YJL048C / UBX6

UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL048C / UBX6

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:3.03|P-value:6.71E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.77|P-value:3.24E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:3.27|P-value:2.71E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:-3.46|P-value:1.22E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:4.09|P-value:7.50E-6 ID:SGTC_291|Compound:4130-1278|FD-Score:3.03|P-value:6.67E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:2.97|P-value:8.20E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:3.42|P-value:1.45E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:-3.11|P-value:4.91E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:5.04|P-value:4.61E-8 ID:SGTC_796|Compound:1234-0020|FD-Score:4.03|P-value:1.00E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:2.97|P-value:8.37E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:2.95|P-value:8.94E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.07|P-value:5.72E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.62|P-value:6.19E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.36|P-value:1.84E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.28|P-value:2.55E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:4.15|P-value:5.50E-6 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.36|P-value:1.82E-4 ID:SGTC_1531|Compound:st059297|FD-Score:6.11|P-value:4.79E-11 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.02|P-value:6.89E-4 ID:SGTC_1548|Compound:st061468|FD-Score:3.33|P-value:2.11E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:2.97|P-value:8.27E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:6.39|P-value:6.50E-12 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.27|P-value:2.68E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.42|P-value:1.45E-4 ID:SGTC_1790|Compound:st045711|FD-Score:-3.33|P-value:2.13E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.48|P-value:1.13E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.38|P-value:1.69E-4 ID:SGTC_2347|Compound:9049783|FD-Score:2.92|P-value:9.82E-4 ID:SGTC_2505|Compound:galangin|FD-Score:3.39|P-value:1.63E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:4.76|P-value:2.32E-7 ID:SGTC_2570|Compound:licareol|FD-Score:2.92|P-value:9.98E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.69|P-value:4.74E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-5.28|P-value:1.10E-8 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.33|P-value:2.12E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.45|P-value:1.26E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.81|P-value:1.70E-7 ID:SGTC_2628|Compound:lathosterol|FD-Score:2.99|P-value:7.63E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.49|P-value:1.07E-4 ID:SGTC_2708|Compound:st078559|FD-Score:3.15|P-value:4.20E-4 ID:SGTC_2715|Compound:st079500|FD-Score:3.72|P-value:4.15E-5 ID:SGTC_2908|Compound:7930301|FD-Score:4.32|P-value:2.42E-6 ID:SGTC_2914|Compound:7968218|FD-Score:3.70|P-value:4.38E-5 ID:SGTC_2956|Compound:9076196|FD-Score:-3.52|P-value:9.64E-5 ID:SGTC_2993|Compound:9054257|FD-Score:-3.61|P-value:6.51E-5 ID:SGTC_3341|Compound:9147222|FD-Score:-3.17|P-value:3.92E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:3.03|P-value:6.71E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.77|P-value:3.24E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:3.27|P-value:2.71E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:-3.46|P-value:1.22E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:4.09|P-value:7.50E-6 ID:SGTC_291|Compound:4130-1278|FD-Score:3.03|P-value:6.67E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:2.97|P-value:8.20E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:3.42|P-value:1.45E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:-3.11|P-value:4.91E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:5.04|P-value:4.61E-8 ID:SGTC_796|Compound:1234-0020|FD-Score:4.03|P-value:1.00E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:2.97|P-value:8.37E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:2.95|P-value:8.94E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.07|P-value:5.72E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.62|P-value:6.19E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.36|P-value:1.84E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.28|P-value:2.55E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:4.15|P-value:5.50E-6 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.36|P-value:1.82E-4 ID:SGTC_1531|Compound:st059297|FD-Score:6.11|P-value:4.79E-11 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.02|P-value:6.89E-4 ID:SGTC_1548|Compound:st061468|FD-Score:3.33|P-value:2.11E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:2.97|P-value:8.27E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:6.39|P-value:6.50E-12 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.27|P-value:2.68E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.42|P-value:1.45E-4 ID:SGTC_1790|Compound:st045711|FD-Score:-3.33|P-value:2.13E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.48|P-value:1.13E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.38|P-value:1.69E-4 ID:SGTC_2347|Compound:9049783|FD-Score:2.92|P-value:9.82E-4 ID:SGTC_2505|Compound:galangin|FD-Score:3.39|P-value:1.63E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:4.76|P-value:2.32E-7 ID:SGTC_2570|Compound:licareol|FD-Score:2.92|P-value:9.98E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.69|P-value:4.74E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-5.28|P-value:1.10E-8 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.33|P-value:2.12E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.45|P-value:1.26E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.81|P-value:1.70E-7 ID:SGTC_2628|Compound:lathosterol|FD-Score:2.99|P-value:7.63E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.49|P-value:1.07E-4 ID:SGTC_2708|Compound:st078559|FD-Score:3.15|P-value:4.20E-4 ID:SGTC_2715|Compound:st079500|FD-Score:3.72|P-value:4.15E-5 ID:SGTC_2908|Compound:7930301|FD-Score:4.32|P-value:2.42E-6 ID:SGTC_2914|Compound:7968218|FD-Score:3.70|P-value:4.38E-5 ID:SGTC_2956|Compound:9076196|FD-Score:-3.52|P-value:9.64E-5 ID:SGTC_2993|Compound:9054257|FD-Score:-3.61|P-value:6.51E-5 ID:SGTC_3341|Compound:9147222|FD-Score:-3.17|P-value:3.92E-4

Top fitness defect scores for YJL048C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1575 cyproterone acetate 6.39 48.0 µM 6.50E-12 3 8.31E-11
2 SGTC_1531 st059297 6.11 52.4 µM 4.79E-11 1 4.95E-10
3 SGTC_766 1391-0721 5.04 126.0 µM 4.61E-8 3 2.30E-7
4 SGTC_2612 dictamnine 4.81 15.5 µM 1.70E-7 RNA pol III & RNase P/MRP 25 7.39E-7
5 SGTC_2519 cryptotanshinone 4.76 88.0 µM 2.32E-7 heme biosynthesis & mitochondrial translocase 6 9.75E-7
6 SGTC_2908 7930301 4.32 100.0 µM 2.42E-6 17 7.96E-6
7 SGTC_1271 0832-2808 4.15 169.0 µM 5.50E-6 8 1.66E-5
8 SGTC_259 usnic acid 4.09 108.9 µM 7.50E-6 15 2.19E-5
9 SGTC_796 1234-0020 4.03 70.7 µM 1.00E-5 SWF1 & branched chain AA biosynthesis 25 2.84E-5
10 SGTC_24 0417-1663 3.77 219.0 µM 3.24E-5 21 8.13E-5
11 SGTC_2715 st079500 3.72 56.4 µM 4.15E-5 14 1.02E-4
12 SGTC_2914 7968218 3.70 45.3 µM 4.38E-5 17 1.07E-4
13 SGTC_2576 guaiol 3.69 23.1 µM 4.74E-5 29 1.14E-4
14 SGTC_1248 0469-0687 3.62 58.6 µM 6.19E-5 38 1.45E-4
15 SGTC_2701 st077767 3.49 14.7 µM 1.07E-4 64 2.38E-4
16 SGTC_1933 st074711 3.48 15.9 µM 1.13E-4 64 2.49E-4
17 SGTC_2611 pyromycin 3.45 23.9 µM 1.26E-4 57 2.76E-4
18 SGTC_1746 st038117 3.42 42.0 µM 1.45E-4 52 3.11E-4
19 SGTC_646 4092-0839 3.42 27.3 µM 1.45E-4 plasma membrane duress 44 3.11E-4
20 SGTC_2505 galangin 3.39 7.9 µM 1.63E-4 RPP1 & pyrimidine depletion 21 3.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.53E-9 YOL037C_d YOL037C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W
0.102 2.89E-9 YDR211W GCD6 het Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress
0.098 1.17E-8 YMR153C-A_d YMR153C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NUP53
0.091 1.16E-7 YGL109W_d YGL109W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C
0.090 1.93E-7 YHR057C CPR2 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway
0.075 1.22E-5 YNL095C_p YNL095C_p hom Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication
0.074 1.66E-5 YJL194W CDC6 het Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.074 1.99E-5 YAL028W FRT2 hom Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication
0.072 2.75E-5 YCL012C YCL012C hom Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene
0.072 2.91E-5 YPL083C SEN54 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
0.071 3.61E-5 YJR010W MET3 hom ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
0.071 4.09E-5 YBR182C SMP1 hom Putative transcription factor of the MADS-box family; involved in regulating the response to osmotic stress; SMP1 has a paralog, RLM1, that arose from the whole genome duplication
0.071 4.15E-5 YGR131W FHN1 hom Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain
0.069 5.95E-5 YLR146C SPE4 hom Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid
0.068 7.20E-5 YIL117C PRM5 hom Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling