YJL047C-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL047C-A / YJL047C-A

Click on Significant Values for Screen Details ID:SGTC_203|Compound:k066-0004|FD-Score:-3.18|P-value:5.27E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:8.41|P-value:2.34E-18 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:4.29|P-value:5.04E-6 ID:SGTC_389|Compound:tpck|FD-Score:-5.23|P-value:3.57E-8 ID:SGTC_871|Compound:0574-0004|FD-Score:4.16|P-value:9.12E-6 ID:SGTC_872|Compound:0588-0139|FD-Score:4.09|P-value:1.26E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:3.12|P-value:6.56E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.02|P-value:9.51E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.41|P-value:2.25E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.34|P-value:2.87E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.40|P-value:2.33E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.34|P-value:3.88E-6 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.35|P-value:2.86E-4 ID:SGTC_1608|Compound:st001473|FD-Score:3.82|P-value:4.25E-5 ID:SGTC_1672|Compound:st016598|FD-Score:3.17|P-value:5.58E-4 ID:SGTC_1713|Compound:st033146|FD-Score:-3.11|P-value:6.83E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.10|P-value:7.02E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.25|P-value:4.18E-4 ID:SGTC_1895|Compound:st058434|FD-Score:-3.02|P-value:9.20E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.62|P-value:9.58E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.01|P-value:9.68E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.06|P-value:8.13E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.75|P-value:5.65E-5 ID:SGTC_2150|Compound:5556613|FD-Score:3.91|P-value:2.80E-5 ID:SGTC_2255|Compound:7941087|FD-Score:-3.16|P-value:5.72E-4 ID:SGTC_2412|Compound:st077135|FD-Score:3.00|P-value:9.97E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.56|P-value:1.26E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.22|P-value:4.62E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.57|P-value:1.19E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-3.41|P-value:2.21E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.28|P-value:3.68E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.48|P-value:1.72E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:-4.64|P-value:8.99E-7 ID:SGTC_2773|Compound:thioridazine|FD-Score:5.46|P-value:9.67E-9 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.69|P-value:7.10E-5 ID:SGTC_2932|Compound:9016711|FD-Score:3.25|P-value:4.10E-4 ID:SGTC_3139|Compound:9095020|FD-Score:3.03|P-value:8.98E-4 ID:SGTC_3205|Compound:9113483|FD-Score:4.55|P-value:1.39E-6 ID:SGTC_3208|Compound:9114115|FD-Score:3.80|P-value:4.58E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:-3.18|P-value:5.27E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:8.41|P-value:2.34E-18 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:4.29|P-value:5.04E-6 ID:SGTC_389|Compound:tpck|FD-Score:-5.23|P-value:3.57E-8 ID:SGTC_871|Compound:0574-0004|FD-Score:4.16|P-value:9.12E-6 ID:SGTC_872|Compound:0588-0139|FD-Score:4.09|P-value:1.26E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:3.12|P-value:6.56E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.02|P-value:9.51E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.41|P-value:2.25E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.34|P-value:2.87E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.40|P-value:2.33E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.34|P-value:3.88E-6 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.35|P-value:2.86E-4 ID:SGTC_1608|Compound:st001473|FD-Score:3.82|P-value:4.25E-5 ID:SGTC_1672|Compound:st016598|FD-Score:3.17|P-value:5.58E-4 ID:SGTC_1713|Compound:st033146|FD-Score:-3.11|P-value:6.83E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.10|P-value:7.02E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.25|P-value:4.18E-4 ID:SGTC_1895|Compound:st058434|FD-Score:-3.02|P-value:9.20E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.62|P-value:9.58E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.01|P-value:9.68E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.06|P-value:8.13E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.75|P-value:5.65E-5 ID:SGTC_2150|Compound:5556613|FD-Score:3.91|P-value:2.80E-5 ID:SGTC_2255|Compound:7941087|FD-Score:-3.16|P-value:5.72E-4 ID:SGTC_2412|Compound:st077135|FD-Score:3.00|P-value:9.97E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.56|P-value:1.26E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.22|P-value:4.62E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.57|P-value:1.19E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-3.41|P-value:2.21E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.28|P-value:3.68E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.48|P-value:1.72E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:-4.64|P-value:8.99E-7 ID:SGTC_2773|Compound:thioridazine|FD-Score:5.46|P-value:9.67E-9 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.69|P-value:7.10E-5 ID:SGTC_2932|Compound:9016711|FD-Score:3.25|P-value:4.10E-4 ID:SGTC_3139|Compound:9095020|FD-Score:3.03|P-value:8.98E-4 ID:SGTC_3205|Compound:9113483|FD-Score:4.55|P-value:1.39E-6 ID:SGTC_3208|Compound:9114115|FD-Score:3.80|P-value:4.58E-5

Top fitness defect scores for YJL047C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 8.41 5.3 µM 2.34E-18 237 2.00E-17
2 SGTC_2773 thioridazine 5.46 9.1 µM 9.67E-9 3 2.42E-8
3 SGTC_3205 9113483 4.55 49.5 µM 1.39E-6 12 2.65E-6
4 SGTC_1243 0416-0003 4.34 5.7 µM 3.88E-6 PDR1 19 6.99E-6
5 SGTC_261 5-fluorouridine 4.29 15.4 µM 5.04E-6 exosome 5 8.95E-6
6 SGTC_871 0574-0004 4.16 149.0 µM 9.12E-6 42 1.57E-5
7 SGTC_872 0588-0139 4.09 234.0 µM 1.26E-5 28 2.13E-5
8 SGTC_2150 5556613 3.91 200.0 µM 2.80E-5 22 4.54E-5
9 SGTC_1608 st001473 3.82 40.5 µM 4.25E-5 39 6.73E-5
10 SGTC_3208 9114115 3.80 49.5 µM 4.58E-5 44 7.22E-5
11 SGTC_2137 5261020 3.75 140.0 µM 5.65E-5 43 8.81E-5
12 SGTC_1989 st071868 3.62 50.2 µM 9.58E-5 17 1.45E-4
13 SGTC_2539 epi(13)torulosol 3.57 80.0 µM 1.19E-4 39 1.78E-4
14 SGTC_2444 5485484 3.56 36.4 µM 1.26E-4 47 1.88E-4
15 SGTC_2752 diclazuril 3.48 33.1 µM 1.72E-4 157 2.53E-4
16 SGTC_1041 0206-0046 3.41 107.0 µM 2.25E-4 49 3.25E-4
17 SGTC_1152 3909-8331 3.40 15.9 µM 2.33E-4 28 3.37E-4
18 SGTC_1263 0774-1208 3.35 64.8 µM 2.86E-4 74 4.09E-4
19 SGTC_2730 imipramine 3.28 71.3 µM 3.68E-4 51 5.20E-4
20 SGTC_2932 9016711 3.25 44.5 µM 4.10E-4 78 5.75E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.280 1.75E-61 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.277 3.12E-60 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.272 1.09E-57 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.268 3.14E-56 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.259 1.97E-52 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.251 3.43E-49 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.247 5.24E-48 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.245 5.66E-47 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.244 8.58E-47 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.238 2.31E-44 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.237 3.97E-44 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.231 5.45E-42 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.227 1.85E-40 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.227 2.08E-40 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.226 4.63E-40 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases