YJL063C / MRPL8

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL063C / MRPL8

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.99|P-value:1.40E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.84|P-value:2.34E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:6.27|P-value:5.40E-9 ID:SGTC_87|Compound:0100-0052|FD-Score:4.12|P-value:8.80E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:-4.21|P-value:6.02E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.39|P-value:3.11E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:4.91|P-value:3.86E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:6.45|P-value:2.08E-9 ID:SGTC_236|Compound:1509-0011|FD-Score:8.60|P-value:2.18E-15 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.88|P-value:4.32E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:9.59|P-value:1.14E-18 ID:SGTC_314|Compound:1671-0008|FD-Score:4.51|P-value:1.98E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.77|P-value:2.87E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.41|P-value:9.39E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:-3.81|P-value:2.53E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.35|P-value:3.56E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.14|P-value:1.40E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.75|P-value:3.08E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:-3.50|P-value:7.10E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:4.72|P-value:8.52E-6 ID:SGTC_629|Compound:3448-6466|FD-Score:3.70|P-value:3.67E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:-3.78|P-value:2.85E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.90|P-value:1.87E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.18|P-value:6.85E-5 ID:SGTC_755|Compound:1995-0008|FD-Score:3.66|P-value:4.19E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.89|P-value:1.99E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.21|P-value:6.20E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:3.59|P-value:5.33E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:4.15|P-value:7.71E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:5.35|P-value:5.41E-7 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.43|P-value:8.95E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.83|P-value:2.43E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:6.88|P-value:1.76E-10 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.93|P-value:1.68E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:5.10|P-value:1.66E-6 ID:SGTC_1529|Compound:apigenin|FD-Score:3.54|P-value:6.24E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.59|P-value:5.32E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.44|P-value:8.72E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.46|P-value:8.04E-4 ID:SGTC_1623|Compound:st003709|FD-Score:5.02|P-value:2.40E-6 ID:SGTC_1742|Compound:st038235|FD-Score:6.46|P-value:1.98E-9 ID:SGTC_1762|Compound:st045503|FD-Score:3.67|P-value:4.11E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.00|P-value:2.51E-6 ID:SGTC_1922|Compound:5578187|FD-Score:4.04|P-value:1.15E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.96|P-value:1.54E-4 ID:SGTC_2142|Compound:5622915|FD-Score:4.38|P-value:3.24E-5 ID:SGTC_2144|Compound:5628481|FD-Score:4.41|P-value:2.94E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:6.07|P-value:1.53E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.76|P-value:3.04E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.71|P-value:3.56E-4 ID:SGTC_2403|Compound:6032726|FD-Score:4.70|P-value:9.31E-6 ID:SGTC_2482|Compound:5981709|FD-Score:-3.48|P-value:7.50E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:4.36|P-value:3.52E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.71|P-value:9.77E-8 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.56|P-value:5.71E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.56|P-value:5.82E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.51|P-value:6.73E-4 ID:SGTC_2835|Compound:9006588|FD-Score:4.80|P-value:6.02E-6 ID:SGTC_2848|Compound:9016370|FD-Score:4.11|P-value:8.91E-5 ID:SGTC_2882|Compound:9058044|FD-Score:3.45|P-value:8.43E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.93|P-value:1.29E-10 ID:SGTC_2900|Compound:5328528|FD-Score:3.44|P-value:8.56E-4 ID:SGTC_2918|Compound:7977171|FD-Score:-4.21|P-value:6.10E-5 ID:SGTC_2925|Compound:9010536|FD-Score:-4.17|P-value:6.98E-5 ID:SGTC_2969|Compound:9091408|FD-Score:-3.91|P-value:1.81E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.57|P-value:5.67E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-4.16|P-value:7.27E-5 ID:SGTC_3143|Compound:9086658|FD-Score:-3.75|P-value:3.06E-4 ID:SGTC_3190|Compound:9110366|FD-Score:3.77|P-value:2.93E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-3.46|P-value:7.96E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.82|P-value:2.49E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.95|P-value:1.54E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-5.97|P-value:2.59E-8 ID:SGTC_3266|Compound:9136860|FD-Score:-3.65|P-value:4.34E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.99|P-value:1.40E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.84|P-value:2.34E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:6.27|P-value:5.40E-9 ID:SGTC_87|Compound:0100-0052|FD-Score:4.12|P-value:8.80E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:-4.21|P-value:6.02E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.39|P-value:3.11E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:4.91|P-value:3.86E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:6.45|P-value:2.08E-9 ID:SGTC_236|Compound:1509-0011|FD-Score:8.60|P-value:2.18E-15 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.88|P-value:4.32E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:9.59|P-value:1.14E-18 ID:SGTC_314|Compound:1671-0008|FD-Score:4.51|P-value:1.98E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.77|P-value:2.87E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.41|P-value:9.39E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:-3.81|P-value:2.53E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.35|P-value:3.56E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.14|P-value:1.40E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.75|P-value:3.08E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:-3.50|P-value:7.10E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:4.72|P-value:8.52E-6 ID:SGTC_629|Compound:3448-6466|FD-Score:3.70|P-value:3.67E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:-3.78|P-value:2.85E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.90|P-value:1.87E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.18|P-value:6.85E-5 ID:SGTC_755|Compound:1995-0008|FD-Score:3.66|P-value:4.19E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.89|P-value:1.99E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.21|P-value:6.20E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:3.59|P-value:5.33E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:4.15|P-value:7.71E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:5.35|P-value:5.41E-7 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.43|P-value:8.95E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.83|P-value:2.43E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:6.88|P-value:1.76E-10 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.93|P-value:1.68E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:5.10|P-value:1.66E-6 ID:SGTC_1529|Compound:apigenin|FD-Score:3.54|P-value:6.24E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.59|P-value:5.32E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.44|P-value:8.72E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.46|P-value:8.04E-4 ID:SGTC_1623|Compound:st003709|FD-Score:5.02|P-value:2.40E-6 ID:SGTC_1742|Compound:st038235|FD-Score:6.46|P-value:1.98E-9 ID:SGTC_1762|Compound:st045503|FD-Score:3.67|P-value:4.11E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.00|P-value:2.51E-6 ID:SGTC_1922|Compound:5578187|FD-Score:4.04|P-value:1.15E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.96|P-value:1.54E-4 ID:SGTC_2142|Compound:5622915|FD-Score:4.38|P-value:3.24E-5 ID:SGTC_2144|Compound:5628481|FD-Score:4.41|P-value:2.94E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:6.07|P-value:1.53E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.76|P-value:3.04E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.71|P-value:3.56E-4 ID:SGTC_2403|Compound:6032726|FD-Score:4.70|P-value:9.31E-6 ID:SGTC_2482|Compound:5981709|FD-Score:-3.48|P-value:7.50E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:4.36|P-value:3.52E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.71|P-value:9.77E-8 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.56|P-value:5.71E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.56|P-value:5.82E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.51|P-value:6.73E-4 ID:SGTC_2835|Compound:9006588|FD-Score:4.80|P-value:6.02E-6 ID:SGTC_2848|Compound:9016370|FD-Score:4.11|P-value:8.91E-5 ID:SGTC_2882|Compound:9058044|FD-Score:3.45|P-value:8.43E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.93|P-value:1.29E-10 ID:SGTC_2900|Compound:5328528|FD-Score:3.44|P-value:8.56E-4 ID:SGTC_2918|Compound:7977171|FD-Score:-4.21|P-value:6.10E-5 ID:SGTC_2925|Compound:9010536|FD-Score:-4.17|P-value:6.98E-5 ID:SGTC_2969|Compound:9091408|FD-Score:-3.91|P-value:1.81E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.57|P-value:5.67E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-4.16|P-value:7.27E-5 ID:SGTC_3143|Compound:9086658|FD-Score:-3.75|P-value:3.06E-4 ID:SGTC_3190|Compound:9110366|FD-Score:3.77|P-value:2.93E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-3.46|P-value:7.96E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.82|P-value:2.49E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.95|P-value:1.54E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-5.97|P-value:2.59E-8 ID:SGTC_3266|Compound:9136860|FD-Score:-3.65|P-value:4.34E-4

Top fitness defect scores for YJL063C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 9.59 1.1 µM 1.14E-18 mitochondrial stress 49 4.46E-22
2 SGTC_236 1509-0011 8.60 5.3 µM 2.18E-15 232 3.85E-18
3 SGTC_1284 0929-0043 6.88 16.0 µM 1.76E-10 3 2.96E-12
4 SGTC_1742 st038235 6.46 28.9 µM 1.98E-9 mitochondrial stress 38 5.35E-11
5 SGTC_173 1273-0061 6.45 2.7 µM 2.08E-9 mitochondrial stress 98 5.69E-11
6 SGTC_63 0099-0242 6.27 26.7 µM 5.40E-9 mitochondrial stress 24 1.78E-10
7 SGTC_2232 chlorophetanol 6.07 41.5 µM 1.53E-8 TRP & mitochondrial translation 41 6.21E-10
8 SGTC_2688 kanamycin b 5.71 96.7 µM 9.77E-8 calcium & mitochondrial duress 179 5.70E-9
9 SGTC_1036 k216-0215 5.35 33.5 µM 5.41E-7 mitochondrial response to ROS 19 4.41E-8
10 SGTC_1373 2887-0003 5.10 58.5 µM 1.66E-6 Golgi 6 1.69E-7
11 SGTC_1623 st003709 5.02 20.3 µM 2.40E-6 calcium & mitochondrial duress 30 2.62E-7
12 SGTC_119 0121-0043 4.91 24.8 µM 3.86E-6 mitochondrial stress 61 4.62E-7
13 SGTC_275 trichlorophene 4.88 5.7 µM 4.32E-6 mitochondrial stress 174 5.28E-7
14 SGTC_2835 9006588 4.80 71.4 µM 6.02E-6 22 7.86E-7
15 SGTC_601 0986-0029 4.72 62.9 µM 8.52E-6 calcium & mitochondrial duress 19 1.19E-6
16 SGTC_2403 6032726 4.70 181.2 µM 9.31E-6 22 1.32E-6
17 SGTC_314 1671-0008 4.51 2.7 µM 1.98E-5 34 3.26E-6
18 SGTC_2144 5628481 4.41 200.0 µM 2.94E-5 ERG2 15 5.23E-6
19 SGTC_118 0083-0097 4.39 135.3 µM 3.11E-5 translation 91 5.58E-6
20 SGTC_2142 5622915 4.38 118.5 µM 3.24E-5 7 5.87E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.451 8.81E-168 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.443 2.76E-161 YLR439W MRPL4 hom Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit
0.440 3.01E-159 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.427 1.39E-148 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.426 8.33E-148 YGR219W_d YGR219W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C
0.424 1.15E-146 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.417 1.45E-141 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.415 6.70E-140 YMR282C AEP2 hom Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
0.406 2.07E-133 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.403 5.63E-131 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.399 1.02E-127 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.397 9.88E-127 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.395 9.64E-126 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.395 2.33E-125 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.393 2.13E-124 YDL045W-A MRP10 hom Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs