YJL064W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL064W / YJL064W

Click on Significant Values for Screen Details ID:SGTC_401|Compound:neomycin|FD-Score:3.20|P-value:5.38E-4 ID:SGTC_714|Compound:4296-0578|FD-Score:-3.88|P-value:4.09E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:-4.53|P-value:2.10E-6 ID:SGTC_729|Compound:4092-0585|FD-Score:4.52|P-value:1.97E-6 ID:SGTC_737|Compound:1950-0117|FD-Score:3.83|P-value:4.58E-5 ID:SGTC_1530|Compound:rhein|FD-Score:5.28|P-value:3.56E-8 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:4.07|P-value:1.61E-5 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:9.78|P-value:9.57E-24 ID:SGTC_1547|Compound:harmine|FD-Score:-4.52|P-value:2.16E-6 ID:SGTC_1556|Compound:plumbagin|FD-Score:4.05|P-value:1.73E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.29|P-value:5.86E-6 ID:SGTC_1567|Compound:st069303|FD-Score:3.66|P-value:9.03E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.90|P-value:3.45E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.30|P-value:4.01E-4 ID:SGTC_1626|Compound:st003712|FD-Score:6.19|P-value:1.36E-10 ID:SGTC_1636|Compound:st007707|FD-Score:5.35|P-value:2.43E-8 ID:SGTC_1678|Compound:st019265|FD-Score:3.09|P-value:7.81E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.68|P-value:9.24E-5 ID:SGTC_1842|Compound:st055362|FD-Score:-3.39|P-value:2.93E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.65|P-value:1.03E-6 ID:SGTC_1939|Compound:st074455|FD-Score:3.46|P-value:2.03E-4 ID:SGTC_1945|Compound:st075991|FD-Score:5.40|P-value:1.79E-8 ID:SGTC_1989|Compound:st071868|FD-Score:4.19|P-value:9.32E-6 ID:SGTC_2066|Compound:5222451|FD-Score:-3.84|P-value:4.75E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.59|P-value:1.22E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.24|P-value:4.62E-4 ID:SGTC_2306|Compound:7482397|FD-Score:4.67|P-value:9.37E-7 ID:SGTC_2315|Compound:7733312|FD-Score:-3.81|P-value:5.45E-5 ID:SGTC_2356|Compound:9061756|FD-Score:-4.23|P-value:8.62E-6 ID:SGTC_2368|Compound:9071271|FD-Score:3.42|P-value:2.39E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-5.82|P-value:1.67E-9 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-4.15|P-value:1.25E-5 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-7.54|P-value:8.44E-15 ID:SGTC_2639|Compound:lactacystin|FD-Score:14.00|P-value:2.51E-46 ID:SGTC_2749|Compound:bexarotene|FD-Score:8.73|P-value:2.76E-19 ID:SGTC_2755|Compound:lomerizine|FD-Score:-4.94|P-value:2.55E-7 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.61|P-value:1.13E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.24|P-value:4.58E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.26|P-value:4.73E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-3.05|P-value:9.89E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-3.32|P-value:3.83E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-4.19|P-value:1.03E-5 ID:SGTC_2919|Compound:7978188|FD-Score:3.18|P-value:5.85E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.81|P-value:5.02E-5 ID:SGTC_3007|Compound:9078383|FD-Score:4.79|P-value:4.94E-7 ID:SGTC_3020|Compound:9089140|FD-Score:3.53|P-value:1.57E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-4.52|P-value:2.19E-6 ID:SGTC_3040|Compound:9091894|FD-Score:3.34|P-value:3.22E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.27|P-value:4.16E-4 ID:SGTC_3097|Compound:9117246|FD-Score:-3.10|P-value:8.41E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.79|P-value:5.56E-7 ID:SGTC_3200|Compound:9114385|FD-Score:3.11|P-value:7.30E-4 ID:SGTC_401|Compound:neomycin|FD-Score:3.20|P-value:5.38E-4 ID:SGTC_714|Compound:4296-0578|FD-Score:-3.88|P-value:4.09E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:-4.53|P-value:2.10E-6 ID:SGTC_729|Compound:4092-0585|FD-Score:4.52|P-value:1.97E-6 ID:SGTC_737|Compound:1950-0117|FD-Score:3.83|P-value:4.58E-5 ID:SGTC_1530|Compound:rhein|FD-Score:5.28|P-value:3.56E-8 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:4.07|P-value:1.61E-5 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:9.78|P-value:9.57E-24 ID:SGTC_1547|Compound:harmine|FD-Score:-4.52|P-value:2.16E-6 ID:SGTC_1556|Compound:plumbagin|FD-Score:4.05|P-value:1.73E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.29|P-value:5.86E-6 ID:SGTC_1567|Compound:st069303|FD-Score:3.66|P-value:9.03E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.90|P-value:3.45E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.30|P-value:4.01E-4 ID:SGTC_1626|Compound:st003712|FD-Score:6.19|P-value:1.36E-10 ID:SGTC_1636|Compound:st007707|FD-Score:5.35|P-value:2.43E-8 ID:SGTC_1678|Compound:st019265|FD-Score:3.09|P-value:7.81E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.68|P-value:9.24E-5 ID:SGTC_1842|Compound:st055362|FD-Score:-3.39|P-value:2.93E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.65|P-value:1.03E-6 ID:SGTC_1939|Compound:st074455|FD-Score:3.46|P-value:2.03E-4 ID:SGTC_1945|Compound:st075991|FD-Score:5.40|P-value:1.79E-8 ID:SGTC_1989|Compound:st071868|FD-Score:4.19|P-value:9.32E-6 ID:SGTC_2066|Compound:5222451|FD-Score:-3.84|P-value:4.75E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.59|P-value:1.22E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.24|P-value:4.62E-4 ID:SGTC_2306|Compound:7482397|FD-Score:4.67|P-value:9.37E-7 ID:SGTC_2315|Compound:7733312|FD-Score:-3.81|P-value:5.45E-5 ID:SGTC_2356|Compound:9061756|FD-Score:-4.23|P-value:8.62E-6 ID:SGTC_2368|Compound:9071271|FD-Score:3.42|P-value:2.39E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-5.82|P-value:1.67E-9 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-4.15|P-value:1.25E-5 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-7.54|P-value:8.44E-15 ID:SGTC_2639|Compound:lactacystin|FD-Score:14.00|P-value:2.51E-46 ID:SGTC_2749|Compound:bexarotene|FD-Score:8.73|P-value:2.76E-19 ID:SGTC_2755|Compound:lomerizine|FD-Score:-4.94|P-value:2.55E-7 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.61|P-value:1.13E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.24|P-value:4.58E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.26|P-value:4.73E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-3.05|P-value:9.89E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-3.32|P-value:3.83E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-4.19|P-value:1.03E-5 ID:SGTC_2919|Compound:7978188|FD-Score:3.18|P-value:5.85E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.81|P-value:5.02E-5 ID:SGTC_3007|Compound:9078383|FD-Score:4.79|P-value:4.94E-7 ID:SGTC_3020|Compound:9089140|FD-Score:3.53|P-value:1.57E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-4.52|P-value:2.19E-6 ID:SGTC_3040|Compound:9091894|FD-Score:3.34|P-value:3.22E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.27|P-value:4.16E-4 ID:SGTC_3097|Compound:9117246|FD-Score:-3.10|P-value:8.41E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.79|P-value:5.56E-7 ID:SGTC_3200|Compound:9114385|FD-Score:3.11|P-value:7.30E-4

Top fitness defect scores for YJL064W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2639 lactacystin 14.00 53.0 µM 2.51E-46 1 1.16E-44
2 SGTC_1542 7-hydroxy-3'-methoxyflavone 9.78 49.7 µM 9.57E-24 1 6.56E-23
3 SGTC_2749 bexarotene 8.73 57.4 µM 2.76E-19 1 1.30E-18
4 SGTC_1626 st003712 6.19 1.8 µM 1.36E-10 7 3.05E-10
5 SGTC_1945 st075991 5.40 56.6 µM 1.79E-8 60S ribosome export 3 3.35E-8
6 SGTC_1636 st007707 5.35 68.9 µM 2.43E-8 23 4.51E-8
7 SGTC_1530 rhein 5.28 70.4 µM 3.56E-8 5 6.51E-8
8 SGTC_3007 9078383 4.79 71.4 µM 4.94E-7 6 8.20E-7
9 SGTC_2306 7482397 4.67 179.5 µM 9.37E-7 RPP1 & pyrimidine depletion 12 1.52E-6
10 SGTC_1844 rapamycin 4.65 4.0 nM 1.03E-6 125 1.66E-6
11 SGTC_729 4092-0585 4.52 94.1 µM 1.97E-6 16 3.10E-6
12 SGTC_1557 sumaresinolic acid 4.29 42.3 µM 5.86E-6 11 8.88E-6
13 SGTC_1989 st071868 4.19 50.2 µM 9.32E-6 8 1.39E-5
14 SGTC_1535 tetrahydropapaveroline hydrobromide 4.07 54.3 µM 1.61E-5 RPP1 & pyrimidine depletion 8 2.35E-5
15 SGTC_1556 plumbagin 4.05 1.5 µM 1.73E-5 superoxide 19 2.52E-5
16 SGTC_1575 cyproterone acetate 3.90 48.0 µM 3.45E-5 20 4.89E-5
17 SGTC_737 1950-0117 3.83 57.9 µM 4.58E-5 28 6.43E-5
18 SGTC_2940 9060638 3.81 45.9 µM 5.02E-5 amide catabolism 32 7.02E-5
19 SGTC_1567 st069303 3.66 68.4 µM 9.03E-5 mitochondrial processes 25 1.24E-4
20 SGTC_2758 dehydroepiandrosterone 3.61 69.3 µM 1.13E-4 51 1.53E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.23E-15 YJR004C SAG1 hom Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
0.124 6.81E-13 YJL107C_p YJL107C_p hom Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
0.118 7.76E-12 YOR288C MPD1 hom Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation
0.115 2.48E-11 YOR344C TYE7 hom Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression
0.113 4.79E-11 YCL041C_d YCL041C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W
0.107 5.43E-10 YFL009W CDC4 het F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p
0.106 7.08E-10 YEL052W AFG1 hom Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain
0.104 1.62E-9 YMR283C RIT1 hom 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA
0.096 2.84E-8 YFR031C-A RPL2A hom Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication
0.090 1.80E-7 YBR181C RPS6B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication
0.089 2.30E-7 YDL229W SSB1 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication
0.088 3.76E-7 YBR218C PYC2 hom Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication
0.086 6.75E-7 YDL172C_d YDL172C_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.086 6.82E-7 YHR095W_d YHR095W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.085 8.97E-7 YDL121C_p YDL121C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein