YJL059W / YHC3

Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis)

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL059W / YHC3

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.23|P-value:3.07E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.76|P-value:3.65E-13 ID:SGTC_127|Compound:0180-0333|FD-Score:4.74|P-value:2.48E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:-4.16|P-value:4.83E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:7.34|P-value:3.24E-15 ID:SGTC_164|Compound:4100-3994|FD-Score:3.22|P-value:3.15E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.07|P-value:5.55E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.36|P-value:1.82E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.05|P-value:6.19E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.02|P-value:6.86E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.14|P-value:4.34E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:3.60|P-value:6.67E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:4.36|P-value:1.88E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:3.28|P-value:2.48E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.22|P-value:3.12E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.06|P-value:5.62E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.27|P-value:2.60E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:-3.15|P-value:4.04E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:3.16|P-value:4.03E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.00|P-value:1.08E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.74|P-value:3.58E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.02|P-value:6.85E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:-3.13|P-value:4.43E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.32|P-value:2.18E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.86|P-value:2.10E-5 ID:SGTC_1855|Compound:st056195|FD-Score:3.10|P-value:5.07E-4 ID:SGTC_1866|Compound:st057638|FD-Score:-3.10|P-value:4.84E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-3.85|P-value:2.12E-5 ID:SGTC_2111|Compound:5486399|FD-Score:6.68|P-value:6.65E-13 ID:SGTC_2161|Compound:5662504|FD-Score:3.07|P-value:5.61E-4 ID:SGTC_2290|Compound:7904846|FD-Score:2.98|P-value:7.76E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-3.22|P-value:3.16E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.08|P-value:5.41E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.29|P-value:2.46E-4 ID:SGTC_2314|Compound:7727897|FD-Score:4.04|P-value:9.20E-6 ID:SGTC_2334|Compound:9017922|FD-Score:-3.34|P-value:1.92E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.42|P-value:1.46E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.26|P-value:2.77E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.85|P-value:1.34E-7 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.21|P-value:3.34E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.60|P-value:6.71E-5 ID:SGTC_2948|Compound:9070189|FD-Score:3.05|P-value:6.15E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.68|P-value:4.62E-5 ID:SGTC_3237|Compound:9133362|FD-Score:3.47|P-value:1.18E-4 ID:SGTC_3301|Compound:9125354|FD-Score:4.77|P-value:2.11E-7 ID:SGTC_25|Compound:0118-0223|FD-Score:3.23|P-value:3.07E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.76|P-value:3.65E-13 ID:SGTC_127|Compound:0180-0333|FD-Score:4.74|P-value:2.48E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:-4.16|P-value:4.83E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:7.34|P-value:3.24E-15 ID:SGTC_164|Compound:4100-3994|FD-Score:3.22|P-value:3.15E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.07|P-value:5.55E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.36|P-value:1.82E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.05|P-value:6.19E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.02|P-value:6.86E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.14|P-value:4.34E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:3.60|P-value:6.67E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:4.36|P-value:1.88E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:3.28|P-value:2.48E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.22|P-value:3.12E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.06|P-value:5.62E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.27|P-value:2.60E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:-3.15|P-value:4.04E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:3.16|P-value:4.03E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.00|P-value:1.08E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.74|P-value:3.58E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.02|P-value:6.85E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:-3.13|P-value:4.43E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.32|P-value:2.18E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.86|P-value:2.10E-5 ID:SGTC_1855|Compound:st056195|FD-Score:3.10|P-value:5.07E-4 ID:SGTC_1866|Compound:st057638|FD-Score:-3.10|P-value:4.84E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-3.85|P-value:2.12E-5 ID:SGTC_2111|Compound:5486399|FD-Score:6.68|P-value:6.65E-13 ID:SGTC_2161|Compound:5662504|FD-Score:3.07|P-value:5.61E-4 ID:SGTC_2290|Compound:7904846|FD-Score:2.98|P-value:7.76E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-3.22|P-value:3.16E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.08|P-value:5.41E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.29|P-value:2.46E-4 ID:SGTC_2314|Compound:7727897|FD-Score:4.04|P-value:9.20E-6 ID:SGTC_2334|Compound:9017922|FD-Score:-3.34|P-value:1.92E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.42|P-value:1.46E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.26|P-value:2.77E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.85|P-value:1.34E-7 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.21|P-value:3.34E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.60|P-value:6.71E-5 ID:SGTC_2948|Compound:9070189|FD-Score:3.05|P-value:6.15E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.68|P-value:4.62E-5 ID:SGTC_3237|Compound:9133362|FD-Score:3.47|P-value:1.18E-4 ID:SGTC_3301|Compound:9125354|FD-Score:4.77|P-value:2.11E-7

Top fitness defect scores for YJL059W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_138 0850-0259 7.34 40.9 µM 3.24E-15 cell wall 70 1.03E-13
2 SGTC_58 0957-0393 6.76 9.0 µM 3.65E-13 cell wall 172 6.91E-12
3 SGTC_2111 5486399 6.68 200.0 µM 6.65E-13 5 1.18E-11
4 SGTC_2569 tetrandrine 4.85 100.0 µM 1.34E-7 9 6.19E-7
5 SGTC_3301 9125354 4.77 19.8 µM 2.11E-7 6 9.31E-7
6 SGTC_127 0180-0333 4.74 59.1 µM 2.48E-7 mitochondrial response to ROS 20 1.07E-6
7 SGTC_736 0958-0254 4.36 92.6 µM 1.88E-6 Golgi 19 6.53E-6
8 SGTC_2314 7727897 4.04 200.0 µM 9.20E-6 21 2.70E-5
9 SGTC_1047 2043-3044 4.00 82.0 µM 1.08E-5 31 3.12E-5
10 SGTC_1635 st007035 3.86 42.4 µM 2.10E-5 217 5.63E-5
11 SGTC_1228 0124-0032 3.74 52.5 µM 3.58E-5 22 9.08E-5
12 SGTC_670 4204-0025 3.60 119.0 µM 6.67E-5 copper-dependent oxidative stress 40 1.58E-4
13 SGTC_2858 9025781 3.60 9.0 µM 6.71E-5 sphingolipid biosynthesis & PDR1 116 1.59E-4
14 SGTC_3237 9133362 3.47 49.5 µM 1.18E-4 46 2.63E-4
15 SGTC_2356 9061756 3.42 189.0 µM 1.46E-4 19 3.19E-4
16 SGTC_259 usnic acid 3.36 108.9 µM 1.82E-4 36 3.89E-4
17 SGTC_1374 2889-5571 3.32 141.0 µM 2.18E-4 RSC complex & mRNA processing 72 4.56E-4
18 SGTC_2312 7706453 3.29 155.7 µM 2.46E-4 55 5.08E-4
19 SGTC_740 k014-0057 3.28 261.0 µM 2.48E-4 48 5.13E-4
20 SGTC_804 1595-0054 3.27 20.9 µM 2.60E-4 sphingolipid biosynthesis & PDR1 69 5.34E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.288 4.94E-65 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.280 1.15E-61 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.252 1.45E-49 YML057C-A_d YML057C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W
0.246 1.98E-47 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.226 3.82E-40 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.216 7.03E-37 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.213 1.09E-35 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
0.211 5.44E-35 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.208 3.53E-34 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.206 2.27E-33 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.205 3.59E-33 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.201 9.08E-32 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.200 1.21E-31 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.196 2.24E-30 YMR316W DIA1 hom Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.193 2.29E-29 YOR051C ETT1 hom Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough