YJL067W_d

Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL067W / YJL067W

Click on Significant Values for Screen Details ID:SGTC_264|Compound:promethazine|FD-Score:-3.00|P-value:6.75E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:-3.14|P-value:3.95E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.21|P-value:2.99E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:2.97|P-value:6.74E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:4.18|P-value:3.39E-6 ID:SGTC_430|Compound:0958-0115|FD-Score:3.30|P-value:1.86E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:-4.25|P-value:2.64E-6 ID:SGTC_553|Compound:k007-0256|FD-Score:3.41|P-value:1.18E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.14|P-value:3.95E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:4.38|P-value:1.23E-6 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.74|P-value:2.84E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.81|P-value:1.98E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:4.11|P-value:4.84E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:3.59|P-value:5.51E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:3.68|P-value:3.69E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.62|P-value:5.35E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-4.28|P-value:2.31E-6 ID:SGTC_1384|Compound:3089-0840|FD-Score:6.94|P-value:4.09E-14 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.49|P-value:8.47E-5 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.14|P-value:3.53E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:4.36|P-value:1.30E-6 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.26|P-value:2.22E-4 ID:SGTC_1591|Compound:genipin|FD-Score:-3.36|P-value:1.65E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.43|P-value:1.09E-4 ID:SGTC_1840|Compound:st055363|FD-Score:-4.90|P-value:7.68E-8 ID:SGTC_1844|Compound:rapamycin|FD-Score:2.89|P-value:9.18E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.18|P-value:3.02E-4 ID:SGTC_1899|Compound:st063254|FD-Score:3.07|P-value:4.72E-4 ID:SGTC_1979|Compound:st071809|FD-Score:-4.69|P-value:2.47E-7 ID:SGTC_1984|Compound:st072354|FD-Score:4.22|P-value:2.72E-6 ID:SGTC_2172|Compound:5754775|FD-Score:-2.92|P-value:8.93E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.42|P-value:1.15E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.04|P-value:5.72E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-3.41|P-value:1.29E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-3.04|P-value:5.62E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.39|P-value:1.45E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.48|P-value:7.12E-7 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-4.82|P-value:1.21E-7 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.32|P-value:1.62E-6 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:2.93|P-value:7.95E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-2.95|P-value:7.96E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.53|P-value:7.23E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:6.84|P-value:9.38E-14 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.02|P-value:5.62E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.73|P-value:2.99E-5 ID:SGTC_2804|Compound:7954240|FD-Score:3.85|P-value:1.69E-5 ID:SGTC_3047|Compound:9092122|FD-Score:-3.67|P-value:4.25E-5 ID:SGTC_3056|Compound:9094900|FD-Score:-2.92|P-value:8.78E-4 ID:SGTC_3189|Compound:9110682|FD-Score:4.71|P-value:2.01E-7 ID:SGTC_3289|Compound:9119912|FD-Score:-3.39|P-value:1.43E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.16|P-value:3.23E-4 ID:SGTC_3337|Compound:9144342|FD-Score:4.30|P-value:1.87E-6 ID:SGTC_3342|Compound:9147791|FD-Score:3.81|P-value:2.01E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-3.00|P-value:6.75E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:-3.14|P-value:3.95E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.21|P-value:2.99E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:2.97|P-value:6.74E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:4.18|P-value:3.39E-6 ID:SGTC_430|Compound:0958-0115|FD-Score:3.30|P-value:1.86E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:-4.25|P-value:2.64E-6 ID:SGTC_553|Compound:k007-0256|FD-Score:3.41|P-value:1.18E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.14|P-value:3.95E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:4.38|P-value:1.23E-6 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.74|P-value:2.84E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.81|P-value:1.98E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:4.11|P-value:4.84E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:3.59|P-value:5.51E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:3.68|P-value:3.69E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.62|P-value:5.35E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-4.28|P-value:2.31E-6 ID:SGTC_1384|Compound:3089-0840|FD-Score:6.94|P-value:4.09E-14 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.49|P-value:8.47E-5 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.14|P-value:3.53E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:4.36|P-value:1.30E-6 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.26|P-value:2.22E-4 ID:SGTC_1591|Compound:genipin|FD-Score:-3.36|P-value:1.65E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.43|P-value:1.09E-4 ID:SGTC_1840|Compound:st055363|FD-Score:-4.90|P-value:7.68E-8 ID:SGTC_1844|Compound:rapamycin|FD-Score:2.89|P-value:9.18E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.18|P-value:3.02E-4 ID:SGTC_1899|Compound:st063254|FD-Score:3.07|P-value:4.72E-4 ID:SGTC_1979|Compound:st071809|FD-Score:-4.69|P-value:2.47E-7 ID:SGTC_1984|Compound:st072354|FD-Score:4.22|P-value:2.72E-6 ID:SGTC_2172|Compound:5754775|FD-Score:-2.92|P-value:8.93E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.42|P-value:1.15E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.04|P-value:5.72E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-3.41|P-value:1.29E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-3.04|P-value:5.62E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.39|P-value:1.45E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.48|P-value:7.12E-7 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-4.82|P-value:1.21E-7 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.32|P-value:1.62E-6 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:2.93|P-value:7.95E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-2.95|P-value:7.96E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.53|P-value:7.23E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:6.84|P-value:9.38E-14 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.02|P-value:5.62E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.73|P-value:2.99E-5 ID:SGTC_2804|Compound:7954240|FD-Score:3.85|P-value:1.69E-5 ID:SGTC_3047|Compound:9092122|FD-Score:-3.67|P-value:4.25E-5 ID:SGTC_3056|Compound:9094900|FD-Score:-2.92|P-value:8.78E-4 ID:SGTC_3189|Compound:9110682|FD-Score:4.71|P-value:2.01E-7 ID:SGTC_3289|Compound:9119912|FD-Score:-3.39|P-value:1.43E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.16|P-value:3.23E-4 ID:SGTC_3337|Compound:9144342|FD-Score:4.30|P-value:1.87E-6 ID:SGTC_3342|Compound:9147791|FD-Score:3.81|P-value:2.01E-5

Top fitness defect scores for YJL067W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1384 3089-0840 6.94 101.0 µM 4.09E-14 2 1.94E-12
2 SGTC_2690 usnic acid 6.84 100.0 µM 9.38E-14 3 3.99E-12
3 SGTC_3189 9110682 4.71 49.5 µM 2.01E-7 20 1.26E-6
4 SGTC_2607 solasodine 4.48 47.4 µM 7.12E-7 42 3.77E-6
5 SGTC_565 1418-0001 4.38 44.5 µM 1.23E-6 10 6.05E-6
6 SGTC_1545 lovastatin 4.36 49.4 µM 1.30E-6 14 6.36E-6
7 SGTC_2636 apigenin dimethyl ether 4.32 100.0 µM 1.62E-6 32 7.70E-6
8 SGTC_3337 9144342 4.30 33.5 µM 1.87E-6 20 8.73E-6
9 SGTC_1984 st072354 4.22 53.1 µM 2.72E-6 12 1.21E-5
10 SGTC_416 estradiol valerate 4.18 100.0 µM 3.39E-6 5 1.46E-5
11 SGTC_807 1315-0151 4.11 48.0 µM 4.84E-6 23 2.00E-5
12 SGTC_2804 7954240 3.85 19.5 µM 1.69E-5 33 5.94E-5
13 SGTC_690 glyoxal 3.81 20.3 µM 1.98E-5 86 6.81E-5
14 SGTC_3342 9147791 3.81 14.5 µM 2.01E-5 18 6.88E-5
15 SGTC_585 0kpi-0023 3.74 191.0 µM 2.84E-5 21 9.33E-5
16 SGTC_2725 haloperidol 3.73 53.2 µM 2.99E-5 plasma membrane duress 43 9.76E-5
17 SGTC_909 3448-9333 3.68 149.0 µM 3.69E-5 23 1.17E-4
18 SGTC_908 3448-7491 3.59 47.7 µM 5.51E-5 mitochondrial stress 145 1.66E-4
19 SGTC_2665 lovastatin 3.53 100.0 µM 7.23E-5 20 2.10E-4
20 SGTC_1436 4092-1007 3.49 8.3 µM 8.47E-5 24 2.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 4.59E-15 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.132 1.54E-14 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.120 3.27E-12 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.114 3.25E-11 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.107 4.80E-10 YJR100C AIM25 hom Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.098 1.17E-8 YJL057C IKS1 hom Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p
0.094 5.09E-8 YJL100W LSB6 hom Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
0.093 6.01E-8 YIL115C NUP159 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)
0.091 1.18E-7 YMR281W GPI12 het ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp
0.088 2.94E-7 YAL004W_d YAL004W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C
0.088 3.52E-7 YJL043W_p YJL043W_p hom Putative protein of unknown function; YJL043W is a non-essential gene
0.088 3.75E-7 YBR135W CKS1 het Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters
0.087 4.81E-7 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.085 9.39E-7 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.083 1.47E-6 YDL217C TIM22 het Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported