YJL053W / PEP8

Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL053W / PEP8

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:5.65|P-value:3.06E-8 ID:SGTC_43|Compound:0570-0105|FD-Score:6.72|P-value:5.87E-11 ID:SGTC_56|Compound:0957-0365|FD-Score:3.46|P-value:4.74E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.09|P-value:3.47E-12 ID:SGTC_117|Compound:lucigenin|FD-Score:5.46|P-value:8.60E-8 ID:SGTC_119|Compound:0121-0043|FD-Score:5.02|P-value:7.67E-7 ID:SGTC_121|Compound:0557-0495|FD-Score:4.10|P-value:4.45E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:4.46|P-value:9.72E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:11.80|P-value:3.44E-30 ID:SGTC_168|Compound:3970-0862|FD-Score:5.86|P-value:9.64E-9 ID:SGTC_172|Compound:1112-0046|FD-Score:6.42|P-value:3.74E-10 ID:SGTC_206|Compound:4546-0025|FD-Score:14.10|P-value:2.53E-42 ID:SGTC_221|Compound:trifluoperazine|FD-Score:18.30|P-value:6.49E-70 ID:SGTC_227|Compound:fluconazole|FD-Score:4.90|P-value:1.33E-6 ID:SGTC_232|Compound:clozapine|FD-Score:14.10|P-value:6.30E-42 ID:SGTC_263|Compound:alizarin|FD-Score:8.27|P-value:1.01E-15 ID:SGTC_301|Compound:4119-0100|FD-Score:23.30|P-value:4.16E-111 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.83|P-value:1.01E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:5.11|P-value:4.98E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.96|P-value:6.11E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:4.24|P-value:2.50E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:3.95|P-value:7.95E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:6.16|P-value:1.75E-9 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.80|P-value:3.48E-11 ID:SGTC_447|Compound:ml7|FD-Score:5.30|P-value:1.94E-7 ID:SGTC_449|Compound:xestospongin c|FD-Score:7.20|P-value:2.48E-12 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-8.32|P-value:4.52E-16 ID:SGTC_455|Compound:paf C-16|FD-Score:-3.26|P-value:7.68E-4 ID:SGTC_459|Compound:nigericin|FD-Score:5.01|P-value:8.04E-7 ID:SGTC_483|Compound:fpl-64176|FD-Score:3.74|P-value:1.74E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.68|P-value:3.76E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:6.34|P-value:5.93E-10 ID:SGTC_562|Compound:3772-2733|FD-Score:4.62|P-value:4.86E-6 ID:SGTC_572|Compound:0960-0087|FD-Score:3.52|P-value:3.79E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.87|P-value:1.08E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:4.90|P-value:1.33E-6 ID:SGTC_769|Compound:0302-0231|FD-Score:-3.19|P-value:9.58E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.32|P-value:1.75E-5 ID:SGTC_888|Compound:0916-0002|FD-Score:8.80|P-value:1.47E-17 ID:SGTC_900|Compound:1112-0045|FD-Score:6.45|P-value:3.02E-10 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.87|P-value:1.08E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.66|P-value:4.13E-6 ID:SGTC_1130|Compound:3454-2858|FD-Score:13.40|P-value:3.22E-38 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.26|P-value:2.25E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:12.50|P-value:1.51E-33 ID:SGTC_1308|Compound:1187-1617|FD-Score:5.22|P-value:2.81E-7 ID:SGTC_1405|Compound:3909-7894|FD-Score:-3.86|P-value:9.07E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:-4.27|P-value:1.77E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:6.21|P-value:1.28E-9 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.51|P-value:3.92E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:-4.54|P-value:5.42E-6 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.33|P-value:7.45E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:3.76|P-value:1.61E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.12|P-value:4.72E-7 ID:SGTC_1591|Compound:genipin|FD-Score:-3.23|P-value:8.47E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.03|P-value:5.81E-5 ID:SGTC_1687|Compound:st020778|FD-Score:5.60|P-value:4.11E-8 ID:SGTC_1712|Compound:st032288|FD-Score:12.30|P-value:1.19E-32 ID:SGTC_1754|Compound:st042065|FD-Score:7.12|P-value:4.28E-12 ID:SGTC_1760|Compound:st045453|FD-Score:10.50|P-value:2.33E-24 ID:SGTC_1771|Compound:st048882|FD-Score:4.01|P-value:6.19E-5 ID:SGTC_1781|Compound:st038725|FD-Score:15.10|P-value:7.41E-48 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.82|P-value:1.96E-6 ID:SGTC_1797|Compound:st048695|FD-Score:7.06|P-value:6.37E-12 ID:SGTC_1800|Compound:st050079|FD-Score:6.68|P-value:7.39E-11 ID:SGTC_1801|Compound:st050089|FD-Score:13.10|P-value:1.09E-36 ID:SGTC_1803|Compound:st050068|FD-Score:12.40|P-value:6.13E-33 ID:SGTC_1810|Compound:st050138|FD-Score:4.08|P-value:4.74E-5 ID:SGTC_1818|Compound:st052136|FD-Score:3.81|P-value:1.35E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.89|P-value:8.13E-9 ID:SGTC_1847|Compound:st056231|FD-Score:3.31|P-value:7.76E-4 ID:SGTC_1856|Compound:st057054|FD-Score:4.15|P-value:3.66E-5 ID:SGTC_1886|Compound:st057356|FD-Score:4.20|P-value:2.90E-5 ID:SGTC_1949|Compound:st076024|FD-Score:3.24|P-value:9.84E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.35|P-value:1.59E-5 ID:SGTC_1972|Compound:st070201|FD-Score:4.34|P-value:1.67E-5 ID:SGTC_1991|Compound:st073000|FD-Score:6.48|P-value:2.60E-10 ID:SGTC_2006|Compound:4011487|FD-Score:6.18|P-value:1.54E-9 ID:SGTC_2021|Compound:4019055|FD-Score:4.69|P-value:3.53E-6 ID:SGTC_2108|Compound:5365811|FD-Score:3.71|P-value:1.93E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.63|P-value:2.62E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.79|P-value:1.46E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.59|P-value:3.07E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:9.50|P-value:3.55E-20 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-4.99|P-value:6.64E-7 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.07|P-value:4.91E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.11|P-value:4.60E-12 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.65|P-value:9.85E-21 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:26.80|P-value:2.07E-146 ID:SGTC_2699|Compound:st077704|FD-Score:3.46|P-value:4.73E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.59|P-value:2.99E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.77|P-value:1.55E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.36|P-value:1.51E-5 ID:SGTC_3027|Compound:9089541|FD-Score:3.38|P-value:6.27E-4 ID:SGTC_3037|Compound:9091026|FD-Score:10.20|P-value:4.45E-23 ID:SGTC_3038|Compound:9091290|FD-Score:-3.55|P-value:2.87E-4 ID:SGTC_3052|Compound:9092717|FD-Score:-4.09|P-value:3.70E-5 ID:SGTC_3070|Compound:9117005|FD-Score:3.31|P-value:7.94E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.64|P-value:2.48E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.45|P-value:4.11E-4 ID:SGTC_3152|Compound:9099253|FD-Score:11.80|P-value:6.88E-30 ID:SGTC_3303|Compound:9125618|FD-Score:-3.46|P-value:3.97E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.70|P-value:2.03E-4 ID:SGTC_3308|Compound:9128332|FD-Score:10.80|P-value:1.41E-25 ID:SGTC_15|Compound:0266-0086|FD-Score:5.65|P-value:3.06E-8 ID:SGTC_43|Compound:0570-0105|FD-Score:6.72|P-value:5.87E-11 ID:SGTC_56|Compound:0957-0365|FD-Score:3.46|P-value:4.74E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.09|P-value:3.47E-12 ID:SGTC_117|Compound:lucigenin|FD-Score:5.46|P-value:8.60E-8 ID:SGTC_119|Compound:0121-0043|FD-Score:5.02|P-value:7.67E-7 ID:SGTC_121|Compound:0557-0495|FD-Score:4.10|P-value:4.45E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:4.46|P-value:9.72E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:11.80|P-value:3.44E-30 ID:SGTC_168|Compound:3970-0862|FD-Score:5.86|P-value:9.64E-9 ID:SGTC_172|Compound:1112-0046|FD-Score:6.42|P-value:3.74E-10 ID:SGTC_206|Compound:4546-0025|FD-Score:14.10|P-value:2.53E-42 ID:SGTC_221|Compound:trifluoperazine|FD-Score:18.30|P-value:6.49E-70 ID:SGTC_227|Compound:fluconazole|FD-Score:4.90|P-value:1.33E-6 ID:SGTC_232|Compound:clozapine|FD-Score:14.10|P-value:6.30E-42 ID:SGTC_263|Compound:alizarin|FD-Score:8.27|P-value:1.01E-15 ID:SGTC_301|Compound:4119-0100|FD-Score:23.30|P-value:4.16E-111 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.83|P-value:1.01E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:5.11|P-value:4.98E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.96|P-value:6.11E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:4.24|P-value:2.50E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:3.95|P-value:7.95E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:6.16|P-value:1.75E-9 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.80|P-value:3.48E-11 ID:SGTC_447|Compound:ml7|FD-Score:5.30|P-value:1.94E-7 ID:SGTC_449|Compound:xestospongin c|FD-Score:7.20|P-value:2.48E-12 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-8.32|P-value:4.52E-16 ID:SGTC_455|Compound:paf C-16|FD-Score:-3.26|P-value:7.68E-4 ID:SGTC_459|Compound:nigericin|FD-Score:5.01|P-value:8.04E-7 ID:SGTC_483|Compound:fpl-64176|FD-Score:3.74|P-value:1.74E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.68|P-value:3.76E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:6.34|P-value:5.93E-10 ID:SGTC_562|Compound:3772-2733|FD-Score:4.62|P-value:4.86E-6 ID:SGTC_572|Compound:0960-0087|FD-Score:3.52|P-value:3.79E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.87|P-value:1.08E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:4.90|P-value:1.33E-6 ID:SGTC_769|Compound:0302-0231|FD-Score:-3.19|P-value:9.58E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.32|P-value:1.75E-5 ID:SGTC_888|Compound:0916-0002|FD-Score:8.80|P-value:1.47E-17 ID:SGTC_900|Compound:1112-0045|FD-Score:6.45|P-value:3.02E-10 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.87|P-value:1.08E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.66|P-value:4.13E-6 ID:SGTC_1130|Compound:3454-2858|FD-Score:13.40|P-value:3.22E-38 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.26|P-value:2.25E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:12.50|P-value:1.51E-33 ID:SGTC_1308|Compound:1187-1617|FD-Score:5.22|P-value:2.81E-7 ID:SGTC_1405|Compound:3909-7894|FD-Score:-3.86|P-value:9.07E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:-4.27|P-value:1.77E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:6.21|P-value:1.28E-9 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.51|P-value:3.92E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:-4.54|P-value:5.42E-6 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.33|P-value:7.45E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:3.76|P-value:1.61E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.12|P-value:4.72E-7 ID:SGTC_1591|Compound:genipin|FD-Score:-3.23|P-value:8.47E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.03|P-value:5.81E-5 ID:SGTC_1687|Compound:st020778|FD-Score:5.60|P-value:4.11E-8 ID:SGTC_1712|Compound:st032288|FD-Score:12.30|P-value:1.19E-32 ID:SGTC_1754|Compound:st042065|FD-Score:7.12|P-value:4.28E-12 ID:SGTC_1760|Compound:st045453|FD-Score:10.50|P-value:2.33E-24 ID:SGTC_1771|Compound:st048882|FD-Score:4.01|P-value:6.19E-5 ID:SGTC_1781|Compound:st038725|FD-Score:15.10|P-value:7.41E-48 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.82|P-value:1.96E-6 ID:SGTC_1797|Compound:st048695|FD-Score:7.06|P-value:6.37E-12 ID:SGTC_1800|Compound:st050079|FD-Score:6.68|P-value:7.39E-11 ID:SGTC_1801|Compound:st050089|FD-Score:13.10|P-value:1.09E-36 ID:SGTC_1803|Compound:st050068|FD-Score:12.40|P-value:6.13E-33 ID:SGTC_1810|Compound:st050138|FD-Score:4.08|P-value:4.74E-5 ID:SGTC_1818|Compound:st052136|FD-Score:3.81|P-value:1.35E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.89|P-value:8.13E-9 ID:SGTC_1847|Compound:st056231|FD-Score:3.31|P-value:7.76E-4 ID:SGTC_1856|Compound:st057054|FD-Score:4.15|P-value:3.66E-5 ID:SGTC_1886|Compound:st057356|FD-Score:4.20|P-value:2.90E-5 ID:SGTC_1949|Compound:st076024|FD-Score:3.24|P-value:9.84E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.35|P-value:1.59E-5 ID:SGTC_1972|Compound:st070201|FD-Score:4.34|P-value:1.67E-5 ID:SGTC_1991|Compound:st073000|FD-Score:6.48|P-value:2.60E-10 ID:SGTC_2006|Compound:4011487|FD-Score:6.18|P-value:1.54E-9 ID:SGTC_2021|Compound:4019055|FD-Score:4.69|P-value:3.53E-6 ID:SGTC_2108|Compound:5365811|FD-Score:3.71|P-value:1.93E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.63|P-value:2.62E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.79|P-value:1.46E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.59|P-value:3.07E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:9.50|P-value:3.55E-20 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-4.99|P-value:6.64E-7 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.07|P-value:4.91E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.11|P-value:4.60E-12 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.65|P-value:9.85E-21 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:26.80|P-value:2.07E-146 ID:SGTC_2699|Compound:st077704|FD-Score:3.46|P-value:4.73E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.59|P-value:2.99E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.77|P-value:1.55E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.36|P-value:1.51E-5 ID:SGTC_3027|Compound:9089541|FD-Score:3.38|P-value:6.27E-4 ID:SGTC_3037|Compound:9091026|FD-Score:10.20|P-value:4.45E-23 ID:SGTC_3038|Compound:9091290|FD-Score:-3.55|P-value:2.87E-4 ID:SGTC_3052|Compound:9092717|FD-Score:-4.09|P-value:3.70E-5 ID:SGTC_3070|Compound:9117005|FD-Score:3.31|P-value:7.94E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.64|P-value:2.48E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.45|P-value:4.11E-4 ID:SGTC_3152|Compound:9099253|FD-Score:11.80|P-value:6.88E-30 ID:SGTC_3303|Compound:9125618|FD-Score:-3.46|P-value:3.97E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.70|P-value:2.03E-4 ID:SGTC_3308|Compound:9128332|FD-Score:10.80|P-value:1.41E-25

Top fitness defect scores for YJL053W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2697 mebhydrolin 26.80 72.4 µM 2.07E-146 NEO1 2 5.29E-158
2 SGTC_301 4119-0100 23.30 24.5 µM 4.16E-111 NEO1 2 6.68E-120
3 SGTC_221 trifluoperazine 18.30 10.3 µM 6.49E-70 NEO1-PIK1 15 1.95E-75
4 SGTC_1781 st038725 15.10 66.3 µM 7.41E-48 NEO1 6 1.28E-51
5 SGTC_206 4546-0025 14.10 72.0 µM 2.53E-42 NEO1 8 1.21E-45
6 SGTC_232 clozapine 14.10 119.0 µM 6.30E-42 NEO1 11 3.23E-45
7 SGTC_1130 3454-2858 13.40 15.9 µM 3.22E-38 NEO1 9 3.27E-41
8 SGTC_1801 st050089 13.10 28.4 µM 1.09E-36 NEO1-PIK1 4 1.46E-39
9 SGTC_1230 0170-0365 12.50 3.8 µM 1.51E-33 endomembrane recycling 2 3.64E-36
10 SGTC_1803 st050068 12.40 52.4 µM 6.13E-33 NEO1-PIK1 12 1.65E-35
11 SGTC_1712 st032288 12.30 53.4 µM 1.19E-32 calcium & mitochondrial duress 8 3.38E-35
12 SGTC_146 3448-8650 11.80 53.1 µM 3.44E-30 NEO1-PIK1 13 1.54E-32
13 SGTC_3152 9099253 11.80 49.5 µM 6.88E-30 NEO1-PIK1 15 3.24E-32
14 SGTC_3308 9128332 10.80 17.6 µM 1.41E-25 plasma membrane duress 19 1.48E-27
15 SGTC_1760 st045453 10.50 10.4 µM 2.33E-24 NEO1-PIK1 30 3.05E-26
16 SGTC_3037 9091026 10.20 49.5 µM 4.45E-23 NEO1-PIK1 5 7.39E-25
17 SGTC_2688 kanamycin b 9.65 96.7 µM 9.85E-21 calcium & mitochondrial duress 32 2.52E-22
18 SGTC_2630 antimycin a 9.50 100.0 µM 3.55E-20 mitochondrial processes 4 1.01E-21
19 SGTC_888 0916-0002 8.80 7.0 µM 1.47E-17 NEO1 12 6.80E-19
20 SGTC_263 alizarin 8.27 107.9 µM 1.01E-15 iron homeostasis 10 6.58E-17

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.750 0 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.718 0 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.599 0 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.564 1.03E-280 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.555 9.09E-271 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.542 2.03E-255 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.518 2.07E-229 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.508 4.12E-219 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.504 1.32E-215 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.498 1.47E-209 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.497 5.17E-208 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.485 2.08E-197 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.464 3.23E-179 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.459 1.21E-173 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.453 1.35E-168 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton