YJL066C / MPM1

Mitochondrial intermembrane space protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL066C / MPM1

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:4.48|P-value:1.18E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:-3.26|P-value:0.00100 ID:SGTC_76|Compound:0433-0009|FD-Score:4.47|P-value:1.19E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:3.35|P-value:7.92E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:-3.59|P-value:3.34E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.32|P-value:8.19E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.57|P-value:3.71E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.47|P-value:5.27E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.84|P-value:1.40E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.44|P-value:5.86E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.50|P-value:4.79E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.94|P-value:1.00E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:-3.34|P-value:7.78E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:3.31|P-value:8.90E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.36|P-value:7.69E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:4.17|P-value:4.15E-5 ID:SGTC_1392|Compound:3455-1037|FD-Score:4.03|P-value:7.04E-5 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.51|P-value:4.57E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.96|P-value:9.13E-5 ID:SGTC_1784|Compound:st039334|FD-Score:3.47|P-value:5.21E-4 ID:SGTC_1889|Compound:st059080|FD-Score:-3.28|P-value:9.38E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-4.55|P-value:8.24E-6 ID:SGTC_2011|Compound:4012611|FD-Score:3.65|P-value:2.88E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.79|P-value:1.72E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.41|P-value:6.35E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.29|P-value:9.57E-4 ID:SGTC_2149|Compound:5554786|FD-Score:4.89|P-value:1.90E-6 ID:SGTC_2315|Compound:7733312|FD-Score:3.89|P-value:1.22E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.87|P-value:1.30E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.80|P-value:1.60E-4 ID:SGTC_2435|Compound:5706476|FD-Score:6.19|P-value:2.46E-9 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.34|P-value:7.77E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.62|P-value:3.19E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-5.37|P-value:1.90E-7 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.36|P-value:7.40E-4 ID:SGTC_2897|Compound:9048598|FD-Score:4.20|P-value:3.70E-5 ID:SGTC_2925|Compound:9010536|FD-Score:4.47|P-value:1.23E-5 ID:SGTC_2934|Compound:9036370|FD-Score:-4.97|P-value:1.28E-6 ID:SGTC_2992|Compound:9074591|FD-Score:6.04|P-value:5.83E-9 ID:SGTC_2994|Compound:9053520|FD-Score:3.57|P-value:3.82E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.82|P-value:1.55E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-3.46|P-value:5.32E-4 ID:SGTC_3103|Compound:9120822|FD-Score:4.06|P-value:6.43E-5 ID:SGTC_3115|Compound:9123671|FD-Score:3.43|P-value:6.04E-4 ID:SGTC_3326|Compound:9140064|FD-Score:4.25|P-value:3.04E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:4.48|P-value:1.18E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:-3.26|P-value:0.00100 ID:SGTC_76|Compound:0433-0009|FD-Score:4.47|P-value:1.19E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:3.35|P-value:7.92E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:-3.59|P-value:3.34E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.32|P-value:8.19E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.57|P-value:3.71E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.47|P-value:5.27E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.84|P-value:1.40E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.44|P-value:5.86E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.50|P-value:4.79E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.94|P-value:1.00E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:-3.34|P-value:7.78E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:3.31|P-value:8.90E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.36|P-value:7.69E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:4.17|P-value:4.15E-5 ID:SGTC_1392|Compound:3455-1037|FD-Score:4.03|P-value:7.04E-5 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.51|P-value:4.57E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.96|P-value:9.13E-5 ID:SGTC_1784|Compound:st039334|FD-Score:3.47|P-value:5.21E-4 ID:SGTC_1889|Compound:st059080|FD-Score:-3.28|P-value:9.38E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-4.55|P-value:8.24E-6 ID:SGTC_2011|Compound:4012611|FD-Score:3.65|P-value:2.88E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.79|P-value:1.72E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.41|P-value:6.35E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.29|P-value:9.57E-4 ID:SGTC_2149|Compound:5554786|FD-Score:4.89|P-value:1.90E-6 ID:SGTC_2315|Compound:7733312|FD-Score:3.89|P-value:1.22E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.87|P-value:1.30E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.80|P-value:1.60E-4 ID:SGTC_2435|Compound:5706476|FD-Score:6.19|P-value:2.46E-9 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.34|P-value:7.77E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.62|P-value:3.19E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-5.37|P-value:1.90E-7 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.36|P-value:7.40E-4 ID:SGTC_2897|Compound:9048598|FD-Score:4.20|P-value:3.70E-5 ID:SGTC_2925|Compound:9010536|FD-Score:4.47|P-value:1.23E-5 ID:SGTC_2934|Compound:9036370|FD-Score:-4.97|P-value:1.28E-6 ID:SGTC_2992|Compound:9074591|FD-Score:6.04|P-value:5.83E-9 ID:SGTC_2994|Compound:9053520|FD-Score:3.57|P-value:3.82E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.82|P-value:1.55E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-3.46|P-value:5.32E-4 ID:SGTC_3103|Compound:9120822|FD-Score:4.06|P-value:6.43E-5 ID:SGTC_3115|Compound:9123671|FD-Score:3.43|P-value:6.04E-4 ID:SGTC_3326|Compound:9140064|FD-Score:4.25|P-value:3.04E-5

Top fitness defect scores for YJL066C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2435 5706476 6.19 10.6 µM 2.46E-9 5 2.96E-10
2 SGTC_2992 9074591 6.04 71.4 µM 5.83E-9 3 7.73E-10
3 SGTC_2149 5554786 4.89 194.8 µM 1.90E-6 cell wall signaling 17 4.93E-7
4 SGTC_22 0964-0034 4.48 14.5 µM 1.18E-5 unfolded protein response 38 3.79E-6
5 SGTC_76 0433-0009 4.47 400.3 µM 1.19E-5 7 3.83E-6
6 SGTC_2925 9010536 4.47 32.5 µM 1.23E-5 azole & statin 30 3.97E-6
7 SGTC_3326 9140064 4.25 16.4 µM 3.04E-5 17 1.08E-5
8 SGTC_2897 9048598 4.20 13.0 µM 3.70E-5 9 1.35E-5
9 SGTC_1299 1079-1439 4.17 3.7 µM 4.15E-5 TSC3-RPN4 9 1.53E-5
10 SGTC_3103 9120822 4.06 49.5 µM 6.43E-5 12 2.50E-5
11 SGTC_1392 3455-1037 4.03 33.9 µM 7.04E-5 14 2.77E-5
12 SGTC_1541 2',3',6-trimethoxyflavone 3.96 64.0 µM 9.13E-5 12 3.69E-5
13 SGTC_821 1114-0266 3.94 29.2 µM 1.00E-4 19 4.09E-5
14 SGTC_2315 7733312 3.89 200.0 µM 1.22E-4 28 5.09E-5
15 SGTC_2369 9071472 3.87 200.0 µM 1.30E-4 17 5.49E-5
16 SGTC_3072 9116419 3.82 49.5 µM 1.55E-4 ERG2 21 6.68E-5
17 SGTC_2035 5154463 3.79 94.6 µM 1.72E-4 16 7.48E-5
18 SGTC_2011 4012611 3.65 177.0 µM 2.88E-4 mitochondrial processes 40 1.33E-4
19 SGTC_2603 homopterocarpin 3.62 100.0 µM 3.19E-4 56 1.48E-4
20 SGTC_471 1-acyl-paf 3.57 4.0 µM 3.71E-4 DNA intercalators 40 1.76E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.45E-12 YGL225W VRG4 het Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
0.090 1.73E-7 YCL025C AGP1 hom Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication
0.080 3.87E-6 YCR101C_p YCR101C_p hom Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene
0.073 2.05E-5 YPL185W_d YPL185W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
0.073 2.21E-5 YMR141C_d YMR141C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.073 2.35E-5 YHR204W MNL1 hom Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation
0.073 2.62E-5 YJL218W_p YJL218W_p hom Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
0.070 4.42E-5 YKL154W SRP102 het Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane
0.069 6.64E-5 YGR073C_d YGR073C_d het Dubious open reading frame unlikely to encode a functional protein, extensively overlaps essential SMD1 gene encoding a U6 snRNP protein
0.069 6.90E-5 YOR296W_p YOR296W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene
0.067 1.01E-4 YPR012W_d YPR012W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene
0.067 1.02E-4 YFR035C_p YFR035C_p hom Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein
0.067 1.03E-4 YFL031W HAC1 hom Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress
0.066 1.21E-4 YBR170C NPL4 hom Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)
0.066 1.23E-4 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction