HIPHOP chemogenomics database

YJL039C / NUP192

Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205

Zygosity: Heterozygous strain

fixedexpanded
Profile for YJL039C / NUP192

Click on Significant Values for Screen Details

Top fitness defect scores for YJL039C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_138	0850-0259	14.90	40.9 µM	3.02E-44	cell wall	5	1.32E-50	1.97
2	SGTC_2408	sulbentine	10.30	18.4 µM	3.32E-22		4	2.90E-25	0.13
3	SGTC_2974	9094440	9.71	9.7 µM	6.88E-20	ergosterol biosynthesis	3	1.33E-22	0.90
4	SGTC_288	1315-0019	9.57	35.1 µM	2.30E-19	RSC & ERG11	5	5.32E-22	1.79
5	SGTC_2799	7812892	8.69	81.8 µM	2.77E-16	superoxide	2	1.85E-18	0.93
6	SGTC_2928	9011484	7.81	9.8 µM	1.70E-13	heme biosynthesis & mitochondrial translocase	4	2.93E-15	0.05
7	SGTC_586	0957-0265	7.76	8.2 µM	2.37E-13	cell wall	17	4.29E-15	0.67
8	SGTC_2459	5811157	7.69	9.2 µM	3.73E-13	mitochondrial processes	5	7.23E-15	2.64
9	SGTC_829	1635-0120	7.63	117.0 µM	5.83E-13	DNA damage response	19	1.21E-14	0.37
10	SGTC_2344	7990960	7.23	77.0 µM	7.77E-12		14	2.36E-13	0.50
11	SGTC_673	1082-0474	6.84	110.0 µM	9.03E-11	RSC complex & mRNA processing	23	3.94E-12	0.15
12	SGTC_145	3737-0113	6.60	38.4 µM	3.71E-10	DNA intercalators	12	1.99E-11	0.10
13	SGTC_1044	1222-0021	6.27	1.8 µM	2.59E-9	heme biosynthesis & mitochondrial translocase	10	1.86E-10	0.00
14	SGTC_22	0964-0034	6.10	14.5 µM	6.47E-9	unfolded protein response	16	5.29E-10	0.07
15	SGTC_1	0258-0098	6.07	57.4 µM	7.72E-9	heme biosynthesis & mitochondrial translocase	6	6.49E-10	0.28
16	SGTC_546	peri-Naphthalide	6.05	147.0 µM	8.36E-9	DNA damage response	7	7.10E-10	0.31
17	SGTC_1722	st034304	5.95	3.6 µM	1.49E-8	mitochondrial processes	3	1.38E-9	0.43
18	SGTC_994	3910-0338	5.79	138.0 µM	3.30E-8	calcium & mitochondrial duress	1	3.43E-9	0.50
19	SGTC_151	3013-0144	5.70	2.3 µM	5.27E-8	iron homeostasis	3	5.86E-9	0.15
20	SGTC_1050	3232-1156	5.60	69.3 µM	8.77E-8	RSC complex & mRNA processing	11	1.05E-8	0.13

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.435	6.38E-155	YDR016C	DAD1	het	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.396	8.95E-126	YIL126W	STH1	het	ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
0.352	6.84E-98	YLR321C	SFH1	het	Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.330	9.94E-86	YLR033W	RSC58	het	Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.310	1.16E-75	YML127W	RSC9	het	Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.302	2.34E-71	YFR037C	RSC8	het	Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.285	1.39E-63	YER165W	PAB1	het	Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.282	3.91E-62	YBR091C	TIM12	het	Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.274	7.95E-59	YPR034W	ARP7	het	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.256	5.81E-51	YEL034W	HYP2	het	Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.251	3.17E-49	YBR143C	SUP45	het	Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p
0.248	3.38E-48	YOR236W	DFR1	het	Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.232	4.17E-42	YPR104C	FHL1	het	Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.227	2.85E-40	YPR107C	YTH1	het	Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
0.226	4.88E-40	YNR016C	ACC1	het	Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;