YJL042W / MHP1

Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL042W / MHP1

Click on Significant Values for Screen Details ID:SGTC_367|Compound:0335-0881|FD-Score:2.91|P-value:8.37E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:4.57|P-value:3.68E-7 ID:SGTC_814|Compound:3342-0569|FD-Score:-3.34|P-value:1.46E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.43|P-value:9.81E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:-2.92|P-value:7.68E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.14|P-value:3.38E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.25|P-value:2.22E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.19|P-value:2.73E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:5.00|P-value:3.09E-8 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.82|P-value:1.79E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:2.89|P-value:8.98E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-2.94|P-value:7.05E-4 ID:SGTC_1614|Compound:st002383|FD-Score:-3.11|P-value:3.70E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.26|P-value:2.08E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-2.87|P-value:9.08E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.15|P-value:3.30E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.47|P-value:8.16E-5 ID:SGTC_2452|Compound:5863136|FD-Score:3.15|P-value:3.30E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.14|P-value:3.38E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.14|P-value:3.47E-4 ID:SGTC_2788|Compound:5282734|FD-Score:2.93|P-value:7.52E-4 ID:SGTC_2807|Compound:7945238|FD-Score:5.23|P-value:7.30E-9 ID:SGTC_2837|Compound:9008476|FD-Score:3.94|P-value:1.03E-5 ID:SGTC_3217|Compound:9129673|FD-Score:3.51|P-value:7.46E-5 ID:SGTC_3219|Compound:9131112|FD-Score:3.16|P-value:3.09E-4 ID:SGTC_3252|Compound:9135871|FD-Score:2.91|P-value:8.36E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:2.91|P-value:8.37E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:4.57|P-value:3.68E-7 ID:SGTC_814|Compound:3342-0569|FD-Score:-3.34|P-value:1.46E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.43|P-value:9.81E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:-2.92|P-value:7.68E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.14|P-value:3.38E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.25|P-value:2.22E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.19|P-value:2.73E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:5.00|P-value:3.09E-8 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.82|P-value:1.79E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:2.89|P-value:8.98E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-2.94|P-value:7.05E-4 ID:SGTC_1614|Compound:st002383|FD-Score:-3.11|P-value:3.70E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.26|P-value:2.08E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-2.87|P-value:9.08E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.15|P-value:3.30E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.47|P-value:8.16E-5 ID:SGTC_2452|Compound:5863136|FD-Score:3.15|P-value:3.30E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.14|P-value:3.38E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.14|P-value:3.47E-4 ID:SGTC_2788|Compound:5282734|FD-Score:2.93|P-value:7.52E-4 ID:SGTC_2807|Compound:7945238|FD-Score:5.23|P-value:7.30E-9 ID:SGTC_2837|Compound:9008476|FD-Score:3.94|P-value:1.03E-5 ID:SGTC_3217|Compound:9129673|FD-Score:3.51|P-value:7.46E-5 ID:SGTC_3219|Compound:9131112|FD-Score:3.16|P-value:3.09E-4 ID:SGTC_3252|Compound:9135871|FD-Score:2.91|P-value:8.36E-4

Top fitness defect scores for YJL042W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2807 7945238 5.23 52.0 µM 7.30E-9 7 8.27E-8
2 SGTC_1388 3346-4487 5.00 254.0 µM 3.09E-8 6 2.85E-7
3 SGTC_534 k292-0788 4.57 63.4 µM 3.68E-7 mitochondrial processes 17 2.38E-6
4 SGTC_2837 9008476 3.94 45.5 µM 1.03E-5 33 4.15E-5
5 SGTC_1579 chlormadinone acetate 3.82 49.4 µM 1.79E-5 9 6.67E-5
6 SGTC_3217 9129673 3.51 49.5 µM 7.46E-5 58 2.28E-4
7 SGTC_1717 st033143 3.26 58.0 µM 2.08E-4 78 5.51E-4
8 SGTC_1322 1348-1070 3.25 12.0 µM 2.22E-4 22 5.84E-4
9 SGTC_3219 9131112 3.16 49.5 µM 3.09E-4 Golgi 63 7.76E-4
10 SGTC_2119 5528445 3.15 120.6 µM 3.30E-4 50 8.21E-4
11 SGTC_2452 5863136 3.15 48.4 µM 3.30E-4 55 8.22E-4
12 SGTC_1235 benzylparaben 3.14 21.5 µM 3.38E-4 37 8.39E-4
13 SGTC_2588 indole-3-carbinol 3.14 100.0 µM 3.38E-4 95 8.39E-4
14 SGTC_2676 harmalol 3.14 100.0 µM 3.47E-4 mitochondrial processes 38 8.58E-4
15 SGTC_2788 5282734 2.93 71.4 µM 7.52E-4 113 0.00167
16 SGTC_3252 9135871 2.91 49.5 µM 8.36E-4 53 0.00183
17 SGTC_367 0335-0881 2.91 7.1 µM 8.37E-4 ubiquinone biosynthesis & proteasome 146 0.00183
18 SGTC_1597 7-benzyloxygramine 2.89 47.5 µM 8.98E-4 calcium & mitochondrial duress 236 0.00195
19 SGTC_2435 5706476 2.84 10.6 µM 0.00108 81 0.00228
20 SGTC_937 3122-0005 2.79 46.7 µM 0.00127 87 0.00263

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 4.71E-17 YLR080W EMP46 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
0.135 4.27E-15 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.134 7.42E-15 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.127 1.77E-13 YHL041W_d YHL041W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.115 2.23E-11 YAL016C-B_d YAL016C-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.110 1.42E-10 YNL249C MPA43 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.099 7.72E-9 YGR091W PRP31 het Splicing factor, component of the U4/U6-U5 snRNP complex
0.097 1.72E-8 YPL110C GDE1 hom Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes
0.095 3.16E-8 YMR195W ICY1 hom Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
0.095 3.69E-8 YLL053C_p YLL053C_p hom Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
0.093 6.48E-8 YOL163W_p YOL163W_p hom Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
0.092 9.09E-8 YLL024C SSA2 hom ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% identical with paralog Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes
0.092 9.91E-8 YDL172C_d YDL172C_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.090 1.97E-7 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.088 3.05E-7 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport