YJL044C / GYP6

GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL044C / GYP6

Click on Significant Values for Screen Details ID:SGTC_32|Compound:0928-0142|FD-Score:5.99|P-value:2.31E-9 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.34|P-value:5.96E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.24|P-value:7.31E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.84|P-value:9.63E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.78|P-value:1.22E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:-3.29|P-value:6.97E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:4.57|P-value:3.78E-6 ID:SGTC_322|Compound:k048-0136|FD-Score:4.38|P-value:8.83E-6 ID:SGTC_323|Compound:4013-0906|FD-Score:3.21|P-value:8.09E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-4.91|P-value:8.87E-7 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.54|P-value:2.92E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:-3.31|P-value:6.67E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.28|P-value:6.42E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:-5.30|P-value:1.30E-7 ID:SGTC_991|Compound:3996-0057|FD-Score:3.65|P-value:1.71E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.96|P-value:5.88E-7 ID:SGTC_1005|Compound:4092-0690|FD-Score:-4.12|P-value:3.11E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:4.50|P-value:5.07E-6 ID:SGTC_1009|Compound:4106-0057|FD-Score:-3.22|P-value:8.89E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.30|P-value:1.24E-5 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.16|P-value:9.66E-4 ID:SGTC_1607|Compound:st000305|FD-Score:-3.39|P-value:4.95E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.95|P-value:5.31E-5 ID:SGTC_1621|Compound:st003705|FD-Score:-3.47|P-value:3.77E-4 ID:SGTC_1624|Compound:st003710|FD-Score:-4.85|P-value:1.24E-6 ID:SGTC_1717|Compound:st033143|FD-Score:4.25|P-value:1.52E-5 ID:SGTC_1725|Compound:st036284|FD-Score:5.99|P-value:2.24E-9 ID:SGTC_1730|Compound:st033808|FD-Score:-3.22|P-value:9.03E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.38|P-value:4.61E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:5.84|P-value:5.28E-9 ID:SGTC_2049|Compound:5262831|FD-Score:3.32|P-value:5.68E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.87|P-value:7.41E-5 ID:SGTC_2266|Compound:7929956|FD-Score:3.42|P-value:3.91E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-4.88|P-value:1.05E-6 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.36|P-value:9.84E-6 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.68|P-value:1.52E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.42|P-value:3.95E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.51|P-value:3.33E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.75|P-value:1.17E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.56|P-value:2.38E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.59|P-value:2.17E-4 ID:SGTC_3039|Compound:9090270|FD-Score:-3.19|P-value:9.82E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.27|P-value:6.59E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.44|P-value:3.72E-4 ID:SGTC_3056|Compound:9094900|FD-Score:4.40|P-value:8.15E-6 ID:SGTC_3180|Compound:9109287|FD-Score:3.22|P-value:7.99E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.28|P-value:7.32E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.22|P-value:8.93E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.29|P-value:7.07E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.45|P-value:3.53E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:5.99|P-value:2.31E-9 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.34|P-value:5.96E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.24|P-value:7.31E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.84|P-value:9.63E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.78|P-value:1.22E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:-3.29|P-value:6.97E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:4.57|P-value:3.78E-6 ID:SGTC_322|Compound:k048-0136|FD-Score:4.38|P-value:8.83E-6 ID:SGTC_323|Compound:4013-0906|FD-Score:3.21|P-value:8.09E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-4.91|P-value:8.87E-7 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.54|P-value:2.92E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:-3.31|P-value:6.67E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.28|P-value:6.42E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:-5.30|P-value:1.30E-7 ID:SGTC_991|Compound:3996-0057|FD-Score:3.65|P-value:1.71E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.96|P-value:5.88E-7 ID:SGTC_1005|Compound:4092-0690|FD-Score:-4.12|P-value:3.11E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:4.50|P-value:5.07E-6 ID:SGTC_1009|Compound:4106-0057|FD-Score:-3.22|P-value:8.89E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.30|P-value:1.24E-5 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.16|P-value:9.66E-4 ID:SGTC_1607|Compound:st000305|FD-Score:-3.39|P-value:4.95E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.95|P-value:5.31E-5 ID:SGTC_1621|Compound:st003705|FD-Score:-3.47|P-value:3.77E-4 ID:SGTC_1624|Compound:st003710|FD-Score:-4.85|P-value:1.24E-6 ID:SGTC_1717|Compound:st033143|FD-Score:4.25|P-value:1.52E-5 ID:SGTC_1725|Compound:st036284|FD-Score:5.99|P-value:2.24E-9 ID:SGTC_1730|Compound:st033808|FD-Score:-3.22|P-value:9.03E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.38|P-value:4.61E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:5.84|P-value:5.28E-9 ID:SGTC_2049|Compound:5262831|FD-Score:3.32|P-value:5.68E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.87|P-value:7.41E-5 ID:SGTC_2266|Compound:7929956|FD-Score:3.42|P-value:3.91E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-4.88|P-value:1.05E-6 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.36|P-value:9.84E-6 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.68|P-value:1.52E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.42|P-value:3.95E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.51|P-value:3.33E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.75|P-value:1.17E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.56|P-value:2.38E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.59|P-value:2.17E-4 ID:SGTC_3039|Compound:9090270|FD-Score:-3.19|P-value:9.82E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.27|P-value:6.59E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.44|P-value:3.72E-4 ID:SGTC_3056|Compound:9094900|FD-Score:4.40|P-value:8.15E-6 ID:SGTC_3180|Compound:9109287|FD-Score:3.22|P-value:7.99E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.28|P-value:7.32E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.22|P-value:8.93E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.29|P-value:7.07E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.45|P-value:3.53E-4

Top fitness defect scores for YJL044C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1725 st036284 5.99 20.6 µM 2.24E-9 6 1.04E-9
2 SGTC_32 0928-0142 5.99 34.1 µM 2.31E-9 TSC3-RPN4 2 1.07E-9
3 SGTC_1879 gemcitabine 5.84 100.0 µM 5.28E-9 1 2.55E-9
4 SGTC_999 4022-0066 4.96 22.7 µM 5.88E-7 Golgi 20 3.51E-7
5 SGTC_157 1348-1695 4.57 65.8 µM 3.78E-6 iron homeostasis 41 2.45E-6
6 SGTC_1007 4101-0031 4.50 70.0 µM 5.07E-6 9 3.33E-6
7 SGTC_3056 9094900 4.40 49.5 µM 8.15E-6 13 5.46E-6
8 SGTC_322 k048-0136 4.38 19.3 µM 8.83E-6 RSC & ERG11 9 5.94E-6
9 SGTC_2552 juarezic acid 4.36 87.0 µM 9.84E-6 TSC3-RPN4 25 6.65E-6
10 SGTC_1244 0416-0015 4.30 52.5 µM 1.24E-5 ERG2 24 8.47E-6
11 SGTC_1717 st033143 4.25 58.0 µM 1.52E-5 32 1.05E-5
12 SGTC_1611 st001856 3.95 99.4 µM 5.31E-5 15 3.86E-5
13 SGTC_2173 5763948 3.87 167.0 µM 7.41E-5 tubulin folding & SWR complex 13 5.47E-5
14 SGTC_2815 7968870 3.75 71.4 µM 1.17E-4 27 8.78E-5
15 SGTC_2639 lactacystin 3.68 53.0 µM 1.52E-4 33 1.15E-4
16 SGTC_991 3996-0057 3.65 64.7 µM 1.71E-4 26 1.30E-4
17 SGTC_2836 9010338 3.59 19.5 µM 2.17E-4 RPP1 & pyrimidine depletion 44 1.68E-4
18 SGTC_2832 7992762 3.56 52.0 µM 2.38E-4 44 1.84E-4
19 SGTC_3339 9145883 3.45 14.9 µM 3.53E-4 23 2.78E-4
20 SGTC_3054 9094397 3.44 49.5 µM 3.72E-4 fatty acid desaturase (OLE1) 50 2.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.31E-11 YMR195W ICY1 hom Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
0.110 1.92E-10 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.108 3.14E-10 YLR297W YLR297W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication
0.097 1.95E-8 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.094 4.30E-8 YER176W ECM32 hom DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
0.094 5.07E-8 YER145C FTR1 hom High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress
0.088 3.46E-7 YOR185C GSP2 hom GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability; protein abundance increases in response to DNA replication stress
0.083 1.62E-6 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 1.97E-6 YJR131W MNS1 hom Alpha-1,2-mannosidase involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation
0.081 2.51E-6 YOR256C TRE2 het Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication
0.077 8.40E-6 YOR007C SGT2 hom Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress
0.074 1.62E-5 YGL104C VPS73 hom Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family
0.071 3.68E-5 YAL064C-A_p TDA8_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene
0.071 4.10E-5 YOL109W ZEO1 hom Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria
0.070 4.61E-5 YPR128C ANT1 hom Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation