YJL056C / ZAP1

Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL056C / ZAP1

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:-3.98|P-value:1.79E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-3.67|P-value:4.77E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.14|P-value:4.16E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.62|P-value:3.44E-7 ID:SGTC_206|Compound:4546-0025|FD-Score:4.04|P-value:5.62E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.90|P-value:3.27E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.97|P-value:6.77E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.52|P-value:7.30E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:5.85|P-value:7.89E-7 ID:SGTC_676|Compound:falcarinol|FD-Score:5.14|P-value:1.38E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:-3.64|P-value:5.16E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:4.63|P-value:8.49E-5 ID:SGTC_723|Compound:4182-0001|FD-Score:8.02|P-value:1.45E-11 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.23|P-value:7.60E-5 ID:SGTC_779|Compound:1360-0071|FD-Score:-4.01|P-value:1.63E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:6.08|P-value:2.94E-7 ID:SGTC_888|Compound:0916-0002|FD-Score:6.39|P-value:7.01E-8 ID:SGTC_892|Compound:0929-0076|FD-Score:5.64|P-value:1.89E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:5.34|P-value:6.25E-6 ID:SGTC_979|Compound:1426-2828|FD-Score:4.74|P-value:5.73E-5 ID:SGTC_987|Compound:1497-1013|FD-Score:-5.16|P-value:2.37E-6 ID:SGTC_989|Compound:1501-0895|FD-Score:-4.22|P-value:8.13E-5 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.92|P-value:7.92E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:-3.44|P-value:9.33E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.27|P-value:2.71E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:5.98|P-value:4.57E-7 ID:SGTC_1405|Compound:3909-7894|FD-Score:-5.27|P-value:1.49E-6 ID:SGTC_1414|Compound:3917-0015|FD-Score:-3.87|P-value:2.52E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.49|P-value:1.34E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:4.41|P-value:1.76E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:6.69|P-value:1.71E-8 ID:SGTC_1658|Compound:st012944|FD-Score:-4.44|P-value:3.66E-5 ID:SGTC_1660|Compound:st012960|FD-Score:-4.69|P-value:1.50E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.37|P-value:4.77E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:5.56|P-value:2.67E-6 ID:SGTC_1892|Compound:st058411|FD-Score:3.93|P-value:7.71E-4 ID:SGTC_1935|Compound:st074532|FD-Score:4.63|P-value:8.31E-5 ID:SGTC_1958|Compound:st076513|FD-Score:-3.49|P-value:8.07E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-4.29|P-value:6.31E-5 ID:SGTC_2006|Compound:4011487|FD-Score:5.51|P-value:3.24E-6 ID:SGTC_2009|Compound:4012297|FD-Score:4.83|P-value:4.18E-5 ID:SGTC_2034|Compound:5197015|FD-Score:5.52|P-value:3.07E-6 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-3.84|P-value:2.76E-4 ID:SGTC_2106|Compound:5357045|FD-Score:4.34|P-value:2.19E-4 ID:SGTC_2110|Compound:5483698|FD-Score:6.06|P-value:3.22E-7 ID:SGTC_2114|Compound:5491910|FD-Score:5.77|P-value:1.11E-6 ID:SGTC_2142|Compound:5622915|FD-Score:4.60|P-value:9.36E-5 ID:SGTC_2160|Compound:5660466|FD-Score:-3.47|P-value:8.46E-4 ID:SGTC_2165|Compound:5727197|FD-Score:4.51|P-value:1.28E-4 ID:SGTC_2304|Compound:7443016|FD-Score:4.30|P-value:2.47E-4 ID:SGTC_2323|Compound:6148992|FD-Score:4.74|P-value:5.82E-5 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-4.13|P-value:1.09E-4 ID:SGTC_2430|Compound:5571206|FD-Score:-3.59|P-value:6.08E-4 ID:SGTC_2486|Compound:5283202|FD-Score:4.30|P-value:2.49E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.53|P-value:2.66E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.86|P-value:9.50E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:4.39|P-value:1.85E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.04|P-value:5.58E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:6.01|P-value:3.97E-7 ID:SGTC_2774|Compound:tamoxifen|FD-Score:4.01|P-value:6.06E-4 ID:SGTC_2833|Compound:9001315|FD-Score:4.08|P-value:4.88E-4 ID:SGTC_2873|Compound:9040596|FD-Score:5.51|P-value:3.24E-6 ID:SGTC_2909|Compound:7941780|FD-Score:6.16|P-value:2.06E-7 ID:SGTC_3099|Compound:9120367|FD-Score:4.14|P-value:4.10E-4 ID:SGTC_3164|Compound:9100705|FD-Score:-5.07|P-value:3.38E-6 ID:SGTC_3170|Compound:9103054|FD-Score:-4.65|P-value:1.72E-5 ID:SGTC_3173|Compound:9105693|FD-Score:-3.44|P-value:9.33E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-3.48|P-value:8.31E-4 ID:SGTC_3284|Compound:9108171|FD-Score:5.19|P-value:1.11E-5 ID:SGTC_3296|Compound:9122258|FD-Score:5.64|P-value:1.90E-6 ID:SGTC_2|Compound:0422-0095|FD-Score:-3.98|P-value:1.79E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-3.67|P-value:4.77E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.14|P-value:4.16E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.62|P-value:3.44E-7 ID:SGTC_206|Compound:4546-0025|FD-Score:4.04|P-value:5.62E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.90|P-value:3.27E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.97|P-value:6.77E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.52|P-value:7.30E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:5.85|P-value:7.89E-7 ID:SGTC_676|Compound:falcarinol|FD-Score:5.14|P-value:1.38E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:-3.64|P-value:5.16E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:4.63|P-value:8.49E-5 ID:SGTC_723|Compound:4182-0001|FD-Score:8.02|P-value:1.45E-11 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.23|P-value:7.60E-5 ID:SGTC_779|Compound:1360-0071|FD-Score:-4.01|P-value:1.63E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:6.08|P-value:2.94E-7 ID:SGTC_888|Compound:0916-0002|FD-Score:6.39|P-value:7.01E-8 ID:SGTC_892|Compound:0929-0076|FD-Score:5.64|P-value:1.89E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:5.34|P-value:6.25E-6 ID:SGTC_979|Compound:1426-2828|FD-Score:4.74|P-value:5.73E-5 ID:SGTC_987|Compound:1497-1013|FD-Score:-5.16|P-value:2.37E-6 ID:SGTC_989|Compound:1501-0895|FD-Score:-4.22|P-value:8.13E-5 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.92|P-value:7.92E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:-3.44|P-value:9.33E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.27|P-value:2.71E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:5.98|P-value:4.57E-7 ID:SGTC_1405|Compound:3909-7894|FD-Score:-5.27|P-value:1.49E-6 ID:SGTC_1414|Compound:3917-0015|FD-Score:-3.87|P-value:2.52E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.49|P-value:1.34E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:4.41|P-value:1.76E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:6.69|P-value:1.71E-8 ID:SGTC_1658|Compound:st012944|FD-Score:-4.44|P-value:3.66E-5 ID:SGTC_1660|Compound:st012960|FD-Score:-4.69|P-value:1.50E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.37|P-value:4.77E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:5.56|P-value:2.67E-6 ID:SGTC_1892|Compound:st058411|FD-Score:3.93|P-value:7.71E-4 ID:SGTC_1935|Compound:st074532|FD-Score:4.63|P-value:8.31E-5 ID:SGTC_1958|Compound:st076513|FD-Score:-3.49|P-value:8.07E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-4.29|P-value:6.31E-5 ID:SGTC_2006|Compound:4011487|FD-Score:5.51|P-value:3.24E-6 ID:SGTC_2009|Compound:4012297|FD-Score:4.83|P-value:4.18E-5 ID:SGTC_2034|Compound:5197015|FD-Score:5.52|P-value:3.07E-6 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-3.84|P-value:2.76E-4 ID:SGTC_2106|Compound:5357045|FD-Score:4.34|P-value:2.19E-4 ID:SGTC_2110|Compound:5483698|FD-Score:6.06|P-value:3.22E-7 ID:SGTC_2114|Compound:5491910|FD-Score:5.77|P-value:1.11E-6 ID:SGTC_2142|Compound:5622915|FD-Score:4.60|P-value:9.36E-5 ID:SGTC_2160|Compound:5660466|FD-Score:-3.47|P-value:8.46E-4 ID:SGTC_2165|Compound:5727197|FD-Score:4.51|P-value:1.28E-4 ID:SGTC_2304|Compound:7443016|FD-Score:4.30|P-value:2.47E-4 ID:SGTC_2323|Compound:6148992|FD-Score:4.74|P-value:5.82E-5 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-4.13|P-value:1.09E-4 ID:SGTC_2430|Compound:5571206|FD-Score:-3.59|P-value:6.08E-4 ID:SGTC_2486|Compound:5283202|FD-Score:4.30|P-value:2.49E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.53|P-value:2.66E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.86|P-value:9.50E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:4.39|P-value:1.85E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.04|P-value:5.58E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:6.01|P-value:3.97E-7 ID:SGTC_2774|Compound:tamoxifen|FD-Score:4.01|P-value:6.06E-4 ID:SGTC_2833|Compound:9001315|FD-Score:4.08|P-value:4.88E-4 ID:SGTC_2873|Compound:9040596|FD-Score:5.51|P-value:3.24E-6 ID:SGTC_2909|Compound:7941780|FD-Score:6.16|P-value:2.06E-7 ID:SGTC_3099|Compound:9120367|FD-Score:4.14|P-value:4.10E-4 ID:SGTC_3164|Compound:9100705|FD-Score:-5.07|P-value:3.38E-6 ID:SGTC_3170|Compound:9103054|FD-Score:-4.65|P-value:1.72E-5 ID:SGTC_3173|Compound:9105693|FD-Score:-3.44|P-value:9.33E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-3.48|P-value:8.31E-4 ID:SGTC_3284|Compound:9108171|FD-Score:5.19|P-value:1.11E-5 ID:SGTC_3296|Compound:9122258|FD-Score:5.64|P-value:1.90E-6

Top fitness defect scores for YJL056C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_723 4182-0001 8.02 115.0 µM 1.45E-11 9 5.22E-16
2 SGTC_1573 oleylamine 6.69 1.1 µM 1.71E-8 7 1.10E-11
3 SGTC_888 0916-0002 6.39 7.0 µM 7.01E-8 NEO1 22 8.08E-11
4 SGTC_2909 7941780 6.16 10.5 µM 2.06E-7 1 3.71E-10
5 SGTC_791 1348-1292 6.08 225.0 µM 2.94E-7 9 6.12E-10
6 SGTC_2110 5483698 6.06 200.0 µM 3.22E-7 TSC3-RPN4 6 6.94E-10
7 SGTC_2769 toremifene 6.01 3.7 µM 3.97E-7 1 9.33E-10
8 SGTC_1181 1222-0449 5.98 220.0 µM 4.57E-7 6 1.14E-9
9 SGTC_661 1304-0007 5.85 33.6 µM 7.89E-7 3 2.46E-9
10 SGTC_2114 5491910 5.77 81.2 µM 1.11E-6 1 3.98E-9
11 SGTC_892 0929-0076 5.64 29.0 µM 1.89E-6 TRP & mitochondrial translation 9 8.47E-9
12 SGTC_3296 9122258 5.64 64.0 µM 1.90E-6 redox potentiating 8 8.51E-9
13 SGTC_1872 amphotericin b 5.56 148.0 nM 2.67E-6 RNA pol III & RNase P/MRP 13 1.38E-8
14 SGTC_2034 5197015 5.52 53.1 µM 3.07E-6 SWF1 & branched chain AA biosynthesis 11 1.68E-8
15 SGTC_2873 9040596 5.51 71.4 µM 3.24E-6 18 1.81E-8
16 SGTC_2006 4011487 5.51 200.0 µM 3.24E-6 endomembrane recycling 50 1.82E-8
17 SGTC_931 2812-0076 5.34 566.0 µM 6.25E-6 7 4.60E-8
18 SGTC_3284 9108171 5.19 64.9 µM 1.11E-5 9 1.03E-7
19 SGTC_676 falcarinol 5.14 140.0 µM 1.38E-5 25 1.41E-7
20 SGTC_221 trifluoperazine 4.90 10.3 µM 3.27E-5 NEO1-PIK1 165 4.79E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.70E-16 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.136 3.53E-15 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.132 1.93E-14 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.127 1.72E-13 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.124 7.34E-13 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.122 1.77E-12 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.116 1.75E-11 YGL071W AFT1 hom Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.109 2.47E-10 YDL033C SLM3 hom tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)
0.109 2.92E-10 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.105 1.02E-9 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.102 3.27E-9 YMR060C SAM37 hom Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability
0.102 3.36E-9 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.102 3.64E-9 YOL072W THP1 hom Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding
0.097 1.70E-8 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.094 5.60E-8 YNL135C FPR1 hom Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function