YJL068C

Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL068C / YJL068C

Click on Significant Values for Screen Details ID:SGTC_135|Compound:0933-0004|FD-Score:2.96|P-value:6.63E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:2.98|P-value:6.24E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:-2.88|P-value:9.06E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:4.92|P-value:4.81E-8 ID:SGTC_321|Compound:4534-3890|FD-Score:3.69|P-value:3.27E-5 ID:SGTC_332|Compound:4112-0506|FD-Score:3.08|P-value:4.31E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:4.46|P-value:6.75E-7 ID:SGTC_404|Compound:fumagillin|FD-Score:3.15|P-value:3.23E-4 ID:SGTC_417|Compound:st075190|FD-Score:-3.03|P-value:5.11E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.53|P-value:6.57E-5 ID:SGTC_443|Compound:clozapine|FD-Score:3.81|P-value:1.82E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.91|P-value:1.14E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:-2.97|P-value:6.45E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-3.05|P-value:4.72E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:5.56|P-value:8.62E-10 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.78|P-value:2.13E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.60|P-value:4.69E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:2.90|P-value:8.52E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.33|P-value:1.58E-4 ID:SGTC_1676|Compound:st018489|FD-Score:4.86|P-value:6.91E-8 ID:SGTC_1710|Compound:st031758|FD-Score:3.14|P-value:3.37E-4 ID:SGTC_1786|Compound:berberine|FD-Score:2.93|P-value:7.65E-4 ID:SGTC_1798|Compound:st045719|FD-Score:-2.90|P-value:8.48E-4 ID:SGTC_1805|Compound:st050013|FD-Score:3.16|P-value:3.08E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.36|P-value:1.34E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.25|P-value:2.04E-6 ID:SGTC_1925|Compound:st057770|FD-Score:3.44|P-value:9.86E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-9.31|P-value:3.24E-24 ID:SGTC_1927|Compound:st060202|FD-Score:4.93|P-value:4.58E-8 ID:SGTC_1933|Compound:st074711|FD-Score:-2.86|P-value:9.85E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.96|P-value:8.75E-6 ID:SGTC_2316|Compound:5844804|FD-Score:-3.42|P-value:1.04E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-3.14|P-value:3.37E-4 ID:SGTC_2327|Compound:6189656|FD-Score:2.99|P-value:6.12E-4 ID:SGTC_2352|Compound:9027995|FD-Score:-3.48|P-value:8.16E-5 ID:SGTC_2453|Compound:5731132|FD-Score:3.84|P-value:1.63E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:4.89|P-value:5.80E-8 ID:SGTC_2821|Compound:7996764|FD-Score:-3.40|P-value:1.13E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.06|P-value:4.61E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.99|P-value:7.62E-6 ID:SGTC_2894|Compound:9048625|FD-Score:3.08|P-value:4.33E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.36|P-value:1.38E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-3.33|P-value:1.51E-4 ID:SGTC_2965|Compound:9082772|FD-Score:2.98|P-value:6.15E-4 ID:SGTC_3098|Compound:9119039|FD-Score:2.91|P-value:7.99E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.78|P-value:2.10E-5 ID:SGTC_3289|Compound:9119912|FD-Score:3.23|P-value:2.37E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.94|P-value:9.93E-6 ID:SGTC_3325|Compound:9138760|FD-Score:2.95|P-value:7.00E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-5.78|P-value:1.87E-10 ID:SGTC_135|Compound:0933-0004|FD-Score:2.96|P-value:6.63E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:2.98|P-value:6.24E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:-2.88|P-value:9.06E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:4.92|P-value:4.81E-8 ID:SGTC_321|Compound:4534-3890|FD-Score:3.69|P-value:3.27E-5 ID:SGTC_332|Compound:4112-0506|FD-Score:3.08|P-value:4.31E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:4.46|P-value:6.75E-7 ID:SGTC_404|Compound:fumagillin|FD-Score:3.15|P-value:3.23E-4 ID:SGTC_417|Compound:st075190|FD-Score:-3.03|P-value:5.11E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.53|P-value:6.57E-5 ID:SGTC_443|Compound:clozapine|FD-Score:3.81|P-value:1.82E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.91|P-value:1.14E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:-2.97|P-value:6.45E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-3.05|P-value:4.72E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:5.56|P-value:8.62E-10 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.78|P-value:2.13E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.60|P-value:4.69E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:2.90|P-value:8.52E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.33|P-value:1.58E-4 ID:SGTC_1676|Compound:st018489|FD-Score:4.86|P-value:6.91E-8 ID:SGTC_1710|Compound:st031758|FD-Score:3.14|P-value:3.37E-4 ID:SGTC_1786|Compound:berberine|FD-Score:2.93|P-value:7.65E-4 ID:SGTC_1798|Compound:st045719|FD-Score:-2.90|P-value:8.48E-4 ID:SGTC_1805|Compound:st050013|FD-Score:3.16|P-value:3.08E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.36|P-value:1.34E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.25|P-value:2.04E-6 ID:SGTC_1925|Compound:st057770|FD-Score:3.44|P-value:9.86E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-9.31|P-value:3.24E-24 ID:SGTC_1927|Compound:st060202|FD-Score:4.93|P-value:4.58E-8 ID:SGTC_1933|Compound:st074711|FD-Score:-2.86|P-value:9.85E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.96|P-value:8.75E-6 ID:SGTC_2316|Compound:5844804|FD-Score:-3.42|P-value:1.04E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-3.14|P-value:3.37E-4 ID:SGTC_2327|Compound:6189656|FD-Score:2.99|P-value:6.12E-4 ID:SGTC_2352|Compound:9027995|FD-Score:-3.48|P-value:8.16E-5 ID:SGTC_2453|Compound:5731132|FD-Score:3.84|P-value:1.63E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:4.89|P-value:5.80E-8 ID:SGTC_2821|Compound:7996764|FD-Score:-3.40|P-value:1.13E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.06|P-value:4.61E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.99|P-value:7.62E-6 ID:SGTC_2894|Compound:9048625|FD-Score:3.08|P-value:4.33E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.36|P-value:1.38E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-3.33|P-value:1.51E-4 ID:SGTC_2965|Compound:9082772|FD-Score:2.98|P-value:6.15E-4 ID:SGTC_3098|Compound:9119039|FD-Score:2.91|P-value:7.99E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.78|P-value:2.10E-5 ID:SGTC_3289|Compound:9119912|FD-Score:3.23|P-value:2.37E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.94|P-value:9.93E-6 ID:SGTC_3325|Compound:9138760|FD-Score:2.95|P-value:7.00E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-5.78|P-value:1.87E-10

Top fitness defect scores for YJL068C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_676 falcarinol 5.56 140.0 µM 8.62E-10 20 1.36E-8
2 SGTC_1927 st060202 4.93 13.8 µM 4.58E-8 12 4.06E-7
3 SGTC_319 1348-1596 4.92 45.5 µM 4.81E-8 RSC & ERG11 8 4.23E-7
4 SGTC_2519 cryptotanshinone 4.89 88.0 µM 5.80E-8 heme biosynthesis & mitochondrial translocase 5 4.98E-7
5 SGTC_1676 st018489 4.86 23.4 µM 6.91E-8 60S ribosome export 14 5.78E-7
6 SGTC_395 anisomycin 4.46 6.2 µM 6.75E-7 7 4.08E-6
7 SGTC_1921 5740136 4.25 50.0 µM 2.04E-6 TRP & mitochondrial translation 46 1.05E-5
8 SGTC_2851 9015922 3.99 71.4 µM 7.62E-6 37 3.26E-5
9 SGTC_2313 7726885 3.96 200.0 µM 8.75E-6 RPP1 & pyrimidine depletion 32 3.67E-5
10 SGTC_453 enantio-paf c16 3.91 10.0 µM 1.14E-5 145 4.59E-5
11 SGTC_2453 5731132 3.84 22.2 µM 1.63E-5 24 6.27E-5
12 SGTC_443 clozapine 3.81 122.0 µM 1.82E-5 NEO1-PIK1 13 6.89E-5
13 SGTC_321 4534-3890 3.69 65.3 µM 3.27E-5 RPP1 & pyrimidine depletion 7 1.14E-4
14 SGTC_418 lividomycin a 3.53 100.0 µM 6.57E-5 18 2.07E-4
15 SGTC_1925 st057770 3.44 10.1 µM 9.86E-5 TSC3-RPN4 33 2.94E-4
16 SGTC_1920 st075728 3.36 45.7 µM 1.34E-4 49 3.83E-4
17 SGTC_2896 9052656 3.36 71.4 µM 1.38E-4 endomembrane recycling 162 3.93E-4
18 SGTC_1388 3346-4487 3.33 254.0 µM 1.58E-4 46 4.41E-4
19 SGTC_3289 9119912 3.23 71.4 µM 2.37E-4 37 6.25E-4
20 SGTC_1805 st050013 3.16 60.3 µM 3.08E-4 21 7.83E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.242 5.77E-46 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.226 5.24E-40 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.185 3.97E-27 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.182 3.18E-26 YLL046C RNP1 hom Ribonucleoprotein that contains two RNA recognition motifs (RRM)
0.177 5.82E-25 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.166 3.05E-22 YDL012C YDL012C hom Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication
0.160 1.05E-20 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.159 2.58E-20 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.157 5.53E-20 YER049W TPA1 hom Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate
0.156 1.27E-19 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.154 2.66E-19 YML084W_d YML084W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.154 3.23E-19 YOR082C_d YOR082C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
0.153 4.80E-19 YDR110W FOB1 hom Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
0.153 5.69E-19 YNL097C-B_p YNL097C-B_p hom Putative protein of unknown function
0.152 8.92E-19 YOR010C TIR2 hom Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis