YJL045W

Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL045W / YJL045W

Click on Significant Values for Screen Details ID:SGTC_251|Compound:melphalan|FD-Score:-3.41|P-value:4.12E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:4.02|P-value:2.95E-5 ID:SGTC_286|Compound:k060-0067|FD-Score:3.28|P-value:5.06E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:4.27|P-value:9.96E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.29|P-value:4.99E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.90|P-value:4.87E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.19|P-value:8.74E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:4.07|P-value:2.32E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:-3.76|P-value:1.11E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.89|P-value:6.53E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:-4.43|P-value:6.52E-6 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.82|P-value:8.75E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.16|P-value:1.58E-5 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.31|P-value:5.89E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-3.51|P-value:2.83E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.41|P-value:4.12E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.27|P-value:5.32E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.23|P-value:6.16E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:5.53|P-value:1.74E-8 ID:SGTC_1453|Compound:4237-0541|FD-Score:4.97|P-value:3.44E-7 ID:SGTC_1476|Compound:4112-3294|FD-Score:4.00|P-value:3.15E-5 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.31|P-value:4.64E-4 ID:SGTC_1548|Compound:st061468|FD-Score:3.11|P-value:9.20E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-4.20|P-value:1.83E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.19|P-value:7.06E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.23|P-value:6.00E-4 ID:SGTC_1979|Compound:st071809|FD-Score:3.38|P-value:3.55E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.12|P-value:8.70E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.28|P-value:9.69E-6 ID:SGTC_2346|Compound:9031566|FD-Score:-4.26|P-value:1.43E-5 ID:SGTC_2404|Compound:5161160|FD-Score:3.21|P-value:6.59E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.90|P-value:4.77E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:3.57|P-value:1.78E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.36|P-value:4.99E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.17|P-value:7.47E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.40|P-value:3.30E-4 ID:SGTC_2800|Compound:7887935|FD-Score:3.81|P-value:7.05E-5 ID:SGTC_2816|Compound:7982706|FD-Score:-5.59|P-value:1.81E-8 ID:SGTC_2853|Compound:9015042|FD-Score:-3.20|P-value:8.50E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.37|P-value:3.77E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.23|P-value:7.70E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-3.60|P-value:2.04E-4 ID:SGTC_3047|Compound:9092122|FD-Score:-3.23|P-value:7.65E-4 ID:SGTC_3113|Compound:9123498|FD-Score:-4.04|P-value:3.57E-5 ID:SGTC_3147|Compound:9097027|FD-Score:3.46|P-value:2.64E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.21|P-value:6.49E-4 ID:SGTC_3175|Compound:9106517|FD-Score:-3.28|P-value:6.48E-4 ID:SGTC_3179|Compound:9107801|FD-Score:-4.33|P-value:1.05E-5 ID:SGTC_3187|Compound:9109394|FD-Score:3.15|P-value:8.12E-4 ID:SGTC_251|Compound:melphalan|FD-Score:-3.41|P-value:4.12E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:4.02|P-value:2.95E-5 ID:SGTC_286|Compound:k060-0067|FD-Score:3.28|P-value:5.06E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:4.27|P-value:9.96E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.29|P-value:4.99E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.90|P-value:4.87E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.19|P-value:8.74E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:4.07|P-value:2.32E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:-3.76|P-value:1.11E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.89|P-value:6.53E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:-4.43|P-value:6.52E-6 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.82|P-value:8.75E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.16|P-value:1.58E-5 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.31|P-value:5.89E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-3.51|P-value:2.83E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.41|P-value:4.12E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.27|P-value:5.32E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.23|P-value:6.16E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:5.53|P-value:1.74E-8 ID:SGTC_1453|Compound:4237-0541|FD-Score:4.97|P-value:3.44E-7 ID:SGTC_1476|Compound:4112-3294|FD-Score:4.00|P-value:3.15E-5 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.31|P-value:4.64E-4 ID:SGTC_1548|Compound:st061468|FD-Score:3.11|P-value:9.20E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-4.20|P-value:1.83E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.19|P-value:7.06E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.23|P-value:6.00E-4 ID:SGTC_1979|Compound:st071809|FD-Score:3.38|P-value:3.55E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.12|P-value:8.70E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.28|P-value:9.69E-6 ID:SGTC_2346|Compound:9031566|FD-Score:-4.26|P-value:1.43E-5 ID:SGTC_2404|Compound:5161160|FD-Score:3.21|P-value:6.59E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.90|P-value:4.77E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:3.57|P-value:1.78E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.36|P-value:4.99E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.17|P-value:7.47E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.40|P-value:3.30E-4 ID:SGTC_2800|Compound:7887935|FD-Score:3.81|P-value:7.05E-5 ID:SGTC_2816|Compound:7982706|FD-Score:-5.59|P-value:1.81E-8 ID:SGTC_2853|Compound:9015042|FD-Score:-3.20|P-value:8.50E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.37|P-value:3.77E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.23|P-value:7.70E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-3.60|P-value:2.04E-4 ID:SGTC_3047|Compound:9092122|FD-Score:-3.23|P-value:7.65E-4 ID:SGTC_3113|Compound:9123498|FD-Score:-4.04|P-value:3.57E-5 ID:SGTC_3147|Compound:9097027|FD-Score:3.46|P-value:2.64E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.21|P-value:6.49E-4 ID:SGTC_3175|Compound:9106517|FD-Score:-3.28|P-value:6.48E-4 ID:SGTC_3179|Compound:9107801|FD-Score:-4.33|P-value:1.05E-5 ID:SGTC_3187|Compound:9109394|FD-Score:3.15|P-value:8.12E-4

Top fitness defect scores for YJL045W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1451 4152-0210 5.53 104.0 µM 1.74E-8 4 1.60E-8
2 SGTC_1453 4237-0541 4.97 195.0 µM 3.44E-7 heme biosynthesis & mitochondrial translocase 11 3.27E-7
3 SGTC_2128 5255449 4.28 168.5 µM 9.69E-6 28 9.52E-6
4 SGTC_420 mitomycin C 4.27 81.9 mM 9.96E-6 14 9.79E-6
5 SGTC_1042 0350-0096 4.16 82.0 µM 1.58E-5 TSC3-RPN4 21 1.56E-5
6 SGTC_588 3970-1144 4.07 52.9 µM 2.32E-5 26 2.30E-5
7 SGTC_285 1486-1325 4.02 46.0 µM 2.95E-5 18 2.93E-5
8 SGTC_1476 4112-3294 4.00 3.3 µM 3.15E-5 60S ribosome export 14 3.13E-5
9 SGTC_2514 salinomycin 3.90 42.7 µM 4.77E-5 49 4.76E-5
10 SGTC_517 1365-0151 3.90 113.0 µM 4.87E-5 33 4.86E-5
11 SGTC_2800 7887935 3.81 81.8 µM 7.05E-5 RPP1 & pyrimidine depletion 39 7.06E-5
12 SGTC_2586 curcumin 3.57 80.0 µM 1.78E-4 iron homeostasis 71 1.79E-4
13 SGTC_3147 9097027 3.46 49.5 µM 2.64E-4 40 2.67E-4
14 SGTC_2742 clothiapine 3.40 36.3 µM 3.30E-4 NEO1 29 3.35E-4
15 SGTC_1979 st071809 3.38 45.3 µM 3.55E-4 RPP1 & pyrimidine depletion 31 3.60E-4
16 SGTC_2877 9040724 3.37 71.4 µM 3.77E-4 31 3.83E-4
17 SGTC_1546 5-methoxyflavanone 3.31 78.7 µM 4.64E-4 25 4.72E-4
18 SGTC_453 enantio-paf c16 3.29 10.0 µM 4.99E-4 209 5.08E-4
19 SGTC_286 k060-0067 3.28 22.9 µM 5.06E-4 tubulin folding & SWR complex 41 5.15E-4
20 SGTC_1188 1403-0014 3.27 4.6 µM 5.32E-4 mitochondrial stress 85 5.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 8.34E-16 YGR295C COS6 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.098 1.43E-8 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.095 3.58E-8 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.091 1.43E-7 YMR074C YMR074C hom Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress
0.089 2.15E-7 YPL249C GYP5 hom GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.085 8.80E-7 YOR364W_d YOR364W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C
0.082 1.83E-6 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.082 1.99E-6 YFL055W AGP3 hom Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
0.080 3.64E-6 YOL097C WRS1 het Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA
0.079 4.46E-6 YGR048W UFD1 het Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP)
0.078 5.39E-6 YMR165C PAH1 hom Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; responsible for de novo lipid synthesis and formation of lipid droplets; phosphorylation by Pho80p-Pho85p decreases catalytic activity and alters Pah1p localization and abundance; phosphorylation by protein kinase A decreases catalytic efficiency; dephosphorylation by Nem1p-Spo7p anchors Pah1p to the membrane increasing substrate catalysis; homologous to mammalian lipins 1 and 2
0.077 7.16E-6 YMR229C RRP5 het RNA binding protein involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; has binding preference for single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress
0.077 8.00E-6 YML002W_p YML002W_p hom Putative protein of unknown function; expression induced by heat and by calcium shortage
0.076 9.44E-6 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.075 1.26E-5 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily