98 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.330 9.94E-86 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.310 1.16E-75 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.302 2.34E-71 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.285 1.39E-63 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.282 3.91E-62 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.274 7.95E-59 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.256 5.81E-51 YEL034W HYP2 het Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.251 3.17E-49 YBR143C SUP45 het Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p
0.248 3.38E-48 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.232 4.17E-42 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.227 2.85E-40 YPR107C YTH1 het Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
0.226 4.88E-40 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;