YJL047C / RTT101

Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL047C / RTT101

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:7.59|P-value:1.77E-12 ID:SGTC_59|Compound:0330-0160|FD-Score:4.78|P-value:6.13E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:4.85|P-value:4.65E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:4.16|P-value:7.04E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:3.91|P-value:1.78E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.53|P-value:5.69E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:4.80|P-value:5.77E-6 ID:SGTC_211|Compound:3455-0679|FD-Score:3.69|P-value:3.69E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:3.99|P-value:1.32E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:6.44|P-value:1.84E-9 ID:SGTC_268|Compound:camptothecin|FD-Score:7.78|P-value:5.19E-13 ID:SGTC_446|Compound:go6976|FD-Score:-3.37|P-value:9.52E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.96|P-value:1.46E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.86|P-value:4.37E-6 ID:SGTC_676|Compound:falcarinol|FD-Score:-5.05|P-value:1.69E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.12|P-value:8.31E-5 ID:SGTC_774|Compound:k060-0086|FD-Score:-3.62|P-value:4.28E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:-6.75|P-value:2.68E-10 ID:SGTC_890|Compound:0929-0006|FD-Score:-5.07|P-value:1.52E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.76|P-value:6.67E-6 ID:SGTC_916|Compound:4466-0038|FD-Score:6.83|P-value:2.06E-10 ID:SGTC_931|Compound:2812-0076|FD-Score:3.44|P-value:8.46E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:-5.67|P-value:9.15E-8 ID:SGTC_1050|Compound:3232-1156|FD-Score:5.13|P-value:1.33E-6 ID:SGTC_1078|Compound:idebenone|FD-Score:8.19|P-value:3.09E-14 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.55|P-value:5.83E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:8.89|P-value:1.87E-16 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.51|P-value:6.66E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.08|P-value:9.57E-5 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.41|P-value:9.24E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.49|P-value:7.13E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.65|P-value:4.22E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.42|P-value:2.67E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:-3.82|P-value:2.15E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:5.51|P-value:2.34E-7 ID:SGTC_1504|Compound:k297-0033|FD-Score:5.35|P-value:4.93E-7 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.57|P-value:5.61E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:6.15|P-value:9.19E-9 ID:SGTC_1540|Compound:guanosine|FD-Score:3.59|P-value:5.12E-4 ID:SGTC_1663|Compound:st014140|FD-Score:3.94|P-value:1.56E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-3.70|P-value:3.27E-4 ID:SGTC_1707|Compound:st032323|FD-Score:5.43|P-value:3.45E-7 ID:SGTC_1724|Compound:st037281|FD-Score:5.63|P-value:1.31E-7 ID:SGTC_1843|Compound:st055809|FD-Score:3.51|P-value:6.81E-4 ID:SGTC_1845|Compound:st056753|FD-Score:13.70|P-value:1.07E-36 ID:SGTC_1913|Compound:st060213|FD-Score:3.67|P-value:4.02E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-3.74|P-value:2.84E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.64|P-value:4.47E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.44|P-value:8.43E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.97|P-value:1.42E-4 ID:SGTC_1976|Compound:st070609|FD-Score:4.37|P-value:3.17E-5 ID:SGTC_2111|Compound:5486399|FD-Score:3.83|P-value:2.31E-4 ID:SGTC_2135|Compound:5326629|FD-Score:4.08|P-value:9.57E-5 ID:SGTC_2188|Compound:6126565|FD-Score:4.45|P-value:2.36E-5 ID:SGTC_2194|Compound:5927483|FD-Score:4.06|P-value:1.02E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.74|P-value:3.11E-4 ID:SGTC_2279|Compound:7948423|FD-Score:4.13|P-value:7.86E-5 ID:SGTC_2354|Compound:9060492|FD-Score:4.62|P-value:1.20E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.70|P-value:3.64E-4 ID:SGTC_2369|Compound:9071472|FD-Score:5.72|P-value:8.31E-8 ID:SGTC_2421|Compound:5690543|FD-Score:4.70|P-value:8.43E-6 ID:SGTC_2507|Compound:purpurin|FD-Score:4.76|P-value:6.60E-6 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:6.84|P-value:1.94E-10 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.77|P-value:2.88E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.73|P-value:3.26E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.42|P-value:8.84E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:4.68|P-value:9.44E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:5.44|P-value:3.26E-7 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.57|P-value:1.76E-7 ID:SGTC_2738|Compound:aclarubicin|FD-Score:6.29|P-value:4.31E-9 ID:SGTC_2743|Compound:auranofin|FD-Score:-4.07|P-value:9.00E-5 ID:SGTC_2747|Compound:doxorubicin|FD-Score:4.38|P-value:3.09E-5 ID:SGTC_2793|Compound:7325131|FD-Score:6.72|P-value:3.81E-10 ID:SGTC_2797|Compound:7859098|FD-Score:4.42|P-value:2.62E-5 ID:SGTC_2864|Compound:9034755|FD-Score:4.18|P-value:6.71E-5 ID:SGTC_2948|Compound:9070189|FD-Score:3.46|P-value:7.88E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.63|P-value:4.48E-4 ID:SGTC_3231|Compound:9132313|FD-Score:4.11|P-value:8.57E-5 ID:SGTC_3236|Compound:9132701|FD-Score:4.94|P-value:3.13E-6 ID:SGTC_3254|Compound:9136651|FD-Score:4.73|P-value:7.53E-6 ID:SGTC_3354|Compound:9151612|FD-Score:3.69|P-value:3.68E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.59|P-value:1.77E-12 ID:SGTC_59|Compound:0330-0160|FD-Score:4.78|P-value:6.13E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:4.85|P-value:4.65E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:4.16|P-value:7.04E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:3.91|P-value:1.78E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.53|P-value:5.69E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:4.80|P-value:5.77E-6 ID:SGTC_211|Compound:3455-0679|FD-Score:3.69|P-value:3.69E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:3.99|P-value:1.32E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:6.44|P-value:1.84E-9 ID:SGTC_268|Compound:camptothecin|FD-Score:7.78|P-value:5.19E-13 ID:SGTC_446|Compound:go6976|FD-Score:-3.37|P-value:9.52E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.96|P-value:1.46E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.86|P-value:4.37E-6 ID:SGTC_676|Compound:falcarinol|FD-Score:-5.05|P-value:1.69E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.12|P-value:8.31E-5 ID:SGTC_774|Compound:k060-0086|FD-Score:-3.62|P-value:4.28E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:-6.75|P-value:2.68E-10 ID:SGTC_890|Compound:0929-0006|FD-Score:-5.07|P-value:1.52E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.76|P-value:6.67E-6 ID:SGTC_916|Compound:4466-0038|FD-Score:6.83|P-value:2.06E-10 ID:SGTC_931|Compound:2812-0076|FD-Score:3.44|P-value:8.46E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:-5.67|P-value:9.15E-8 ID:SGTC_1050|Compound:3232-1156|FD-Score:5.13|P-value:1.33E-6 ID:SGTC_1078|Compound:idebenone|FD-Score:8.19|P-value:3.09E-14 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.55|P-value:5.83E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:8.89|P-value:1.87E-16 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.51|P-value:6.66E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.08|P-value:9.57E-5 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.41|P-value:9.24E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.49|P-value:7.13E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.65|P-value:4.22E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.42|P-value:2.67E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:-3.82|P-value:2.15E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:5.51|P-value:2.34E-7 ID:SGTC_1504|Compound:k297-0033|FD-Score:5.35|P-value:4.93E-7 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.57|P-value:5.61E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:6.15|P-value:9.19E-9 ID:SGTC_1540|Compound:guanosine|FD-Score:3.59|P-value:5.12E-4 ID:SGTC_1663|Compound:st014140|FD-Score:3.94|P-value:1.56E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-3.70|P-value:3.27E-4 ID:SGTC_1707|Compound:st032323|FD-Score:5.43|P-value:3.45E-7 ID:SGTC_1724|Compound:st037281|FD-Score:5.63|P-value:1.31E-7 ID:SGTC_1843|Compound:st055809|FD-Score:3.51|P-value:6.81E-4 ID:SGTC_1845|Compound:st056753|FD-Score:13.70|P-value:1.07E-36 ID:SGTC_1913|Compound:st060213|FD-Score:3.67|P-value:4.02E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-3.74|P-value:2.84E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.64|P-value:4.47E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.44|P-value:8.43E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.97|P-value:1.42E-4 ID:SGTC_1976|Compound:st070609|FD-Score:4.37|P-value:3.17E-5 ID:SGTC_2111|Compound:5486399|FD-Score:3.83|P-value:2.31E-4 ID:SGTC_2135|Compound:5326629|FD-Score:4.08|P-value:9.57E-5 ID:SGTC_2188|Compound:6126565|FD-Score:4.45|P-value:2.36E-5 ID:SGTC_2194|Compound:5927483|FD-Score:4.06|P-value:1.02E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.74|P-value:3.11E-4 ID:SGTC_2279|Compound:7948423|FD-Score:4.13|P-value:7.86E-5 ID:SGTC_2354|Compound:9060492|FD-Score:4.62|P-value:1.20E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.70|P-value:3.64E-4 ID:SGTC_2369|Compound:9071472|FD-Score:5.72|P-value:8.31E-8 ID:SGTC_2421|Compound:5690543|FD-Score:4.70|P-value:8.43E-6 ID:SGTC_2507|Compound:purpurin|FD-Score:4.76|P-value:6.60E-6 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:6.84|P-value:1.94E-10 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.77|P-value:2.88E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.73|P-value:3.26E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.42|P-value:8.84E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:4.68|P-value:9.44E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:5.44|P-value:3.26E-7 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.57|P-value:1.76E-7 ID:SGTC_2738|Compound:aclarubicin|FD-Score:6.29|P-value:4.31E-9 ID:SGTC_2743|Compound:auranofin|FD-Score:-4.07|P-value:9.00E-5 ID:SGTC_2747|Compound:doxorubicin|FD-Score:4.38|P-value:3.09E-5 ID:SGTC_2793|Compound:7325131|FD-Score:6.72|P-value:3.81E-10 ID:SGTC_2797|Compound:7859098|FD-Score:4.42|P-value:2.62E-5 ID:SGTC_2864|Compound:9034755|FD-Score:4.18|P-value:6.71E-5 ID:SGTC_2948|Compound:9070189|FD-Score:3.46|P-value:7.88E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.63|P-value:4.48E-4 ID:SGTC_3231|Compound:9132313|FD-Score:4.11|P-value:8.57E-5 ID:SGTC_3236|Compound:9132701|FD-Score:4.94|P-value:3.13E-6 ID:SGTC_3254|Compound:9136651|FD-Score:4.73|P-value:7.53E-6 ID:SGTC_3354|Compound:9151612|FD-Score:3.69|P-value:3.68E-4

Top fitness defect scores for YJL047C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1845 st056753 13.70 3.0 µM 1.07E-36 TSC3-RPN4 2 2.74E-43
2 SGTC_1082 camptothecin 8.89 424.9 nM 1.87E-16 DNA damage response 9 2.97E-19
3 SGTC_1078 idebenone 8.19 36.1 µM 3.09E-14 Golgi 7 1.27E-16
4 SGTC_268 camptothecin 7.78 39.6 µM 5.19E-13 DNA damage response 16 3.62E-15
5 SGTC_58 0957-0393 7.59 9.0 µM 1.77E-12 cell wall 139 1.55E-14
6 SGTC_2531 methyl deoxycholate 6.84 70.1 µM 1.94E-10 3 4.08E-12
7 SGTC_916 4466-0038 6.83 42.0 nM 2.06E-10 cell wall 20 4.37E-12
8 SGTC_2793 7325131 6.72 81.8 µM 3.81E-10 2 9.06E-12
9 SGTC_248 streptozotocin 6.44 5.2 mM 1.84E-9 DNA damage response 11 5.86E-11
10 SGTC_2738 aclarubicin 6.29 5.5 µM 4.31E-9 RNA pol III & RNase P/MRP 1 1.61E-10
11 SGTC_1507 4075-3230 6.15 155.0 µM 9.19E-9 3 3.95E-10
12 SGTC_2369 9071472 5.72 200.0 µM 8.31E-8 4 5.36E-9
13 SGTC_1724 st037281 5.63 8.3 µM 1.31E-7 12 9.21E-9
14 SGTC_2612 dictamnine 5.57 15.5 µM 1.76E-7 RNA pol III & RNase P/MRP 15 1.30E-8
15 SGTC_1452 4194-0072 5.51 190.0 µM 2.34E-7 2 1.83E-8
16 SGTC_2584 androsterone 5.44 48.7 µM 3.26E-7 cell wall 67 2.71E-8
17 SGTC_1707 st032323 5.43 6.3 µM 3.45E-7 DNA damage response 25 2.89E-8
18 SGTC_1504 k297-0033 5.35 30.0 µM 4.93E-7 2 4.42E-8
19 SGTC_1050 3232-1156 5.13 69.3 µM 1.33E-6 RSC complex & mRNA processing 9 1.43E-7
20 SGTC_3236 9132701 4.94 49.5 µM 3.13E-6 TSC3-RPN4 9 3.95E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.354 1.74E-99 YBR098W MMS4 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.313 4.54E-77 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.289 2.12E-65 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.285 1.12E-63 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.231 9.18E-42 YDR076W RAD55 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
0.219 1.03E-37 YGL163C RAD54 hom DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress
0.215 1.95E-36 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.184 6.46E-27 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.177 6.56E-25 YDR004W RAD57 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
0.173 5.13E-24 YJL092W SRS2 hom DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability
0.165 5.35E-22 YDR369C XRS2 hom Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling
0.164 1.33E-21 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.163 1.93E-21 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.161 6.25E-21 YER095W RAD51 hom Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
0.159 1.70E-20 YDR172W SUP35 het Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype